iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mcc-054655

Ensembl Protein ID

ENSMMUP00000026374.3

UniProt Accession

F7G9X3; H9Z5L7; F7G9X3_MACMU

Genbank Protein ID

AFH31232.1; AFH31233.1

Protein Name

Serine/threonine-protein kinase SIK1

Genbank Nucleotide ID

JSUE03027021; JU474429

Gene Name

SIK1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMMUG00000020050.3	ENSMMUT00000028189.3	ENSMMUP00000026374.3

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
UBD/Alpha-Helix/UBA	96.69	0.00e+00	1333.00	IUUC-Hsa-046775

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Macaca mulatta

Protein Sequence
(Fasta)

MVIMSEFSAD PAGQGQGLQK PLRVGFYDIE RTLGKGNFAV VKLARHRVTK TQVAIKIIDK 60
TRLDSSNLEK IYREVQLMKL LNHPHIIKLY QVMETKDMLY IVTEFAKNGE MFDYLTSNGH 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGCGGCGGGC GGCGGGGCGG GGCGGGCGGC CGGCGGCGGG GGCGCGGGCG GTCCGGGCAT 60
GACATGCCGG CGCGGACCCG GAGGCGGCAA GCAGCTGCGC GGCGGCCGGA GCAGTAGGCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0418--Kinase
KW-1185--Reference proteome
KW-0808--Transferase

Interpro

IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR008271--Ser/Thr_kinase_AS
IPR034672--SIK
IPR015940--UBA

PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00108--PROTEIN_KINASE_ST
PS50030--UBA

Pfam

PF00069--Pkinase

SMART

SM00220--S_TKc

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0005524--F:ATP binding
GO:0000287--F:magnesium ion binding
GO:0004674--F:protein serine/threonine kinase activity
GO:0043276--P:anoikis
GO:0055007--P:cardiac muscle cell differentiation
GO:0032870--P:cellular response to hormone stimulus
GO:0043153--P:entrainment of circadian clock by photoperiod
GO:0035556--P:intracellular signal transduction
GO:0032792--P:negative regulation of CREB transcription factor activity
GO:0045721--P:negative regulation of gluconeogenesis
GO:0010868--P:negative regulation of triglyceride biosynthetic process
GO:0006468--P:protein phosphorylation
GO:0007346--P:regulation of mitotic cell cycle
GO:0010830--P:regulation of myotube differentiation

KEGG

mcc:722303

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001538	Ailuropoda melanoleuca	46.62	9.00e-123	434.00
IUUC-Aca-004739	Anolis carolinensis	64.58	0.00e+00	916.00
IUUC-Ame-011603	Astyanax mexicanus	65.53	0.00e+00	763.00
IUUC-Cja-019873	Callithrix jacchus	92.40	0.00e+00	1310.00
IUUC-Cfa-020801	Canis familiaris	73.24	0.00e+00	965.00
IUUC-Cpo-022296	Cavia porcellus	76.81	0.00e+00	982.00
IUUC-Csa-023676	Chlorocebus sabaeus	98.47	0.00e+00	1360.00
IUUC-Cho-025021	Choloepus hoffmanni	76.15	8.00e-157	547.00
IUUC-Cin-025762	Ciona intestinalis	61.90	4.00e-125	442.00
IUUC-Dre-028021	Danio rerio	63.80	0.00e+00	745.00
IUUC-Dno-029103	Dasypus novemcinctus	74.76	0.00e+00	790.00
IUUC-Ete-033190	Echinops telfairi	82.95	0.00e+00	724.00
IUUC-Gmo-039423	Gadus morhua	61.46	0.00e+00	748.00
IUUC-Gga-040174	Gallus gallus	65.22	0.00e+00	888.00
IUUC-Gac-041875	Gasterosteus aculeatus	68.17	2.00e-156	546.00
IUUC-Ggo-045090	Gorilla gorilla	95.82	0.00e+00	1349.00
IUUC-Hsa-046775	Homo sapiens	96.69	0.00e+00	1329.00
IUUC-Itr-048715	Ictidomys tridecemlineatus	81.09	0.00e+00	1083.00
IUUC-Lch-049933	Latimeria chalumnae	56.97	0.00e+00	785.00
IUUC-Loc-052048	Lepisosteus oculatus	58.49	0.00e+00	778.00
IUUC-Laf-054466	Loxodonta africana	77.38	0.00e+00	1081.00
IUUC-Meu-056705	Macropus eugenii	74.74	0.00e+00	799.00
IUUC-Mmr-061419	Microcebus murinus	82.38	0.00e+00	1109.00
IUUC-Mdo-062854	Monodelphis domestica	67.21	0.00e+00	874.00
IUUC-Mmu-064252	Mus musculus	77.90	0.00e+00	1152.00
IUUC-Nle-069329	Nomascus leucogenys	92.49	0.00e+00	1265.00
IUUC-Opr-071101	Ochotona princeps	63.53	0.00e+00	658.00
IUUC-Ont-071887	Oreochromis niloticus	58.89	0.00e+00	697.00
IUUC-Oan-073050	Ornithorhynchus anatinus	74.38	0.00e+00	878.00
IUUC-Oga-088220	Otolemur garnettii	83.46	0.00e+00	1145.00
IUUC-Oar-089420	Ovis aries	74.05	0.00e+00	924.00
IUUC-Ptr-091258	Pan troglodytes	96.82	0.00e+00	1329.00
IUUC-Pan-092031	Papio anubis	99.36	0.00e+00	1375.00
IUUC-Pfo-097451	Poecilia formosa	62.52	0.00e+00	704.00
IUUC-Pab-097806	Pongo abelii	97.32	0.00e+00	1335.00
IUUC-Pva-102182	Pteropus vampyrus	75.22	0.00e+00	746.00
IUUC-Sha-107262	Sarcophilus harrisii	67.59	0.00e+00	956.00
IUUC-Ssc-115584	Sus scrofa	95.56	3.00e-144	503.00
IUUC-Tgu-116973	Taeniopygia guttata	64.45	0.00e+00	897.00
IUUC-Tsy-119567	Tarsius syrichta	45.74	2.00e-114	406.00
IUUC-Ttr-128365	Tursiops truncatus	78.10	0.00e+00	888.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence