iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Bta-013306

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Nucleoporin SEH1; Nup107-160 subcomplex subunit SEH1

Genbank Nucleotide ID

BC151606

Gene Name

SEH1L

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSBTAG00000010792.5	ENSBTAT00000049050.3	ENSBTAP00000045994.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.00e-21	76.3	11	40

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf..sdtllvsGsdDgtikvWD 29
           H+d +++++f  ++++++++s D ++kvWD
   Q: 11   HKDLIHDVSFdfHGRRMATCSSDQSVKVWD 40
           9*********976599************** PP

Organism

Bos taurus

Functional Description
(View)

As a component of the GATOR subcomplex GATOR2, functions within the amino acid-sensing branch of the TORC1 signaling pathway. Indirectly activates mTORC1 and the TORC1 signaling pathway through the inhibition of the GATOR1 subcomplex. It is negatively regulated by the upstream amino acid sensors SESN2 and GATSL3.

Protein Sequence
(Fasta)

MFVARSIAAD HKDLIHDVSF DFHGRRMATC SSDQSVKVWD KSESGEWHCT ASWKTHSGSV 60
WRVTWAHPEF GQVLASCSFD RTAAVWEEIV GESNDKLRGQ SHWVKRTTLV DSRTSVTDVK 120

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Nucleotide Sequence
(Fasta)

ACGCGGGAAG CACCGCCGTG CGCGCCCCGG CGCCGGGTCC GGGTGGGCTG CGGTCCGCGA 60
GCCGCCGCGC CGCCGTGTCG GAGGCGGGAG GGGCCCGGCG CAGCCATGTT CGTGGCGCGC 120

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Sequence Source

Ensembl

Keyword

KW-0131--Cell cycle
KW-0132--Cell division
KW-0137--Centromere
KW-0158--Chromosome
KW-0159--Chromosome partition
KW-0181--Complete proteome
KW-0995--Kinetochore
KW-0498--Mitosis
KW-0509--mRNA transport
KW-0906--Nuclear pore complex
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0677--Repeat
KW-0811--Translocation
KW-0813--Transport
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom

PROSITE

PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0000777--C:condensed chromosome kinetochore
GO:0061700--C:GATOR2 complex
GO:0031080--C:nuclear pore outer ring
GO:0051315--P:attachment of mitotic spindle microtubules to kinetochore
GO:0051301--P:cell division
GO:0034629--P:cellular protein complex localization
GO:0034198--P:cellular response to amino acid starvation
GO:0002534--P:cytokine production involved in inflammatory response
GO:0050830--P:defense response to Gram-positive bacterium
GO:0007080--P:mitotic metaphase plate congression
GO:0051028--P:mRNA transport
GO:0006999--P:nuclear pore organization
GO:1904263--P:positive regulation of TORC1 signaling
GO:0015031--P:protein transport

KEGG

bta:506509

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001926	Ailuropoda melanoleuca	98.12	0.00e+00	628.00
IUUC-Apl-003654	Anas platyrhynchos	93.12	2.00e-170	591.00
IUUC-Aca-004378	Anolis carolinensis	91.28	3.00e-168	584.00
IUUC-Ago-007816	Ashbya gossypii	34.62	2.00e-50	192.00
IUUC-Ame-011945	Astyanax mexicanus	85.79	4.00e-173	600.00
IUUC-Cel-018235	Caenorhabditis elegans	42.31	7.00e-75	274.00
IUUC-Cja-018849	Callithrix jacchus	98.32	0.00e+00	649.00
IUUC-Cfa-020841	Canis familiaris	98.07	2.00e-179	624.00
IUUC-Cpo-021379	Cavia porcellus	97.22	0.00e+00	653.00
IUUC-Csa-023900	Chlorocebus sabaeus	98.60	0.00e+00	654.00
IUUC-Cho-024660	Choloepus hoffmanni	96.24	6.00e-178	616.00
IUUC-Cin-025471	Ciona intestinalis	54.47	3.00e-103	368.00
IUUC-Csv-026242	Ciona savignyi	58.96	1.00e-88	318.00
IUUC-Dre-028068	Danio rerio	83.57	0.00e+00	629.00
IUUC-Dno-029981	Dasypus novemcinctus	90.40	3.00e-172	597.00
IUUC-Dme-031763	Drosophila melanogaster	58.23	1.00e-112	399.00
IUUC-Ete-032243	Echinops telfairi	62.36	7.00e-118	416.00
IUUC-Eca-033425	Equus caballus	97.52	3.00e-167	580.00
IUUC-Eeu-035119	Erinaceus europaeus	77.56	1.00e-117	416.00
IUUC-Fca-036520	Felis catus	97.97	0.00e+00	676.00
IUUC-Fal-037234	Ficedula albicollis	93.44	7.00e-174	605.00
IUUC-Gmo-039013	Gadus morhua	86.59	5.00e-178	616.00
IUUC-Gga-041059	Gallus gallus	93.84	0.00e+00	668.00
IUUC-Gac-041337	Gasterosteus aculeatus	86.03	1.00e-172	598.00
IUUC-Ggo-044944	Gorilla gorilla	98.60	0.00e+00	704.00
IUUC-Hsa-046038	Homo sapiens	98.32	0.00e+00	702.00
IUUC-Itr-048858	Ictidomys tridecemlineatus	98.12	7.00e-166	576.00
IUUC-Kpa-049201	Komagataella pastoris	36.25	3.00e-50	192.00
IUUC-Lch-050466	Latimeria chalumnae	79.75	5.00e-179	620.00
IUUC-Loc-052773	Lepisosteus oculatus	75.84	2.00e-170	592.00
IUUC-Laf-053409	Loxodonta africana	96.67	0.00e+00	652.00
IUUC-Meu-055958	Macropus eugenii	70.09	3.00e-123	434.00
IUUC-Mga-059348	Meleagris gallopavo	92.90	1.00e-171	595.00
IUUC-Mmr-060977	Microcebus murinus	97.94	4.00e-134	470.00
IUUC-Mdo-061806	Monodelphis domestica	95.01	0.00e+00	684.00
IUUC-Mmu-064328	Mus musculus	95.83	0.00e+00	674.00
IUUC-Mpu-066873	Mustela putorius furo	98.44	0.00e+00	628.00
IUUC-Mlu-067563	Myotis lucifugus	91.39	0.00e+00	650.00
IUUC-Nle-068977	Nomascus leucogenys	98.50	0.00e+00	655.00
IUUC-Opr-070773	Ochotona princeps	65.65	5.00e-89	321.00
IUUC-Ont-072644	Oreochromis niloticus	86.87	5.00e-178	616.00
IUUC-Oan-073098	Ornithorhynchus anatinus	94.46	5.00e-167	579.00
IUUC-Ocu-073911	Oryctolagus cuniculus	98.32	0.00e+00	701.00
IUUC-Ola-087096	Oryzias latipes	85.99	8.00e-173	599.00
IUUC-Oga-088798	Otolemur garnettii	97.76	0.00e+00	701.00
IUUC-Oar-090298	Ovis aries	99.07	3.00e-169	590.00
IUUC-Ptr-091074	Pan troglodytes	98.33	0.00e+00	710.00
IUUC-Pan-092013	Papio anubis	98.82	6.00e-142	496.00
IUUC-Psi-093508	Pelodiscus sinensis	92.57	1.00e-172	598.00
IUUC-Pma-094288	Petromyzon marinus	84.29	5.00e-104	369.00
IUUC-Pfo-096384	Poecilia formosa	85.75	1.00e-175	608.00
IUUC-Pab-098629	Pongo abelii	98.61	0.00e+00	711.00
IUUC-Pca-100322	Procavia capensis	73.12	2.00e-111	395.00
IUUC-Pva-102861	Pteropus vampyrus	97.48	0.00e+00	648.00
IUUC-Rno-104895	Rattus norvegicus	93.96	0.00e+00	659.00
IUUC-Sce-106420	Saccharomyces cerevisiae	34.76	3.00e-54	205.00
IUUC-Sha-106829	Sarcophilus harrisii	89.53	0.00e+00	635.00
IUUC-Sja-107923	Schizosaccharomyces japonicus	40.29	8.00e-67	247.00
IUUC-Spo-108184	Schizosaccharomyces pombe	38.73	6.00e-65	240.00
IUUC-Smo-109282	Selaginella moellendorffii	32.91	9.00e-38	150.00
IUUC-Sar-113279	Sorex araneus	98.12	5.00e-166	577.00
IUUC-Ssc-115589	Sus scrofa	95.37	1.00e-177	615.00
IUUC-Tgu-117523	Taeniopygia guttata	93.56	0.00e+00	667.00
IUUC-Tru-117985	Takifugu rubripes	83.04	3.00e-158	553.00
IUUC-Tsy-118913	Tarsius syrichta	97.69	8.00e-168	582.00
IUUC-Tni-120670	Tetraodon nigroviridis	86.39	1.00e-177	615.00
IUUC-Tme-126885	Tuber melanosporum	36.98	2.00e-56	212.00
IUUC-Tbe-127344	Tupaia belangeri	78.99	2.00e-136	478.00
IUUC-Ttr-128347	Tursiops truncatus	98.75	1.00e-166	579.00
IUUC-Vpa-130656	Vicugna pacos	97.88	2.00e-158	551.00
IUUC-Xtr-132736	Xenopus tropicalis	90.81	0.00e+00	647.00
IUUC-Xma-133678	Xiphophorus maculatus	86.31	4.00e-177	613.00
IUUC-Yli-134659	Yarrowia lipolytica	40.62	2.00e-63	236.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence