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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-063167
Ensembl Protein ID ENSMUSP00000050076.4
UniProt Accession Q9JKV1; Q3UKZ8; Q8BPH8; Q922A7; ADRM1_MOUSE
Genbank Protein ID AAF33401.1; BAC35889.1; BAE26457.1; BAE26653.1; BAE39089.1; CAM16214.1; AAH08974.1; AAH31517.1
Protein Name Proteasomal ubiquitin receptor ADRM1; 110 kDa cell membrane glycoprotein; Adhesion-regulating molecule 1; Rpn13 homolog
Genbank Nucleotide ID AF225959; AK075674; AK145474; AK145792; AK166878; AL663027; BC008974; BC031517
Gene Name Adrm1; Gp110
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000039041.15 ENSMUST00000061437.4 ENSMUSP00000050076.4
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
microRNATRANSFACRepTarmiRNAMap
RAID2
Protein-protein Interaction
IIDiRefIndexHINTMentha
Protein 3D Structure
PDBMMDB
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
Phospho.ELMmUbiSiDa
Protein Expression/Proteomics
GPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
UBD/PRU UBD/PRU 18497827
Organism Mus musculus
Functional Description
(View)

Functional Description


     Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. Within the complex, functions as a proteasomal ubiquitin receptor. Engages and thus activates 19S-associated deubiquitinases UCHL5 and PSMD14 during protein degradation. UCHL5 reversibly associate with the 19S regulatory particle whereas PSMD14 is an intrinsic subunit of the proteasome lid subcomplex.
 Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. Within the complex, functions as a proteasomal ubiquitin receptor. Engages and thus activates 19S-associated deubiquitinases UCHL5 and PSMD14 during protein degradation. UCHL5 reversibly associate with the 19S regulatory particle whereas PSMD14 is an intrinsic subunit of the proteasome lid subcomplex.
Protein Sequence
(Fasta)
MTTSGALFPS LVPGSRGSST KYLVEFRAGK MSLKGTTVTP DKRKGLVYIQ QTDDSLIHFC 60
WKDRTSGTVE DDLIIFPDDC EFKRVPQCPS GRVYVLKFKA GSKRLFFWMQ EPKTDQDEEH 120
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Protein Fasta Sequence


>IUUC-Mmu-063167|UBD,PRU|Mus musculus
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Nucleotide Sequence
(Fasta)
CGCGGAGGCG GGCCGGATGC GATGGACGGT GACCAGGGCC AATCGGGACC TGGTCGGGGC 60
CGGCCGCGCG GCTGACGGAA CTCAATCCGC GGCGAGAGCG GCGGCGGGGC GGGCCAAGCA 120
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Nucleotide Fasta Sequence


>IUUC-Mmu-063167|UBD,PRU|Mus musculus
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Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-1017--Isopeptide bond
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0647--Proteasome
KW-1185--Reference proteome
KW-0832--Ubl conjugation
Interpro

IPR006773--26S_Psome_Ubiquitin-recp_Rpn13
IPR032368--RPN13_C
Pfam

PF04683--Proteasom_Rpn13
PF16550--RPN13_C
Gene Ontology

GO:0005829--C:cytosol
GO:0005654--C:nucleoplasm
GO:0005886--C:plasma membrane
GO:0000502--C:proteasome complex
GO:0008541--C:proteasome regulatory particle, lid subcomplex
GO:0061133--F:endopeptidase activator activity
GO:0002020--F:protease binding
GO:0070628--F:proteasome binding
GO:0043130--F:ubiquitin binding
GO:0060612--P:adipose tissue development
GO:0042699--P:follicle-stimulating hormone signaling pathway
GO:0048477--P:oogenesis
GO:0001541--P:ovarian follicle development
GO:0060399--P:positive regulation of growth hormone receptor signaling pathway
GO:0043248--P:proteasome assembly
GO:0033081--P:regulation of T cell differentiation in thymus
GO:0072520--P:seminiferous tubule development
GO:0060009--P:Sertoli cell development
GO:0007286--P:spermatid development
GO:0048538--P:thymus development
GO:0006368--P:transcription elongation from RNA polymerase II promoter
GO:0006511--P:ubiquitin-dependent protein catabolic process
KEGG mmu:56436
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000735 Aegilops tauschii 39.01 8.00e-23 100.00
IUUC-Apl-003608 Anas platyrhynchos 89.31 5.00e-65 241.00
IUUC-Aly-006501 Arabidopsis lyrata 55.86 3.00e-34 139.00
IUUC-Acl-008240 Aspergillus clavatus 36.63 1.00e-12 67.80
IUUC-Afu-009026 Aspergillus fumigatus 52.38 5.00e-03 35.40
IUUC-Ang-009696 Aspergillus niger 34.26 3.00e-12 66.60
IUUC-Bgr-012116 Blumeria graminis 35.29 2.00e-13 70.50
IUUC-Bta-012686 Bos taurus 97.09 1.00e-82 300.00
IUUC-Bci-013772 Botrytis cinerea 33.98 2.00e-10 60.10
IUUC-Bol-015418 Brassica oleracea 52.25 2.00e-31 130.00
IUUC-Bra-018022 Brassica rapa 52.25 6.00e-32 131.00
IUUC-Cja-019223 Callithrix jacchus 95.35 5.00e-81 295.00
IUUC-Cfa-020426 Canis familiaris 95.93 2.00e-82 299.00
IUUC-Csa-023622 Chlorocebus sabaeus 97.09 2.00e-82 299.00
IUUC-Cme-027138 Cyanidioschyzon merolae 41.59 2.00e-25 109.00
IUUC-Dre-027576 Danio rerio 87.65 9.00e-69 254.00
IUUC-Dno-029119 Dasypus novemcinctus 98.26 2.00e-84 306.00
IUUC-Dor-030837 Dipodomys ordii 97.01 5.00e-72 265.00
IUUC-Dse-031557 Dothistroma septosporum 40.40 2.00e-16 80.50
IUUC-Dme-031872 Drosophila melanogaster 71.56 2.00e-49 189.00
IUUC-Ete-032654 Echinops telfairi 94.34 6.00e-72 264.00
IUUC-Fox-037975 Fusarium oxysporum 29.92 1.00e-11 64.70
IUUC-Gmo-038621 Gadus morhua 86.98 3.00e-68 252.00
IUUC-Gga-040784 Gallus gallus 91.28 2.00e-79 289.00
IUUC-Gac-041531 Gasterosteus aculeatus 82.14 5.00e-76 278.00
IUUC-Gma-044281 Glycine max 45.31 1.00e-30 126.00
IUUC-Itr-048195 Ictidomys tridecemlineatus 97.67 3.00e-83 302.00
IUUC-Kpa-049226 Komagataella pastoris 25.96 3.00e-07 47.00
IUUC-Lch-049418 Latimeria chalumnae 87.65 2.00e-74 273.00
IUUC-Lpe-050742 Leersia perrieri 56.88 3.00e-35 142.00
IUUC-Lma-053330 Leptosphaeria maculans 36.61 2.00e-13 69.30
IUUC-Laf-053604 Loxodonta africana 97.09 4.00e-83 301.00
IUUC-Mcc-055359 Macaca mulatta 97.09 2.00e-82 299.00
IUUC-Meu-056243 Macropus eugenii 91.50 4.00e-66 244.00
IUUC-Mla-059042 Melampsora laricipopulina 35.29 9.00e-15 73.90
IUUC-Mga-059762 Meleagris gallopavo 88.05 6.00e-65 239.00
IUUC-Mvi-060526 Microbotryum violaceum 42.59 4.00e-20 92.00
IUUC-Mmr-061152 Microcebus murinus 96.51 1.00e-82 300.00
IUUC-Mpu-066924 Mustela putorius furo 95.71 3.00e-72 265.00
IUUC-Nle-069563 Nomascus leucogenys 94.77 2.00e-80 292.00
IUUC-Oan-072770 Ornithorhynchus anatinus 92.94 4.00e-79 288.00
IUUC-Oba-075129 Oryza barthii 54.13 1.00e-32 133.00
IUUC-Oni-083080 Oryza nivara 54.13 1.00e-32 133.00
IUUC-Opu-083569 Oryza punctata 53.21 7.00e-32 130.00
IUUC-Ola-087324 Oryzias latipes 82.94 3.00e-72 265.00
IUUC-Oga-089045 Otolemur garnettii 97.67 8.00e-83 300.00
IUUC-Oar-090402 Ovis aries 97.09 1.00e-82 300.00
IUUC-Ptr-090578 Pan troglodytes 96.92 3.00e-76 278.00
IUUC-Pan-092872 Papio anubis 97.09 2.00e-82 299.00
IUUC-Ppa-095547 Physcomitrella patens 54.13 7.00e-32 131.00
IUUC-Pfo-096879 Poecilia formosa 86.90 1.00e-64 240.00
IUUC-Pca-100816 Procavia capensis 95.27 2.00e-69 256.00
IUUC-Pva-103198 Pteropus vampyrus 96.23 8.00e-75 273.00
IUUC-Pgr-103494 Puccinia graminis 38.39 4.00e-19 88.60
IUUC-Ptt-103732 Puccinia triticina 30.59 1.00e-04 38.50
IUUC-Rno-105937 Rattus norvegicus 99.42 3.00e-85 308.00
IUUC-Sha-106986 Sarcophilus harrisii 94.12 2.00e-79 289.00
IUUC-Sja-107713 Schizosaccharomyces japonicus 48.67 7.00e-28 118.00
IUUC-Smo-109349 Selaginella moellendorffii 25.83 1.00e-03 38.90
IUUC-Tgu-116881 Taeniopygia guttata 87.97 3.00e-77 280.00
IUUC-Tca-121244 Theobroma cacao 38.67 2.00e-26 113.00
IUUC-Tre-122090 Trichoderma reesei 37.25 1.00e-11 64.30
IUUC-Tvi-122267 Trichoderma virens 36.54 3.00e-12 66.20
IUUC-Tae-124010 Triticum aestivum 46.10 1.00e-32 133.00
IUUC-Tbe-127777 Tupaia belangeri 93.23 3.00e-63 234.00
IUUC-Ttr-128473 Tursiops truncatus 96.51 6.00e-93 334.00
IUUC-Xma-133590 Xiphophorus maculatus 86.23 9.00e-66 244.00
Created Date 25-Jun-2017

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