iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000138002.14	ENST00000260570.7	ENSP00000260570.3
ENSG00000138002.14	ENST00000509128.5	ENSP00000427255.1
ENSG00000138002.14	ENST00000450564.1	ENSP00000399017.1
ENSG00000138002.14	ENST00000443889.1	ENSP00000404082.1
ENSG00000138002.14	ENST00000359466.10	ENSP00000352443.6

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
TargetScan	RepTar	SomamiR	miRcode
RAID2
Protein-protein Interaction
IID	iRefIndex	HINT	Mentha
InWeb_IM
Disease-associated Variation
ClinVar	GWASdb	GWAS Central	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
UniProt	BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	8.90e-08	33.8	69	94

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 6    vtclaf.sd.tllvsGsdDgtikvWD 29
           v ++af +d t ++ G  D+ i+v+ 
   Q: 69   VKGMAFsPDsTKIAIGQTDNIIYVYK 94
           67899**999*************997 PP

Organism

Homo sapiens

Functional Description
(View)

Required for the maintenance and formation of cilia. Plays an indirect role in hedgehog (Hh) signaling, cilia being required for all activity of the hedgehog pathway (By similarity).

Protein Sequence
(Fasta)

MHLKHLRTLL SPQDGAAKVT CMAWSQNNAK FAVCTVDRVV LLYDEHGERR DKFSTKPADM 60
KYGRKSYMVK GMAFSPDSTK IAIGQTDNII YVYKIGEDWG DKKVICNKFI QTSAVTCLQW 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ACGTGTGACC TTGCGACGCG TGTTGCGCTC CGGTCGCATA AGCGTCAGTG CCTGTCGCTG 60
CGGCTGCGTG GCGGGTTGTC CAGGTAACCA CGGGAGTTGT CGCTGTCTAG GAGCATCTGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0966--Cell projection
KW-1186--Ciliopathy
KW-0969--Cilium
KW-0181--Complete proteome
KW-0217--Developmental protein
KW-0225--Disease mutation
KW-1017--Isopeptide bond
KW-0488--Methylation
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0682--Retinitis pigmentosa
KW-0802--TPR repeat
KW-0832--Ubl conjugation
KW-0853--WD repeat

Interpro

IPR016024--ARM-type_fold
IPR011990--TPR-like_helical_dom
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom

Pfam

PF00400--WD40

SMART

SM00320--WD40

Gene Ontology

GO:0005930--C:axoneme
GO:0036064--C:ciliary basal body
GO:0097542--C:ciliary tip
GO:0005929--C:cilium
GO:1903561--C:extracellular vesicle
GO:0030992--C:intraciliary transport particle B
GO:0097598--C:sperm cytoplasmic droplet
GO:0097225--C:sperm midpiece
GO:0097228--C:sperm principal piece
GO:0060348--P:bone development
GO:0007420--P:brain development
GO:0060271--P:cilium assembly
GO:0031122--P:cytoplasmic microtubule organization
GO:0009953--P:dorsal/ventral pattern formation
GO:0008544--P:epidermis development
GO:0001947--P:heart looping
GO:0061525--P:hindgut development
GO:0035735--P:intraciliary transport involved in cilium assembly
GO:0070986--P:left/right axis specification
GO:0060173--P:limb development
GO:0050680--P:negative regulation of epithelial cell proliferation
GO:0001843--P:neural tube closure
GO:1905515--P:non-motile cilium assembly
GO:0007219--P:Notch signaling pathway
GO:0060021--P:palate development
GO:0045880--P:positive regulation of smoothened signaling pathway
GO:0016485--P:protein processing
GO:0007224--P:smoothened signaling pathway
GO:0021522--P:spinal cord motor neuron differentiation

KEGG

hsa:26160

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001775	Ailuropoda melanoleuca	95.68	0.00e+00	1035.00
IUUC-Apl-004180	Anas platyrhynchos	83.69	0.00e+00	918.00
IUUC-Bta-012784	Bos taurus	95.87	0.00e+00	1009.00
IUUC-Cfa-020359	Canis familiaris	95.28	0.00e+00	1031.00
IUUC-Cho-024397	Choloepus hoffmanni	81.93	0.00e+00	840.00
IUUC-Cin-025243	Ciona intestinalis	73.78	0.00e+00	775.00
IUUC-Csv-025964	Ciona savignyi	75.34	0.00e+00	838.00
IUUC-Dno-029782	Dasypus novemcinctus	96.07	0.00e+00	1034.00
IUUC-Eca-033288	Equus caballus	96.66	0.00e+00	1045.00
IUUC-Fca-036387	Felis catus	96.27	0.00e+00	1038.00
IUUC-Loc-052126	Lepisosteus oculatus	76.31	0.00e+00	827.00
IUUC-Laf-054242	Loxodonta africana	96.07	0.00e+00	1038.00
IUUC-Mcc-055460	Macaca mulatta	83.33	0.00e+00	840.00
IUUC-Meu-056864	Macropus eugenii	91.75	0.00e+00	988.00
IUUC-Mmr-060951	Microcebus murinus	94.30	0.00e+00	1010.00
IUUC-Mdo-062290	Monodelphis domestica	94.70	0.00e+00	1025.00
IUUC-Mlu-067149	Myotis lucifugus	94.70	0.00e+00	1019.00
IUUC-Nle-069497	Nomascus leucogenys	96.86	0.00e+00	1041.00
IUUC-Opr-070642	Ochotona princeps	95.28	0.00e+00	1021.00
IUUC-Ocu-074484	Oryctolagus cuniculus	96.46	0.00e+00	1045.00
IUUC-Ola-086935	Oryzias latipes	70.53	0.00e+00	758.00
IUUC-Ptr-090769	Pan troglodytes	99.41	0.00e+00	1066.00
IUUC-Psi-093021	Pelodiscus sinensis	88.45	0.00e+00	950.00
IUUC-Pva-102604	Pteropus vampyrus	95.28	0.00e+00	1024.00
IUUC-Rno-104875	Rattus norvegicus	90.40	0.00e+00	940.00
IUUC-Tgu-116577	Taeniopygia guttata	83.33	0.00e+00	936.00
IUUC-Tru-117611	Takifugu rubripes	75.15	0.00e+00	823.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence