iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mpu-066347

Ensembl Protein ID

ENSMPUP00000009956.1

UniProt Accession

M3YF49; M3YF49_MUSPF

Genbank Protein ID

ENSMPUP00000009956

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AEYP01055535

Gene Name

AIRE

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMPUG00000010031.1	ENSMPUT00000010116.1	ENSMPUP00000009956.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/PHD	1.50e-13	50.8	298	352

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/PHD

   S: 2    kvClvCgeggedekslveCekCrewfHpaClkls...veeelpnsek....wiCpkCrs 53
           + C+vC++gge    l++C+ C ++fH aCl+++   + ++l + +     w C++C +
   Q: 298  DECAVCRDGGE----LICCDGCPRAFHLACLSPPlrdIPRPLAGGHGssgtWRCSRCLQ 352
           57*********....*******************88855555555444556******76 PP

Organism

Mustela putorius furo

Protein Sequence
(Fasta)

RAGGDAVLRR LLRLHRTEIA VAVDSAFPLL HALADHDVVP EDKFQETLRL KEKEGCPQAF 60
HALLSWLLTQ DAAAILDFWR VLFKDYNLER YARLQPILDG FPKDVDLTQP RKARKPPTGP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGGGCAGGTG GGGACGCTGT GCTGCGCCGT CTCCTGAGGC TGCACCGCAC AGAGATCGCC 60
GTGGCCGTGG ACAGCGCCTT CCCGCTGCTG CACGCGCTGG CCGACCACGA CGTGGTCCCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR008087--AIRE
IPR004865--HSR_dom
IPR000770--SAND_dom
IPR010919--SAND_dom-like
IPR019786--Zinc_finger_PHD-type_CS
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS51414--HSR
PS50864--SAND
PS01359--ZF_PHD_1
PS50016--ZF_PHD_2

Pfam

PF03172--HSR
PF00628--PHD
PF01342--SAND

PRINTS

PR01711--AIREGULATOR

SMART

SM00249--PHD
SM00258--SAND

Gene Ontology

GO:0005737--C:cytoplasm
GO:0016604--C:nuclear body
GO:0003682--F:chromatin binding
GO:0000977--F:RNA polymerase II regulatory region sequence-specific DNA binding
GO:0045182--F:translation regulator activity
GO:0008270--F:zinc ion binding
GO:0002509--P:central tolerance induction to self antigen
GO:0032602--P:chemokine production
GO:0006959--P:humoral immune response
GO:0045060--P:negative thymic T cell selection
GO:0002458--P:peripheral T cell tolerance induction
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:2000410--P:regulation of thymocyte migration
GO:0097536--P:thymus epithelium morphogenesis

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001612	Ailuropoda melanoleuca	81.48	0.00e+00	703.00
IUUC-Aca-004543	Anolis carolinensis	67.74	6.00e-24	101.00
IUUC-Bta-012988	Bos taurus	76.49	0.00e+00	686.00
IUUC-Cja-019486	Callithrix jacchus	70.55	3.00e-102	364.00
IUUC-Cfa-021069	Canis familiaris	78.71	0.00e+00	697.00
IUUC-Cpo-021649	Cavia porcellus	69.45	3.00e-163	568.00
IUUC-Csa-023960	Chlorocebus sabaeus	75.78	2.00e-177	615.00
IUUC-Dre-028583	Danio rerio	38.89	2.00e-58	220.00
IUUC-Dno-029869	Dasypus novemcinctus	67.91	5.00e-140	491.00
IUUC-Dor-030263	Dipodomys ordii	86.17	2.00e-46	179.00
IUUC-Ete-032778	Echinops telfairi	91.82	2.00e-49	189.00
IUUC-Eca-034328	Equus caballus	75.00	0.00e+00	656.00
IUUC-Fca-035400	Felis catus	78.21	0.00e+00	665.00
IUUC-Fal-036644	Ficedula albicollis	49.25	9.00e-69	254.00
IUUC-Fso-038262	Fusarium solani	34.44	3.00e-09	57.80
IUUC-Ggo-045250	Gorilla gorilla	75.83	0.00e+00	632.00
IUUC-Hsa-046603	Homo sapiens	75.65	0.00e+00	629.00
IUUC-Itr-048977	Ictidomys tridecemlineatus	73.48	7.00e-173	600.00
IUUC-Lch-050310	Latimeria chalumnae	40.75	9.00e-95	340.00
IUUC-Loc-052508	Lepisosteus oculatus	36.53	1.00e-88	320.00
IUUC-Laf-054028	Loxodonta africana	78.77	3.00e-129	455.00
IUUC-Mcc-054935	Macaca mulatta	75.96	0.00e+00	654.00
IUUC-Mga-059318	Meleagris gallopavo	41.76	8.00e-54	203.00
IUUC-Mmr-061557	Microcebus murinus	62.27	3.00e-133	468.00
IUUC-Mdo-062475	Monodelphis domestica	47.62	3.00e-115	409.00
IUUC-Mmu-063994	Mus musculus	67.31	0.00e+00	660.00
IUUC-Mlu-068239	Myotis lucifugus	65.71	1.00e-93	336.00
IUUC-Nle-069544	Nomascus leucogenys	80.00	8.00e-23	100.00
IUUC-Opr-071199	Ochotona princeps	74.19	1.00e-73	270.00
IUUC-Ont-072571	Oreochromis niloticus	30.88	5.00e-35	142.00
IUUC-Oan-073739	Ornithorhynchus anatinus	54.28	6.00e-146	510.00
IUUC-Ola-086528	Oryzias latipes	34.32	9.00e-42	164.00
IUUC-Oga-088353	Otolemur garnettii	74.12	0.00e+00	670.00
IUUC-Oar-090065	Ovis aries	74.87	3.00e-148	518.00
IUUC-Ptr-091347	Pan troglodytes	76.01	2.00e-177	615.00
IUUC-Pan-092423	Papio anubis	75.68	0.00e+00	655.00
IUUC-Psi-093798	Pelodiscus sinensis	49.27	9.00e-124	437.00
IUUC-Pfo-096145	Poecilia formosa	60.32	4.00e-18	85.90
IUUC-Pab-098369	Pongo abelii	78.65	2.00e-123	435.00
IUUC-Pca-100537	Procavia capensis	68.74	9.00e-166	576.00
IUUC-Pva-102639	Pteropus vampyrus	76.24	0.00e+00	648.00
IUUC-Rno-105285	Rattus norvegicus	68.86	0.00e+00	663.00
IUUC-Sha-107159	Sarcophilus harrisii	47.08	8.00e-116	410.00
IUUC-Ssc-115773	Sus scrofa	77.87	0.00e+00	706.00
IUUC-Tgu-116922	Taeniopygia guttata	46.13	7.00e-66	243.00
IUUC-Tru-118263	Takifugu rubripes	30.87	7.00e-55	208.00
IUUC-Tsy-119270	Tarsius syrichta	68.80	6.00e-92	331.00
IUUC-Tni-120138	Tetraodon nigroviridis	29.50	2.00e-53	203.00
IUUC-Tbe-128077	Tupaia belangeri	69.95	0.00e+00	647.00
IUUC-Ttr-128781	Tursiops truncatus	81.62	2.00e-77	283.00
IUUC-Xtr-132665	Xenopus tropicalis	33.33	6.00e-15	74.70
IUUC-Xma-133054	Xiphophorus maculatus	28.95	4.00e-51	195.00
IUUC-Yli-134436	Yarrowia lipolytica	34.55	1.00e-11	64.70

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence