iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ptr-090834

UUCD1 version

UUC-PaT-00402

Ensembl Protein ID

ENSPTRP00000026201.2

UniProt Accession

H2QN18; H2QN18_PANTR

Genbank Protein ID

JAA10416.1; JAA19798.1; JAA27923.1; JAA35689.1

Protein Name

Cas-Br-M (Murine) ecotropic retroviral transforming sequence b

Genbank Nucleotide ID

AACZ03024937; GABF01002347; GABD01005177; GABE01009050

Gene Name

CBLB

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPTRG00000015184.5	ENSPTRT00000028392.2	ENSPTRP00000026201.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	8.10e-08	32.7	373	412

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C iC e  kd +++ pCgH+++++Cl +w    ++s ++  CP Cr
   Q: 373  CKICAENDKD-VKIEPCGHLMCTSCLTAW----QESDGQ-GCPFCR 412
           99********.******************....555555.5****8 PP

Organism

Pan troglodytes

Protein Sequence
(Fasta)

MANSMNGRNP GGRGGNPRKG RILGIIDAIQ DAVGPPKQAA ADRRTVEKTW KLMDKVVRLC 60
QNPKLQLKNS PPYILDILPD TYQHLRLILS KYDDNQKLAQ LSENEYFKIY IDSLMKKSKR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTGGGTCCTG TGTGTGCCAC AGGGGTGGGG TGTCCAGCGA GCGGTCTCCT CCTCCTGCTA 60
GTGCTGCTGC GGCGTCCCGC GGCCTCCCCG AGTCGGGCGG GAGGGGAGAG CGGGTGTGGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR024162--Adaptor_Cbl
IPR014741--Adaptor_Cbl_EF_hand-like
IPR003153--Adaptor_Cbl_N_hlx
IPR014742--Adaptor_Cbl_SH2-like
IPR024159--Cbl_PTB
IPR011992--EF-hand-dom_pair
IPR000980--SH2
IPR015940--UBA
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS51506--CBL_PTB
PS50030--UBA
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF02262--Cbl_N
PF02761--Cbl_N2
PF02762--Cbl_N3

SMART

SM00184--RING
SM00165--UBA

Gene Ontology

GO:0005829--C:cytosol
GO:0045121--C:membrane raft
GO:0005654--C:nucleoplasm
GO:0005886--C:plasma membrane
GO:0005509--F:calcium ion binding
GO:0030971--F:receptor tyrosine kinase binding
GO:0017124--F:SH3 domain binding
GO:0004871--F:signal transducer activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0007173--P:epidermal growth factor receptor signaling pathway
GO:0007175--P:negative regulation of epidermal growth factor-activated receptor activity
GO:0006508--P:proteolysis

KEGG

ptr:460566

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001412	Ailuropoda melanoleuca	96.74	0.00e+00	1652.00
IUUC-Apl-004148	Anas platyrhynchos	86.26	0.00e+00	1472.00
IUUC-Aca-005204	Anolis carolinensis	82.57	0.00e+00	1409.00
IUUC-Ame-011919	Astyanax mexicanus	64.91	0.00e+00	1050.00
IUUC-Bta-013044	Bos taurus	97.05	0.00e+00	1656.00
IUUC-Cel-018674	Caenorhabditis elegans	56.92	2.00e-133	469.00
IUUC-Cja-018813	Callithrix jacchus	89.85	0.00e+00	1563.00
IUUC-Cfa-021054	Canis familiaris	96.95	0.00e+00	1692.00
IUUC-Cpo-022514	Cavia porcellus	90.74	0.00e+00	1627.00
IUUC-Csa-024110	Chlorocebus sabaeus	99.59	0.00e+00	1735.00
IUUC-Cho-024886	Choloepus hoffmanni	80.38	0.00e+00	1118.00
IUUC-Dre-027480	Danio rerio	64.61	0.00e+00	1027.00
IUUC-Dno-028923	Dasypus novemcinctus	96.95	0.00e+00	1654.00
IUUC-Dor-031040	Dipodomys ordii	89.98	0.00e+00	811.00
IUUC-Ete-032406	Echinops telfairi	91.37	0.00e+00	1504.00
IUUC-Eca-033849	Equus caballus	96.13	0.00e+00	1677.00
IUUC-Fca-036224	Felis catus	97.26	0.00e+00	1667.00
IUUC-Fal-036860	Ficedula albicollis	96.89	0.00e+00	1006.00
IUUC-Gga-040159	Gallus gallus	83.23	0.00e+00	1433.00
IUUC-Gac-042312	Gasterosteus aculeatus	84.92	0.00e+00	890.00
IUUC-Ggo-045175	Gorilla gorilla	90.65	0.00e+00	1574.00
IUUC-Hsa-046306	Homo sapiens	99.90	0.00e+00	1739.00
IUUC-Lch-049931	Latimeria chalumnae	61.45	0.00e+00	856.00
IUUC-Loc-052524	Lepisosteus oculatus	69.57	0.00e+00	1098.00
IUUC-Laf-053635	Loxodonta africana	92.99	0.00e+00	1599.00
IUUC-Mcc-055536	Macaca mulatta	99.49	0.00e+00	1733.00
IUUC-Meu-056045	Macropus eugenii	79.00	0.00e+00	1287.00
IUUC-Mga-060177	Meleagris gallopavo	93.13	0.00e+00	1115.00
IUUC-Mmr-061088	Microcebus murinus	97.97	0.00e+00	1696.00
IUUC-Mdo-062020	Monodelphis domestica	91.58	0.00e+00	1574.00
IUUC-Mmu-063114	Mus musculus	90.34	0.00e+00	1584.00
IUUC-Mpu-066632	Mustela putorius furo	97.66	0.00e+00	1701.00
IUUC-Mlu-067145	Myotis lucifugus	96.95	0.00e+00	1688.00
IUUC-Ont-072323	Oreochromis niloticus	84.44	0.00e+00	891.00
IUUC-Oan-073165	Ornithorhynchus anatinus	89.54	0.00e+00	1588.00
IUUC-Ocu-074723	Oryctolagus cuniculus	97.15	0.00e+00	1692.00
IUUC-Oga-088021	Otolemur garnettii	96.44	0.00e+00	1664.00
IUUC-Oar-089809	Ovis aries	96.85	0.00e+00	1659.00
IUUC-Pan-092225	Papio anubis	99.49	0.00e+00	1734.00
IUUC-Psi-093317	Pelodiscus sinensis	86.73	0.00e+00	1518.00
IUUC-Pma-094249	Petromyzon marinus	77.61	5.00e-127	446.00
IUUC-Pab-097595	Pongo abelii	99.69	0.00e+00	1735.00
IUUC-Pca-100844	Procavia capensis	80.06	0.00e+00	1311.00
IUUC-Pva-103216	Pteropus vampyrus	89.92	0.00e+00	1588.00
IUUC-Rno-105381	Rattus norvegicus	94.61	0.00e+00	1668.00
IUUC-Sha-107574	Sarcophilus harrisii	91.40	0.00e+00	1565.00
IUUC-Sar-113500	Sorex araneus	84.86	0.00e+00	1355.00
IUUC-Ssc-115856	Sus scrofa	96.60	0.00e+00	1441.00
IUUC-Tgu-116866	Taeniopygia guttata	86.02	0.00e+00	1457.00
IUUC-Tru-118579	Takifugu rubripes	86.15	0.00e+00	887.00
IUUC-Tsy-119167	Tarsius syrichta	85.03	0.00e+00	1406.00
IUUC-Tni-120788	Tetraodon nigroviridis	85.03	0.00e+00	898.00
IUUC-Tbe-127830	Tupaia belangeri	94.22	0.00e+00	1162.00
IUUC-Ttr-128631	Tursiops truncatus	97.46	0.00e+00	1693.00
IUUC-Vpa-130713	Vicugna pacos	96.27	0.00e+00	1457.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence