iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mdo-062177

UUCD1 version

UUC-MoD-00569

Ensembl Protein ID

ENSMODP00000013730.2

UniProt Accession

F7AQD7; F7AQD7_MONDO

Protein Name

Uncharacterized protein

Gene Name

HERC1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMODG00000010971.3	ENSMODT00000013980.3	ENSMODP00000013730.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	3.20e-93	312.9	4506	4840
E3 adaptor/Cullin RING/DCX/DWD	5.10e-18	64.6	3423	3453

Active Site

Position(s)	Description	Evidence
4809	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 6    kkrle.vefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknp.....ehlklFeflGrllgkalqdgr 86
            +r++ v++vgE + d+gGv+ ++++++++el++  + l+  s+n ++++ +n+d++l np     ehl  F+flG+l+g+a+++++
   Q: 4506 PSRAWkVKLVGEGADDAGGVFDDTITEMCQELETGVVDLLIPSPNATAEVGYNRDRFLFNPsafldEHLMQFKFLGILMGVAIRTKK 4592
           466666********************************************************************************* PP
   S: 87   lldlplsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeee..LkpgGenipVtneNke 171
           +ldl+l+++++k+l+  +l+ledleevd  ++++l++i++ ++s i+e++++ ++  ++ + ++++ ++  ++pgG++ip t +N++
   Q: 4593 PLDLHLAPMVWKQLCCIPLTLEDLEEVDLLYVQTLNSILHIEDSGITEENFHEMIPLDSFVGQSADGKMvpIIPGGNSIPLTFSNRK 4679
           *******************************************************9999887777766666**************** PP
   S: 172  eYvklvveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefss 258
           eYv++ +eyrl+e +++qv+a+reG++++ip  llsl+t+++le+++cG++ei+ve lkk  +y++ + e+++ +qwFw++leefs+
   Q: 4680 EYVERAIEYRLHE-MDRQVAAVREGMSWIIPVPLLSLLTAKQLEQMVCGMPEISVEVLKKVVRYRE-VDEQHQLVQWFWHTLEEFSN 4764
           *************.**************************************************88.******************** PP
   S: 259  eerkafLqFvTgssrlPlgGfaelkprlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           eer  f++Fv+g+srlP+ + a+++ ++f+i k d+  d+lP+s+TCf++L+LP+Yss+ i+ e+L+yAi++++++++
   Q: 4765 EERVLFMRFVSGRSRLPA-NTADIS-QRFQIMKvDRPYDSLPTSQTCFFQLRLPPYSSQLIMAERLRYAINNCRSIDM 4840
           *****************6.899999.679999956666***********************************99987 PP

E3 adaptor/Cullin RING/DCX/DWD

   S: 3    tds.vtclaf.sd.tllvsGsdDgtikvWDlr 31
           +++ +tc+ + +  +ll+++++Dgti+vW+++
   Q: 3423 QNRvMTCV-WcNKkGLLATSGNDGTIRVWNVT 3453
           55416677.*9778****************97 PP

Organism

Monodelphis domestica

Protein Sequence
(Fasta)

MAAMVPPVKL KWLEHLNSSW ITEDSESIAT REGVSVLYSK LISNKEVVLL PQQVLCLKGP 60
QLPDFERESL SSDEQDHYLD ALLTSQLALA KMVCSDSPFA GALRKRLLVL QRVFYALSNK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TATGTTGGAG GTGGGGGGTG GGGGGTGGAG GGAGGTTAGA AGGATGTTTG GGTTAGGACT 60
GAAATTGTTA ATTTTGTTTT AGTAGGTGAC TTTCACAGAT ATTTGGGATG TTTCCTCTAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0853--WD repeat

Interpro

IPR001870--B30.2/SPRY
IPR013320--ConA-like_dom
IPR000569--HECT_dom
IPR016106--Pyr-dep_his-deCO2ase_subdom
IPR009091--RCC1/BLIP-II
IPR000408--Reg_chr_condens
IPR003877--SPRY_dom
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50188--B302_SPRY
PS50237--HECT
PS00626--RCC1_2
PS50012--RCC1_3
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00632--HECT
PF00415--RCC1
PF00622--SPRY
PF00400--WD40

PRINTS

PR00633--RCCNDNSATION

SMART

SM00119--HECTc
SM00449--SPRY
SM00320--WD40

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity
GO:0021702--P:cerebellar Purkinje cell differentiation
GO:0010507--P:negative regulation of autophagy
GO:0050885--P:neuromuscular process controlling balance
GO:0031175--P:neuron projection development

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001830	Ailuropoda melanoleuca	92.30	0.00e+00	8324.00
IUUC-Apl-003461	Anas platyrhynchos	91.17	0.00e+00	8196.00
IUUC-Aca-004452	Anolis carolinensis	83.41	0.00e+00	7248.00
IUUC-Aly-006545	Arabidopsis lyrata	36.36	2.00e-48	188.00
IUUC-Ame-011268	Astyanax mexicanus	60.46	0.00e+00	2235.00
IUUC-Bta-013213	Bos taurus	92.85	0.00e+00	8325.00
IUUC-Bdi-014791	Brachypodium distachyon	34.69	3.00e-52	199.00
IUUC-Bra-017584	Brassica rapa	34.46	5.00e-50	193.00
IUUC-Cja-019298	Callithrix jacchus	92.46	0.00e+00	8346.00
IUUC-Cfa-021213	Canis familiaris	92.42	0.00e+00	8398.00
IUUC-Cpo-021674	Cavia porcellus	92.81	0.00e+00	5729.00
IUUC-Csa-023341	Chlorocebus sabaeus	92.07	0.00e+00	8302.00
IUUC-Cho-024567	Choloepus hoffmanni	92.58	0.00e+00	1740.00
IUUC-Dre-028289	Danio rerio	78.09	0.00e+00	6951.00
IUUC-Dno-029988	Dasypus novemcinctus	91.93	0.00e+00	8270.00
IUUC-Dor-030636	Dipodomys ordii	92.04	0.00e+00	2105.00
IUUC-Ete-032598	Echinops telfairi	83.91	0.00e+00	1360.00
IUUC-Eca-033754	Equus caballus	92.28	0.00e+00	8315.00
IUUC-Eeu-034702	Erinaceus europaeus	88.65	0.00e+00	1451.00
IUUC-Fca-035900	Felis catus	92.81	0.00e+00	8373.00
IUUC-Fal-037034	Ficedula albicollis	88.70	0.00e+00	6997.00
IUUC-Gmo-038634	Gadus morhua	91.32	0.00e+00	1221.00
IUUC-Gga-040321	Gallus gallus	90.82	0.00e+00	8225.00
IUUC-Gac-042444	Gasterosteus aculeatus	57.48	0.00e+00	2242.00
IUUC-Gma-043808	Glycine max	33.42	2.00e-46	181.00
IUUC-Ggo-045134	Gorilla gorilla	93.81	0.00e+00	3340.00
IUUC-Hsa-046516	Homo sapiens	92.36	0.00e+00	8311.00
IUUC-Itr-048914	Ictidomys tridecemlineatus	94.75	0.00e+00	2509.00
IUUC-Lch-049903	Latimeria chalumnae	85.53	0.00e+00	7727.00
IUUC-Lpe-051165	Leersia perrieri	34.33	2.00e-49	189.00
IUUC-Loc-052149	Lepisosteus oculatus	82.99	0.00e+00	7370.00
IUUC-Laf-053426	Loxodonta africana	92.17	0.00e+00	8353.00
IUUC-Mcc-055826	Macaca mulatta	92.38	0.00e+00	8352.00
IUUC-Meu-056521	Macropus eugenii	87.50	0.00e+00	2301.00
IUUC-Mga-059567	Meleagris gallopavo	91.87	0.00e+00	1961.00
IUUC-Mmr-061512	Microcebus murinus	92.03	0.00e+00	8232.00
IUUC-Mmu-064373	Mus musculus	92.33	0.00e+00	8301.00
IUUC-Mpu-066148	Mustela putorius furo	92.25	0.00e+00	8321.00
IUUC-Mlu-067680	Myotis lucifugus	92.13	0.00e+00	8276.00
IUUC-Nle-069633	Nomascus leucogenys	92.13	0.00e+00	8248.00
IUUC-Opr-070609	Ochotona princeps	90.37	0.00e+00	1382.00
IUUC-Ont-071249	Oreochromis niloticus	79.71	0.00e+00	7294.00
IUUC-Oan-073157	Ornithorhynchus anatinus	91.93	0.00e+00	8197.00
IUUC-Ocu-074841	Oryctolagus cuniculus	92.19	0.00e+00	8360.00
IUUC-Oba-075262	Oryza barthii	34.55	6.00e-48	184.00
IUUC-Obr-076115	Oryza brachyantha	36.63	3.00e-48	186.00
IUUC-Ogl-077586	Oryza glaberrima	34.55	6.00e-48	185.00
IUUC-Ogu-078796	Oryza glumaepatula	34.34	6.00e-48	184.00
IUUC-Oin-079298	Oryza indica	34.34	6.00e-48	184.00
IUUC-Olo-080768	Oryza longistaminata	34.78	3.00e-53	202.00
IUUC-Ome-081908	Oryza meridionalis	34.15	1.00e-47	184.00
IUUC-Oni-082049	Oryza nivara	34.34	6.00e-48	184.00
IUUC-Opu-083608	Oryza punctata	33.92	1.00e-48	187.00
IUUC-Oru-084712	Oryza rufipogon	34.34	6.00e-48	184.00
IUUC-Osa-086078	Oryza sativa	34.34	6.00e-48	184.00
IUUC-Ola-086889	Oryzias latipes	78.20	0.00e+00	7120.00
IUUC-Oga-088459	Otolemur garnettii	92.56	0.00e+00	8288.00
IUUC-Oar-089888	Ovis aries	92.85	0.00e+00	8307.00
IUUC-Ptr-091114	Pan troglodytes	92.36	0.00e+00	8337.00
IUUC-Pan-092442	Papio anubis	92.25	0.00e+00	8328.00
IUUC-Psi-093833	Pelodiscus sinensis	92.10	0.00e+00	5504.00
IUUC-Pma-094275	Petromyzon marinus	74.90	0.00e+00	1618.00
IUUC-Ppa-095790	Physcomitrella patens	36.17	1.00e-54	207.00
IUUC-Pfo-097262	Poecilia formosa	78.66	0.00e+00	7008.00
IUUC-Pab-097760	Pongo abelii	93.62	0.00e+00	4797.00
IUUC-Pop-099121	Populus trichocarpa	36.63	7.00e-52	199.00
IUUC-Pca-100465	Procavia capensis	93.27	0.00e+00	4465.00
IUUC-Ppe-101345	Prunus persica	33.76	6.00e-52	199.00
IUUC-Pva-102950	Pteropus vampyrus	89.78	0.00e+00	3844.00
IUUC-Rno-104892	Rattus norvegicus	91.96	0.00e+00	8213.00
IUUC-Sha-106633	Sarcophilus harrisii	94.29	0.00e+00	8336.00
IUUC-Smo-108827	Selaginella moellendorffii	35.40	4.00e-52	200.00
IUUC-Sit-110415	Setaria italica	35.86	1.00e-52	200.00
IUUC-Sly-111155	Solanum lycopersicum	37.10	3.00e-53	203.00
IUUC-Stu-112166	Solanum tuberosum	31.71	6.00e-49	189.00
IUUC-Sar-113251	Sorex araneus	84.67	0.00e+00	2421.00
IUUC-Ssc-116391	Sus scrofa	92.48	0.00e+00	8358.00
IUUC-Tgu-116554	Taeniopygia guttata	90.23	0.00e+00	8143.00
IUUC-Tru-118695	Takifugu rubripes	79.29	0.00e+00	7253.00
IUUC-Tsy-119647	Tarsius syrichta	84.92	0.00e+00	5229.00
IUUC-Tni-120707	Tetraodon nigroviridis	79.21	0.00e+00	7222.00
IUUC-Tbe-127346	Tupaia belangeri	86.40	0.00e+00	2516.00
IUUC-Ttr-128542	Tursiops truncatus	87.51	0.00e+00	5511.00
IUUC-Vpa-130611	Vicugna pacos	90.63	0.00e+00	3720.00
IUUC-Xtr-131933	Xenopus tropicalis	83.06	0.00e+00	7479.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence