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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Hsa-046259
Ensembl Protein ID ENSP00000258428.3
UniProt Accession Q9UBZ9; O95941; Q53SI7; Q9C0J4; Q9NUP2; REV1_HUMAN
Genbank Protein ID AAF06731.1; AAF18986.1; BAB21441.1; AAK43708.1; BAA92079.1; AAY24314.1; CAB38231.1
Protein Name DNA repair protein REV1; Alpha integrin-binding protein 80; Rev1-like terminal deoxycytidyl transferase
Genbank Nucleotide ID AF151538; AF206019; AB047646; AF357886; AK002087; AC018690; AJ131720
Gene Name REV1; REV1L
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000135945.9 ENST00000393445.7 ENSP00000377091.3
ENSG00000135945.9 ENST00000258428.7 ENSP00000258428.3
ENSG00000135945.9 ENST00000413697.5 ENSP00000416274.1
ENSG00000135945.9 ENST00000438366.1 ENSP00000404213.1
ENSG00000135945.9 ENST00000450415.1 ENSP00000414875.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
RepTarmiRNAMapSomamiRmiRcode
RAID2
Protein-protein Interaction
IIDPINAHINTMentha
InWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Information
ClinVarGWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDBioGRID
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
UBD/Alpha-Helix/UBM UBM 16982685; 18498753
Classification
Family E-value Score Start End
UBD/Alpha-Helix/UBM 3.40e-21 75.8 1012 1040
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/Alpha-Helix/UBM
   S: 1    lPsqvDpeVfsqLPeeiQeEvmaelrqqk 29
           ++sqvDpeVf++LP+e+Q+E++a+++q++
   Q: 1012 AFSQVDPEVFAALPAELQRELKAAYDQRQ 1040
           59*************************98 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template-dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents.
 Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template-dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents.
Protein Sequence
(Fasta)
MRRGGWRKRA ENDGWETWGG YMAAKVQKLE EQFRSDAAMQ KDGTSSTIFS GVAIYVNGYT 60
DPSAEELRKL MMLHGGQYHV YYSRSKTTHI IATNLPNAKI KELKGEKVIR PEWIVESIKA 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046259|UBD,UBM|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CGGAGGGGGA GGGGCGGAGA GCCACCGCGG AGCGCGCGCG GGGTTGGTTG CCGCGAGCGT 60
GGGGGAGCGT GGACCGCGGC GCTGCTCAGC GGTGGGGCTG CCTTCCCCCG GCCCTCCTCC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046259|UBD,UBM|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0227--DNA damage
KW-0234--DNA repair
KW-0237--DNA synthesis
KW-0238--DNA-binding
KW-0460--Magnesium
KW-0479--Metal-binding
KW-0548--Nucleotidyltransferase
KW-0539--Nucleus
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0808--Transferase
Interpro

IPR001357--BRCT_dom
IPR017961--DNA_pol_Y-fam_little_finger
IPR025527--DUF4414
IPR012112--REV1
IPR031991--Rev1_C
IPR001126--UmuC
PROSITE

PS50172--BRCT
PS50173--UMUC
Pfam

PF16589--BRCT_2
PF14377--DUF4414
PF00817--IMS
PF11799--IMS_C
PF16727--REV1_C
SMART

SM00292--BRCT
Gene Ontology

GO:0005654--C:nucleoplasm
GO:0003684--F:damaged DNA binding
GO:0017125--F:deoxycytidyl transferase activity
GO:0046872--F:metal ion binding
GO:0006260--P:DNA replication
GO:0042276--P:error-prone translesion synthesis
GO:0009411--P:response to UV
GO:0019985--P:translesion synthesis
KEGG hsa:51455
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000375 Aegilops tauschii 30.48 1.00e-31 132.00
IUUC-Aml-001185 Ailuropoda melanoleuca 88.68 0.00e+00 2174.00
IUUC-Atr-002915 Amborella trichopoda 29.73 4.00e-108 386.00
IUUC-Apl-004054 Anas platyrhynchos 76.10 0.00e+00 1803.00
IUUC-Aca-004304 Anolis carolinensis 68.94 0.00e+00 1651.00
IUUC-Aly-005696 Arabidopsis lyrata 36.42 2.00e-86 314.00
IUUC-Ath-006893 Arabidopsis thaliana 36.31 4.00e-87 317.00
IUUC-Ago-007722 Ashbya gossypii 27.72 9.00e-39 155.00
IUUC-Acl-008347 Aspergillus clavatus 34.64 7.00e-89 322.00
IUUC-Afl-008444 Aspergillus flavus 36.01 1.00e-89 325.00
IUUC-Afu-008837 Aspergillus fumigatus 31.30 1.00e-86 315.00
IUUC-Ani-009188 Aspergillus nidulans 38.71 1.00e-92 335.00
IUUC-Ang-009866 Aspergillus niger 33.48 7.00e-98 352.00
IUUC-Aor-010107 Aspergillus oryzae 36.01 2.00e-89 324.00
IUUC-Ate-010359 Aspergillus terreus 32.04 3.00e-93 337.00
IUUC-Ame-010664 Astyanax mexicanus 54.47 0.00e+00 902.00
IUUC-Bgr-012244 Blumeria graminis 31.85 3.00e-85 310.00
IUUC-Bta-013405 Bos taurus 80.65 0.00e+00 1824.00
IUUC-Bci-013849 Botrytis cinerea 31.46 4.00e-88 320.00
IUUC-Bdi-014066 Brachypodium distachyon 36.52 3.00e-85 310.00
IUUC-Bol-015544 Brassica oleracea 37.08 3.00e-89 323.00
IUUC-Bra-017792 Brassica rapa 35.02 6.00e-85 309.00
IUUC-Cel-018148 Caenorhabditis elegans 35.74 7.00e-82 299.00
IUUC-Cja-019742 Callithrix jacchus 81.85 0.00e+00 1628.00
IUUC-Cfa-020112 Canis familiaris 89.39 0.00e+00 2214.00
IUUC-Cpo-022152 Cavia porcellus 84.84 0.00e+00 2135.00
IUUC-Cre-022951 Chlamydomonas reinhardtii 42.15 7.00e-40 159.00
IUUC-Csa-023504 Chlorocebus sabaeus 96.64 0.00e+00 2397.00
IUUC-Cho-024780 Choloepus hoffmanni 65.77 0.00e+00 723.00
IUUC-Cin-025276 Ciona intestinalis 42.89 5.00e-113 402.00
IUUC-Csv-026283 Ciona savignyi 45.40 4.00e-116 412.00
IUUC-Cgl-026726 Colletotrichum gloeosporioides 28.77 2.00e-91 330.00
IUUC-Cne-027079 Cryptococcus neoformans 34.32 1.00e-78 288.00
IUUC-Cme-027346 Cyanidioschyzon merolae 28.95 4.00e-48 187.00
IUUC-Dre-028073 Danio rerio 50.64 0.00e+00 1102.00
IUUC-Dno-030038 Dasypus novemcinctus 81.99 0.00e+00 2023.00
IUUC-Dor-031100 Dipodomys ordii 84.67 0.00e+00 1541.00
IUUC-Dse-031310 Dothistroma septosporum 29.78 1.00e-85 311.00
IUUC-Dme-031991 Drosophila melanogaster 42.94 2.00e-112 400.00
IUUC-Ete-033082 Echinops telfairi 77.13 0.00e+00 1431.00
IUUC-Eca-033471 Equus caballus 88.04 0.00e+00 2168.00
IUUC-Eeu-034993 Erinaceus europaeus 85.33 0.00e+00 1424.00
IUUC-Fca-035367 Felis catus 88.96 0.00e+00 2116.00
IUUC-Fal-036973 Ficedula albicollis 75.30 0.00e+00 1739.00
IUUC-Fox-037677 Fusarium oxysporum 30.75 4.00e-87 316.00
IUUC-Fso-038252 Fusarium solani 30.75 2.00e-89 324.00
IUUC-Gmo-039669 Gadus morhua 52.30 0.00e+00 819.00
IUUC-Ggr-039988 Gaeumannomyces graminis 32.45 4.00e-87 317.00
IUUC-Gga-040423 Gallus gallus 75.87 0.00e+00 1798.00
IUUC-Gac-042134 Gasterosteus aculeatus 48.05 0.00e+00 973.00
IUUC-Gma-042929 Glycine max 33.17 1.00e-90 328.00
IUUC-Ggo-044528 Gorilla gorilla 99.44 0.00e+00 2440.00
IUUC-Hvu-047139 Hordeum vulgare 37.16 3.00e-59 222.00
IUUC-Itr-048621 Ictidomys tridecemlineatus 88.76 0.00e+00 2191.00
IUUC-Kpa-049169 Komagataella pastoris 28.88 7.00e-61 229.00
IUUC-Lch-050471 Latimeria chalumnae 66.09 0.00e+00 1553.00
IUUC-Lpe-050800 Leersia perrieri 33.54 4.00e-90 326.00
IUUC-Loc-052320 Lepisosteus oculatus 47.20 0.00e+00 942.00
IUUC-Lma-053149 Leptosphaeria maculans 29.45 3.00e-86 313.00
IUUC-Laf-053810 Loxodonta africana 82.62 0.00e+00 1970.00
IUUC-Mcc-055574 Macaca mulatta 97.84 0.00e+00 2366.00
IUUC-Meu-055945 Macropus eugenii 65.82 0.00e+00 1146.00
IUUC-Mor-057195 Magnaporthe oryzae 30.00 1.00e-91 332.00
IUUC-Mpo-057488 Magnaporthe poae 35.06 3.00e-87 317.00
IUUC-Mtr-057955 Medicago truncatula 36.75 5.00e-90 326.00
IUUC-Mla-059027 Melampsora laricipopulina 36.04 8.00e-81 295.00
IUUC-Mga-060156 Meleagris gallopavo 75.39 0.00e+00 1790.00
IUUC-Mvi-060398 Microbotryum violaceum 36.42 1.00e-82 301.00
IUUC-Mmr-061113 Microcebus murinus 91.63 0.00e+00 2221.00
IUUC-Mdo-063001 Monodelphis domestica 82.92 0.00e+00 1995.00
IUUC-Mmu-063180 Mus musculus 82.70 0.00e+00 2034.00
IUUC-Mac-065551 Musa acuminata 38.38 3.00e-55 210.00
IUUC-Mpu-066525 Mustela putorius furo 89.15 0.00e+00 2182.00
IUUC-Mlu-067877 Myotis lucifugus 86.20 0.00e+00 2100.00
IUUC-Nfi-068418 Neosartorya fischeri 31.92 9.00e-87 315.00
IUUC-Ncr-068648 Neurospora crassa 32.39 5.00e-89 323.00
IUUC-Nle-069959 Nomascus leucogenys 98.88 0.00e+00 2392.00
IUUC-Opr-070522 Ochotona princeps 83.01 0.00e+00 1190.00
IUUC-Ont-072293 Oreochromis niloticus 49.44 0.00e+00 790.00
IUUC-Oan-073519 Ornithorhynchus anatinus 79.05 0.00e+00 1898.00
IUUC-Ocu-074492 Oryctolagus cuniculus 85.29 0.00e+00 1935.00
IUUC-Oba-075567 Oryza barthii 32.97 2.00e-90 327.00
IUUC-Obr-076332 Oryza brachyantha 36.49 2.00e-87 317.00
IUUC-Ogl-077348 Oryza glaberrima 32.97 3.00e-90 327.00
IUUC-Ogu-078779 Oryza glumaepatula 32.82 6.00e-90 326.00
IUUC-Oin-079738 Oryza indica 30.30 5.00e-78 286.00
IUUC-Olo-080701 Oryza longistaminata 30.36 2.00e-78 287.00
IUUC-Ome-081708 Oryza meridionalis 32.91 9.00e-87 315.00
IUUC-Oni-082251 Oryza nivara 32.65 2.00e-87 317.00
IUUC-Opu-083528 Oryza punctata 32.75 2.00e-81 297.00
IUUC-Oru-084293 Oryza rufipogon 32.20 3.00e-85 310.00
IUUC-Osa-085549 Oryza sativa 32.97 6.00e-90 326.00
IUUC-Ola-086793 Oryzias latipes 46.58 0.00e+00 1007.00
IUUC-Olu-087786 Ostreococcus lucimarinus 29.12 2.00e-60 226.00
IUUC-Oga-089006 Otolemur garnettii 90.71 0.00e+00 2205.00
IUUC-Oar-089597 Ovis aries 81.75 0.00e+00 1980.00
IUUC-Ptr-091520 Pan troglodytes 99.60 0.00e+00 2413.00
IUUC-Pan-092333 Papio anubis 97.60 0.00e+00 2335.00
IUUC-Psi-094004 Pelodiscus sinensis 77.94 0.00e+00 1870.00
IUUC-Pma-094128 Petromyzon marinus 53.55 3.00e-94 339.00
IUUC-Pno-094849 Phaeosphaeria nodorum 29.25 6.00e-81 296.00
IUUC-Ppa-095714 Physcomitrella patens 30.83 9.00e-92 332.00
IUUC-Pfo-096569 Poecilia formosa 51.47 0.00e+00 807.00
IUUC-Pab-097960 Pongo abelii 98.64 0.00e+00 2395.00
IUUC-Pop-098921 Populus trichocarpa 30.37 6.00e-85 309.00
IUUC-Pca-100509 Procavia capensis 68.90 0.00e+00 1197.00
IUUC-Ppe-101730 Prunus persica 33.66 2.00e-118 420.00
IUUC-Pva-102142 Pteropus vampyrus 85.49 0.00e+00 2071.00
IUUC-Pgr-103446 Puccinia graminis 31.22 5.00e-70 259.00
IUUC-Ptt-103849 Puccinia triticina 30.26 8.00e-75 276.00
IUUC-Pte-104128 Pyrenophora teres 29.31 5.00e-84 306.00
IUUC-Pyt-104754 Pyrenophora triticirepentis 34.61 2.00e-81 297.00
IUUC-Rno-104871 Rattus norvegicus 80.46 0.00e+00 1990.00
IUUC-Sce-106236 Saccharomyces cerevisiae 27.57 5.00e-42 166.00
IUUC-Sha-106962 Sarcophilus harrisii 82.04 0.00e+00 1982.00
IUUC-Sja-107691 Schizosaccharomyces japonicus 33.20 2.00e-65 244.00
IUUC-Spo-108170 Schizosaccharomyces pombe 30.82 3.00e-66 246.00
IUUC-Ssl-108668 Sclerotinia sclerotiorum 34.99 1.00e-87 318.00
IUUC-Smo-109554 Selaginella moellendorffii 36.67 1.00e-85 311.00
IUUC-Sit-110479 Setaria italica 35.86 2.00e-72 267.00
IUUC-Sly-111752 Solanum lycopersicum 31.14 4.00e-92 333.00
IUUC-Sar-113304 Sorex araneus 85.56 0.00e+00 2039.00
IUUC-Sbi-114196 Sorghum bicolor 36.55 2.00e-72 268.00
IUUC-Sre-115151 Sporisorium reilianum 32.82 1.00e-84 308.00
IUUC-Ssc-116104 Sus scrofa 86.56 0.00e+00 2094.00
IUUC-Tgu-117438 Taeniopygia guttata 75.55 0.00e+00 1761.00
IUUC-Tru-118553 Takifugu rubripes 47.23 0.00e+00 993.00
IUUC-Tsy-119056 Tarsius syrichta 86.46 0.00e+00 2041.00
IUUC-Tni-119933 Tetraodon nigroviridis 47.47 0.00e+00 800.00
IUUC-Tca-121376 Theobroma cacao 32.31 4.00e-114 406.00
IUUC-Tre-121972 Trichoderma reesei 30.73 1.00e-83 304.00
IUUC-Tvi-122342 Trichoderma virens 30.79 7.00e-81 295.00
IUUC-Tae-123898 Triticum aestivum 33.75 7.00e-91 328.00
IUUC-Tur-126735 Triticum urartu 30.84 5.00e-36 147.00
IUUC-Tme-126999 Tuber melanosporum 33.00 4.00e-81 297.00
IUUC-Tbe-127280 Tupaia belangeri 88.25 8.00e-145 508.00
IUUC-Ttr-129104 Tursiops truncatus 86.14 0.00e+00 2088.00
IUUC-Uma-129562 Ustilago maydis 30.79 2.00e-84 308.00
IUUC-Vda-129862 Verticillium dahliae 31.29 2.00e-92 334.00
IUUC-Vpa-130819 Vicugna pacos 83.26 0.00e+00 1092.00
IUUC-Vvi-131111 Vitis vinifera 35.21 3.00e-86 313.00
IUUC-Xtr-132629 Xenopus tropicalis 62.80 0.00e+00 1432.00
IUUC-Xma-134065 Xiphophorus maculatus 51.64 0.00e+00 796.00
IUUC-Yli-134633 Yarrowia lipolytica 32.47 8.00e-63 236.00
IUUC-Zma-135176 Zea mays 36.76 1.00e-87 318.00
Created Date 25-Jun-2017

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