iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mpu-065726

Ensembl Protein ID

ENSMPUP00000002819.1

UniProt Accession

M3XUR9; M3XUR9_MUSPF

Genbank Protein ID

ENSMPUP00000002819

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AEYP01033806

Gene Name

WSB2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMPUG00000002848.1	ENSMPUT00000002878.1	ENSMPUP00000002819.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box	7.40e-15	54.6	366	413
E3 adaptor/Cullin RING/DCX/DWD	2.90e-32	109.3	161	194
UBD/Beta-Prp	1.40e-45	155.7	135	370

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box

   S: 1    lsklwllrseprSLqhLCRlaIrrclgsqrlkaidkLPLPksLkdYLlyed 51
           ++++w++++   SL+hLCR+a r++l+++++    +LP+Pk++k++L y++
   Q: 366  HVQFWTAPRVLSSLKHLCRKALRSFLTTYQV---LALPIPKKMKEFLTYRT 413
           689****************************...***************86 PP

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf..sd.tllvsGsdDgtikvWDlr 31
           gH+d v++l+f  s+  +lvs+s+D+t+++WDl 
   Q: 161  GHQDVVRDLSFtpSGsLILVSASRDKTLRIWDLN 194
           8***********6556779*************85 PP

UBD/Beta-Prp

   S: 24   llatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgk.ilvtgseDrtikvwdls.tgkcvhtlkghedsvlslsfspsgdklv 110
           +latg  dg ik+w+v+tg ll  lsgh++ v++++f p+g+ ilv++s+D+t+++wdl+  gk++++l+gh + v+++s+sp+ + l 
   Q: 135  ILATGLNDGQIKIWEVQTGLLLLNLSGHQDVVRDLSFTPSGSlILVSASRDKTLRIWDLNkHGKQIQVLSGHLQWVYCCSISPDCSMLC 223
           79****************************************9****************9789********************99**** PP
   S: 111  sGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtl...........tgghtdsvyslsf 188
           s+   + + +w +++++ ++  l+gh+++v +  ++pd+ llv++s+D+ v +Wd  tg+ lr l           +  h +s +s+ f
   Q: 224  SAAGEKSVFLWSMRSYTLIR-KLEGHQSSVVSCDFSPDSALLVTASYDTNVIMWDPYTGERLRLLhhtqleppvedSDVHISSLRSVCF 311
           ********************.***********************************99999999988889999888777888888888* PP
   S: 189  dsngkelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriW 249
           +++g +l+++++d+ +++w l+ ++   +  +  +n ++  f+p++  +++g+ Dg +++W
   Q: 312  SPEGLYLATVADDRLLRIWALELKT--PIAFAPMTNGLCCTFFPHGGVIATGTRDGHVQFW 370
           *********************9885..7899****************************** PP

Organism

Mustela putorius furo

Protein Sequence
(Fasta)

MMEGAPEPVI SSWPEEPLLL AELKPGRPQQ FDWKSSCETW SVAFSPDGSW FAWSQGHCIV 60
KLIPWPLEEQ FIPKGFEAKS RSSKNDTKGR GSPKEKTLDC GQIVWALAFS QWSSPPGRKL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGATGGAAG GTGCACCGGA ACCTGTGATA TCATCCTGGC CAGGTAAAAT TCATGTGACG 60
CAGTAAGTGC CAACTGGTAA TTCTCACTCA CCGTGGGAGT GACCAGGAAC TGCTGCAAAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR027295--Quinoprotein_ADH-like_fam
IPR001496--SOCS_box
IPR023294--Tachylectin2
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50225--SOCS
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF07525--SOCS_box
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00253--SOCS
SM00969--SOCS_box
SM00320--WD40

Gene Ontology

GO:0005622--C:intracellular
GO:0035556--P:intracellular signal transduction
GO:0016567--P:protein ubiquitination

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002221	Ailuropoda melanoleuca	97.50	0.00e+00	803.00
IUUC-Apl-004107	Anas platyrhynchos	68.50	3.00e-131	461.00
IUUC-Aca-004354	Anolis carolinensis	72.57	7.00e-167	579.00
IUUC-Bta-012627	Bos taurus	96.93	0.00e+00	771.00
IUUC-Cja-018897	Callithrix jacchus	94.86	0.00e+00	760.00
IUUC-Cfa-020122	Canis familiaris	96.80	0.00e+00	805.00
IUUC-Cpo-022540	Cavia porcellus	95.65	0.00e+00	773.00
IUUC-Csa-023719	Chlorocebus sabaeus	96.13	0.00e+00	772.00
IUUC-Cho-024367	Choloepus hoffmanni	96.63	4.00e-171	593.00
IUUC-Dno-029021	Dasypus novemcinctus	96.68	0.00e+00	781.00
IUUC-Dor-030321	Dipodomys ordii	95.62	0.00e+00	767.00
IUUC-Ete-032955	Echinops telfairi	95.74	0.00e+00	774.00
IUUC-Eca-033485	Equus caballus	96.93	0.00e+00	753.00
IUUC-Fca-035389	Felis catus	97.17	0.00e+00	778.00
IUUC-Fal-037184	Ficedula albicollis	84.10	3.00e-142	497.00
IUUC-Gga-041014	Gallus gallus	77.49	3.00e-175	607.00
IUUC-Ggo-045585	Gorilla gorilla	96.42	0.00e+00	781.00
IUUC-Hsa-046344	Homo sapiens	96.42	0.00e+00	780.00
IUUC-Itr-049085	Ictidomys tridecemlineatus	96.92	0.00e+00	777.00
IUUC-Lch-050131	Latimeria chalumnae	69.38	6.00e-169	586.00
IUUC-Loc-052807	Lepisosteus oculatus	51.04	4.00e-117	414.00
IUUC-Laf-053528	Loxodonta africana	96.16	0.00e+00	765.00
IUUC-Mcc-055665	Macaca mulatta	96.42	0.00e+00	780.00
IUUC-Meu-056054	Macropus eugenii	86.84	0.00e+00	686.00
IUUC-Mga-059326	Meleagris gallopavo	77.19	0.00e+00	626.00
IUUC-Mmr-060815	Microcebus murinus	95.14	0.00e+00	767.00
IUUC-Mdo-062000	Monodelphis domestica	87.65	0.00e+00	736.00
IUUC-Mmu-063927	Mus musculus	94.86	0.00e+00	766.00
IUUC-Mlu-067527	Myotis lucifugus	95.71	3.00e-116	410.00
IUUC-Nle-069680	Nomascus leucogenys	96.42	0.00e+00	773.00
IUUC-Opr-070356	Ochotona princeps	96.24	0.00e+00	786.00
IUUC-Oan-073647	Ornithorhynchus anatinus	83.58	2.00e-135	475.00
IUUC-Ocu-073973	Oryctolagus cuniculus	95.14	0.00e+00	766.00
IUUC-Oga-088797	Otolemur garnettii	95.92	0.00e+00	771.00
IUUC-Oar-089187	Ovis aries	96.93	0.00e+00	772.00
IUUC-Ptr-091317	Pan troglodytes	96.42	0.00e+00	780.00
IUUC-Pan-092694	Papio anubis	88.31	0.00e+00	670.00
IUUC-Psi-093392	Pelodiscus sinensis	80.15	0.00e+00	640.00
IUUC-Pab-098145	Pongo abelii	96.13	0.00e+00	772.00
IUUC-Pca-100454	Procavia capensis	87.72	0.00e+00	709.00
IUUC-Pva-102986	Pteropus vampyrus	88.47	0.00e+00	711.00
IUUC-Rno-104931	Rattus norvegicus	94.33	0.00e+00	759.00
IUUC-Sha-106476	Sarcophilus harrisii	90.75	0.00e+00	734.00
IUUC-Ssc-115643	Sus scrofa	97.42	0.00e+00	778.00
IUUC-Tgu-117522	Taeniopygia guttata	64.27	1.00e-135	476.00
IUUC-Tsy-119301	Tarsius syrichta	96.74	0.00e+00	795.00
IUUC-Ttr-128683	Tursiops truncatus	97.42	0.00e+00	778.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence