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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Sce-106156
Ensembl Protein ID YHR186C
UniProt Accession P38873; D3DLD4; KOG1_YEAST
Genbank Protein ID AAB68364.1; DAA06878.1
Protein Name Target of rapamycin complex 1 subunit KOG1; Kontroller of growth protein 1; Local anesthetic-sensitive protein 24
Genbank Nucleotide ID U00030; BK006934
Gene Name KOG1; LAS24; YHR186C; H9998.14
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
YHR186C YHR186C YHR186C
Annotation
mRNA Expression
GEOFFGED
Protein-protein Interaction
IIDiRefIndexHINTMentha
Post-translational Modifications (PTMs)
CPLMdbPAFdbPTMBioGRID
Protein Expression/Proteomics
GPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
UBD/Beta-Prp Beta-Prp 21070969
Classification
Family E-value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 7.60e-12 43.5 1404 1438
UBD/Beta-Prp 1.70e-56 190.0 1202 1551
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 5    svtclaf..sd.tllvsGsdDgtikvWDlrtgvll 36
           +++ +++   + + lvsG+ +g++ +WD+r+ +++
   Q: 1404 WINNVHLqrGGyRELVSGATNGVVELWDIRSEDPV 1438
           67777777533577***************999876 PP
   

   UBD/Beta-Prp
   S: 3    ktlkghhksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheae...vtavkfspdgk..ilvtgseDrtikvw....dlstgkcvhtlkg 92
           k ++ ++ks+ + +kf++++++l+t+ +++ti+v+d+++gk+l+++s+ +++   vt++k++++++  +l+tgs+D++ik++    d++t+k+v++++g
   Q: 1202 KLISLNNKSQPKLMKFAQFEDQLITADDRSTITVFDWEKGKTLSKFSNGTPFgtkVTDLKLINEDDsaLLLTGSSDGVIKIYrdyqDVDTFKIVSAWRG 1300
           5678899*******************************************99999********99999***************999999********** PP
   S: 93   hedsvls.......lsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdg.nllvsGslDrtvrlWdl...ktgkllrtltgght 180
            +d++l+       +++ + + +l++++++++irvwd +t+++  ++ +++++++++++ ++ + n++v+G++D+ +r++d    ++++++r+++ g++
   Q: 1301 LTDMLLTprstgllTEWLQIRGSLLTTGDVKVIRVWDAHTETVEVDIPAKTSSLITSLTADQLAgNIFVAGFADGSLRVYDRrldPRDSMIRRWRAGND 1399
           **********************************************************************************99999*******999** PP
   S: 181  dsvysls...fdsng.kelvsgsldgtvklwdlqtgecvrtlnght...........dnvksvrfspnderlvsgssDgsiriWdlrsgdllktlqlhn 264
           ++  +++   +++ g +elvsg+++g v+lwd+++++ v+++ +++           +++++++++++  ++++g+  ++i+iW ++sgdll+++++++
   Q: 1400 KQGVWINnvhLQRGGyRELVSGATNGVVELWDIRSEDPVESFVDQNvtsqygsqqkpTTMTCMQVHEHAPIIATGT--KQIKIW-TTSGDLLNSFKNSH 1495
           **99999765555559****************************999****************************9..******.9************* PP
   S: 265  ..............ssvisvav.......lsfg...dnvlvlgse..dskvniwklkk 296
                         +s++++++       +      +++++++++  ds+vni+k++ 
   Q: 1496 nngvtstlaatgipKSLSYSSTsdaflssM--AfhpHRMMIAATNshDSIVNIYKCED 1551
           888888888888884444444455555332..233566666666668********975 PP
   
Organism Saccharomyces cerevisiae
Functional Description
(View)

Functional Description


     Component of TORC1, which regulates multiple cellular processes to control cell growth in response to environmental signals. Nutrient limitation and environmental stress signals cause inactivation of TORC1. Active TORC1 positively controls ribosome biogenesis via control of rRNA, ribosomal protein and tRNA gene expression, and rRNA processing. TORC1 positively controls protein biosynthesis by regulation of mRNA stability, translation initiation factor activity, and high-affinity amino acid permeases that serve to provide amino acids for use by the translation machinery. TORC1 also promotes growth by sequestering a number of nutrient and general stress-responsive transcription factors in the cytoplasm. TORC1 negatively controls macroautophagy, a process to recycle surplus cytoplasmic mass under nutrient starvation conditions. KOG1 may have a role in binding and recruiting substrates of TORC1.
 Component of TORC1, which regulates multiple cellular processes to control cell growth in response to environmental signals. Nutrient limitation and environmental stress signals cause inactivation of TORC1. Active TORC1 positively controls ribosome biogenesis via control of rRNA, ribosomal protein and tRNA gene expression, and rRNA processing. TORC1 positively controls protein biosynthesis by regulation of mRNA stability, translation initiation factor activity, and high-affinity amino acid permeases that serve to provide amino acids for use by the translation machinery. TORC1 also promotes growth by sequestering a number of nutrient and general stress-responsive transcription factors in the cytoplasm. TORC1 negatively controls macroautophagy, a process to recycle surplus cytoplasmic mass under nutrient starvation conditions. KOG1 may have a role in binding and recruiting substrates of TORC1.
Protein Sequence
(Fasta)
MPEIYGPQPL KPLNTVMRHG FEEQYQSDQL LQSLANDFIF YFDDKRHKTN GNPIPEEDKQ 60
RDVNRYYQPI TDWKIMKDRQ KTVSAALLLC LNLGVDPPDV MKTHPCARVE AWVDPLNFQD 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Sce-106156|UBD,Beta-Prp;E3,WD_repeat|Saccharomyces cerevisiae
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ATGCCGGAGA TTTATGGACC TCAGCCATTA AAGCCACTCA ATACGGTGAT GAGACATGGG 60
TTTGAAGAGC AATACCAAAG TGACCAACTT TTACAATCAC TCGCGAATGA TTTCATATTC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Sce-106156|UBD,Beta-Prp;E3,WD_repeat|Saccharomyces cerevisiae
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0472--Membrane
KW-1185--Reference proteome
KW-0677--Repeat
KW-0926--Vacuole
KW-0853--WD repeat
Interpro

IPR011989--ARM-like
IPR016024--ARM-type_fold
IPR029030--Caspase-like_dom
IPR000357--HEAT
IPR004083--Raptor
IPR029347--Raptor_N
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF02985--HEAT
PF14538--Raptor_N
SMART

SM01302--Raptor_N
SM00320--WD40
Gene Ontology

GO:0010494--C:cytoplasmic stress granule
GO:0000329--C:fungal-type vacuole membrane
GO:0005886--C:plasma membrane
GO:0031931--C:TORC1 complex
GO:0030674--F:protein binding, bridging
GO:0043130--F:ubiquitin binding
GO:0071230--P:cellular response to amino acid stimulus
GO:0009267--P:cellular response to starvation
GO:0030307--P:positive regulation of cell growth
GO:0071902--P:positive regulation of protein serine/threonine kinase activity
GO:0010506--P:regulation of autophagy
GO:0001558--P:regulation of cell growth
GO:0008361--P:regulation of cell size
GO:0031929--P:TOR signaling
KEGG sce:YHR186C
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000354 Aegilops tauschii 46.06 3.00e-77 281.00
IUUC-Aml-001499 Ailuropoda melanoleuca 55.88 2.00e-120 425.00
IUUC-Atr-002704 Amborella trichopoda 43.72 6.00e-97 347.00
IUUC-Apl-003540 Anas platyrhynchos 55.61 2.00e-120 425.00
IUUC-Aca-004449 Anolis carolinensis 51.48 7.00e-89 319.00
IUUC-Aly-006524 Arabidopsis lyrata 46.59 1.00e-96 346.00
IUUC-Ath-007242 Arabidopsis thaliana 46.59 3.00e-96 345.00
IUUC-Ago-007709 Ashbya gossypii 69.05 0.00e+00 1153.00
IUUC-Acl-008215 Aspergillus clavatus 55.90 4.00e-136 477.00
IUUC-Afl-008401 Aspergillus flavus 55.63 2.00e-136 478.00
IUUC-Afu-008797 Aspergillus fumigatus 55.40 6.00e-136 477.00
IUUC-Ani-009268 Aspergillus nidulans 55.32 2.00e-135 475.00
IUUC-Ang-009608 Aspergillus niger 55.56 8.00e-133 466.00
IUUC-Aor-009894 Aspergillus oryzae 55.63 2.00e-136 478.00
IUUC-Ate-010357 Aspergillus terreus 55.16 2.00e-135 475.00
IUUC-Ame-011186 Astyanax mexicanus 54.15 2.00e-100 358.00
IUUC-Bgr-012085 Blumeria graminis 37.08 3.00e-125 441.00
IUUC-Bta-013422 Bos taurus 55.88 2.00e-120 425.00
IUUC-Bci-013736 Botrytis cinerea 54.65 5.00e-129 454.00
IUUC-Bdi-015042 Brachypodium distachyon 44.82 4.00e-80 291.00
IUUC-Bol-016048 Brassica oleracea 46.98 3.00e-97 348.00
IUUC-Bra-016961 Brassica rapa 46.98 1.00e-97 350.00
IUUC-Cel-018321 Caenorhabditis elegans 43.90 5.00e-70 258.00
IUUC-Cja-018939 Callithrix jacchus 55.61 3.00e-120 424.00
IUUC-Cfa-020898 Canis familiaris 55.88 1.00e-120 426.00
IUUC-Cpo-021514 Cavia porcellus 55.61 2.00e-120 425.00
IUUC-Cre-022818 Chlamydomonas reinhardtii 49.20 2.00e-87 313.00
IUUC-Csa-023314 Chlorocebus sabaeus 55.61 3.00e-120 424.00
IUUC-Cin-025701 Ciona intestinalis 56.32 1.00e-118 419.00
IUUC-Csv-026362 Ciona savignyi 54.88 3.00e-119 420.00
IUUC-Cgl-026561 Colletotrichum gloeosporioides 53.81 6.00e-123 433.00
IUUC-Cne-027009 Cryptococcus neoformans 52.83 8.00e-120 423.00
IUUC-Cme-027253 Cyanidioschyzon merolae 41.81 2.00e-99 355.00
IUUC-Dre-028485 Danio rerio 55.88 1.00e-120 426.00
IUUC-Dno-029901 Dasypus novemcinctus 53.95 2.00e-93 335.00
IUUC-Dor-030140 Dipodomys ordii 53.54 6.00e-99 353.00
IUUC-Dse-031462 Dothistroma septosporum 42.86 2.00e-177 614.00
IUUC-Dme-031670 Drosophila melanogaster 46.55 2.00e-103 369.00
IUUC-Ete-032578 Echinops telfairi 63.58 1.00e-62 233.00
IUUC-Eca-034076 Equus caballus 55.61 5.00e-120 424.00
IUUC-Eeu-035140 Erinaceus europaeus 55.74 2.00e-117 415.00
IUUC-Fca-035651 Felis catus 55.88 1.00e-120 426.00
IUUC-Fal-037244 Ficedula albicollis 55.35 2.00e-119 421.00
IUUC-Fox-037742 Fusarium oxysporum 51.07 1.00e-117 416.00
IUUC-Fso-038369 Fusarium solani 54.18 5.00e-128 450.00
IUUC-Gmo-039007 Gadus morhua 30.97 3.00e-46 178.00
IUUC-Ggr-039836 Gaeumannomyces graminis 52.31 1.00e-129 456.00
IUUC-Gga-041121 Gallus gallus 55.61 2.00e-120 425.00
IUUC-Gac-041430 Gasterosteus aculeatus 55.35 7.00e-120 423.00
IUUC-Gma-042942 Glycine max 47.41 1.00e-96 346.00
IUUC-Ggo-044934 Gorilla gorilla 55.46 2.00e-117 414.00
IUUC-Hsa-045887 Homo sapiens 55.61 2.00e-120 425.00
IUUC-Hvu-047823 Hordeum vulgare 47.41 7.00e-96 343.00
IUUC-Itr-048274 Ictidomys tridecemlineatus 71.13 3.00e-37 147.00
IUUC-Kpa-049399 Komagataella pastoris 55.67 0.00e+00 877.00
IUUC-Lch-050405 Latimeria chalumnae 55.09 3.00e-120 424.00
IUUC-Lpe-050864 Leersia perrieri 46.87 5.00e-97 346.00
IUUC-Loc-051868 Lepisosteus oculatus 55.61 4.00e-120 424.00
IUUC-Lma-052993 Leptosphaeria maculans 51.06 3.00e-128 451.00
IUUC-Laf-053339 Loxodonta africana 55.88 1.00e-120 425.00
IUUC-Mcc-055591 Macaca mulatta 55.61 3.00e-120 424.00
IUUC-Meu-056642 Macropus eugenii 54.62 3.00e-115 408.00
IUUC-Mor-057204 Magnaporthe oryzae 53.76 3.00e-129 454.00
IUUC-Mpo-057532 Magnaporthe poae 53.00 3.00e-124 437.00
IUUC-Mtr-058553 Medicago truncatula 44.19 2.00e-97 348.00
IUUC-Mla-058907 Melampsora laricipopulina 40.68 4.00e-95 341.00
IUUC-Mga-059256 Meleagris gallopavo 55.61 1.00e-120 426.00
IUUC-Mvi-060457 Microbotryum violaceum 47.20 2.00e-120 425.00
IUUC-Mmr-060874 Microcebus murinus 55.61 6.00e-120 423.00
IUUC-Mdo-062436 Monodelphis domestica 55.61 1.00e-119 422.00
IUUC-Mmu-063264 Mus musculus 55.61 3.00e-120 424.00
IUUC-Mac-065524 Musa acuminata 47.84 7.00e-99 353.00
IUUC-Mpu-065899 Mustela putorius furo 54.15 4.00e-100 357.00
IUUC-Mlu-067344 Myotis lucifugus 50.51 1.00e-49 189.00
IUUC-Nfi-068615 Neosartorya fischeri 55.40 5.00e-136 477.00
IUUC-Ncr-068744 Neurospora crassa 54.59 2.00e-132 465.00
IUUC-Nle-069014 Nomascus leucogenys 55.61 3.00e-120 424.00
IUUC-Opr-070548 Ochotona princeps 52.12 2.00e-83 302.00
IUUC-Ont-072485 Oreochromis niloticus 55.61 5.00e-120 424.00
IUUC-Oan-073253 Ornithorhynchus anatinus 36.61 1.00e-44 171.00
IUUC-Ocu-074290 Oryctolagus cuniculus 32.96 9.00e-23 99.40
IUUC-Oba-075130 Oryza barthii 47.75 1.00e-93 336.00
IUUC-Obr-076161 Oryza brachyantha 47.68 2.00e-96 345.00
IUUC-Ogl-077800 Oryza glaberrima 47.55 8.00e-97 347.00
IUUC-Ogu-078292 Oryza glumaepatula 55.17 1.00e-35 141.00
IUUC-Oin-080126 Oryza indica 48.34 3.00e-88 319.00
IUUC-Olo-080598 Oryza longistaminata 35.09 3.00e-08 51.20
IUUC-Ome-081293 Oryza meridionalis 46.89 3.00e-40 159.00
IUUC-Oni-082236 Oryza nivara 47.60 6.00e-62 231.00
IUUC-Opu-083423 Oryza punctata 47.41 2.00e-95 342.00
IUUC-Oru-085086 Oryza rufipogon 47.77 3.00e-94 338.00
IUUC-Osa-086012 Oryza sativa 47.09 3.00e-89 322.00
IUUC-Ola-086662 Oryzias latipes 49.61 3.00e-66 245.00
IUUC-Olu-087760 Ostreococcus lucimarinus 47.22 1.00e-104 373.00
IUUC-Oga-088053 Otolemur garnettii 53.85 2.00e-100 358.00
IUUC-Oar-089466 Ovis aries 55.88 2.00e-120 425.00
IUUC-Ptr-090868 Pan troglodytes 55.61 3.00e-120 424.00
IUUC-Pan-092259 Papio anubis 55.61 3.00e-120 424.00
IUUC-Psi-093641 Pelodiscus sinensis 53.21 6.00e-95 340.00
IUUC-Pno-094789 Phaeosphaeria nodorum 46.70 4.00e-116 410.00
IUUC-Ppa-095973 Physcomitrella patens 48.85 3.00e-105 374.00
IUUC-Pfo-096837 Poecilia formosa 51.72 3.00e-119 421.00
IUUC-Pab-097545 Pongo abelii 37.50 1.00e-37 149.00
IUUC-Pop-099209 Populus trichocarpa 47.68 4.00e-98 351.00
IUUC-Pca-100579 Procavia capensis 47.75 1.00e-47 182.00
IUUC-Ppe-101494 Prunus persica 47.14 3.00e-99 355.00
IUUC-Pva-103245 Pteropus vampyrus 50.25 1.00e-47 183.00
IUUC-Pgr-103460 Puccinia graminis 29.79 7.00e-53 201.00
IUUC-Ptt-103797 Puccinia triticina 31.17 4.00e-53 202.00
IUUC-Pte-104367 Pyrenophora teres 50.83 4.00e-127 447.00
IUUC-Pyt-104771 Pyrenophora triticirepentis 50.83 3.00e-127 447.00
IUUC-Rno-104965 Rattus norvegicus 55.61 2.00e-120 425.00
IUUC-Sha-106474 Sarcophilus harrisii 27.00 8.00e-53 200.00
IUUC-Sja-107888 Schizosaccharomyces japonicus 53.46 4.00e-128 451.00
IUUC-Spo-108057 Schizosaccharomyces pombe 53.74 2.00e-133 468.00
IUUC-Ssl-108423 Sclerotinia sclerotiorum 54.65 4.00e-130 457.00
IUUC-Smo-109363 Selaginella moellendorffii 47.14 2.00e-98 352.00
IUUC-Sit-109884 Setaria italica 47.41 2.00e-96 345.00
IUUC-Sly-110910 Solanum lycopersicum 45.68 1.00e-95 342.00
IUUC-Stu-112814 Solanum tuberosum 45.41 3.00e-94 338.00
IUUC-Sbi-113810 Sorghum bicolor 46.87 2.00e-93 335.00
IUUC-Sre-115168 Sporisorium reilianum 48.36 2.00e-125 442.00
IUUC-Ssc-115398 Sus scrofa 30.19 5.00e-53 201.00
IUUC-Tgu-117361 Taeniopygia guttata 55.61 2.00e-120 425.00
IUUC-Tsy-119587 Tarsius syrichta 55.46 4.00e-117 414.00
IUUC-Tni-119757 Tetraodon nigroviridis 55.08 1.00e-117 416.00
IUUC-Tca-121570 Theobroma cacao 47.41 4.00e-97 347.00
IUUC-Tre-122024 Trichoderma reesei 54.03 2.00e-126 445.00
IUUC-Tvi-122502 Trichoderma virens 54.18 2.00e-129 455.00
IUUC-Tae-125799 Triticum aestivum 46.87 2.00e-95 342.00
IUUC-Tme-127001 Tuber melanosporum 35.79 5.00e-168 583.00
IUUC-Ttr-129128 Tursiops truncatus 55.30 1.00e-94 339.00
IUUC-Uma-129588 Ustilago maydis 48.57 4.00e-124 438.00
IUUC-Vda-129990 Verticillium dahliae 35.29 5.00e-111 394.00
IUUC-Vvi-131611 Vitis vinifera 46.81 1.00e-98 352.00
IUUC-Xtr-132727 Xenopus tropicalis 55.61 2.00e-120 425.00
IUUC-Xma-133492 Xiphophorus maculatus 52.21 1.00e-120 425.00
IUUC-Yli-134358 Yarrowia lipolytica 61.27 7.00e-156 543.00
IUUC-Zma-135844 Zea mays 43.85 2.00e-81 295.00
Created Date 25-Jun-2017

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