iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Bta-013241

Ensembl Protein ID

ENSBTAP00000027887.4

UniProt Accession

Q6E804; NOD2_BOVIN

Genbank Protein ID

AAS09824.1; AAS09826.1; AAS09826.1; AAS09826.1; AAS09826.1; AAS09826.1; AAS09826.1; AAS09826.1; AAS09826.1; AAS09826.1; AAS09826.1

Protein Name

Nucleotide-binding oligomerization domain-containing protein 2; Caspase recruitment domain-containing protein 15

Genbank Nucleotide ID

AY518737; AY518748; AY518739; AY518740; AY518741; AY518742; AY518743; AY518744; AY518745; AY518746; AY518747

Gene Name

CARD15; NOD2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSBTAG00000020936.4	ENSBTAT00000027887.4	ENSBTAP00000027887.4

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/CARD	1.90e-14	54.1	140	199

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/CARD

   S: 2    deeyrlllstlqdrvrklLdvtdvldkylseflleeekelilaaaetkgnmqaaelLLktL 62
           ++e+r++++t ++r+r+lLd+++v++++l++fll+  +el+++ a + ++++++ + ++ L
   Q: 140  TDEIRRPIFTSSQRARRLLDLATVKANGLAAFLLQCIQELPVPLALPFEDAACK-KYVSKL 199
           59***************************************************9.777766 PP

Organism

Bos taurus

Functional Description
(View)

Involved in gastrointestinal immunity. Upon stimulation by muramyl dipeptide (MDP), a fragment of bacterial peptidoglycan, binds the proximal adapter receptor-interacting RIPK2, which recruits ubiquitin ligases as XIAP, BIRC2, BIRC3 and the LUBAC complex, triggering activation of MAP kinases and activation of NF-kappa-B signaling. This in turn leads to the transcriptional activation of hundreds of genes involved in immune response. Required for MDP-induced NLRP1-dependent CASP1 activation and IL1B release in macrophages.

Protein Sequence
(Fasta)

MCAQDAFQTQ RSQLVELLVS GSLEGFESIL DRLLSREVLS WEDYEGLSLV GQPISHLARR 60
LLDTIWNKGT WGCEQLTAAV REAQADSQPP ELPSSWDPHS PHPARDLQSH RPAIVRRLYG 120

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Nucleotide Sequence
(Fasta)

CTCTGGACTC CGTGACCATC ACAGGAGGGA ACCTGCTGAG AGATTTCCTC TGCTGCGTGG 60
GGACCCTGCC AGGGCTTGGA GCTCTGTGAG ATCGCTTCCC ACGGACTCCC AGGACCCAGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0391--Immunity
KW-0399--Innate immunity
KW-0433--Leucine-rich repeat
KW-0472--Membrane
KW-0547--Nucleotide-binding
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0832--Ubl conjugation

Interpro

IPR001315--CARD
IPR011029--DEATH-like_dom
IPR001611--Leu-rich_rpt
IPR007111--NACHT_NTPase
IPR027417--P-loop_NTPase

PROSITE

PS50209--CARD
PS51450--LRR
PS50837--NACHT

Pfam

PF00619--CARD
PF13516--LRR_6

Gene Ontology

GO:0016323--C:basolateral plasma membrane
GO:0009986--C:cell surface
GO:0008180--C:COP9 signalosome
GO:0005737--C:cytoplasm
GO:0005856--C:cytoskeleton
GO:0005829--C:cytosol
GO:0005794--C:Golgi apparatus
GO:0043234--C:protein complex
GO:0031982--C:vesicle
GO:0005524--F:ATP binding
GO:0032500--F:muramyl dipeptide binding
GO:0042834--F:peptidoglycan binding
GO:0071225--P:cellular response to muramyl dipeptide
GO:0002374--P:cytokine secretion involved in immune response
GO:0042742--P:defense response to bacterium
GO:0016045--P:detection of bacterium
GO:0032498--P:detection of muramyl dipeptide
GO:0045087--P:innate immune response
GO:0030277--P:maintenance of gastrointestinal epithelium
GO:0070431--P:nucleotide-binding oligomerization domain containing 2 signaling pathway
GO:0050871--P:positive regulation of B cell activation
GO:1900017--P:positive regulation of cytokine production involved in inflammatory response
GO:0046645--P:positive regulation of gamma-delta T cell activation
GO:0043123--P:positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0050718--P:positive regulation of interleukin-1 beta secretion
GO:0032740--P:positive regulation of interleukin-17 production
GO:0032755--P:positive regulation of interleukin-6 production
GO:0032757--P:positive regulation of interleukin-8 production
GO:0046330--P:positive regulation of JNK cascade
GO:0051092--P:positive regulation of NF-kappaB transcription factor activity
GO:1901224--P:positive regulation of NIK/NF-kappaB signaling
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0032760--P:positive regulation of tumor necrosis factor production
GO:0002830--P:positive regulation of type 2 immune response
GO:0042981--P:regulation of apoptotic process
GO:0032495--P:response to muramyl dipeptide

KEGG

bta:444867

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000642	Aegilops tauschii	30.51	3.40e-01	28.90
IUUC-Aml-001822	Ailuropoda melanoleuca	81.34	0.00e+00	1431.00
IUUC-Ame-011021	Astyanax mexicanus	44.74	0.00e+00	843.00
IUUC-Cja-019633	Callithrix jacchus	77.48	0.00e+00	1145.00
IUUC-Cfa-020039	Canis familiaris	82.53	0.00e+00	1565.00
IUUC-Cpo-022337	Cavia porcellus	76.60	0.00e+00	1439.00
IUUC-Csa-023906	Chlorocebus sabaeus	81.54	0.00e+00	1563.00
IUUC-Dre-027568	Danio rerio	46.27	0.00e+00	803.00
IUUC-Dno-029098	Dasypus novemcinctus	79.59	0.00e+00	1413.00
IUUC-Dor-031102	Dipodomys ordii	71.58	0.00e+00	655.00
IUUC-Ete-032943	Echinops telfairi	75.24	0.00e+00	1059.00
IUUC-Eca-034310	Equus caballus	83.71	0.00e+00	1571.00
IUUC-Eeu-034589	Erinaceus europaeus	74.02	2.00e-154	540.00
IUUC-Fca-036252	Felis catus	80.18	0.00e+00	789.00
IUUC-Gac-041442	Gasterosteus aculeatus	44.99	0.00e+00	809.00
IUUC-Ggo-044861	Gorilla gorilla	81.64	0.00e+00	1511.00
IUUC-Hsa-046093	Homo sapiens	81.24	0.00e+00	1503.00
IUUC-Itr-048543	Ictidomys tridecemlineatus	79.21	0.00e+00	1401.00
IUUC-Lch-049454	Latimeria chalumnae	53.88	0.00e+00	924.00
IUUC-Laf-053553	Loxodonta africana	80.95	0.00e+00	1429.00
IUUC-Mcc-055772	Macaca mulatta	81.54	0.00e+00	1533.00
IUUC-Meu-056785	Macropus eugenii	68.55	8.00e-112	398.00
IUUC-Mmr-060596	Microcebus murinus	80.85	0.00e+00	1486.00
IUUC-Mdo-062983	Monodelphis domestica	68.26	0.00e+00	1102.00
IUUC-Mmu-063951	Mus musculus	74.30	0.00e+00	1440.00
IUUC-Mpu-066412	Mustela putorius furo	81.74	0.00e+00	1555.00
IUUC-Mlu-067601	Myotis lucifugus	79.74	0.00e+00	1401.00
IUUC-Nle-069913	Nomascus leucogenys	81.92	0.00e+00	1273.00
IUUC-Opr-070999	Ochotona princeps	78.50	0.00e+00	899.00
IUUC-Ont-072512	Oreochromis niloticus	46.11	0.00e+00	860.00
IUUC-Oan-073564	Ornithorhynchus anatinus	61.23	0.00e+00	1065.00
IUUC-Ocu-074837	Oryctolagus cuniculus	81.84	0.00e+00	1514.00
IUUC-Ola-086555	Oryzias latipes	45.52	0.00e+00	810.00
IUUC-Oga-088909	Otolemur garnettii	80.26	0.00e+00	1497.00
IUUC-Oar-089315	Ovis aries	96.06	0.00e+00	1840.00
IUUC-Ptr-090542	Pan troglodytes	81.84	0.00e+00	1514.00
IUUC-Pan-092545	Papio anubis	81.64	0.00e+00	1530.00
IUUC-Pma-094167	Petromyzon marinus	33.18	2.00e-63	236.00
IUUC-Pfo-096976	Poecilia formosa	43.23	0.00e+00	795.00
IUUC-Pab-098481	Pongo abelii	81.15	0.00e+00	1497.00
IUUC-Pca-100135	Procavia capensis	74.85	0.00e+00	1266.00
IUUC-Pva-102127	Pteropus vampyrus	80.45	0.00e+00	1406.00
IUUC-Rno-105783	Rattus norvegicus	76.16	0.00e+00	1412.00
IUUC-Sar-113448	Sorex araneus	74.57	0.00e+00	919.00
IUUC-Tru-118708	Takifugu rubripes	44.22	0.00e+00	776.00
IUUC-Tni-120172	Tetraodon nigroviridis	36.75	4.00e-33	135.00
IUUC-Tbe-127661	Tupaia belangeri	82.61	0.00e+00	793.00
IUUC-Ttr-128318	Tursiops truncatus	82.33	0.00e+00	1485.00
IUUC-Vpa-130502	Vicugna pacos	76.46	3.00e-161	562.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence