iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Hvu-047846

Ensembl Protein ID

MLOC_34537.1

UniProt Accession

M0VMT0; M0VMT0_HORVV

Protein Name

Uncharacterized protein

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
MLOC_34537	MLOC_34537.1	MLOC_34537.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E1	8.00e-170	566.6	455	942

Active Site

Position(s)	Description	Evidence
636	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU10132}

Domain Profile

   S: 1    YDRQirlwGeeaqeklksakvllvGagglGcEllKnLvlaGv.....gsitvvDmdtvevsnlnrqFLfraedvgksKAevaaealkelnpdvnvea 92
           YD Qi ++G++ q+k++ +++++vG g+lGcE+lKn++l+Gv     g++t++D+d +e+snl+rqFLfr++++g+ K+ vaa a+  +n++ +++a
   Q: 455  YDAQISVFGSKLQKKMRDSNIFVVGSGALGCEFLKNFALMGVscgrkGKLTITDDDVIEKSNLSRQFLFRDWNIGQAKSTVAATAASAINSSFHIDA 551
           ************************************************************************************************* PP
   S: 93   heesiteleeeiv...FfkkfdvVvlaldnrearrkvnrlclnarvpliesgtlGllGqvrviikgltecyscsddppqktiPfctlketpnaaeht 186
            +++ ++++e+++   F + +d V++aldn+ ar++++ +cl+ ++pl+esgtlG + +++ +i++lte y +s+dpp+k++P+ct+ ++p +++h+
   Q: 552  LQNRACPETEHVFndaFWEGLDAVINALDNVNARMYMDMRCLYFQKPLLESGTLGPKCNTQMVIPHLTENYGASRDPPEKQAPMCTVHSFPHNIDHC 648
           ***********99999********************************************************************************* PP
   S: 187  iewa............vlfnklleeeageeevlekldseekeegkdkvkselksedeenfeeaieiavkafakttinsikqllksfecdivtksksp 271
           ++wa              +n ++++ a+      k   ++ +e +++v++ l +e+ + fe++i++a+ +f+ +++n +kql+  f+ d  t+ ++p
   Q: 649  LTWArsefegllekapNEVNSFMSNPAEYAAAMRKAGDAQARELLERVRECLDKERCDKFEDCIAWARLKFEDYFSNRVKQLTFTFPEDAGTSTGAP 745
           *************999788888888888888888889999********************************************************* PP
   S: 272  fwv.........................................................sfcsna.ealqvpekvekdeevvkasap.lylllral 309
           fw+                                                         +f++ +  +++++ek+++   ++ ++a+ ++ ll++l
   Q: 746  FWSapkrfphpvqfsavdsshiqfilaasilravsfgipipdwaknmgnladvvskvavpEFEPKSgVKIETDEKATDLSSASVDDAAvIEDLLTKL 842
           ***********************************************98888888887775544441445555555555444444444999999999 PP
   S: 310  erfekk..kgrkpgelsfekddds..avdlvtaaanlraeslgiepkldddlikeiagniipaiattnavvgGlaaqEviKvvsg..kfeplknffl 400
           e  +kk  +g +++ ++fekddd   ++dl++ +an+ra ++gi++ +d+ + k iag+iipaiatt+a+  Gl+++E++Kv+ g  + e ++n+f 
   Q: 843  EACAKKlpSGFQMKPIQFEKDDDTnfHMDLIAGLANMRARNYGIQE-VDKLKAKFIAGRIIPAIATTTAMATGLVCLELYKVLAGdhPVEDYRNTFA 938
           99999866899***********************************.*************************************9989999*****9 PP
   S: 401  fdae 404
           ++a+
   Q: 939  NLAL 942
           9875 PP

Organism

Hordeum vulgare

Protein Sequence
(Fasta)

MLPTKRADGA EDSGDAAAKK ARVGESAAEA GSEAMVAGET VGGGSNGNGV AEIDEDLHSR 60
QLAVYGRETM RLLFASNVLV SGLNGLGAET AKNLALAGVK SVTLHDVENV DMWDLSGNFF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCCCTCTGCC CTCCCCACCC CCAAGCCTCT CCACCGCGCC GCATCGGCGA CTCAATCCAA 60
CACCACCACC ACCTTGCCTT GCCGCAAAAC CCCACCGCGC CCGCCCCTTT CTATATATAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0436--Ligase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR032420--E1_4HB
IPR032418--E1_FCCH
IPR016040--NAD(P)-bd_dom
IPR000594--ThiF_NAD_FAD-bd
IPR018965--Ub-activating_enz_E1_C
IPR019572--UBA_E1_Cys
IPR018075--UBQ-activ_enz_E1
IPR018074--UBQ-activ_enz_E1_CS
IPR033127--UBQ-activ_enz_E1_Cys_AS
IPR000011--UBQ/SUMO-activ_enz_E1-like

PROSITE

PS00536--UBIQUITIN_ACTIVAT_1
PS00865--UBIQUITIN_ACTIVAT_2

Pfam

PF16191--E1_4HB
PF16190--E1_FCCH
PF09358--E1_UFD
PF00899--ThiF
PF10585--UBA_e1_thiolCys

PRINTS

PR01849--UBIQUITINACT

SMART

SM00985--UBA_e1_C

Gene Ontology

GO:0005524--F:ATP binding
GO:0008641--F:small protein activating enzyme activity
GO:0006464--P:cellular protein modification process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Apl-004158	Anas platyrhynchos	40.02	0.00e+00	678.00
IUUC-Cel-018260	Caenorhabditis elegans	38.87	0.00e+00	654.00
IUUC-Cho-024682	Choloepus hoffmanni	37.16	2.00e-103	369.00
IUUC-Eeu-035323	Erinaceus europaeus	41.11	3.00e-152	531.00
IUUC-Gga-040747	Gallus gallus	39.41	0.00e+00	676.00
IUUC-Lpe-051520	Leersia perrieri	88.80	0.00e+00	1847.00
IUUC-Oan-073268	Ornithorhynchus anatinus	39.86	0.00e+00	639.00
IUUC-Oba-075913	Oryza barthii	89.09	0.00e+00	1816.00
IUUC-Ogl-077371	Oryza glaberrima	89.09	0.00e+00	1816.00
IUUC-Ogu-078793	Oryza glumaepatula	89.09	0.00e+00	1816.00
IUUC-Oin-079710	Oryza indica	89.19	0.00e+00	1811.00
IUUC-Olo-080255	Oryza longistaminata	88.79	0.00e+00	1814.00
IUUC-Ome-081171	Oryza meridionalis	88.89	0.00e+00	1811.00
IUUC-Oni-082436	Oryza nivara	89.09	0.00e+00	1816.00
IUUC-Opu-083161	Oryza punctata	88.42	0.00e+00	1793.00
IUUC-Oru-085015	Oryza rufipogon	87.22	0.00e+00	1831.00
IUUC-Osa-085455	Oryza sativa	87.03	0.00e+00	1827.00
IUUC-Ptr-090609	Pan troglodytes	39.72	0.00e+00	686.00
IUUC-Sit-109722	Setaria italica	84.87	0.00e+00	1650.00
IUUC-Tsy-119436	Tarsius syrichta	35.48	2.00e-162	565.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence