iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Dre-028149

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Ubiquitin-like modifier-activating enzyme 1

Genbank Nucleotide ID

CR339046

Gene Name

uba1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSDARG00000037559.5	ENSDART00000054691.5	ENSDARP00000054690.4

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E1	1.70e-227	756.3	452	931

Active Site

Position(s)	Description	Evidence
632	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU10132}

Domain Profile

   S: 1    YDRQirlwGeeaqeklksakvllvGagglGcEllKnLvlaGv....gsitvvDmdtvevsnlnrqFLfraedvgksKAevaaealkeln 85
           YD+Qi+++G++ qe l +++++lvGag++GcEllKn++++G+    g++ v+Dmdt+e+snlnrqFLfr++dv k K+e+aa+a+k++n
   Q: 452  YDGQIAVFGSKLQELLAKQRYFLVGAGAIGCELLKNFAMMGLasgeGEVIVTDMDTIEKSNLNRQFLFRPWDVTKMKSETAAAAVKQMN 540
           ***************************************************************************************** PP
   S: 86   pdvnveaheesiteleeeiv...FfkkfdvVvlaldnrearrkvnrlclnarvpliesgtlGllGqvrviikgltecyscsddppqkti 171
           p+v+++ h++++ +++e+++   Ff+ +d+V++aldn++ar++++r+c+++r+pl+esgtlG++G+v+v+i+ +te+ys+s+dpp+k+i
   Q: 541  PSVRITGHQNRVGPDTEKVYdddFFECLDGVANALDNVDARMYMDRRCVYYRKPLLESGTLGTKGNVQVVIPFITESYSSSQDPPEKSI 629
           ***************************************************************************************** PP
   S: 172  Pfctlketpnaaehtiewa............vlfnklleeeageeevlekldseekeegkdkvkselksedeenfeeaieiavkafakt 248
           P+ctlk++pna+eht++wa            + + ++l +++++ e++ kl  ++++e+ + v ++l++ +++n+++++++a+++++ +
   Q: 630  PICTLKNFPNAIEHTLQWArdefeglfkqpaENALQYL-TDSKFMERTLKLPGAQPLEVVESVYKSLVTDRPRNWDDCVTWARNHWQCQ 717
           *************************9999998899999.5566666777799************************************* PP
   S: 249  tinsikqllksfecdivtkskspfwv..........................................sfcsnaealqvp........e 287
           ++n+i+qll++f++d++t+s++pfw+                                           + ++ + ++vp        +
   Q: 718  YNNNIRQLLHNFPPDQLTSSGAPFWSgpkrcphplefstnndlhmdyilaaanlyalsyglpscndrsALTKLLQDIKVPeftpksgvK 806
           ***********************************************************999999988555555555544444444446 PP
   S: 288  kvekdeevvkasap.....lylllralerfekkkgrkpgelsfekddds..avdlvtaaanlraeslgiepkldddlikeiagniipai 369
            +++d+e ++a+a+     l+ l++ l ++e+ ++ k   ++fekddd   ++d++ aa+nlrae+++i+p +d+++ k iag+iipai
   Q: 807  IHVSDQELQSANASvddsrLEELKTLLPSLEASSQFKLCPIEFEKDDDTnfHMDFIVAASNLRAENYDIPP-ADRHKSKLIAGKIIPAI 894
           6666666666666677888****************************************************.***************** PP
   S: 370  attnavvgGlaaqEviKvvsg..kfeplknfflfdae 404
           att+a+v Gl+++E++K+v+g  k e +kn f+++a+
   Q: 895  ATTTAAVVGLVCLELLKIVQGhkKLESYKNGFMNLAL 931
           *********************99999******99875 PP

Organism

Danio rerio

Protein Sequence
(Fasta)

MSSSPLSKKR RVSGSETKTG SHCSSSNSVR TELSHTPANG MAKNGNDAEI DEGLYSRQLY 60
VLGHDAMKRM QSSNVLISGL RGLGVEIAKN VILGGVKSVT LHDQGVAEWK DLSSQFYLRE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTGCACATGT TGGTTCTACG CTCATGAACT GAAGAATACT TGCCGAACTG TTAACGGTAC 60
AGGGAATAGC CGGTCAGGCA ACCGTCCAGC CTCCCCTCAC ACTGGAAAGT CACGGAGCTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0436--Ligase
KW-0547--Nucleotide-binding
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR032420--E1_4HB
IPR032418--E1_FCCH
IPR016040--NAD(P)-bd_dom
IPR000594--ThiF_NAD_FAD-bd
IPR018965--Ub-activating_enz_E1_C
IPR019572--UBA_E1_Cys
IPR018075--UBQ-activ_enz_E1
IPR033127--UBQ-activ_enz_E1_Cys_AS
IPR000011--UBQ/SUMO-activ_enz_E1-like

PROSITE

PS00865--UBIQUITIN_ACTIVAT_2

Pfam

PF16191--E1_4HB
PF16190--E1_FCCH
PF09358--E1_UFD
PF00899--ThiF
PF10585--UBA_e1_thiolCys

PRINTS

PR01849--UBIQUITINACT

SMART

SM00985--UBA_e1_C

Gene Ontology

GO:0005524--F:ATP binding
GO:0008641--F:small protein activating enzyme activity
GO:0007409--P:axonogenesis
GO:0006464--P:cellular protein modification process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000456	Aegilops tauschii	47.04	0.00e+00	907.00
IUUC-Aml-001311	Ailuropoda melanoleuca	78.17	0.00e+00	1749.00
IUUC-Atr-002684	Amborella trichopoda	44.65	0.00e+00	900.00
IUUC-Aca-004620	Anolis carolinensis	78.83	0.00e+00	1737.00
IUUC-Aly-005515	Arabidopsis lyrata	45.73	0.00e+00	924.00
IUUC-Ath-006891	Arabidopsis thaliana	46.83	0.00e+00	925.00
IUUC-Ago-007873	Ashbya gossypii	53.79	0.00e+00	1053.00
IUUC-Acl-008181	Aspergillus clavatus	56.15	0.00e+00	1098.00
IUUC-Afl-008455	Aspergillus flavus	54.76	0.00e+00	1037.00
IUUC-Afu-009065	Aspergillus fumigatus	55.57	0.00e+00	1108.00
IUUC-Ani-009371	Aspergillus nidulans	54.83	0.00e+00	1074.00
IUUC-Ang-009737	Aspergillus niger	55.53	0.00e+00	1090.00
IUUC-Aor-010007	Aspergillus oryzae	54.76	0.00e+00	1037.00
IUUC-Ate-010466	Aspergillus terreus	54.97	0.00e+00	1108.00
IUUC-Ame-010933	Astyanax mexicanus	92.91	0.00e+00	1942.00
IUUC-Bgr-012281	Blumeria graminis	53.27	0.00e+00	1076.00
IUUC-Bta-012767	Bos taurus	79.13	0.00e+00	1770.00
IUUC-Bci-013721	Botrytis cinerea	55.36	0.00e+00	1042.00
IUUC-Bdi-014335	Brachypodium distachyon	45.81	0.00e+00	911.00
IUUC-Bol-015665	Brassica oleracea	45.35	0.00e+00	911.00
IUUC-Bra-017252	Brassica rapa	44.18	0.00e+00	914.00
IUUC-Cel-018260	Caenorhabditis elegans	49.71	0.00e+00	959.00
IUUC-Cja-019152	Callithrix jacchus	78.75	0.00e+00	1756.00
IUUC-Cfa-020622	Canis familiaris	77.53	0.00e+00	1702.00
IUUC-Cpo-022526	Cavia porcellus	78.47	0.00e+00	1743.00
IUUC-Cre-022702	Chlamydomonas reinhardtii	46.58	0.00e+00	894.00
IUUC-Csa-023780	Chlorocebus sabaeus	78.94	0.00e+00	1764.00
IUUC-Cin-025790	Ciona intestinalis	64.57	0.00e+00	1378.00
IUUC-Csv-026084	Ciona savignyi	61.50	0.00e+00	1364.00
IUUC-Cgl-026512	Colletotrichum gloeosporioides	54.25	0.00e+00	1102.00
IUUC-Cne-026960	Cryptococcus neoformans	56.66	0.00e+00	1125.00
IUUC-Cme-027290	Cyanidioschyzon merolae	44.93	0.00e+00	848.00
IUUC-Dno-028884	Dasypus novemcinctus	79.04	0.00e+00	1762.00
IUUC-Dor-030229	Dipodomys ordii	75.17	0.00e+00	1675.00
IUUC-Dse-031524	Dothistroma septosporum	54.12	0.00e+00	1076.00
IUUC-Dme-032045	Drosophila melanogaster	61.22	0.00e+00	1304.00
IUUC-Ete-032544	Echinops telfairi	68.44	0.00e+00	724.00
IUUC-Eca-033330	Equus caballus	78.94	0.00e+00	1769.00
IUUC-Eeu-034717	Erinaceus europaeus	43.45	1.00e-167	583.00
IUUC-Fca-036255	Felis catus	79.04	0.00e+00	1754.00
IUUC-Fal-037445	Ficedula albicollis	47.70	0.00e+00	878.00
IUUC-Fox-038007	Fusarium oxysporum	53.66	5.00e-163	567.00
IUUC-Fso-038339	Fusarium solani	54.44	0.00e+00	1056.00
IUUC-Gmo-039338	Gadus morhua	85.07	0.00e+00	1805.00
IUUC-Ggr-039823	Gaeumannomyces graminis	54.32	0.00e+00	1123.00
IUUC-Gga-040365	Gallus gallus	47.47	0.00e+00	800.00
IUUC-Gac-041773	Gasterosteus aculeatus	85.17	0.00e+00	1803.00
IUUC-Gma-043198	Glycine max	45.22	0.00e+00	880.00
IUUC-Ggo-045336	Gorilla gorilla	79.13	0.00e+00	1750.00
IUUC-Hsa-045982	Homo sapiens	78.94	0.00e+00	1746.00
IUUC-Hvu-047418	Hordeum vulgare	46.34	0.00e+00	886.00
IUUC-Itr-048460	Ictidomys tridecemlineatus	79.32	0.00e+00	1777.00
IUUC-Kpa-049112	Komagataella pastoris	52.21	0.00e+00	1016.00
IUUC-Lch-050371	Latimeria chalumnae	82.91	0.00e+00	1823.00
IUUC-Lpe-051299	Leersia perrieri	45.19	0.00e+00	891.00
IUUC-Loc-052936	Lepisosteus oculatus	89.14	0.00e+00	1925.00
IUUC-Lma-053315	Leptosphaeria maculans	54.71	0.00e+00	1113.00
IUUC-Laf-053948	Loxodonta africana	77.62	0.00e+00	1713.00
IUUC-Mcc-055843	Macaca mulatta	78.94	0.00e+00	1766.00
IUUC-Meu-056258	Macropus eugenii	78.38	0.00e+00	1730.00
IUUC-Mor-057269	Magnaporthe oryzae	55.19	0.00e+00	1103.00
IUUC-Mpo-057435	Magnaporthe poae	54.67	0.00e+00	1101.00
IUUC-Mtr-058572	Medicago truncatula	45.40	0.00e+00	857.00
IUUC-Mla-059176	Melampsora laricipopulina	56.14	0.00e+00	1100.00
IUUC-Mvi-060437	Microbotryum violaceum	54.80	0.00e+00	1087.00
IUUC-Mmr-061405	Microcebus murinus	76.96	0.00e+00	1707.00
IUUC-Mdo-062032	Monodelphis domestica	76.78	0.00e+00	1696.00
IUUC-Mmu-063280	Mus musculus	78.47	0.00e+00	1746.00
IUUC-Mac-065505	Musa acuminata	46.60	0.00e+00	901.00
IUUC-Mpu-066409	Mustela putorius furo	78.75	0.00e+00	1764.00
IUUC-Mlu-067217	Myotis lucifugus	78.09	0.00e+00	1740.00
IUUC-Nfi-068407	Neosartorya fischeri	55.66	0.00e+00	1090.00
IUUC-Ncr-068698	Neurospora crassa	55.49	0.00e+00	1108.00
IUUC-Nle-070072	Nomascus leucogenys	75.05	0.00e+00	1635.00
IUUC-Opr-070715	Ochotona princeps	42.56	0.00e+00	764.00
IUUC-Ont-071671	Oreochromis niloticus	87.46	0.00e+00	1886.00
IUUC-Oan-073306	Ornithorhynchus anatinus	47.31	0.00e+00	711.00
IUUC-Ocu-074544	Oryctolagus cuniculus	79.32	0.00e+00	1775.00
IUUC-Oba-075120	Oryza barthii	45.06	0.00e+00	882.00
IUUC-Obr-076557	Oryza brachyantha	46.43	0.00e+00	867.00
IUUC-Ogl-077887	Oryza glaberrima	45.16	0.00e+00	885.00
IUUC-Ogu-078305	Oryza glumaepatula	44.28	0.00e+00	875.00
IUUC-Oin-079370	Oryza indica	44.41	0.00e+00	861.00
IUUC-Olo-081089	Oryza longistaminata	44.48	0.00e+00	876.00
IUUC-Ome-081942	Oryza meridionalis	45.54	0.00e+00	882.00
IUUC-Oni-082365	Oryza nivara	45.45	0.00e+00	882.00
IUUC-Opu-083301	Oryza punctata	45.16	0.00e+00	887.00
IUUC-Oru-084469	Oryza rufipogon	44.38	0.00e+00	878.00
IUUC-Osa-085949	Oryza sativa	44.77	0.00e+00	887.00
IUUC-Ola-087002	Oryzias latipes	87.56	0.00e+00	1886.00
IUUC-Olu-087687	Ostreococcus lucimarinus	45.86	0.00e+00	830.00
IUUC-Oga-088594	Otolemur garnettii	78.96	0.00e+00	1750.00
IUUC-Oar-090068	Ovis aries	79.06	0.00e+00	1768.00
IUUC-Ptr-090581	Pan troglodytes	45.04	0.00e+00	765.00
IUUC-Pan-092114	Papio anubis	79.13	0.00e+00	1768.00
IUUC-Pma-094214	Petromyzon marinus	60.36	3.00e-54	204.00
IUUC-Pno-095154	Phaeosphaeria nodorum	54.02	0.00e+00	1120.00
IUUC-Ppa-095416	Physcomitrella patens	45.92	0.00e+00	905.00
IUUC-Pfo-097184	Poecilia formosa	86.41	0.00e+00	1873.00
IUUC-Pab-097861	Pongo abelii	78.94	0.00e+00	1737.00
IUUC-Pop-098934	Populus trichocarpa	44.27	0.00e+00	912.00
IUUC-Pca-100347	Procavia capensis	76.31	0.00e+00	1400.00
IUUC-Ppe-102012	Prunus persica	44.99	0.00e+00	897.00
IUUC-Pva-102584	Pteropus vampyrus	78.75	0.00e+00	1784.00
IUUC-Pgr-103336	Puccinia graminis	55.66	0.00e+00	1079.00
IUUC-Ptt-103939	Puccinia triticina	54.97	0.00e+00	1076.00
IUUC-Pte-104200	Pyrenophora teres	54.66	0.00e+00	1110.00
IUUC-Pyt-104441	Pyrenophora triticirepentis	53.63	0.00e+00	1099.00
IUUC-Rno-105462	Rattus norvegicus	78.85	0.00e+00	1742.00
IUUC-Sce-106245	Saccharomyces cerevisiae	51.52	0.00e+00	1057.00
IUUC-Sha-107142	Sarcophilus harrisii	78.75	0.00e+00	1750.00
IUUC-Sja-107841	Schizosaccharomyces japonicus	55.60	0.00e+00	1131.00
IUUC-Spo-108034	Schizosaccharomyces pombe	55.46	0.00e+00	1089.00
IUUC-Ssl-108497	Sclerotinia sclerotiorum	55.78	0.00e+00	1069.00
IUUC-Smo-109211	Selaginella moellendorffii	45.23	0.00e+00	892.00
IUUC-Sit-110281	Setaria italica	46.35	0.00e+00	905.00
IUUC-Sly-110914	Solanum lycopersicum	45.72	0.00e+00	911.00
IUUC-Stu-112109	Solanum tuberosum	45.62	0.00e+00	915.00
IUUC-Sar-113737	Sorex araneus	78.47	0.00e+00	1746.00
IUUC-Sbi-114520	Sorghum bicolor	46.43	0.00e+00	905.00
IUUC-Sre-115148	Sporisorium reilianum	55.27	0.00e+00	1090.00
IUUC-Ssc-115777	Sus scrofa	79.06	0.00e+00	1761.00
IUUC-Tru-118742	Takifugu rubripes	86.60	0.00e+00	1810.00
IUUC-Tni-120401	Tetraodon nigroviridis	86.51	0.00e+00	1808.00
IUUC-Tca-121672	Theobroma cacao	45.41	0.00e+00	895.00
IUUC-Tre-122009	Trichoderma reesei	53.62	0.00e+00	1046.00
IUUC-Tvi-122259	Trichoderma virens	53.70	0.00e+00	1027.00
IUUC-Tae-125113	Triticum aestivum	47.10	0.00e+00	868.00
IUUC-Tur-126189	Triticum urartu	47.00	0.00e+00	869.00
IUUC-Tme-127055	Tuber melanosporum	53.95	0.00e+00	1006.00
IUUC-Tbe-127487	Tupaia belangeri	75.79	0.00e+00	854.00
IUUC-Ttr-128331	Tursiops truncatus	78.66	0.00e+00	1742.00
IUUC-Uma-129387	Ustilago maydis	56.11	0.00e+00	1090.00
IUUC-Vda-129977	Verticillium dahliae	53.94	0.00e+00	1014.00
IUUC-Vvi-130857	Vitis vinifera	45.52	0.00e+00	897.00
IUUC-Xtr-132026	Xenopus tropicalis	65.69	0.00e+00	1292.00
IUUC-Xma-133805	Xiphophorus maculatus	86.70	0.00e+00	1853.00
IUUC-Yli-134547	Yarrowia lipolytica	53.74	0.00e+00	1103.00
IUUC-Zma-135052	Zea mays	46.39	0.00e+00	910.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence