iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Bta-012503

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Suppressor of cytokine signaling 4

Genbank Nucleotide ID

BC120292

Gene Name

SOCS4

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSBTAG00000021988.2	ENSBTAT00000029320.2	ENSBTAP00000029320.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box	4.80e-17	61.7	378	425

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box

   S: 3    klwllrseprSLqhLCRlaIrrclgsqrlkaidkLPLPksLkdYLlyedyq 53
           +++l+r+ p+SLqh+CR +I++c++++++   d+LP+P+s+k YL++++y+
   Q: 378  STPLIRTFPFSLQHICRTVICNCTTYDGI---DALPIPSSMKLYLKEYHYK 425
           678899***********************...****************985 PP

Organism

Bos taurus

Functional Description
(View)

SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. Substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Inhibits EGF signaling by mediating the degradation of the Tyr-phosphorylated EGF receptor/EGFR (By similarity).

Protein Sequence
(Fasta)

MAENSESNSK NVDVRPKTSR SRSADRKDGY VWSGKKLSWS KKSESCSDAE TVSAIEKTEV 60
PLRSQERKHS CSSIELDLDH SCGHRFLGRS LKQKLQDAVG QCFPIKNCSS RHSSGLPSKR 120

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Nucleotide Sequence
(Fasta)

AGAAAGGGAG GGAGCCGAAC ACGGAAGTGG TGGCAGTGCC GGCGGAGCAG GTGGAGGCGG 60
TGAGTGCGAT GTCTGCGATG AGAACCCGGC ACCTCAGGAT GGGGGCTTGC AGACCGACAA 120

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Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0341--Growth regulation
KW-1185--Reference proteome
KW-0727--SH2 domain
KW-0734--Signal transduction inhibitor
KW-0833--Ubl conjugation pathway

Interpro

IPR000980--SH2
IPR028416--SOCS4
IPR022252--SOCS4/SOCS5_dom
IPR001496--SOCS_box

PROSITE

PS50001--SH2
PS50225--SOCS

Pfam

PF00017--SH2
PF12610--SOCS
PF07525--SOCS_box

SMART

SM00252--SH2
SM00253--SOCS
SM00969--SOCS_box

Gene Ontology

GO:0005737--C:cytoplasm
GO:0004860--F:protein kinase inhibitor activity
GO:0019221--P:cytokine-mediated signaling pathway
GO:0035556--P:intracellular signal transduction
GO:0042059--P:negative regulation of epidermal growth factor receptor signaling pathway
GO:0007175--P:negative regulation of epidermal growth factor-activated receptor activity
GO:0046426--P:negative regulation of JAK-STAT cascade
GO:0006469--P:negative regulation of protein kinase activity
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0016567--P:protein ubiquitination
GO:0040008--P:regulation of growth

KEGG

bta:540412

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001789	Ailuropoda melanoleuca	94.98	0.00e+00	801.00
IUUC-Apl-003839	Anas platyrhynchos	81.09	0.00e+00	651.00
IUUC-Aca-004840	Anolis carolinensis	79.50	0.00e+00	697.00
IUUC-Ame-010732	Astyanax mexicanus	79.65	2.00e-85	310.00
IUUC-Bol-016597	Brassica oleracea	29.11	1.80e-01	31.20
IUUC-Cja-019284	Callithrix jacchus	92.73	0.00e+00	781.00
IUUC-Cfa-020890	Canis familiaris	93.64	0.00e+00	793.00
IUUC-Cpo-022081	Cavia porcellus	79.15	0.00e+00	683.00
IUUC-Csa-023076	Chlorocebus sabaeus	92.27	0.00e+00	782.00
IUUC-Cho-024700	Choloepus hoffmanni	93.65	0.00e+00	830.00
IUUC-Dno-029961	Dasypus novemcinctus	94.10	0.00e+00	828.00
IUUC-Dor-030273	Dipodomys ordii	92.97	0.00e+00	791.00
IUUC-Ete-032972	Echinops telfairi	92.63	1.00e-170	592.00
IUUC-Eca-034289	Equus caballus	94.56	0.00e+00	796.00
IUUC-Eeu-035208	Erinaceus europaeus	91.72	0.00e+00	758.00
IUUC-Fal-036829	Ficedula albicollis	81.09	0.00e+00	651.00
IUUC-Gga-040725	Gallus gallus	79.04	0.00e+00	667.00
IUUC-Ggo-044886	Gorilla gorilla	93.20	0.00e+00	785.00
IUUC-Hsa-046322	Homo sapiens	92.97	0.00e+00	784.00
IUUC-Itr-048585	Ictidomys tridecemlineatus	94.48	0.00e+00	794.00
IUUC-Lch-049459	Latimeria chalumnae	58.22	4.00e-139	487.00
IUUC-Laf-053484	Loxodonta africana	94.48	0.00e+00	790.00
IUUC-Mcc-054890	Macaca mulatta	92.05	0.00e+00	781.00
IUUC-Meu-056532	Macropus eugenii	84.30	0.00e+00	649.00
IUUC-Mvi-060418	Microbotryum violaceum	32.10	1.60e-02	32.70
IUUC-Mmr-061714	Microcebus murinus	94.56	0.00e+00	792.00
IUUC-Mmu-063161	Mus musculus	87.02	0.00e+00	738.00
IUUC-Mac-064598	Musa acuminata	31.71	3.90e-01	27.70
IUUC-Mpu-066499	Mustela putorius furo	94.55	0.00e+00	818.00
IUUC-Mlu-066945	Myotis lucifugus	93.42	0.00e+00	783.00
IUUC-Nle-069976	Nomascus leucogenys	92.97	0.00e+00	783.00
IUUC-Opr-070255	Ochotona princeps	88.86	0.00e+00	767.00
IUUC-Ocu-074764	Oryctolagus cuniculus	95.01	0.00e+00	805.00
IUUC-Oga-088910	Otolemur garnettii	88.01	0.00e+00	768.00
IUUC-Oar-090330	Ovis aries	99.32	0.00e+00	834.00
IUUC-Ptr-090709	Pan troglodytes	93.20	0.00e+00	785.00
IUUC-Pan-092540	Papio anubis	92.27	0.00e+00	782.00
IUUC-Psi-093678	Pelodiscus sinensis	82.00	0.00e+00	725.00
IUUC-Pfo-097139	Poecilia formosa	80.81	4.00e-87	315.00
IUUC-Pab-097970	Pongo abelii	91.18	0.00e+00	640.00
IUUC-Pop-098820	Populus trichocarpa	41.18	1.50e-01	30.80
IUUC-Pca-100211	Procavia capensis	83.45	0.00e+00	677.00
IUUC-Rno-106014	Rattus norvegicus	84.74	0.00e+00	726.00
IUUC-Sha-106822	Sarcophilus harrisii	84.51	0.00e+00	723.00
IUUC-Ssc-115821	Sus scrofa	96.37	0.00e+00	812.00
IUUC-Tgu-117117	Taeniopygia guttata	81.32	0.00e+00	653.00
IUUC-Tsy-118979	Tarsius syrichta	96.60	5.00e-126	442.00
IUUC-Tca-121131	Theobroma cacao	30.77	2.00e-03	36.60
IUUC-Vpa-130626	Vicugna pacos	96.37	0.00e+00	820.00
IUUC-Vvi-131327	Vitis vinifera	43.24	1.00e-01	31.20
IUUC-Xtr-132138	Xenopus tropicalis	70.62	8.00e-178	616.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence