iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Nle-069686

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Ubiquitin carboxyl-terminal hydrolase

Genbank Nucleotide ID

ADFV01182654

Gene Name

UCHL1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSNLEG00000017176.2	ENSNLET00000021922.2	ENSNLEP00000020878.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/UCH	4.30e-65	220.2	2	222

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/UCH

   S: 7    ewleLesdPglftllvedfgvkrdiqveelysLdpenlglyqepvegllllFkinekressrksqvtsndlevvdediiktiffakqvi 95
           ++ ++e +P+++++++ ++gv +++++ ++ +L++e+lg+++ p ++llllF+++ ++e++rk+q++    e +++++  +++f+kq+i
   Q: 2    QLKPMEINPEMLNKVLTRLGVAGQWRFVDVLGLEEESLGSVPAPACALLLLFPLTAQHENFRKKQIE----ELKGQEVSPKVYFMKQTI 86
           5789*************************************************************99....99**************** PP
   S: 96   gNsCatyAllsvllncedkl.ldlGttlsrlkestkaespenkalalgnqqvlecihnslariesrseperqdedneqytkeafhfvsy 183
           gNsC+t++l+++++n++dkl ++ G+ l++++++t+++spe++a++++++++++++h+++a++++++ +          +k +fhf+++
   Q: 87   GNSCGTIGLIHAVANNQDKLgFEDGSVLKQFLSETEKMSPEDRAKCFEKNEAIQAAHDAVAQEGQCRVD----------DKVNFHFILF 165
           *******************************************************************99..........5679****** PP
   S: 184  vningrlyeldglkpfPldlgkkketeelkdklkvvraflerikllesdeirfnllaivad 244
            n++g+lyeldg++pfP+++g+++e++ lkd++kv+r+f+er    e++e+rf+++a++++
   Q: 166  NNVDGHLYELDGRMPFPVNHGASSEDTLLKDAAKVCREFTER----EQGEVRFSAVALCKA 222
           ******************************************....************987 PP

Organism

Nomascus leucogenys

Protein Sequence
(Fasta)

MQLKPMEINP EMLNKVLTRL GVAGQWRFVD VLGLEEESLG SVPAPACALL LLFPLTAQHE 60
NFRKKQIEEL KGQEVSPKVY FMKQTIGNSC GTIGLIHAVA NNQDKLGFED GSVLKQFLSE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGAGCTTTAG AGTAATTGGG ATGGTGAAAG GATGGGTTTC CAGAAACTTC GCCCAAAATT 60
AAAGACTCCA TCAAAAGGAC TGCTCCATAC ACTCAAGGAA CACCCACCAA CAAATCCCGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR001578--Peptidase_C12_UCH
IPR030297--UCHL1

PROSITE

PS00140--UCH_1

Pfam

PF01088--Peptidase_C12

PRINTS

PR00707--UBCTHYDRLASE

Gene Ontology

GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0005654--C:nucleoplasm
GO:0005886--C:plasma membrane
GO:0004197--F:cysteine-type endopeptidase activity
GO:0016874--F:ligase activity
GO:0008242--F:omega peptidase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0043407--P:negative regulation of MAP kinase activity
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

nle:100588568

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000360	Aegilops tauschii	38.86	1.00e-44	172.00
IUUC-Aml-001376	Ailuropoda melanoleuca	80.08	1.00e-112	398.00
IUUC-Apl-003693	Anas platyrhynchos	69.64	3.00e-91	327.00
IUUC-Aca-004716	Anolis carolinensis	77.23	8.00e-103	365.00
IUUC-Ame-011806	Astyanax mexicanus	68.16	8.00e-86	309.00
IUUC-Bta-013521	Bos taurus	82.14	5.00e-115	406.00
IUUC-Bdi-014330	Brachypodium distachyon	42.27	4.00e-47	181.00
IUUC-Cel-018302	Caenorhabditis elegans	37.67	1.00e-34	139.00
IUUC-Cja-018752	Callithrix jacchus	98.21	1.00e-119	421.00
IUUC-Cfa-020442	Canis familiaris	95.54	2.00e-116	410.00
IUUC-Cpo-021723	Cavia porcellus	96.99	3.00e-94	337.00
IUUC-Cre-022599	Chlamydomonas reinhardtii	40.28	7.00e-34	136.00
IUUC-Csa-023626	Chlorocebus sabaeus	98.65	2.00e-120	424.00
IUUC-Cho-024548	Choloepus hoffmanni	85.19	4.00e-40	157.00
IUUC-Dre-027854	Danio rerio	65.62	2.00e-84	304.00
IUUC-Dno-029325	Dasypus novemcinctus	95.96	5.00e-118	416.00
IUUC-Dor-030114	Dipodomys ordii	94.62	2.00e-126	444.00
IUUC-Ete-033092	Echinops telfairi	77.58	4.00e-97	347.00
IUUC-Eca-033854	Equus caballus	96.48	2.00e-79	286.00
IUUC-Eeu-034493	Erinaceus europaeus	93.27	1.00e-113	401.00
IUUC-Fal-036693	Ficedula albicollis	73.81	2.00e-92	331.00
IUUC-Gmo-038848	Gadus morhua	60.85	2.00e-74	271.00
IUUC-Gga-041078	Gallus gallus	74.55	2.00e-101	360.00
IUUC-Gac-042064	Gasterosteus aculeatus	62.27	3.00e-78	284.00
IUUC-Ggo-044827	Gorilla gorilla	99.55	8.00e-122	428.00
IUUC-Hsa-045820	Homo sapiens	99.55	8.00e-122	428.00
IUUC-Hvu-047176	Hordeum vulgare	34.38	2.00e-36	145.00
IUUC-Itr-048496	Ictidomys tridecemlineatus	95.96	3.00e-117	414.00
IUUC-Lch-050121	Latimeria chalumnae	74.32	3.00e-98	350.00
IUUC-Lpe-051377	Leersia perrieri	43.08	7.00e-41	159.00
IUUC-Loc-052342	Lepisosteus oculatus	69.91	3.00e-92	330.00
IUUC-Laf-053916	Loxodonta africana	94.22	1.00e-115	408.00
IUUC-Mcc-054838	Macaca mulatta	98.65	2.00e-120	424.00
IUUC-Meu-056478	Macropus eugenii	89.69	7.00e-122	429.00
IUUC-Mpo-057343	Magnaporthe poae	32.05	4.00e-19	87.40
IUUC-Mga-059878	Meleagris gallopavo	73.27	3.00e-95	340.00
IUUC-Mdo-062544	Monodelphis domestica	88.34	2.00e-110	390.00
IUUC-Mmu-063300	Mus musculus	95.52	3.00e-127	446.00
IUUC-Mpu-066128	Mustela putorius furo	95.00	3.00e-103	367.00
IUUC-Mlu-067778	Myotis lucifugus	94.17	2.00e-125	441.00
IUUC-Opr-070535	Ochotona princeps	78.48	3.00e-99	353.00
IUUC-Ont-071510	Oreochromis niloticus	62.61	8.00e-80	289.00
IUUC-Ocu-074590	Oryctolagus cuniculus	95.96	3.00e-118	416.00
IUUC-Oba-075098	Oryza barthii	38.25	9.00e-44	169.00
IUUC-Obr-076041	Oryza brachyantha	41.18	6.00e-46	176.00
IUUC-Ogl-076980	Oryza glaberrima	41.63	2.00e-45	175.00
IUUC-Ogu-078978	Oryza glumaepatula	36.18	8.00e-42	163.00
IUUC-Oin-079285	Oryza indica	37.79	4.00e-43	167.00
IUUC-Olo-080671	Oryza longistaminata	37.79	1.00e-42	166.00
IUUC-Ome-081428	Oryza meridionalis	36.87	4.00e-41	160.00
IUUC-Oni-082406	Oryza nivara	38.25	9.00e-44	169.00
IUUC-Opu-083305	Oryza punctata	36.87	4.00e-42	164.00
IUUC-Oru-084969	Oryza rufipogon	38.25	9.00e-44	169.00
IUUC-Osa-085830	Oryza sativa	41.63	2.00e-45	175.00
IUUC-Ola-087552	Oryzias latipes	58.77	5.00e-74	270.00
IUUC-Oga-089013	Otolemur garnettii	82.14	1.00e-113	402.00
IUUC-Oar-089861	Ovis aries	82.14	4.00e-115	407.00
IUUC-Ptr-091536	Pan troglodytes	97.76	2.00e-119	421.00
IUUC-Pan-092909	Papio anubis	98.65	2.00e-120	424.00
IUUC-Psi-093818	Pelodiscus sinensis	79.46	1.00e-104	371.00
IUUC-Pfo-097335	Poecilia formosa	60.00	7.00e-79	286.00
IUUC-Pab-098048	Pongo abelii	99.55	8.00e-122	428.00
IUUC-Pca-100818	Procavia capensis	72.31	2.00e-66	244.00
IUUC-Pva-102954	Pteropus vampyrus	95.07	7.00e-113	399.00
IUUC-Pyt-104587	Pyrenophora triticirepentis	37.50	5.00e-31	127.00
IUUC-Rno-105966	Rattus norvegicus	95.52	3.00e-127	446.00
IUUC-Sha-107111	Sarcophilus harrisii	87.27	2.00e-87	314.00
IUUC-Spo-108322	Schizosaccharomyces pombe	33.19	8.00e-24	103.00
IUUC-Sly-111832	Solanum lycopersicum	45.41	2.00e-49	188.00
IUUC-Stu-112526	Solanum tuberosum	45.41	1.00e-49	189.00
IUUC-Sar-113190	Sorex araneus	74.56	2.00e-38	150.00
IUUC-Ssc-115908	Sus scrofa	78.22	4.00e-99	353.00
IUUC-Tgu-117465	Taeniopygia guttata	69.67	4.00e-86	310.00
IUUC-Tru-118565	Takifugu rubripes	60.78	5.00e-70	256.00
IUUC-Tsy-119561	Tarsius syrichta	77.58	2.00e-96	345.00
IUUC-Tae-122693	Triticum aestivum	40.27	4.00e-46	177.00
IUUC-Tur-126250	Triticum urartu	38.86	4.00e-44	171.00
IUUC-Tbe-128048	Tupaia belangeri	95.15	2.00e-92	330.00
IUUC-Ttr-128494	Tursiops truncatus	95.05	3.00e-114	404.00
IUUC-Vda-129850	Verticillium dahliae	34.63	3.00e-29	121.00
IUUC-Xtr-132286	Xenopus tropicalis	69.96	1.00e-92	332.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence