iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Bta-012591

Ensembl Protein ID

ENSBTAP00000001338.3

UniProt Accession

Q3SYW3; Q3SYW3_BOVIN

Genbank Protein ID

AAI03356.1

Protein Name

Hematopoietic cell-specific Lyn substrate 1

Genbank Nucleotide ID

DAAA02001584

Gene Name

HCLS1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSBTAG00000001009.3	ENSBTAT00000001338.3	ENSBTAP00000001338.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	3.00e-11	43.2	433	484

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 7    qvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekl 62
            +lydy+++ +de ++   dv++ i  e  degW++g    +g  GlfP+n+v+ l
   Q: 433  VALYDYQGEGSDEISFDPDDVITDI--EMVDEGWWRG--RCHGHFGLFPANYVKLL 484
           68**********************9..9*********..8*************977 PP

Organism

Bos taurus

Protein Sequence
(Fasta)

MWKSVVGHDV SVTVETQGDD WDTDPDFVND ISEKEQRWGA KTIEGSGRTE HINIHQLRNK 60
VSEEHDILKK KEMESGPKAS HGYGGRFGVE KDRMDKSAVG HEYVAEVEKH SSQTDAARGF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGAAAACCTG AATACGGAAC TGAAATAGCA GCTTAGAGTT TCTTGCTCTG AAGTGGCAGC 60
AGCTAGAAAG GGGTCGAGTG TCTTCGTGAG GAGCTGAGAG AGCAAACGCA CAGTTGAAGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1267--Proteomics identification
KW-1185--Reference proteome

Interpro

IPR028534--HS1
IPR003134--Hs1_Cortactin
IPR001452--SH3_domain

PROSITE

PS51090--CORTACTIN
PS50002--SH3

Pfam

PF02218--HS1_rep
PF00018--SH3_1

PRINTS

PR00452--SH3DOMAIN

SMART

SM00326--SH3

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0005667--C:transcription factor complex
GO:0030041--P:actin filament polymerization
GO:0071345--P:cellular response to cytokine stimulus
GO:0030218--P:erythrocyte differentiation
GO:2000107--P:negative regulation of leukocyte apoptotic process
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0008284--P:positive regulation of cell proliferation
GO:0030854--P:positive regulation of granulocyte differentiation
GO:0045651--P:positive regulation of macrophage differentiation
GO:0033138--P:positive regulation of peptidyl-serine phosphorylation
GO:0014068--P:positive regulation of phosphatidylinositol 3-kinase signaling
GO:0051897--P:positive regulation of protein kinase B signaling
GO:0042993--P:positive regulation of transcription factor import into nucleus
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0042531--P:positive regulation of tyrosine phosphorylation of STAT protein
GO:0030833--P:regulation of actin filament polymerization
GO:0009725--P:response to hormone

KEGG

bta:508445

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001194	Ailuropoda melanoleuca	86.94	0.00e+00	761.00
IUUC-Cja-019982	Callithrix jacchus	84.46	0.00e+00	701.00
IUUC-Cfa-020262	Canis familiaris	86.91	0.00e+00	681.00
IUUC-Cpo-021362	Cavia porcellus	83.92	0.00e+00	660.00
IUUC-Csa-023911	Chlorocebus sabaeus	86.63	0.00e+00	696.00
IUUC-Dor-030437	Dipodomys ordii	77.57	1.00e-175	608.00
IUUC-Ete-033160	Echinops telfairi	74.84	7.00e-157	546.00
IUUC-Eca-033269	Equus caballus	88.80	0.00e+00	744.00
IUUC-Eeu-035032	Erinaceus europaeus	73.45	1.00e-129	456.00
IUUC-Fca-035999	Felis catus	85.77	0.00e+00	768.00
IUUC-Fal-037107	Ficedula albicollis	49.81	2.00e-123	436.00
IUUC-Gga-040335	Gallus gallus	66.78	9.00e-106	377.00
IUUC-Ggo-044505	Gorilla gorilla	82.58	0.00e+00	686.00
IUUC-Hsa-046728	Homo sapiens	89.27	4.00e-168	584.00
IUUC-Itr-048592	Ictidomys tridecemlineatus	67.20	8.00e-166	576.00
IUUC-Laf-054202	Loxodonta africana	85.66	0.00e+00	703.00
IUUC-Mcc-055824	Macaca mulatta	85.39	0.00e+00	699.00
IUUC-Mmr-061281	Microcebus murinus	75.93	4.00e-171	593.00
IUUC-Mdo-062515	Monodelphis domestica	69.15	4.00e-153	534.00
IUUC-Mmu-064341	Mus musculus	83.30	0.00e+00	690.00
IUUC-Mpu-066565	Mustela putorius furo	83.92	0.00e+00	712.00
IUUC-Mlu-066942	Myotis lucifugus	83.10	0.00e+00	689.00
IUUC-Nle-069436	Nomascus leucogenys	87.01	0.00e+00	702.00
IUUC-Opr-070288	Ochotona princeps	76.64	3.00e-166	578.00
IUUC-Ocu-074686	Oryctolagus cuniculus	82.17	0.00e+00	633.00
IUUC-Ola-086894	Oryzias latipes	59.79	1.00e-94	340.00
IUUC-Oga-088585	Otolemur garnettii	78.02	0.00e+00	676.00
IUUC-Oar-089686	Ovis aries	95.31	0.00e+00	792.00
IUUC-Ptr-090461	Pan troglodytes	90.11	1.00e-169	589.00
IUUC-Pan-091887	Papio anubis	90.11	1.00e-170	592.00
IUUC-Psi-093785	Pelodiscus sinensis	52.26	1.00e-142	499.00
IUUC-Pab-098222	Pongo abelii	86.83	0.00e+00	694.00
IUUC-Pca-100668	Procavia capensis	83.58	0.00e+00	691.00
IUUC-Pva-102767	Pteropus vampyrus	75.46	2.00e-173	601.00
IUUC-Rno-106001	Rattus norvegicus	84.25	0.00e+00	691.00
IUUC-Sha-106912	Sarcophilus harrisii	56.34	2.00e-145	509.00
IUUC-Sar-113338	Sorex araneus	81.40	0.00e+00	634.00
IUUC-Ssc-116027	Sus scrofa	90.26	0.00e+00	753.00
IUUC-Tgu-117472	Taeniopygia guttata	56.77	3.00e-151	528.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence