iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mga-060011

UUCD1 version

UUC-MeG-00865

Ensembl Protein ID

ENSMGAP00000019311.1

UniProt Accession

G3UU62; G3UU62_MELGA

Protein Name

Uncharacterized protein

Gene Name

USP28

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMGAG00000002883.2	ENSMGAT00000018299.1	ENSMGAP00000019311.1
ENSMGAG00000002883.2	ENSMGAT00000003237.2	ENSMGAP00000002557.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	2.00e-60	204.5	141	636

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle.....kkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeef 84
           +G+kN+gNtC++ +v+Q+L+++p++r+l+l+     +  e+++ +   +++ +++++lq lf+ ++ +++k v+p++ l+ l+++ ++ 
   Q: 141  VGMKNIGNTCWFSAVIQSLFQLPQFRRLVLSysfppSVLESCRTR-TGKRNIAFMQELQCLFALMLGTRRKFVDPSAALELLRDAFKS- 227
           6*******************************8887777777766.489999*******************************99998. PP
   S: 85   sgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldls 173
           ++ +qqD++Ef++ lld le++++          +        + +++++  k+++++++lF g++ ++ +    +n+ s+ e+f +++
   Q: 228  TEEQQQDVSEFTHKLLDWLEDAFQL---------TV-------NVKNRSPGDKSENPMVQLFYGTFLTEGVH--EGNTFSKIETFGQYP 298
           789********************22.........22.......235688999***************99887..6788899******** PP
   S: 174  lpvpgkeetkkeslqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdls 262
           l+v+g +     +l++cLe  + e e+++      e+ +++++ +++ +++klP+vL+++L+Rf+f+++ +++eki++k+efp+++ ++
   Q: 299  LQVNGYR-----NLNECLEGAMVEGEMDE------ETATQSVKYVQERWFTKLPPVLTFELSRFEFNQSLGQPEKIHTKLEFPQTIYMD 376
           *******.....9*****98888888876......5667777788899*************************************9999 PP
   S: 263  p..fcts.................................................................................. 267
           +  +c++                                                                                  
   Q: 377  RylYCSKeliqtkreelkklkekmlilqqklerymkygsgparfplpdmlqyvlefittkpagavssacissnedsqmmdrqsqgesli 465
           85567778888877777777777777777777777777777777777777777777777777777777766666666666555555555 PP
   S: 268  .............peekqke..................................................................... 274
                        +     +                                                                     
   Q: 466  lgtpsqpdsmldgK-----Dgkpedeavllansstqqqlntplqpsappaemldcpaphvvseeemnlvttclqrwrneieqdvrdlke 549
           55555555555550.....0555555555555555556667777777777777777777777777778888888888888888888888 PP
   S: 275  ...................kkkYeLiavvvHsGslssGHYvayvknekgk.WllfdDskVtevkeeevleetg.....staYvlfYk 336
                              ++ Y L+av+vH+G+++ GHY+a+++++ +k Wl+++D +Vte+++ee ++++      ++aY+l+Y 
   Q: 550  siarvslsidemycdphlqQVPYHLHAVLVHEGQANAGHYWAFIYDQPRKsWLKYNDISVTESSWEELERDSFgglrnASAYCLMYI 636
           8888999999999999998***************************77667*******************8779************6 PP

Organism

Meleagris gallopavo

Protein Sequence
(Fasta)

QVLNKMKEIT GIQDADFLHA ALKAAKGNLM EALIVLTEER DQEPGQNTAA AEPSSWEGSA 60
VGKEPPQGGA AFDPEKKGDI HSAVAYRQLE SPKAHAAERL VELPQEVHSP ENKNRSKRKR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGATTACCAG GTTTTAAACA AGATGAAAGA GATAACAGGA ATTCAGGATG CAGATTTCCT 60
TCACGCTGCT CTCAAGGTTT GTATGTGCTG TCACTGCCCT TTTGAAAGAA GGCTGCTGAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR001394--Peptidase_C19_UCH
IPR009060--UBA-like
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH

Gene Ontology

GO:0016604--C:nuclear body
GO:0043234--C:protein complex
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008283--P:cell proliferation
GO:0034644--P:cellular response to UV
GO:0000077--P:DNA damage checkpoint
GO:0042771--P:intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0016579--P:protein deubiquitination
GO:0007265--P:Ras protein signal transduction
GO:0031647--P:regulation of protein stability
GO:0010212--P:response to ionizing radiation
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001836	Ailuropoda melanoleuca	67.44	0.00e+00	1430.00
IUUC-Apl-004010	Anas platyrhynchos	83.26	0.00e+00	1820.00
IUUC-Aca-004741	Anolis carolinensis	59.87	0.00e+00	860.00
IUUC-Bta-013377	Bos taurus	67.23	0.00e+00	1388.00
IUUC-Cel-018346	Caenorhabditis elegans	28.81	4.00e-29	123.00
IUUC-Cja-019977	Callithrix jacchus	67.95	0.00e+00	1424.00
IUUC-Cfa-020378	Canis familiaris	63.70	0.00e+00	926.00
IUUC-Cpo-021817	Cavia porcellus	67.16	0.00e+00	1407.00
IUUC-Csa-023446	Chlorocebus sabaeus	63.68	0.00e+00	918.00
IUUC-Cho-024717	Choloepus hoffmanni	59.47	7.00e-176	610.00
IUUC-Dno-029559	Dasypus novemcinctus	66.06	0.00e+00	1103.00
IUUC-Dor-030955	Dipodomys ordii	65.24	0.00e+00	1350.00
IUUC-Ete-032828	Echinops telfairi	63.87	0.00e+00	887.00
IUUC-Eca-034300	Equus caballus	67.64	0.00e+00	1392.00
IUUC-Eeu-034458	Erinaceus europaeus	64.49	0.00e+00	1214.00
IUUC-Fca-035753	Felis catus	67.85	0.00e+00	1426.00
IUUC-Fal-037062	Ficedula albicollis	73.32	0.00e+00	1045.00
IUUC-Gmo-039593	Gadus morhua	51.53	0.00e+00	1009.00
IUUC-Gga-040878	Gallus gallus	93.82	0.00e+00	1987.00
IUUC-Gac-041867	Gasterosteus aculeatus	52.68	0.00e+00	1065.00
IUUC-Ggo-045384	Gorilla gorilla	67.85	0.00e+00	1415.00
IUUC-Hsa-046277	Homo sapiens	67.75	0.00e+00	1414.00
IUUC-Itr-048276	Ictidomys tridecemlineatus	62.36	0.00e+00	810.00
IUUC-Lch-049692	Latimeria chalumnae	61.74	0.00e+00	1292.00
IUUC-Laf-053808	Loxodonta africana	61.77	0.00e+00	1278.00
IUUC-Mcc-055473	Macaca mulatta	63.68	0.00e+00	919.00
IUUC-Meu-056416	Macropus eugenii	57.74	0.00e+00	1129.00
IUUC-Mmr-060720	Microcebus murinus	66.32	0.00e+00	1355.00
IUUC-Mdo-061955	Monodelphis domestica	62.07	0.00e+00	1263.00
IUUC-Mmu-063870	Mus musculus	63.17	0.00e+00	1325.00
IUUC-Mpu-066454	Mustela putorius furo	63.22	0.00e+00	892.00
IUUC-Mlu-067487	Myotis lucifugus	65.01	0.00e+00	1334.00
IUUC-Nle-070044	Nomascus leucogenys	67.54	0.00e+00	1411.00
IUUC-Opr-070888	Ochotona princeps	74.10	1.00e-121	431.00
IUUC-Ocu-074523	Oryctolagus cuniculus	66.92	0.00e+00	1399.00
IUUC-Ola-086393	Oryzias latipes	53.15	0.00e+00	1069.00
IUUC-Oga-088618	Otolemur garnettii	67.20	0.00e+00	1397.00
IUUC-Oar-089848	Ovis aries	61.82	0.00e+00	1305.00
IUUC-Ptr-091630	Pan troglodytes	69.48	0.00e+00	1126.00
IUUC-Pan-092882	Papio anubis	63.29	6.00e-164	570.00
IUUC-Psi-093422	Pelodiscus sinensis	66.31	0.00e+00	1464.00
IUUC-Pma-094250	Petromyzon marinus	44.32	3.00e-63	234.00
IUUC-Pab-098337	Pongo abelii	67.85	0.00e+00	1414.00
IUUC-Pca-100901	Procavia capensis	72.40	0.00e+00	804.00
IUUC-Pva-102226	Pteropus vampyrus	63.71	0.00e+00	1230.00
IUUC-Rno-105735	Rattus norvegicus	61.01	0.00e+00	1333.00
IUUC-Sha-107489	Sarcophilus harrisii	68.19	0.00e+00	1434.00
IUUC-Tgu-116609	Taeniopygia guttata	78.52	0.00e+00	1622.00
IUUC-Tru-117807	Takifugu rubripes	52.61	0.00e+00	1057.00
IUUC-Tsy-118971	Tarsius syrichta	66.53	0.00e+00	925.00
IUUC-Tni-119983	Tetraodon nigroviridis	52.73	0.00e+00	1053.00
IUUC-Ttr-128887	Tursiops truncatus	63.81	0.00e+00	1318.00
IUUC-Vpa-130614	Vicugna pacos	68.36	0.00e+00	1101.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence