iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Loc-052647

Ensembl Protein ID

ENSLOCP00000001036.1

UniProt Accession

W5LY29; W5LY29_LEPOC

Genbank Protein ID

ENSLOCP00000001036

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AHAT01021272

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLOCG00000000888.1	ENSLOCT00000001015.1	ENSLOCP00000001011.1
ENSLOCG00000000888.1	ENSLOCT00000001040.1	ENSLOCP00000001036.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	3.90e-134	447.4	573	907

Active Site

Position(s)	Description	Evidence
874	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dl++rl++ f +Eegld+gGv+re+++lls+e+ np+++lf+y  +d+++lq+np+s++ np+hlk+F+f+Gr++++al++g+++d+
   Q: 573  AQDLRRRLWIIFPEEEGLDYGGVAREWFFLLSHEVLNPMYCLFEYAGKDNYCLQINPASYI-NPDHLKYFKFIGRFIAMALFHGKFIDT 660
           689*********************************************************9.89************************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
            +s +fyk++l+k+l l+dle++dpe+y+sl +iken   +iee+gl++ fsv++eilge++++eLkp+G+n+ Vt+eNkeeY+klv+e
   Q: 661  GFSLPFYKRILNKPLALKDLESIDPEFYNSLIWIKEN---NIEECGLEMYFSVDKEILGEVTTHELKPDGSNVLVTEENKEEYIKLVAE 746
           ***********************************99...9************************************************ PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +rl +g++eq++af eGfnev+p++ l++F+++ele+++cG++eid+ d++++t y++ y ++s++i wFw+ ++e+++e+r ++LqFv
   Q: 747  WRLSRGVEEQTQAFFEGFNEVLPQQYLQYFDAKELEVMLCGMQEIDLADWQRNTIYRH-YARSSKQIVWFWQLIKEMDNEKRMRLLQFV 834
           ********************************************************99.****************************** PP
   S: 269  TgssrlPlgGfaelk....prlfvirkdasddrlPssnTC..fnyLkLPeYsskeilkekLlyAieetkgFel 335
           Tg++rlP+gGfa+l+    p++f+i+k +++++lP+s+TC  fn+L+LP+Y+s+e+lkekLl+Aieet+gF++
   Q: 835  TGTCRLPVGGFADLMgsngPQKFCIEKVGKENWLPRSHTCssFNRLDLPPYKSYEQLKEKLLFAIEETEGFGQ 907
           ****************************************888****************************96 PP

Organism

Lepisosteus oculatus

Protein Sequence
(Fasta)

MACSTARPSS VNGLTMKAQL QITVLSAKLK ENKKNWFGPS PYVEVAVDGQ SKKTEKCNNT 60
HSPKWNQPLT VIVTPFSKLI FRVWSHQTLK ADVMLGIATL DVTETLKSNN MKISEVVQTL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTATTTATCT GATATGTAAA TAATAATGTC TAGCTTTGAA GATATGGATA TGGCGTAAGA 60
CCGAAGGGGA ATTTGGACTT GCTTAATATG TACTGTACTT ACACTAAAAA TGTGCTGGTA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002302	Ailuropoda melanoleuca	84.14	0.00e+00	1130.00
IUUC-Apl-003752	Anas platyrhynchos	73.11	0.00e+00	1320.00
IUUC-Aca-005338	Anolis carolinensis	69.81	0.00e+00	1251.00
IUUC-Ame-010601	Astyanax mexicanus	91.82	0.00e+00	1160.00
IUUC-Bta-012782	Bos taurus	87.19	0.00e+00	1124.00
IUUC-Cja-018899	Callithrix jacchus	73.33	0.00e+00	1332.00
IUUC-Cfa-020648	Canis familiaris	82.66	0.00e+00	1097.00
IUUC-Cpo-022073	Cavia porcellus	83.83	0.00e+00	1143.00
IUUC-Csa-023252	Chlorocebus sabaeus	82.73	0.00e+00	1133.00
IUUC-Cho-024695	Choloepus hoffmanni	71.16	0.00e+00	1291.00
IUUC-Cne-026849	Cryptococcus neoformans	48.73	9.00e-158	550.00
IUUC-Dre-028451	Danio rerio	76.77	0.00e+00	1372.00
IUUC-Dno-029884	Dasypus novemcinctus	83.36	0.00e+00	1145.00
IUUC-Eca-033793	Equus caballus	83.99	0.00e+00	1128.00
IUUC-Fca-035605	Felis catus	84.14	0.00e+00	1149.00
IUUC-Fal-037126	Ficedula albicollis	72.75	0.00e+00	1331.00
IUUC-Gmo-038596	Gadus morhua	82.68	0.00e+00	1034.00
IUUC-Gga-040832	Gallus gallus	72.71	0.00e+00	1324.00
IUUC-Gac-041520	Gasterosteus aculeatus	92.89	0.00e+00	1163.00
IUUC-Ggo-044535	Gorilla gorilla	72.12	0.00e+00	1306.00
IUUC-Hsa-046564	Homo sapiens	73.22	0.00e+00	1365.00
IUUC-Itr-048918	Ictidomys tridecemlineatus	86.54	0.00e+00	1136.00
IUUC-Lch-050454	Latimeria chalumnae	73.92	0.00e+00	1351.00
IUUC-Laf-054383	Loxodonta africana	83.67	0.00e+00	1140.00
IUUC-Mcc-055532	Macaca mulatta	82.73	0.00e+00	1133.00
IUUC-Mga-059661	Meleagris gallopavo	69.20	0.00e+00	1231.00
IUUC-Mmr-061135	Microcebus murinus	74.48	0.00e+00	1350.00
IUUC-Mdo-062505	Monodelphis domestica	88.34	0.00e+00	1139.00
IUUC-Mmu-063375	Mus musculus	87.01	0.00e+00	1142.00
IUUC-Mpu-066203	Mustela putorius furo	84.14	0.00e+00	1128.00
IUUC-Mlu-067837	Myotis lucifugus	84.30	0.00e+00	1129.00
IUUC-Nle-069244	Nomascus leucogenys	87.52	0.00e+00	1133.00
IUUC-Opr-070585	Ochotona princeps	87.69	0.00e+00	1128.00
IUUC-Ont-071822	Oreochromis niloticus	74.60	0.00e+00	1414.00
IUUC-Ocu-074298	Oryctolagus cuniculus	87.01	0.00e+00	1143.00
IUUC-Ola-087250	Oryzias latipes	72.00	0.00e+00	1294.00
IUUC-Oga-088167	Otolemur garnettii	78.12	0.00e+00	1050.00
IUUC-Ptr-090819	Pan troglodytes	72.57	0.00e+00	1328.00
IUUC-Pan-092454	Papio anubis	82.73	0.00e+00	1132.00
IUUC-Psi-093319	Pelodiscus sinensis	71.77	0.00e+00	1288.00
IUUC-Pfo-097346	Poecilia formosa	89.21	0.00e+00	1125.00
IUUC-Pab-097580	Pongo abelii	67.21	0.00e+00	1211.00
IUUC-Pca-100923	Procavia capensis	75.35	0.00e+00	1008.00
IUUC-Pva-103209	Pteropus vampyrus	83.52	0.00e+00	1110.00
IUUC-Rno-104924	Rattus norvegicus	85.78	0.00e+00	1146.00
IUUC-Sha-107175	Sarcophilus harrisii	84.49	0.00e+00	1142.00
IUUC-Spo-108171	Schizosaccharomyces pombe	50.09	7.00e-159	554.00
IUUC-Sar-113761	Sorex araneus	83.83	0.00e+00	1118.00
IUUC-Tgu-116632	Taeniopygia guttata	70.92	0.00e+00	1222.00
IUUC-Tru-118442	Takifugu rubripes	92.76	0.00e+00	1159.00
IUUC-Tsy-119198	Tarsius syrichta	75.98	0.00e+00	1010.00
IUUC-Tni-120168	Tetraodon nigroviridis	91.85	0.00e+00	1101.00
IUUC-Tbe-127756	Tupaia belangeri	72.73	0.00e+00	841.00
IUUC-Vpa-130103	Vicugna pacos	75.66	0.00e+00	961.00
IUUC-Xtr-132885	Xenopus tropicalis	72.20	0.00e+00	1330.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence