iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCJAG00000004368.2	ENSCJAT00000008447.2	ENSCJAP00000007991.2
ENSCJAG00000004368.2	ENSCJAT00000008436.2	ENSCJAP00000007982.2
ENSCJAG00000004368.2	ENSCJAT00000026134.2	ENSCJAP00000024711.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E1	1.50e-212	707.1	415	890

Active Site

Position(s)	Description	Evidence
599	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU10132}

Domain Profile

   S: 1    YDRQirlwGeeaqeklksakvllvGagglGcEllKnLvlaGv.....gsitvvDmdtvevsnlnrqFLfraedvgksKAevaaealkel 84
           YD+Qi+++G+  qekl+++++llvGag++GcEllK ++l+G+     g +tv Dmd++e+snl+rqFLfr +d+g++KAevaa+a++ l
   Q: 415  YDGQIAVFGAGFQEKLGRQHYLLVGAGAIGCELLKGFALVGLgagnsGGLTVADMDRIELSNLSRQFLFRSQDIGRPKAEVAAAAAQGL 503
           ***************************************************************************************** PP
   S: 85   npdvnveaheesiteleeeiv...FfkkfdvVvlaldnrearrkvnrlclnarvpliesgtlGllGqvrviikgltecyscsd...dpp 167
           npd +v + ++++++++e+i+   Ff+ +d+V++ald+++arr+v+ +c+++ +pl+e+gtlG+ G ++v+++++te+y+++     ++
   Q: 504  NPDLQVIPLTYPLDPTTERIYgdnFFSHVDGVAAALDSFQARRYVAARCTHYLKPLLEAGTLGTRGSAQVFVPHVTEAYRAPAsaaASE 592
           ************************************************************************************999** PP
   S: 168  qktiPfctlketpnaaehtiewa........vlfnklleeeageeevlekldseekeegkdkvkselksedeenfeeaieiavkafakt 248
           ++++P+ct++ +p++aeht++wa        +l ++++++++++++ l ++d +++++ ++ v+  l++ +++n+++++++a+ +++ +
   Q: 593  DTSYPVCTVRYFPSTAEHTLQWArnefeglfRLSAETINHHQQAHTSLTDMDGTQTLTLLKSVFGVLRE-RPQNWQDCVAWALGHWELC 680
           ***************************************************************777666.7****************** PP
   S: 249  tinsikqllksfecdivtkskspfwv................................................sfcsnaealqvpekv 289
           ++++ikqll+++++++v ++++pfw+                                                ++ ++ + +q+ +  
   Q: 681  FHYGIKQLLRHLPPNKVLEDGTPFWSgpkrcpqplefdtnqdthllyilaaanlyaqmhglpdsrdwtalrellKLLPQPDPQQMVPIF 769
           ***************************************************************************************** PP
   S: 290  ekdeevvkasap.....lylllralerfekkkgrkpgelsfekddds..avdlvtaaanlraeslgiepkldddlikeiagniipaiat 371
            ++ e  +asa+     l+ l +ale ++  + +kp  l+fekddds  +vd+v+aaa+lr++++gi+p +++ + k i+g+iipaiat
   Q: 770  PSNPELASASAEfgpeqLKELNKALEVWSMGPPLKP--LMFEKDDDSnfHVDFVAAAASLRCQNYGIPP-VNRAQSKLIVGQIIPAIAT 855
           *********999***********************9..*******************************.******************* PP
   S: 372  tnavvgGlaaqEviKvvsg..kfeplknfflfdae 404
           t+a+v+Gl+ +E++Kvv g  + +++++ +l++ae
   Q: 856  TTAAVAGLVILELYKVVGGprPRSAFRHSYLHLAE 890
           *******************7777789988888765 PP

Organism

Callithrix jacchus

Protein Sequence
(Fasta)

MDALNASKLL NEELYSRQLY VLGSPAMQKI RGARVLLSGL QGLGAEVAKN LVLMGVGSLT 60
LHDPHPTCWS DLAAQFLLSE QDLERSRAEA SQELLAQLNR DVKVVMHTGD ITEDLLLDFQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGGAGCCAGG AAGAGAGCTG TAACCAGCAG CCACTCTTAC TTCCTTGGCC TTGGTGCCTG 60
TTCGCACTGG CTACAGCAGG GCGCTGGTCC CTGCTGTCAC TGCCTCCTAC GTGAAGACCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0436--Ligase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR032420--E1_4HB
IPR032418--E1_FCCH
IPR016040--NAD(P)-bd_dom
IPR000594--ThiF_NAD_FAD-bd
IPR018965--Ub-activating_enz_E1_C
IPR019572--UBA_E1_Cys
IPR018075--UBQ-activ_enz_E1
IPR033127--UBQ-activ_enz_E1_Cys_AS
IPR000011--UBQ/SUMO-activ_enz_E1-like

PROSITE

PS00865--UBIQUITIN_ACTIVAT_2

Pfam

PF16191--E1_4HB
PF16190--E1_FCCH
PF09358--E1_UFD
PF00899--ThiF
PF10585--UBA_e1_thiolCys

PRINTS

PR01849--UBIQUITINACT

SMART

SM00985--UBA_e1_C

Gene Ontology

GO:0005524--F:ATP binding
GO:0019782--F:ISG15 activating enzyme activity
GO:0032020--P:ISG15-protein conjugation
GO:0019941--P:modification-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001816	Ailuropoda melanoleuca	77.39	0.00e+00	1435.00
IUUC-Bta-012665	Bos taurus	74.21	0.00e+00	1315.00
IUUC-Cfa-021225	Canis familiaris	78.36	0.00e+00	1497.00
IUUC-Cpo-022336	Cavia porcellus	69.35	0.00e+00	1295.00
IUUC-Csa-023462	Chlorocebus sabaeus	91.11	0.00e+00	1680.00
IUUC-Cho-024436	Choloepus hoffmanni	74.68	5.00e-96	345.00
IUUC-Dno-029347	Dasypus novemcinctus	76.88	0.00e+00	1426.00
IUUC-Dor-030997	Dipodomys ordii	73.42	0.00e+00	1350.00
IUUC-Ete-033124	Echinops telfairi	72.63	0.00e+00	925.00
IUUC-Eca-033929	Equus caballus	79.25	0.00e+00	1539.00
IUUC-Eeu-034717	Erinaceus europaeus	66.99	0.00e+00	945.00
IUUC-Fca-036564	Felis catus	79.09	0.00e+00	1471.00
IUUC-Ggo-044480	Gorilla gorilla	91.13	0.00e+00	1681.00
IUUC-Hsa-046498	Homo sapiens	90.02	0.00e+00	1646.00
IUUC-Itr-048657	Ictidomys tridecemlineatus	76.21	0.00e+00	1405.00
IUUC-Laf-054119	Loxodonta africana	76.09	0.00e+00	1452.00
IUUC-Mcc-055597	Macaca mulatta	89.05	0.00e+00	1615.00
IUUC-Meu-056534	Macropus eugenii	48.69	0.00e+00	871.00
IUUC-Mdo-063058	Monodelphis domestica	55.57	0.00e+00	986.00
IUUC-Mmu-063578	Mus musculus	70.65	0.00e+00	1352.00
IUUC-Mpu-066255	Mustela putorius furo	76.82	0.00e+00	1465.00
IUUC-Mlu-067814	Myotis lucifugus	73.87	0.00e+00	1308.00
IUUC-Nle-069193	Nomascus leucogenys	89.33	0.00e+00	1654.00
IUUC-Opr-070715	Ochotona princeps	71.73	0.00e+00	1350.00
IUUC-Ocu-074162	Oryctolagus cuniculus	75.62	0.00e+00	1413.00
IUUC-Oga-088895	Otolemur garnettii	79.34	0.00e+00	1452.00
IUUC-Oar-089579	Ovis aries	73.80	0.00e+00	1307.00
IUUC-Ptr-090581	Pan troglodytes	90.43	0.00e+00	1615.00
IUUC-Pan-092458	Papio anubis	91.11	0.00e+00	1678.00
IUUC-Pab-098653	Pongo abelii	84.29	0.00e+00	1554.00
IUUC-Pca-100578	Procavia capensis	73.98	0.00e+00	853.00
IUUC-Pva-102914	Pteropus vampyrus	77.75	0.00e+00	1175.00
IUUC-Rno-106066	Rattus norvegicus	70.72	0.00e+00	1370.00
IUUC-Sha-107368	Sarcophilus harrisii	58.37	0.00e+00	1087.00
IUUC-Ssc-115743	Sus scrofa	80.14	0.00e+00	1478.00
IUUC-Tbe-127587	Tupaia belangeri	72.97	0.00e+00	1201.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence