iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mdo-062302

UUCD1 version

UUC-MoD-01154

Ensembl Protein ID

ENSMODP00000026626.3

UniProt Accession

F7G3T7; F7G3T7_MONDO

Protein Name

Ubiquitinyl hydrolase 1

Gene Name

USP13

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMODG00000021299.3	ENSMODT00000027102.3	ENSMODP00000026626.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	7.90e-55	186.5	346	873
UBD/Alpha-Helix/UBA	7.10e-20	70.6	740	777

Active Site

Position(s)	Description	Evidence
355	Nucleophile	{ECO:0000256\|PIRSR:PIRSR016308-1}
836	Proton acceptor	{ECO:0000256\|PIRSR:PIRSR016308-1}

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeel......................wkskkka 67
           tG+kNlgN+CY+ +v+Q++++ipe+++++   +  ++ + +p +p++++ ++++kl + l                       k +++ 
   Q: 346  TGMKNLGNSCYLSAVMQAIFSIPEFQRMYVG-NLARIFDYSPLDPTQDFNTQMAKLGHGLlsgqyskppmkselieqvmkeeHKPQQNG 433
           7******************************.66666677789****************98888888888888777765543378888* PP
   S: 68   vsprellkalkkeaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikc 156
           +sp ++++ ++k ++efs+++qqDaqEf+ +l++ +e++                               +++  sd+F++ ++++i+c
   Q: 434  ISPCMFKAFVSKSHPEFSSNRQQDAQEFFLHLVNLVERNR-----------------------------IGSENPSDVFRFVVEERIQC 493
           *************************************998.............................688899************** PP
   S: 157  lecdnvssreepfldlslpvpgkeetkke...........................slqdcLesftkeeelegenkyycekckkkqeae 218
            + ++v  +e   + ++lpv ++  t+k                             ++ cL++f++++++e+   ++++  ++k+  +
   Q: 494  CQSRKVRYTERVDYLMQLPVAMEAATNKDeliayeltrreaetsrrplpelvrariPFSACLQAFSEPDNVED---FWSSALQAKSAGV 579
           ******9999999999999999998887799*****************************************7...************* PP
   S: 219  kklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfcts........................................ 267
           k+ ++ ++Pe+L++++k+f+f  + ++++k++ ++++p+ Ld+++  ++                                        
   Q: 580  KTSRFASFPEYLVVQIKKFTFGLD-WVPKKFDVSIDMPDLLDINHLRATglqpgeeelpdiappivipddpkdrlmnhymeppdidess 667
           *********************997.*******************988888999999999999999998888888888888888888888 PP
   S: 268  ......................................................................................... 267
                                                                                                    
   Q: 668  vmqlaemgfpleacrkavyytgnmgpevafnwiighmeepdfaeplslpgfggsaalgatafgaigldnqppeeivaiitsmgfqrnqa 756
           88888888888888888888888888888888888777777777777777777777777777777777777777777777777776666 PP
   S: 268  .....................peekqke....................................kkkYeLiavvvHsG.slssGHYvay 298
                                p     e                                    + +YeL++ ++H+G s+ sGHYv++
   Q: 757  iqalkatnnnleraldwifshP-----EleednefaahmmemennananiiseskpdgprvkdgSGRYELFGFISHMGpSTMSGHYVCH 840
           6666665555555555555551.....0555555666666666666677888888888888888************************* PP
   S: 299  vknekgkWllfdDskVtevkeeevleetgstaYvlfYkr 337
           +k+ +g+W+ ++D+kV ++  e+  +   + +Y++fY+r
   Q: 841  IKK-EGRWVIYNDHKVCAS--ERPPK---DLGYMYFYHR 873
           ***.9***********999..78888...89******97 PP

UBD/Alpha-Helix/UBA

   S: 4    edkleqlveMGFdreealqaLraannnleaAveyLldg 41
           e++++ +++MGF r++a+qaL a+nnnle+A+++++++
   Q: 740  EEIVAIITSMGFQRNQAIQALKATNNNLERALDWIFSH 777
           899*********************************97 PP

Organism

Monodelphis domestica

Protein Sequence
(Fasta)

MQRAALFGSP GGGPGGGSGP GPGPGPGKMA AGDLGELLVP YMPTIRVPRS GDRVYKAECA 60
FSYDSPISEG GLYVCMNTFL AFGREHVERH YRKTGQCVYM HLKRHVREKV TGASGGVLPK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AAAGGAGATG GGACTAGTTG ACCTCTTAAG TCTTTTCCAG CTCTTGGTCT CTTGAAGGGC 60
TCGACAAGAC CGTGATTTCT TTCAGGCAAA TACTGTCTGT CATATGAGCA AGGGGCCCGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR015940--UBA
IPR009060--UBA-like
IPR016652--Ubiquitinyl_hydrolase
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS50030--UBA
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00627--UBA
PF00443--UCH
PF02148--zf-UBP

SMART

SM00165--UBA
SM00290--ZnF_UBP

Gene Ontology

GO:0004197--F:cysteine-type endopeptidase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:1904454--F:ubiquitin-specific protease activity involved in positive regulation of ERAD pathway
GO:0008270--F:zinc ion binding
GO:0008283--P:cell proliferation
GO:1904378--P:maintenance of unfolded protein involved in ERAD pathway
GO:0035523--P:protein K29-linked deubiquitination
GO:0044313--P:protein K6-linked deubiquitination
GO:0070536--P:protein K63-linked deubiquitination
GO:0050821--P:protein stabilization
GO:0010506--P:regulation of autophagy
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

mdo:100013861

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001356	Ailuropoda melanoleuca	89.37	0.00e+00	1478.00
IUUC-Apl-003712	Anas platyrhynchos	85.80	0.00e+00	1400.00
IUUC-Aca-004634	Anolis carolinensis	86.29	0.00e+00	1459.00
IUUC-Ame-011470	Astyanax mexicanus	75.96	0.00e+00	1327.00
IUUC-Bta-013349	Bos taurus	88.69	0.00e+00	1501.00
IUUC-Cja-019021	Callithrix jacchus	88.46	0.00e+00	1459.00
IUUC-Cfa-020614	Canis familiaris	89.61	0.00e+00	1476.00
IUUC-Cpo-022484	Cavia porcellus	88.86	0.00e+00	1403.00
IUUC-Csa-024078	Chlorocebus sabaeus	89.63	0.00e+00	1480.00
IUUC-Cho-024522	Choloepus hoffmanni	74.29	0.00e+00	1123.00
IUUC-Cme-027335	Cyanidioschyzon merolae	25.82	1.00e-52	202.00
IUUC-Dre-027651	Danio rerio	76.57	0.00e+00	1399.00
IUUC-Dno-028975	Dasypus novemcinctus	89.31	0.00e+00	1469.00
IUUC-Dor-030130	Dipodomys ordii	65.57	0.00e+00	988.00
IUUC-Ete-032251	Echinops telfairi	75.03	0.00e+00	1184.00
IUUC-Eca-033568	Equus caballus	89.49	0.00e+00	1404.00
IUUC-Eeu-034612	Erinaceus europaeus	71.20	0.00e+00	1080.00
IUUC-Fca-036280	Felis catus	89.59	0.00e+00	1404.00
IUUC-Fal-036610	Ficedula albicollis	85.52	0.00e+00	1372.00
IUUC-Gmo-038906	Gadus morhua	74.15	0.00e+00	1304.00
IUUC-Gga-041215	Gallus gallus	83.58	0.00e+00	1464.00
IUUC-Gac-042441	Gasterosteus aculeatus	74.27	0.00e+00	1326.00
IUUC-Ggo-044446	Gorilla gorilla	89.63	0.00e+00	1483.00
IUUC-Hsa-046546	Homo sapiens	89.52	0.00e+00	1480.00
IUUC-Itr-048147	Ictidomys tridecemlineatus	81.52	0.00e+00	1333.00
IUUC-Lch-050425	Latimeria chalumnae	79.88	0.00e+00	1425.00
IUUC-Loc-052072	Lepisosteus oculatus	78.47	0.00e+00	1358.00
IUUC-Laf-053909	Loxodonta africana	88.03	0.00e+00	1463.00
IUUC-Mcc-054686	Macaca mulatta	89.87	0.00e+00	1483.00
IUUC-Meu-056361	Macropus eugenii	89.05	0.00e+00	1455.00
IUUC-Mga-059972	Meleagris gallopavo	80.53	0.00e+00	1336.00
IUUC-Mmr-060916	Microcebus murinus	89.05	0.00e+00	1474.00
IUUC-Mmu-063639	Mus musculus	88.23	0.00e+00	1498.00
IUUC-Mpu-066533	Mustela putorius furo	89.49	0.00e+00	1477.00
IUUC-Mlu-067786	Myotis lucifugus	82.92	0.00e+00	1374.00
IUUC-Nle-069997	Nomascus leucogenys	89.26	0.00e+00	1392.00
IUUC-Ont-071859	Oreochromis niloticus	74.23	0.00e+00	1328.00
IUUC-Oan-072959	Ornithorhynchus anatinus	88.70	2.00e-130	457.00
IUUC-Ocu-074265	Oryctolagus cuniculus	89.63	0.00e+00	1475.00
IUUC-Ola-087344	Oryzias latipes	73.59	0.00e+00	1336.00
IUUC-Oga-088734	Otolemur garnettii	89.22	0.00e+00	1450.00
IUUC-Oar-089636	Ovis aries	88.50	0.00e+00	1460.00
IUUC-Ptr-090982	Pan troglodytes	89.52	0.00e+00	1483.00
IUUC-Pan-091991	Papio anubis	89.75	0.00e+00	1482.00
IUUC-Psi-093509	Pelodiscus sinensis	86.30	0.00e+00	1523.00
IUUC-Pfo-096029	Poecilia formosa	75.67	0.00e+00	1368.00
IUUC-Pab-098672	Pongo abelii	85.63	0.00e+00	1389.00
IUUC-Pca-100860	Procavia capensis	68.58	0.00e+00	974.00
IUUC-Pva-102545	Pteropus vampyrus	81.74	0.00e+00	1332.00
IUUC-Rno-105210	Rattus norvegicus	88.23	0.00e+00	1469.00
IUUC-Sha-106805	Sarcophilus harrisii	98.51	0.00e+00	838.00
IUUC-Sar-113733	Sorex araneus	87.34	0.00e+00	718.00
IUUC-Tgu-116591	Taeniopygia guttata	84.02	0.00e+00	1465.00
IUUC-Tru-118627	Takifugu rubripes	72.81	0.00e+00	1345.00
IUUC-Tsy-119278	Tarsius syrichta	80.47	0.00e+00	1274.00
IUUC-Tni-120804	Tetraodon nigroviridis	75.43	0.00e+00	1370.00
IUUC-Tbe-127699	Tupaia belangeri	73.20	0.00e+00	820.00
IUUC-Ttr-128295	Tursiops truncatus	81.29	0.00e+00	1331.00
IUUC-Vpa-130170	Vicugna pacos	78.99	0.00e+00	1232.00
IUUC-Xtr-132809	Xenopus tropicalis	75.44	0.00e+00	1303.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence