iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Sce-106133

UUCD1 version

UUC-SaC-00254

Ensembl Protein ID

YOR339C

UniProt Accession

P52492; D6W334; UBC11_YEAST

Genbank Protein ID

CAA65027.1; CAA99663.1; DAA11100.1

Protein Name

Ubiquitin-conjugating enzyme E2-18 kDa; E2 ubiquitin-conjugating enzyme 11; Ubiquitin carrier protein; Ubiquitin-protein ligase

Genbank Nucleotide ID

X95720; Z75247; BK006948

Gene Name

UBC11; YOR339C; O6268

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
YOR339C	YOR339C	YOR339C

Annotation

mRNA Expression
GEO	FFGED
Protein-protein Interaction
IID	iRefIndex	HINT	Mentha
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E2/UBC	E2_UBC	12724408

Classification

Family	E-value	Score	Start	End
E2/UBC	1.70e-51	172.1	12	146

Active Site

Position(s)	Description	Evidence
93	Glycyl thioester intermediate	{ECO:0000255\|PROSITE-ProRule:PRU00388, ECO:0000255\|PROSITE-ProRule:PRU10133}

Domain Profile

E2/UBC

   S: 1    RlkkelkelekdppegisakpvdesdltewevlilGpedtpYeggvFkleiefpedYPfkPPkvkfltkifhPnvyenGkvClsilkeeekWspalsvesvl 102
           Rl++el +l ++++e+isa pvd++dlt w   i+Gp+dtpY g +Fk++++fp++YPf+PP +kfl++++hPnv+++G++Cl+ilk  ekWs++++ve++l
   Q: 12   RLQNELLQLLSSTTESISAFPVDDNDLTYWVGYITGPKDTPYSGLKFKVSLKFPQNYPFHPPMIKFLSPMWHPNVDKSGNICLDILK--EKWSAVYNVETIL 111
           99************************************************************************************9..************* PP
   S: 103  lsiqsllaepnpesplneeaaellkknreeykkkv 137
           ls+qsll epn++spln+ aael+ ++ eey+kkv
   Q: 112  LSLQSLLGEPNNRSPLNAVAAELWDADMEEYRKKV 146
           *********************************98 PP

Organism

Saccharomyces cerevisiae

Functional Description
(View)

Catalyzes the covalent attachment of ubiquitin to other proteins.

Protein Sequence
(Fasta)

MAVEEGGCVT KRLQNELLQL LSSTTESISA FPVDDNDLTY WVGYITGPKD TPYSGLKFKV 60
SLKFPQNYPF HPPMIKFLSP MWHPNVDKSG NICLDILKEK WSAVYNVETI LLSLQSLLGE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCAGTAG AAGAGGGTGG TTGCGTGACG AAACGTTTAC AAAATGAGCT GCTACAGCTA 60
CTTAGTTCTA CAACAGAAAG TATTAGTGCG TTTCCCGTAG ACGATAATGA TTTAACATAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000608--UBQ-conjugat_E2
IPR023313--UBQ-conjugating_AS
IPR016135--UBQ-conjugating_enzyme/RWD

PROSITE

PS00183--UBIQUITIN_CONJUGAT_1
PS50127--UBIQUITIN_CONJUGAT_2

Pfam

PF00179--UQ_con

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0005524--F:ATP binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0031625--F:ubiquitin protein ligase binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0031145--P:anaphase-promoting complex-dependent catabolic process
GO:0006513--P:protein monoubiquitination
GO:0000209--P:protein polyubiquitination
GO:0030071--P:regulation of mitotic metaphase/anaphase transition

KEGG

sce:YOR339C

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001924	Ailuropoda melanoleuca	56.08	1.00e-40	157.00
IUUC-Atr-002885	Amborella trichopoda	57.24	2.00e-42	163.00
IUUC-Aly-006017	Arabidopsis lyrata	55.94	3.00e-39	152.00
IUUC-Ath-007128	Arabidopsis thaliana	55.94	3.00e-39	152.00
IUUC-Acl-008223	Aspergillus clavatus	65.54	8.00e-50	187.00
IUUC-Afl-008675	Aspergillus flavus	61.59	2.00e-48	182.00
IUUC-Afu-008997	Aspergillus fumigatus	63.51	3.00e-48	182.00
IUUC-Ani-009470	Aspergillus nidulans	63.27	2.00e-47	179.00
IUUC-Ang-009648	Aspergillus niger	62.84	7.00e-48	181.00
IUUC-Aor-009977	Aspergillus oryzae	63.57	1.00e-41	160.00
IUUC-Ate-010318	Aspergillus terreus	62.91	2.00e-48	182.00
IUUC-Ame-011302	Astyanax mexicanus	54.48	4.00e-44	168.00
IUUC-Bta-013101	Bos taurus	62.02	4.00e-42	162.00
IUUC-Bci-013787	Botrytis cinerea	58.28	4.00e-52	194.00
IUUC-Bdi-014144	Brachypodium distachyon	54.55	2.00e-42	162.00
IUUC-Bol-015613	Brassica oleracea	56.64	2.00e-41	159.00
IUUC-Bra-017248	Brassica rapa	56.64	2.00e-41	159.00
IUUC-Cfa-020588	Canis familiaris	62.02	5.00e-42	161.00
IUUC-Cpo-021384	Cavia porcellus	61.24	6.00e-42	160.00
IUUC-Csa-023437	Chlorocebus sabaeus	62.02	2.00e-42	162.00
IUUC-Cho-024330	Choloepus hoffmanni	61.95	9.00e-37	142.00
IUUC-Csv-025933	Ciona savignyi	54.36	6.00e-42	161.00
IUUC-Cgl-026494	Colletotrichum gloeosporioides	58.11	1.00e-51	193.00
IUUC-Cme-027266	Cyanidioschyzon merolae	54.36	1.00e-39	153.00
IUUC-Dre-027375	Danio rerio	55.17	3.00e-45	172.00
IUUC-Dno-029921	Dasypus novemcinctus	59.69	3.00e-40	155.00
IUUC-Dor-030209	Dipodomys ordii	59.69	2.00e-39	153.00
IUUC-Dse-031516	Dothistroma septosporum	54.55	2.00e-44	169.00
IUUC-Dme-031942	Drosophila melanogaster	54.19	3.00e-45	172.00
IUUC-Eca-034073	Equus caballus	62.02	4.00e-42	161.00
IUUC-Eeu-034854	Erinaceus europaeus	67.47	7.00e-31	124.00
IUUC-Fca-035666	Felis catus	62.02	4.00e-42	161.00
IUUC-Fal-037652	Ficedula albicollis	60.20	2.00e-31	124.00
IUUC-Fox-037793	Fusarium oxysporum	60.14	3.00e-53	198.00
IUUC-Fso-038151	Fusarium solani	59.46	1.00e-52	196.00
IUUC-Gmo-038894	Gadus morhua	60.16	5.00e-41	157.00
IUUC-Ggr-039730	Gaeumannomyces graminis	60.14	2.00e-46	176.00
IUUC-Gga-040537	Gallus gallus	54.55	3.00e-37	144.00
IUUC-Gac-041346	Gasterosteus aculeatus	51.43	3.00e-39	152.00
IUUC-Gma-043989	Glycine max	56.16	2.00e-43	166.00
IUUC-Ggo-045594	Gorilla gorilla	61.83	2.00e-41	159.00
IUUC-Hsa-046216	Homo sapiens	62.79	9.00e-43	164.00
IUUC-Hvu-047797	Hordeum vulgare	53.24	3.00e-40	155.00
IUUC-Itr-048402	Ictidomys tridecemlineatus	62.02	4.00e-42	161.00
IUUC-Kpa-049294	Komagataella pastoris	68.63	5.00e-60	221.00
IUUC-Lch-049761	Latimeria chalumnae	54.48	2.00e-40	155.00
IUUC-Lpe-051089	Leersia perrieri	54.55	3.00e-42	162.00
IUUC-Loc-052297	Lepisosteus oculatus	57.93	3.00e-46	176.00
IUUC-Lma-053214	Leptosphaeria maculans	56.69	8.00e-51	190.00
IUUC-Laf-054468	Loxodonta africana	61.07	3.00e-41	159.00
IUUC-Mcc-055082	Macaca mulatta	62.79	2.00e-42	162.00
IUUC-Meu-056147	Macropus eugenii	61.24	3.00e-42	162.00
IUUC-Mor-057239	Magnaporthe oryzae	60.81	9.00e-54	200.00
IUUC-Mpo-057491	Magnaporthe poae	60.14	2.00e-53	199.00
IUUC-Mtr-058382	Medicago truncatula	56.25	1.00e-41	159.00
IUUC-Mla-058880	Melampsora laricipopulina	62.59	5.00e-50	187.00
IUUC-Mvi-060528	Microbotryum violaceum	51.66	2.00e-41	159.00
IUUC-Mmr-060747	Microcebus murinus	62.02	6.00e-42	160.00
IUUC-Mdo-062343	Monodelphis domestica	56.94	1.00e-42	163.00
IUUC-Mmu-063563	Mus musculus	62.02	4.00e-42	161.00
IUUC-Mac-064823	Musa acuminata	55.63	6.00e-44	167.00
IUUC-Mpu-066541	Mustela putorius furo	61.24	4.00e-41	158.00
IUUC-Mlu-067388	Myotis lucifugus	61.07	6.00e-41	157.00
IUUC-Nfi-068577	Neosartorya fischeri	62.16	5.00e-47	178.00
IUUC-Ncr-068803	Neurospora crassa	56.21	5.00e-44	167.00
IUUC-Opr-070902	Ochotona princeps	61.24	3.00e-42	162.00
IUUC-Ont-071672	Oreochromis niloticus	56.43	7.00e-43	164.00
IUUC-Ocu-074566	Oryctolagus cuniculus	59.23	8.00e-41	157.00
IUUC-Oba-075538	Oryza barthii	52.24	3.00e-37	145.00
IUUC-Obr-076757	Oryza brachyantha	57.73	6.00e-31	123.00
IUUC-Ogu-078467	Oryza glumaepatula	52.67	1.00e-42	163.00
IUUC-Oin-079533	Oryza indica	52.24	2.00e-37	145.00
IUUC-Olo-080673	Oryza longistaminata	52.24	2.00e-37	145.00
IUUC-Ome-081483	Oryza meridionalis	53.06	5.00e-42	161.00
IUUC-Oni-082321	Oryza nivara	52.67	1.00e-42	163.00
IUUC-Opu-083245	Oryza punctata	52.38	2.00e-41	159.00
IUUC-Oru-084641	Oryza rufipogon	50.00	3.00e-40	155.00
IUUC-Osa-085992	Oryza sativa	52.67	1.00e-42	163.00
IUUC-Ola-086807	Oryzias latipes	52.67	1.00e-43	167.00
IUUC-Olu-087834	Ostreococcus lucimarinus	61.15	3.00e-43	165.00
IUUC-Oga-089033	Otolemur garnettii	59.69	5.00e-41	157.00
IUUC-Oar-089542	Ovis aries	61.07	2.00e-40	156.00
IUUC-Ptr-091069	Pan troglodytes	62.79	9.00e-43	164.00
IUUC-Pan-092533	Papio anubis	61.07	7.00e-41	157.00
IUUC-Psi-093206	Pelodiscus sinensis	67.47	1.00e-31	125.00
IUUC-Pma-094607	Petromyzon marinus	57.24	3.00e-44	168.00
IUUC-Pno-094829	Phaeosphaeria nodorum	59.33	2.00e-47	179.00
IUUC-Ppa-095861	Physcomitrella patens	55.56	2.00e-43	166.00
IUUC-Pfo-096836	Poecilia formosa	54.17	9.00e-44	167.00
IUUC-Pab-098707	Pongo abelii	62.79	9.00e-43	164.00
IUUC-Pop-099870	Populus trichocarpa	58.04	5.00e-43	164.00
IUUC-Pca-100661	Procavia capensis	62.02	1.00e-42	163.00
IUUC-Ppe-101289	Prunus persica	55.24	3.00e-41	159.00
IUUC-Pva-103235	Pteropus vampyrus	57.75	3.00e-40	155.00
IUUC-Pte-104292	Pyrenophora teres	57.82	9.00e-48	180.00
IUUC-Rno-105501	Rattus norvegicus	62.02	3.00e-42	162.00
IUUC-Sha-107205	Sarcophilus harrisii	55.97	2.00e-37	146.00
IUUC-Sja-108009	Schizosaccharomyces japonicus	64.90	1.00e-55	206.00
IUUC-Spo-108136	Schizosaccharomyces pombe	67.10	2.00e-58	215.00
IUUC-Ssl-108394	Sclerotinia sclerotiorum	58.94	2.00e-52	196.00
IUUC-Smo-109014	Selaginella moellendorffii	56.25	4.00e-44	168.00
IUUC-Sit-110754	Setaria italica	53.06	5.00e-42	161.00
IUUC-Sly-111137	Solanum lycopersicum	57.45	6.00e-42	161.00
IUUC-Stu-112305	Solanum tuberosum	57.34	2.00e-42	162.00
IUUC-Sbi-114299	Sorghum bicolor	52.70	3.00e-43	165.00
IUUC-Ssc-115625	Sus scrofa	62.02	4.00e-42	161.00
IUUC-Tni-120070	Tetraodon nigroviridis	56.72	2.00e-41	159.00
IUUC-Tca-121158	Theobroma cacao	57.34	6.00e-43	164.00
IUUC-Tre-121973	Trichoderma reesei	61.49	8.00e-54	200.00
IUUC-Tvi-122496	Trichoderma virens	62.16	2.00e-54	202.00
IUUC-Tae-123596	Triticum aestivum	53.06	9.00e-43	164.00
IUUC-Tur-126818	Triticum urartu	57.66	8.00e-36	140.00
IUUC-Tme-127044	Tuber melanosporum	63.33	1.00e-48	183.00
IUUC-Ttr-128548	Tursiops truncatus	67.47	7.00e-31	124.00
IUUC-Vda-129840	Verticillium dahliae	59.60	2.00e-54	202.00
IUUC-Vvi-131685	Vitis vinifera	56.55	7.00e-43	164.00
IUUC-Xtr-132953	Xenopus tropicalis	56.46	6.00e-43	164.00
IUUC-Xma-134093	Xiphophorus maculatus	53.47	3.00e-43	165.00
IUUC-Yli-134548	Yarrowia lipolytica	69.54	6.00e-61	224.00
IUUC-Zma-135182	Zea mays	53.74	1.00e-42	163.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence