iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Lch-050371

Ensembl Protein ID

ENSLACP00000002173.1

UniProt Accession

H2ZXQ2; H2ZXQ2_LATCH

Genbank Protein ID

ENSLACP00000002173

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AFYH01145899

Gene Name

UBA1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLACG00000001943.1	ENSLACT00000002190.1	ENSLACP00000002173.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E1	1.00e-228	759.7	452	932

Active Site

Position(s)	Description	Evidence
633	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU10132}

Domain Profile

   S: 1    YDRQirlwGeeaqeklksakvllvGagglGcEllKnLvlaGv.....gsitvvDmdtvevsnlnrqFLfraedvgksKAevaaealkel 84
           YD+Qi+++G++ qekl+++k++lvGag++GcEllKn++++G+     g itv+Dmdt+e+snlnrqFLfr++dv   K+e+aa+a+k++
   Q: 452  YDGQIAVFGSDLQEKLGKQKYFLVGAGAIGCELLKNFAMIGLacgegGDITVTDMDTIEKSNLNRQFLFRPRDVTNMKSETAAAAVKQM 540
           ***************************************************************************************** PP
   S: 85   npdvnveaheesiteleeeiv...FfkkfdvVvlaldnrearrkvnrlclnarvpliesgtlGllGqvrviikgltecyscsddppqkt 170
           np+++++ h++++ +++e+++   Ff+ +d+V++aldn++ar++++r+c+++r+pl+esgtlG++G+v+vii+ lte+ys+s+dpp+k+
   Q: 541  NPSIHITGHQNRVGPDTEKVYdddFFEALDGVANALDNVDARMYMDRRCVYYRKPLLESGTLGTKGNVQVIIPFLTESYSSSQDPPEKS 629
           ***************************************************************************************** PP
   S: 171  iPfctlketpnaaehtiewa............vlfnklleeeageeevlekldseekeegkdkvkselksedeenfeeaieiavkafak 247
           iP+ctlk++pna+eht++wa              + +++++ a++ e++ kl  ++++e++++v ++l+ e+++++e+++++a++++++
   Q: 630  IPICTLKNFPNAIEHTLQWArdefeglfkqpaDNVTQYISD-AKFMERTLKLPGTQPLEVLEAVYKSLVVERPKSWEDCVAWARNHWQS 717
           **************************999999999999965.55566666699************************************ PP
   S: 248  ttinsikqllksfecdivtkskspfwv......................................................sfcsnaea 282
           +++n+i+qll++f++d++t+s++pfw+                                                      +f      
   Q: 718  QYNNNIRQLLHNFPPDQLTSSGAPFWSgpkrcphplqfdmnnplhldyvvaganllaqsyningsrdasavveilksvkvpEFT----- 801
           **********************************************************99999999999666655554444222..... PP
   S: 283  lqvp....ekvekdeevvkasap.....lylllralerfekkkgrkpgelsfekddds..avdlvtaaanlraeslgiepkldddlike 360
              p    + +++d+e + a+a+     l+ l+  l ++e+  g k++ ++fekddd   ++d++ aa+nlrae+++i+p +d+++ k 
   Q: 802  ---PksgvKIHVSDQELQNANASvddsrLEELKSQLPSAEQLAGFKMNAIEFEKDDDTnfHMDFIVAASNLRAENYDIPP-ADRHKSKL 886
           ...0223344444444444444466668****************************************************.******** PP
   S: 361  iagniipaiattnavvgGlaaqEviKvvsg..kfeplknfflfdae 404
           iag+iipaiatt+a+v Gl+++E++K+v+g  k e +kn f+++a+
   Q: 887  IAGKIIPAIATTTAAVVGLVCLELYKIVQGhkKIESYKNGFMNLAL 932
           ******************************889999*****99875 PP

Organism

Latimeria chalumnae

Protein Sequence
(Fasta)

MSSSPLSKKR RVSGSETKTG SNCSSSNSIR TESLAAPANG MAKNGNEAEI DEGLYSRQLY 60
VLGHEAMKRL QNASILVSGM RGLGVEIAKN IILGGVKSVT IHDQGAAEWL DLSSQFYLRE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCGCCCACTT ATGTGCGCTG CGTATCCACC TCTTAGTGGT TAATTCATGA AGTTGTAGGC 60
GCGGCTTGAG CTTTGAGATT AAATATTCAT GAGCGTTTGG TCGCCTGTAG ACATCAGTAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0436--Ligase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR032420--E1_4HB
IPR032418--E1_FCCH
IPR016040--NAD(P)-bd_dom
IPR000594--ThiF_NAD_FAD-bd
IPR018965--Ub-activating_enz_E1_C
IPR019572--UBA_E1_Cys
IPR018075--UBQ-activ_enz_E1
IPR018074--UBQ-activ_enz_E1_CS
IPR033127--UBQ-activ_enz_E1_Cys_AS
IPR000011--UBQ/SUMO-activ_enz_E1-like

PROSITE

PS00536--UBIQUITIN_ACTIVAT_1
PS00865--UBIQUITIN_ACTIVAT_2

Pfam

PF16191--E1_4HB
PF16190--E1_FCCH
PF09358--E1_UFD
PF00899--ThiF
PF10585--UBA_e1_thiolCys

PRINTS

PR01849--UBIQUITINACT

SMART

SM00985--UBA_e1_C

Gene Ontology

GO:0005524--F:ATP binding
GO:0008641--F:small protein activating enzyme activity
GO:0007409--P:axonogenesis
GO:0006464--P:cellular protein modification process

KEGG

lcm:102348081

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000456	Aegilops tauschii	46.30	0.00e+00	907.00
IUUC-Aml-001311	Ailuropoda melanoleuca	79.02	0.00e+00	1781.00
IUUC-Atr-002684	Amborella trichopoda	45.49	0.00e+00	907.00
IUUC-Aca-004620	Anolis carolinensis	80.27	0.00e+00	1778.00
IUUC-Aly-005515	Arabidopsis lyrata	44.37	0.00e+00	917.00
IUUC-Ath-006891	Arabidopsis thaliana	45.69	0.00e+00	918.00
IUUC-Ago-007873	Ashbya gossypii	53.69	0.00e+00	1056.00
IUUC-Acl-008181	Aspergillus clavatus	55.03	0.00e+00	1077.00
IUUC-Afl-008455	Aspergillus flavus	54.76	0.00e+00	1048.00
IUUC-Afu-009065	Aspergillus fumigatus	55.47	0.00e+00	1105.00
IUUC-Ani-009371	Aspergillus nidulans	54.20	0.00e+00	1065.00
IUUC-Ang-009737	Aspergillus niger	54.85	0.00e+00	1080.00
IUUC-Aor-010007	Aspergillus oryzae	54.76	0.00e+00	1048.00
IUUC-Ate-010466	Aspergillus terreus	53.73	0.00e+00	1100.00
IUUC-Ame-010933	Astyanax mexicanus	82.44	0.00e+00	1760.00
IUUC-Bgr-012281	Blumeria graminis	54.21	0.00e+00	1090.00
IUUC-Bta-012767	Bos taurus	80.08	0.00e+00	1804.00
IUUC-Bci-013721	Botrytis cinerea	56.29	0.00e+00	1056.00
IUUC-Bdi-014335	Brachypodium distachyon	44.64	0.00e+00	905.00
IUUC-Bol-015665	Brassica oleracea	44.83	0.00e+00	908.00
IUUC-Bra-017252	Brassica rapa	43.54	0.00e+00	910.00
IUUC-Cel-018260	Caenorhabditis elegans	49.86	0.00e+00	975.00
IUUC-Cja-019152	Callithrix jacchus	80.08	0.00e+00	1799.00
IUUC-Cfa-020622	Canis familiaris	78.19	0.00e+00	1732.00
IUUC-Cpo-022526	Cavia porcellus	80.17	0.00e+00	1779.00
IUUC-Cre-022702	Chlamydomonas reinhardtii	45.60	0.00e+00	872.00
IUUC-Csa-023780	Chlorocebus sabaeus	80.36	0.00e+00	1813.00
IUUC-Cin-025790	Ciona intestinalis	62.90	0.00e+00	1352.00
IUUC-Csv-026084	Ciona savignyi	61.22	0.00e+00	1345.00
IUUC-Cgl-026512	Colletotrichum gloeosporioides	54.26	0.00e+00	1107.00
IUUC-Cne-026960	Cryptococcus neoformans	57.58	0.00e+00	1140.00
IUUC-Cme-027290	Cyanidioschyzon merolae	44.57	0.00e+00	841.00
IUUC-Dre-028149	Danio rerio	82.91	0.00e+00	1798.00
IUUC-Dno-028884	Dasypus novemcinctus	79.89	0.00e+00	1802.00
IUUC-Dor-030229	Dipodomys ordii	76.58	0.00e+00	1714.00
IUUC-Dse-031524	Dothistroma septosporum	53.33	0.00e+00	1065.00
IUUC-Dme-032045	Drosophila melanogaster	60.10	0.00e+00	1274.00
IUUC-Ete-032544	Echinops telfairi	68.82	0.00e+00	739.00
IUUC-Eca-033330	Equus caballus	80.36	0.00e+00	1811.00
IUUC-Eeu-034717	Erinaceus europaeus	42.76	9.00e-168	583.00
IUUC-Fca-036255	Felis catus	80.36	0.00e+00	1797.00
IUUC-Fal-037445	Ficedula albicollis	48.22	0.00e+00	882.00
IUUC-Fox-038007	Fusarium oxysporum	54.36	6.00e-167	580.00
IUUC-Fso-038339	Fusarium solani	54.58	0.00e+00	1063.00
IUUC-Gmo-039338	Gadus morhua	79.16	0.00e+00	1692.00
IUUC-Ggr-039823	Gaeumannomyces graminis	54.78	0.00e+00	1138.00
IUUC-Gga-040365	Gallus gallus	47.79	0.00e+00	828.00
IUUC-Gac-041773	Gasterosteus aculeatus	81.07	0.00e+00	1729.00
IUUC-Gma-043198	Glycine max	45.35	0.00e+00	882.00
IUUC-Ggo-045336	Gorilla gorilla	80.36	0.00e+00	1783.00
IUUC-Hsa-045982	Homo sapiens	80.26	0.00e+00	1780.00
IUUC-Hvu-047418	Hordeum vulgare	45.55	0.00e+00	886.00
IUUC-Itr-048460	Ictidomys tridecemlineatus	80.26	0.00e+00	1805.00
IUUC-Kpa-049112	Komagataella pastoris	52.70	0.00e+00	1027.00
IUUC-Lpe-051299	Leersia perrieri	45.19	0.00e+00	899.00
IUUC-Loc-052936	Lepisosteus oculatus	84.14	0.00e+00	1834.00
IUUC-Lma-053315	Leptosphaeria maculans	53.99	0.00e+00	1107.00
IUUC-Laf-053948	Loxodonta africana	78.38	0.00e+00	1746.00
IUUC-Mcc-055843	Macaca mulatta	80.36	0.00e+00	1811.00
IUUC-Meu-056258	Macropus eugenii	78.47	0.00e+00	1761.00
IUUC-Mor-057269	Magnaporthe oryzae	55.21	0.00e+00	1115.00
IUUC-Mpo-057435	Magnaporthe poae	54.93	0.00e+00	1107.00
IUUC-Mtr-058572	Medicago truncatula	45.54	0.00e+00	868.00
IUUC-Mla-059176	Melampsora laricipopulina	56.94	0.00e+00	1124.00
IUUC-Mvi-060437	Microbotryum violaceum	54.90	0.00e+00	1084.00
IUUC-Mmr-061405	Microcebus murinus	78.09	0.00e+00	1741.00
IUUC-Mdo-062032	Monodelphis domestica	77.34	0.00e+00	1736.00
IUUC-Mmu-063280	Mus musculus	79.60	0.00e+00	1779.00
IUUC-Mac-065505	Musa acuminata	46.32	0.00e+00	901.00
IUUC-Mpu-066409	Mustela putorius furo	79.98	0.00e+00	1805.00
IUUC-Mlu-067217	Myotis lucifugus	79.23	0.00e+00	1777.00
IUUC-Nfi-068407	Neosartorya fischeri	55.57	0.00e+00	1088.00
IUUC-Ncr-068698	Neurospora crassa	55.39	0.00e+00	1127.00
IUUC-Nle-070072	Nomascus leucogenys	75.98	0.00e+00	1667.00
IUUC-Opr-070715	Ochotona princeps	42.66	0.00e+00	769.00
IUUC-Ont-071671	Oreochromis niloticus	82.03	0.00e+00	1776.00
IUUC-Oan-073306	Ornithorhynchus anatinus	47.49	0.00e+00	720.00
IUUC-Ocu-074544	Oryctolagus cuniculus	80.36	0.00e+00	1811.00
IUUC-Oba-075120	Oryza barthii	45.05	0.00e+00	892.00
IUUC-Obr-076557	Oryza brachyantha	45.85	0.00e+00	878.00
IUUC-Ogl-077887	Oryza glaberrima	45.05	0.00e+00	894.00
IUUC-Ogu-078305	Oryza glumaepatula	45.15	0.00e+00	900.00
IUUC-Oin-080154	Oryza indica	45.15	0.00e+00	899.00
IUUC-Olo-081089	Oryza longistaminata	45.24	0.00e+00	900.00
IUUC-Ome-081942	Oryza meridionalis	45.28	0.00e+00	895.00
IUUC-Oni-082365	Oryza nivara	45.25	0.00e+00	899.00
IUUC-Opu-083977	Oryza punctata	45.53	0.00e+00	899.00
IUUC-Oru-084469	Oryza rufipogon	45.24	0.00e+00	902.00
IUUC-Osa-085949	Oryza sativa	45.15	0.00e+00	900.00
IUUC-Ola-087002	Oryzias latipes	81.93	0.00e+00	1775.00
IUUC-Olu-087687	Ostreococcus lucimarinus	44.22	0.00e+00	816.00
IUUC-Oga-088594	Otolemur garnettii	80.19	0.00e+00	1779.00
IUUC-Oar-090068	Ovis aries	79.91	0.00e+00	1801.00
IUUC-Ptr-090581	Pan troglodytes	44.98	0.00e+00	778.00
IUUC-Pan-092114	Papio anubis	80.36	0.00e+00	1812.00
IUUC-Pma-094214	Petromyzon marinus	62.13	5.00e-55	206.00
IUUC-Pno-095154	Phaeosphaeria nodorum	53.68	0.00e+00	1107.00
IUUC-Ppa-095416	Physcomitrella patens	46.36	0.00e+00	919.00
IUUC-Pfo-097184	Poecilia formosa	80.98	0.00e+00	1755.00
IUUC-Pab-097861	Pongo abelii	80.17	0.00e+00	1769.00
IUUC-Pop-098934	Populus trichocarpa	44.69	0.00e+00	924.00
IUUC-Pca-100347	Procavia capensis	76.64	0.00e+00	1429.00
IUUC-Ppe-102012	Prunus persica	45.53	0.00e+00	911.00
IUUC-Pva-102584	Pteropus vampyrus	80.17	0.00e+00	1830.00
IUUC-Pgr-103336	Puccinia graminis	55.56	0.00e+00	1089.00
IUUC-Ptt-103939	Puccinia triticina	54.55	0.00e+00	1088.00
IUUC-Pte-104200	Pyrenophora teres	52.84	0.00e+00	1104.00
IUUC-Pyt-104441	Pyrenophora triticirepentis	52.96	0.00e+00	1092.00
IUUC-Rno-105462	Rattus norvegicus	79.98	0.00e+00	1780.00
IUUC-Sce-106245	Saccharomyces cerevisiae	51.06	0.00e+00	1067.00
IUUC-Sha-107142	Sarcophilus harrisii	79.32	0.00e+00	1785.00
IUUC-Sja-107841	Schizosaccharomyces japonicus	55.36	0.00e+00	1134.00
IUUC-Spo-108034	Schizosaccharomyces pombe	54.54	0.00e+00	1093.00
IUUC-Ssl-108497	Sclerotinia sclerotiorum	56.00	0.00e+00	1082.00
IUUC-Smo-109211	Selaginella moellendorffii	45.62	0.00e+00	890.00
IUUC-Sit-110281	Setaria italica	45.99	0.00e+00	912.00
IUUC-Sly-110914	Solanum lycopersicum	45.85	0.00e+00	910.00
IUUC-Stu-112109	Solanum tuberosum	45.85	0.00e+00	914.00
IUUC-Sar-113737	Sorex araneus	79.41	0.00e+00	1784.00
IUUC-Sbi-114089	Sorghum bicolor	44.60	0.00e+00	910.00
IUUC-Sre-115148	Sporisorium reilianum	55.85	0.00e+00	1110.00
IUUC-Ssc-115777	Sus scrofa	80.38	0.00e+00	1808.00
IUUC-Tru-118742	Takifugu rubripes	82.31	0.00e+00	1740.00
IUUC-Tni-120401	Tetraodon nigroviridis	81.74	0.00e+00	1728.00
IUUC-Tca-121672	Theobroma cacao	45.74	0.00e+00	915.00
IUUC-Tre-122009	Trichoderma reesei	54.80	0.00e+00	1049.00
IUUC-Tvi-122259	Trichoderma virens	54.65	0.00e+00	1035.00
IUUC-Tae-125113	Triticum aestivum	46.07	0.00e+00	868.00
IUUC-Tur-126330	Triticum urartu	46.30	0.00e+00	912.00
IUUC-Tme-127055	Tuber melanosporum	52.39	0.00e+00	1011.00
IUUC-Tbe-127487	Tupaia belangeri	76.72	0.00e+00	867.00
IUUC-Ttr-128331	Tursiops truncatus	79.98	0.00e+00	1785.00
IUUC-Uma-129387	Ustilago maydis	56.22	0.00e+00	1112.00
IUUC-Vda-129977	Verticillium dahliae	53.79	0.00e+00	1019.00
IUUC-Vvi-130857	Vitis vinifera	45.37	0.00e+00	903.00
IUUC-Xtr-132026	Xenopus tropicalis	66.57	0.00e+00	1310.00
IUUC-Xma-133805	Xiphophorus maculatus	81.17	0.00e+00	1741.00
IUUC-Yli-134547	Yarrowia lipolytica	53.79	0.00e+00	1117.00
IUUC-Zma-135052	Zea mays	44.55	0.00e+00	907.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence