iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	UniProt
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	1.20e-18	67.2	124	181

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 2    skekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekl 62
           ++e+v++lyd+ +++ ++L +kkG+ + +i  e+ +e W+++ ++  g+ G++P  +vekl
   Q: 124  NLEYVRTLYDFPGNDAEDLPFKKGELLVII--EKPEEQWWSA-RNKDGRVGMIPVPYVEKL 181
           5789**************************..88999***99.6**************997 PP

Organism

Rattus norvegicus

Functional Description
(View)

May mediate the transduction of intracellular signals.

Protein Sequence
(Fasta)

MSSARFDSSD RSAWYMGPVS RQEAQTRLQG QRHGMFLVRD SSTCPGDYVL SVSENSRVSH 60
YIINSLPNRR FKIGDQEFDH LPALLEFYKI HYLDTTTLIE PAPRYPNPPM GSVSAPNLST 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGTACGCTGG ACCAAGGGGG AGGTGCCCGG TCGCTTCTCC CGCGTCCGCC ATTTTGTTGC 60
TGTGGCTATT GGGAACGGGT AGGGTAGGAC GGTCCGGGAG GCGCGACTGT TGTTGGAGTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0727--SH2 domain
KW-0728--SH3 domain

Interpro

IPR000980--SH2
IPR011511--SH3_2
IPR001452--SH3_domain

PROSITE

PS50001--SH2
PS50002--SH3

Pfam

PF00017--SH2
PF00018--SH3_1
PF07653--SH3_2

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN

SMART

SM00252--SH2
SM00326--SH3

Gene Ontology

GO:0005737--C:cytoplasm
GO:0070062--C:extracellular exosome
GO:0003723--F:RNA binding
GO:0009887--P:animal organ morphogenesis
GO:0009952--P:anterior/posterior pattern specification
GO:0001568--P:blood vessel development
GO:0007507--P:heart development
GO:0060017--P:parathyroid gland development
GO:0008284--P:positive regulation of cell proliferation
GO:1900026--P:positive regulation of substrate adhesion-dependent cell spreading
GO:0048538--P:thymus development

KEGG

rno:100911248; rno:287942

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002025	Ailuropoda melanoleuca	97.24	3.00e-171	593.00
IUUC-Apl-004166	Anas platyrhynchos	89.07	7.00e-159	552.00
IUUC-Aca-004695	Anolis carolinensis	53.22	7.00e-84	303.00
IUUC-Ame-011285	Astyanax mexicanus	80.13	8.00e-140	489.00
IUUC-Bta-013076	Bos taurus	75.68	2.00e-112	398.00
IUUC-Cja-019850	Callithrix jacchus	96.55	6.00e-170	589.00
IUUC-Cfa-020428	Canis familiaris	96.55	9.00e-170	588.00
IUUC-Cpo-022079	Cavia porcellus	95.86	9.00e-169	585.00
IUUC-Csa-023877	Chlorocebus sabaeus	96.21	8.00e-170	588.00
IUUC-Cin-025128	Ciona intestinalis	50.78	3.00e-80	291.00
IUUC-Csv-026340	Ciona savignyi	48.50	4.00e-70	258.00
IUUC-Dre-027833	Danio rerio	80.34	1.00e-134	472.00
IUUC-Dno-029510	Dasypus novemcinctus	95.52	8.00e-169	585.00
IUUC-Dor-030297	Dipodomys ordii	96.70	2.00e-175	608.00
IUUC-Dme-031600	Drosophila melanogaster	44.56	5.00e-68	250.00
IUUC-Eca-033810	Equus caballus	96.90	2.00e-170	591.00
IUUC-Fca-036412	Felis catus	97.24	3.00e-171	593.00
IUUC-Fal-037170	Ficedula albicollis	91.72	3.00e-154	537.00
IUUC-Gga-040733	Gallus gallus	92.07	5.00e-142	496.00
IUUC-Gac-042398	Gasterosteus aculeatus	79.17	2.00e-142	498.00
IUUC-Ggo-044447	Gorilla gorilla	94.97	2.00e-112	397.00
IUUC-Hsa-046989	Homo sapiens	96.55	5.00e-170	589.00
IUUC-Itr-048092	Ictidomys tridecemlineatus	97.24	2.00e-170	591.00
IUUC-Kpa-049154	Komagataella pastoris	42.42	1.00e-10	60.80
IUUC-Lch-050385	Latimeria chalumnae	59.86	3.00e-99	354.00
IUUC-Loc-052916	Lepisosteus oculatus	85.57	3.00e-149	520.00
IUUC-Laf-053545	Loxodonta africana	95.50	4.00e-113	399.00
IUUC-Mga-059586	Meleagris gallopavo	93.79	7.00e-156	542.00
IUUC-Mvi-060518	Microbotryum violaceum	34.52	8.00e-11	60.80
IUUC-Mdo-061868	Monodelphis domestica	88.62	2.00e-157	547.00
IUUC-Mmu-063179	Mus musculus	98.62	1.00e-172	598.00
IUUC-Mpu-065863	Mustela putorius furo	96.90	9.00e-171	592.00
IUUC-Mlu-067290	Myotis lucifugus	96.21	2.00e-169	587.00
IUUC-Nle-069118	Nomascus leucogenys	96.55	5.00e-170	589.00
IUUC-Opr-070565	Ochotona princeps	94.72	9.00e-173	598.00
IUUC-Ont-071608	Oreochromis niloticus	80.83	2.00e-147	514.00
IUUC-Oan-072801	Ornithorhynchus anatinus	88.45	4.00e-161	560.00
IUUC-Ocu-073759	Oryctolagus cuniculus	96.55	9.00e-170	588.00
IUUC-Ola-086748	Oryzias latipes	74.67	1.00e-123	436.00
IUUC-Oga-088248	Otolemur garnettii	97.24	1.00e-170	591.00
IUUC-Oar-089525	Ovis aries	75.77	2.00e-121	428.00
IUUC-Ptr-091553	Pan troglodytes	96.55	5.00e-170	589.00
IUUC-Pan-092639	Papio anubis	96.55	5.00e-170	589.00
IUUC-Psi-093546	Pelodiscus sinensis	86.36	2.00e-100	357.00
IUUC-Pma-094340	Petromyzon marinus	58.97	1.00e-103	369.00
IUUC-Pfo-096090	Poecilia formosa	80.72	1.00e-146	512.00
IUUC-Pab-097876	Pongo abelii	95.71	5.00e-134	469.00
IUUC-Pca-100447	Procavia capensis	96.90	1.00e-170	591.00
IUUC-Pva-102346	Pteropus vampyrus	96.54	1.00e-168	585.00
IUUC-Sha-106511	Sarcophilus harrisii	88.14	1.00e-101	362.00
IUUC-Sar-113583	Sorex araneus	95.86	8.00e-169	585.00
IUUC-Sre-115190	Sporisorium reilianum	29.67	2.00e-09	58.50
IUUC-Ssc-115339	Sus scrofa	95.17	5.00e-167	580.00
IUUC-Tgu-116454	Taeniopygia guttata	90.66	3.00e-98	350.00
IUUC-Tru-118580	Takifugu rubripes	76.85	2.00e-136	478.00
IUUC-Tsy-119327	Tarsius syrichta	94.85	1.00e-165	575.00
IUUC-Tni-120626	Tetraodon nigroviridis	76.92	2.00e-137	481.00
IUUC-Ttr-128248	Tursiops truncatus	95.86	5.00e-169	586.00
IUUC-Xtr-132626	Xenopus tropicalis	85.81	5.00e-151	526.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence