iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Bta-013345

UUCD1 version

UUC-BoT-00971

Ensembl Protein ID

ENSBTAP00000038956.2

UniProt Accession

Q4U5R4; A5D9G2; Q3T0F8; RN114_BOVIN

Genbank Protein ID

AAY33866.1; AAI02413.1; ABQ13021.1

Protein Name

E3 ubiquitin-protein ligase RNF114; RING finger protein 114; RING-type E3 ubiquitin transferase RNF114; Zinc finger protein 313

Genbank Nucleotide ID

DQ010409; BC102412; BT030581

Gene Name

RNF114; ZNF313

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSBTAG00000027317.2	ENSBTAT00000039156.2	ENSBTAP00000038956.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/U-box	1.10e-07	32.0	28	74
E3 activity/RING/RING	2.00e-06	28.3	31	70

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/U-box

   S: 5    eflCpIslelMrdPvvlpsGitydrssIekwlasggktcPvtrqplt 51
            f Cp+ le+ + Pv +p+G+++  ++++++l+ ++  c v+r+ l+
   Q: 28   RFTCPVCLEVYEKPVQVPCGHVFCSACLQECLKPKKPVCGVCRSALA 74
           69*****************************************9986 PP

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C++Cle +++ p+ +pCgHvf+  Clq       ++ k+  C +Cr
   Q: 31   CPVCLEVYEK-PVQVPCGHVFCSACLQEC-----LKPKKPVCGVCR 70
           **********.999************555.....499999*****8 PP

Organism

Bos taurus

Functional Description
(View)

E3 ubiquitin-protein ligase promoting the ubiquitination and degradation of the CDK inhibitor CDKN1A and probably also CDKN1B and CDKN1C. These activities stimulate cell cycle's G1-to-S phase transition and suppress cellular senescence. May play a role in spermatogenesis.

Protein Sequence
(Fasta)

MAAQAQAPAR DGGAQLAGPA AEADPLGRFT CPVCLEVYEK PVQVPCGHVF CSACLQECLK 60
PKKPVCGVCR SALAPGVRAV ELERQIESTE TSCHGCRKNF FLSKIRAHVA TCSKYQNYIM 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCTGAGGCGC GGCGGTCCGC GGCAGCAAGA TGGCGGCGCA GGCGCAGGCC CCGGCCCGTG 60
ATGGTGGTGC GCAGCTGGCA GGACCTGCGG CGGAGGCCGA CCCCCTGGGC CGCTTCACGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0217--Developmental protein
KW-0221--Differentiation
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0744--Spermatogenesis
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR008598--Di19_Zn_binding_dom
IPR034734--ZF_C2HC_RNF
IPR027370--Znf-RING_LisH
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS51803--ZF_C2HC_RNF
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF05605--zf-Di19
PF13445--zf-RING_UBOX

SMART

SM00184--RING

Gene Ontology

GO:0005829--C:cytosol
GO:0005622--C:intracellular
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0031624--F:ubiquitin conjugating enzyme binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0030154--P:cell differentiation
GO:0007275--P:multicellular organism development
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0000209--P:protein polyubiquitination
GO:0007283--P:spermatogenesis

KEGG

bta:513479

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002315	Ailuropoda melanoleuca	95.65	1.00e-130	458.00
IUUC-Apl-004036	Anas platyrhynchos	75.69	3.00e-82	296.00
IUUC-Aca-004569	Anolis carolinensis	70.74	2.00e-98	351.00
IUUC-Cja-019919	Callithrix jacchus	93.48	2.00e-127	447.00
IUUC-Cfa-021164	Canis familiaris	93.91	9.00e-128	448.00
IUUC-Cpo-022051	Cavia porcellus	84.35	6.00e-116	409.00
IUUC-Csa-023956	Chlorocebus sabaeus	95.17	2.00e-118	418.00
IUUC-Dre-027499	Danio rerio	54.23	4.00e-68	250.00
IUUC-Dno-029437	Dasypus novemcinctus	93.97	2.00e-124	437.00
IUUC-Dor-030428	Dipodomys ordii	79.57	8.00e-105	372.00
IUUC-Ete-032855	Echinops telfairi	76.29	5.00e-91	326.00
IUUC-Eca-034236	Equus caballus	96.69	5.00e-104	369.00
IUUC-Eeu-034875	Erinaceus europaeus	97.34	3.00e-109	387.00
IUUC-Fca-036017	Felis catus	97.64	2.00e-124	437.00
IUUC-Fal-037133	Ficedula albicollis	75.69	3.00e-84	304.00
IUUC-Gga-040752	Gallus gallus	70.22	3.00e-95	340.00
IUUC-Ggo-044654	Gorilla gorilla	93.13	2.00e-72	264.00
IUUC-Hsa-046280	Homo sapiens	95.65	8.00e-119	419.00
IUUC-Itr-048594	Ictidomys tridecemlineatus	95.16	3.00e-104	370.00
IUUC-Lch-050028	Latimeria chalumnae	63.33	2.00e-80	291.00
IUUC-Loc-051797	Lepisosteus oculatus	59.90	6.00e-71	259.00
IUUC-Laf-054248	Loxodonta africana	94.48	4.00e-103	366.00
IUUC-Mcc-054724	Macaca mulatta	95.17	2.00e-118	418.00
IUUC-Meu-056464	Macropus eugenii	59.12	2.00e-52	197.00
IUUC-Mga-059403	Meleagris gallopavo	72.14	5.00e-61	226.00
IUUC-Mmr-061582	Microcebus murinus	97.24	1.00e-105	374.00
IUUC-Mdo-062106	Monodelphis domestica	78.83	2.00e-101	361.00
IUUC-Mmu-064176	Mus musculus	89.47	1.00e-114	405.00
IUUC-Mpu-066083	Mustela putorius furo	95.22	3.00e-130	457.00
IUUC-Mlu-067060	Myotis lucifugus	94.69	2.00e-117	414.00
IUUC-Nle-069353	Nomascus leucogenys	95.17	6.00e-109	386.00
IUUC-Opr-070916	Ochotona princeps	87.39	7.00e-120	422.00
IUUC-Ont-072284	Oreochromis niloticus	57.69	3.00e-73	267.00
IUUC-Oan-072858	Ornithorhynchus anatinus	75.14	6.00e-82	296.00
IUUC-Ocu-074471	Oryctolagus cuniculus	97.03	3.00e-118	417.00
IUUC-Ola-087569	Oryzias latipes	54.13	6.00e-73	266.00
IUUC-Olu-087618	Ostreococcus lucimarinus	40.91	2.00e-08	52.80
IUUC-Oga-089164	Otolemur garnettii	97.16	4.00e-123	433.00
IUUC-Oar-089436	Ovis aries	98.26	4.00e-135	473.00
IUUC-Ptr-090945	Pan troglodytes	95.65	8.00e-119	419.00
IUUC-Pan-092765	Papio anubis	95.17	2.00e-118	418.00
IUUC-Psi-093593	Pelodiscus sinensis	76.06	3.00e-65	239.00
IUUC-Pfo-096157	Poecilia formosa	55.19	1.00e-70	259.00
IUUC-Pab-098509	Pongo abelii	94.74	3.00e-119	420.00
IUUC-Pca-100293	Procavia capensis	90.10	8.00e-107	379.00
IUUC-Pva-102556	Pteropus vampyrus	92.17	4.00e-125	439.00
IUUC-Rno-105634	Rattus norvegicus	88.60	2.00e-112	398.00
IUUC-Sha-107052	Sarcophilus harrisii	77.88	1.00e-91	328.00
IUUC-Sar-113680	Sorex araneus	92.82	2.00e-92	330.00
IUUC-Ssc-115451	Sus scrofa	95.58	4.00e-104	369.00
IUUC-Tgu-116515	Taeniopygia guttata	74.32	8.00e-83	298.00
IUUC-Tru-117712	Takifugu rubripes	53.95	3.00e-73	267.00
IUUC-Tsy-119419	Tarsius syrichta	96.69	1.00e-104	371.00
IUUC-Tni-119774	Tetraodon nigroviridis	54.82	2.00e-72	264.00
IUUC-Tbe-127924	Tupaia belangeri	91.56	8.00e-119	419.00
IUUC-Ttr-128721	Tursiops truncatus	94.35	2.00e-129	454.00
IUUC-Vpa-130175	Vicugna pacos	71.18	2.00e-87	314.00
IUUC-Xtr-131851	Xenopus tropicalis	56.31	3.00e-72	264.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence