iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Spo-108136

UUCD1 version

UUC-ScP-00256

Ensembl Protein ID

SPCC1259.15c.1:pep

UniProt Accession

O00103; UBC11_SCHPO

Genbank Protein ID

BAA20375.1; CAB38416.1

Protein Name

Ubiquitin-conjugating enzyme E2-20 kDa; E2 ubiquitin-conjugating enzyme 11; Ubiquitin carrier protein; Ubiquitin-protein ligase

Genbank Nucleotide ID

D85545; CU329672

Gene Name

ubc11; ubcp4; SPCC1259.15c

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
SPCC1259.15c	SPCC1259.15c.1	SPCC1259.15c.1:pep

Annotation

mRNA Expression
GEO
Protein-protein Interaction
iRefIndex
Protein Expression/Proteomics

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E2/UBC	E2_UBC	12724408

Classification

Family	E-value	Score	Start	End
E2/UBC	3.30e-50	167.5	32	165

Active Site

Position(s)	Description	Evidence
113	Glycyl thioester intermediate	{ECO:0000255\|PROSITE-ProRule:PRU00388, ECO:0000255\|PROSITE-ProRule:PRU10133}

Domain Profile

E2/UBC

   S: 1    RlkkelkelekdppegisakpvdesdltewevlilGpedtpYeggvFkleiefpedYPfkPPkvkfltkifhPnvyenGkvClsilkeeek 91
           Rl+ el++l+ ++++gisa p+++s+l +w  +i+Gp+dt+Yeg +Fk++++fp +YP++PP++ f+++++hPnv+ +G++Cl+ilk  +k
   Q: 32   RLRSELMSLMMSNTPGISAFPDSDSNLLHWAGTITGPSDTYYEGLKFKISMSFPANYPYSPPTIIFTSPMWHPNVDMSGNICLDILK--DK 120
           89************************************************************************************9..** PP
   S: 92   Wspalsvesvllsiqsllaepnpesplneeaaellkknreeykkk 136
           Ws++++v+++lls+qsll epn++spln++aael++k++ eyk+ 
   Q: 121  WSAVYNVQTILLSLQSLLGEPNNASPLNAQAAELWSKDPIEYKRL 165
           ******************************************986 PP

Organism

Schizosaccharomyces pombe

Functional Description
(View)

S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.

Protein Sequence
(Fasta)

MDSDMQNQNP HTNSKNSSSA GMAVDGHSVT KRLRSELMSL MMSNTPGISA FPDSDSNLLH 60
WAGTITGPSD TYYEGLKFKI SMSFPANYPY SPPTIIFTSP MWHPNVDMSG NICLDILKDK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTTTACTTGT GTACATTAGC ACATGTTGTG TTGTGTTTAT AACTTACTCT CCTACCACCA 60
CGTACTCATT GAGAAACTAC AGTAACAACT TGAGGAATGG ATTCTGATAT GCAAAACCAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0131--Cell cycle
KW-0132--Cell division
KW-0181--Complete proteome
KW-0498--Mitosis
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000608--UBQ-conjugat_E2
IPR023313--UBQ-conjugating_AS
IPR016135--UBQ-conjugating_enzyme/RWD

PROSITE

PS00183--UBIQUITIN_CONJUGAT_1
PS50127--UBIQUITIN_CONJUGAT_2

Pfam

PF00179--UQ_con

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0005524--F:ATP binding
GO:0061631--F:ubiquitin conjugating enzyme activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0031625--F:ubiquitin protein ligase binding
GO:0031145--P:anaphase-promoting complex-dependent catabolic process
GO:0051301--P:cell division
GO:1902426--P:deactivation of mitotic spindle assembly checkpoint
GO:0007067--P:mitotic nuclear division
GO:0045842--P:positive regulation of mitotic metaphase/anaphase transition
GO:0000209--P:protein polyubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process

KEGG

spo:SPCC1259.15c

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001924	Ailuropoda melanoleuca	58.71	6.00e-48	181.00
IUUC-Atr-002885	Amborella trichopoda	57.32	1.00e-52	196.00
IUUC-Aly-006086	Arabidopsis lyrata	53.99	3.00e-49	185.00
IUUC-Ath-006897	Arabidopsis thaliana	55.28	5.00e-50	188.00
IUUC-Acl-008223	Aspergillus clavatus	66.09	3.00e-60	222.00
IUUC-Afl-008675	Aspergillus flavus	63.79	1.00e-57	213.00
IUUC-Afu-008997	Aspergillus fumigatus	64.94	2.00e-58	216.00
IUUC-Ani-009470	Aspergillus nidulans	64.44	2.00e-58	215.00
IUUC-Ang-009648	Aspergillus niger	65.14	2.00e-58	216.00
IUUC-Aor-009977	Aspergillus oryzae	69.23	1.00e-47	180.00
IUUC-Ate-010318	Aspergillus terreus	66.09	1.00e-60	223.00
IUUC-Ame-011302	Astyanax mexicanus	54.71	4.00e-48	181.00
IUUC-Bta-013101	Bos taurus	55.81	2.00e-50	189.00
IUUC-Bci-013787	Botrytis cinerea	63.58	2.00e-59	219.00
IUUC-Bdi-014144	Brachypodium distachyon	57.24	1.00e-49	186.00
IUUC-Bol-015613	Brassica oleracea	57.59	1.00e-50	190.00
IUUC-Bra-017562	Brassica rapa	57.59	1.00e-50	190.00
IUUC-Cfa-020588	Canis familiaris	60.13	8.00e-50	187.00
IUUC-Cpo-021384	Cavia porcellus	56.47	3.00e-50	189.00
IUUC-Csa-023437	Chlorocebus sabaeus	55.56	2.00e-51	193.00
IUUC-Cho-024330	Choloepus hoffmanni	65.25	2.00e-41	158.00
IUUC-Csv-025933	Ciona savignyi	53.76	5.00e-50	187.00
IUUC-Cgl-026494	Colletotrichum gloeosporioides	56.98	5.00e-60	221.00
IUUC-Cme-027266	Cyanidioschyzon merolae	51.28	3.00e-41	159.00
IUUC-Dre-027375	Danio rerio	55.29	6.00e-48	181.00
IUUC-Dno-029921	Dasypus novemcinctus	58.82	3.00e-48	182.00
IUUC-Dor-030209	Dipodomys ordii	54.71	7.00e-48	181.00
IUUC-Dse-031516	Dothistroma septosporum	51.88	8.00e-47	177.00
IUUC-Dme-031942	Drosophila melanogaster	56.60	5.00e-50	187.00
IUUC-Eca-034073	Equus caballus	60.13	8.00e-50	187.00
IUUC-Eeu-034854	Erinaceus europaeus	63.27	9.00e-35	137.00
IUUC-Fca-035666	Felis catus	60.13	8.00e-50	187.00
IUUC-Fal-037652	Ficedula albicollis	60.20	5.00e-34	133.00
IUUC-Fox-037793	Fusarium oxysporum	57.80	7.00e-60	220.00
IUUC-Fso-038151	Fusarium solani	63.58	3.00e-60	221.00
IUUC-Gmo-038894	Gadus morhua	63.78	3.00e-45	172.00
IUUC-Ggr-039730	Gaeumannomyces graminis	66.89	3.00e-53	198.00
IUUC-Gga-040537	Gallus gallus	60.77	2.00e-43	166.00
IUUC-Gac-041346	Gasterosteus aculeatus	61.79	2.00e-42	162.00
IUUC-Gma-043989	Glycine max	59.46	2.00e-50	189.00
IUUC-Ggo-045594	Gorilla gorilla	54.34	1.00e-49	186.00
IUUC-Hsa-046216	Homo sapiens	54.97	5.00e-51	191.00
IUUC-Hvu-047797	Hordeum vulgare	59.15	4.00e-49	185.00
IUUC-Itr-048402	Ictidomys tridecemlineatus	60.13	8.00e-50	187.00
IUUC-Kpa-049294	Komagataella pastoris	76.82	1.00e-67	247.00
IUUC-Lch-049761	Latimeria chalumnae	54.12	6.00e-47	177.00
IUUC-Lpe-051089	Leersia perrieri	54.38	7.00e-51	191.00
IUUC-Loc-052297	Lepisosteus oculatus	57.96	4.00e-49	186.00
IUUC-Lma-053214	Leptosphaeria maculans	63.76	6.00e-56	207.00
IUUC-Laf-054468	Loxodonta africana	56.32	2.00e-50	189.00
IUUC-Mcc-055338	Macaca mulatta	55.56	2.00e-51	193.00
IUUC-Meu-056147	Macropus eugenii	55.62	1.00e-50	190.00
IUUC-Mor-057239	Magnaporthe oryzae	61.71	9.00e-62	227.00
IUUC-Mpo-057491	Magnaporthe poae	65.56	1.00e-61	226.00
IUUC-Mtr-058382	Medicago truncatula	58.39	2.00e-49	185.00
IUUC-Mla-058880	Melampsora laricipopulina	60.00	5.00e-53	197.00
IUUC-Mga-059929	Meleagris gallopavo	61.54	1.00e-30	122.00
IUUC-Mvi-060528	Microbotryum violaceum	60.54	4.00e-48	182.00
IUUC-Mmr-060747	Microcebus murinus	63.57	3.00e-47	178.00
IUUC-Mdo-062343	Monodelphis domestica	55.29	7.00e-51	191.00
IUUC-Mmu-063563	Mus musculus	55.23	2.00e-49	186.00
IUUC-Mac-065004	Musa acuminata	59.33	4.00e-50	188.00
IUUC-Mpu-066541	Mustela putorius furo	59.48	5.00e-49	184.00
IUUC-Mlu-067388	Myotis lucifugus	58.71	1.00e-47	180.00
IUUC-Nfi-068577	Neosartorya fischeri	69.08	2.00e-56	209.00
IUUC-Ncr-068803	Neurospora crassa	58.38	9.00e-53	197.00
IUUC-Opr-070902	Ochotona princeps	59.48	4.00e-49	185.00
IUUC-Ont-071672	Oreochromis niloticus	65.85	1.00e-45	173.00
IUUC-Ocu-074566	Oryctolagus cuniculus	59.86	1.00e-48	183.00
IUUC-Oba-075538	Oryza barthii	56.72	3.00e-44	168.00
IUUC-Ogu-078467	Oryza glumaepatula	56.29	8.00e-51	191.00
IUUC-Oin-079533	Oryza indica	56.72	4.00e-44	167.00
IUUC-Olo-080673	Oryza longistaminata	56.72	3.00e-44	168.00
IUUC-Ome-081483	Oryza meridionalis	57.14	2.00e-49	186.00
IUUC-Oni-082321	Oryza nivara	56.29	8.00e-51	191.00
IUUC-Opu-083245	Oryza punctata	56.46	7.00e-49	184.00
IUUC-Oru-084641	Oryza rufipogon	53.46	2.00e-48	183.00
IUUC-Osa-085992	Oryza sativa	56.29	8.00e-51	191.00
IUUC-Ola-086807	Oryzias latipes	64.84	1.00e-47	180.00
IUUC-Olu-087834	Ostreococcus lucimarinus	62.59	2.00e-48	182.00
IUUC-Oga-088699	Otolemur garnettii	56.00	9.00e-50	187.00
IUUC-Oar-089542	Ovis aries	59.35	2.00e-48	182.00
IUUC-Ptr-091069	Pan troglodytes	54.97	5.00e-51	191.00
IUUC-Pan-092533	Papio anubis	54.91	4.00e-50	188.00
IUUC-Psi-093206	Pelodiscus sinensis	61.22	1.00e-33	132.00
IUUC-Pma-094607	Petromyzon marinus	54.71	5.00e-50	187.00
IUUC-Pno-094829	Phaeosphaeria nodorum	65.77	2.00e-56	209.00
IUUC-Ppa-095861	Physcomitrella patens	58.82	4.00e-52	194.00
IUUC-Pfo-096836	Poecilia formosa	66.14	8.00e-48	180.00
IUUC-Pab-098707	Pongo abelii	54.97	5.00e-51	191.00
IUUC-Pop-099870	Populus trichocarpa	57.50	2.00e-51	192.00
IUUC-Pca-100661	Procavia capensis	57.06	3.00e-51	192.00
IUUC-Ppe-101289	Prunus persica	55.62	7.00e-51	191.00
IUUC-Pva-103235	Pteropus vampyrus	62.50	1.00e-45	173.00
IUUC-Pte-104292	Pyrenophora teres	65.07	2.00e-56	208.00
IUUC-Rno-105501	Rattus norvegicus	56.47	1.00e-50	190.00
IUUC-Sce-106133	Saccharomyces cerevisiae	67.10	2.00e-53	199.00
IUUC-Sha-107205	Sarcophilus harrisii	58.39	4.00e-45	172.00
IUUC-Sja-108009	Schizosaccharomyces japonicus	88.76	2.00e-92	328.00
IUUC-Ssl-108394	Sclerotinia sclerotiorum	64.24	9.00e-60	220.00
IUUC-Smo-109014	Selaginella moellendorffii	54.71	4.00e-51	191.00
IUUC-Sit-110754	Setaria italica	57.14	2.00e-50	189.00
IUUC-Sly-111137	Solanum lycopersicum	59.57	3.00e-48	182.00
IUUC-Stu-112305	Solanum tuberosum	56.69	4.00e-51	191.00
IUUC-Sbi-114299	Sorghum bicolor	56.00	6.00e-51	191.00
IUUC-Ssc-115625	Sus scrofa	60.13	8.00e-50	187.00
IUUC-Tni-120070	Tetraodon nigroviridis	58.21	2.00e-42	162.00
IUUC-Tca-121158	Theobroma cacao	55.62	6.00e-51	191.00
IUUC-Tre-121973	Trichoderma reesei	59.55	4.00e-62	228.00
IUUC-Tvi-122496	Trichoderma virens	60.11	2.00e-62	229.00
IUUC-Tae-123596	Triticum aestivum	56.38	1.00e-50	190.00
IUUC-Tur-126818	Triticum urartu	56.25	1.00e-37	145.00
IUUC-Tme-127044	Tuber melanosporum	69.05	7.00e-60	220.00
IUUC-Ttr-128548	Tursiops truncatus	63.27	7.00e-35	137.00
IUUC-Vda-129840	Verticillium dahliae	57.23	7.00e-59	217.00
IUUC-Vvi-131685	Vitis vinifera	58.94	5.00e-51	191.00
IUUC-Xtr-132953	Xenopus tropicalis	55.68	7.00e-50	187.00
IUUC-Xma-134093	Xiphophorus maculatus	66.14	9.00e-48	180.00
IUUC-Yli-134548	Yarrowia lipolytica	69.49	5.00e-69	251.00
IUUC-Zma-135182	Zea mays	57.82	1.00e-51	193.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence