iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mlu-067407

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAPE02007747

Gene Name

HERC6

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMLUG00000012209.2	ENSMLUT00000012223.2	ENSMLUP00000011136.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	3.00e-84	283.3	702	1021

Active Site

Position(s)	Description	Evidence
992	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 3    sdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlld 89
            dl+k+l +ef +E      Gv++ef++ +++e+ ++++g+f+y e+++++++p + ++    e+ ++F  +Grl+g++l++ ++ d
   Q: 702  TDLRKELVIEFINEIRSVGYGVKSEFFYFIFQEMTKTEYGMFMYPEEGSYMWFPISPKI----EKKRYFL-FGRLCGLSLYHLNVAD 783
           6899**********965555***********************************9998....6788995.5*************** PP
   S: 90   lplsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvkl 176
           +p++ +++k+ll++k sledl+e+ p l k+l+e+++++ +di e+ l++ fs       ++++++L+p+G +i V ++Nk +Yv++
   Q: 784  IPFPLALFKKLLDQKPSLEDLKELSPLLGKNLQEVLNYEADDIGEA-LCIYFSLRW----DQHNVDLIPNGISILVDQTNKTDYVSQ 865
           **************************************98888887.999998555....678899********************* PP
   S: 177  vveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerka 263
            v+y++++++k  +e+f++Gf+ev+++e+l+lF++eel++ i G++++d+++++k+  y+ +y+e++p+iq+Fw+++++++ +e+++
   Q: 866  CVDYIFNTSVKAVYEEFQRGFYEVCDKEILRLFHPEELRTAIIGNTDYDWKQFEKNSVYEPEYHESHPTIQMFWKAFHKLTLDEKRQ 952
           *************************************************************************************** PP
   S: 264  fLqFvTgssrlPlgGfaelkprlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgF 333
           fL F+Tg++r  ++G++e++   f +++  s++++P+   C + L+LP+Ys++e l+e L++Ai++++gF
   Q: 953  FLFFLTGNDRQTARGLQEMR-ITFRCPETLSERDYPRPLVCHSILDLPRYSTMERLEEALQVAIRSNRGF 1021
           ********************.557777789**************************************99 PP

Organism

Myotis lucifugus

Protein Sequence
(Fasta)

MYFCSGLGPG RLQRREPSGR TELRRAASGE RHSLLLLSDG TVHAWGDNSR GQLGRRGARR 60
GDRPEEPIKA LETLQVVFVS CGKEHSLVVC HKGRVFAWGA GSEGQLGIGE FKEKIFTPKK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGTACTTCT GCAGCGGCCT CGGCCCCGGG AGGCTGCAGC GCCGGGAACC CTCCGGCAGA 60
ACCGAGCTGC GGCGGGCGGC CAGCGGGGAG CGCCACTCGC TGCTGCTGCT GAGCGACGGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom
IPR009091--RCC1/BLIP-II
IPR000408--Reg_chr_condens

PROSITE

PS50237--HECT
PS00626--RCC1_2
PS50012--RCC1_3

Pfam

PF00632--HECT
PF00415--RCC1

PRINTS

PR00633--RCCNDNSATION

SMART

SM00119--HECTc

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001374	Ailuropoda melanoleuca	72.76	0.00e+00	1359.00
IUUC-Aca-004663	Anolis carolinensis	47.38	0.00e+00	853.00
IUUC-Bta-013080	Bos taurus	71.43	0.00e+00	1392.00
IUUC-Cja-018891	Callithrix jacchus	70.90	0.00e+00	1390.00
IUUC-Cfa-020763	Canis familiaris	72.45	0.00e+00	1335.00
IUUC-Cpo-022346	Cavia porcellus	66.17	0.00e+00	1338.00
IUUC-Csa-023049	Chlorocebus sabaeus	73.18	0.00e+00	1491.00
IUUC-Dno-029093	Dasypus novemcinctus	69.75	0.00e+00	1413.00
IUUC-Eca-034098	Equus caballus	75.18	0.00e+00	1431.00
IUUC-Eeu-035028	Erinaceus europaeus	66.67	2.00e-148	520.00
IUUC-Fca-036283	Felis catus	75.22	0.00e+00	1445.00
IUUC-Ggo-045553	Gorilla gorilla	71.21	0.00e+00	1416.00
IUUC-Hsa-046396	Homo sapiens	73.11	0.00e+00	1466.00
IUUC-Loc-052700	Lepisosteus oculatus	39.59	0.00e+00	742.00
IUUC-Laf-054433	Loxodonta africana	68.47	0.00e+00	1426.00
IUUC-Mcc-055014	Macaca mulatta	69.12	0.00e+00	1413.00
IUUC-Mdo-061839	Monodelphis domestica	55.77	0.00e+00	984.00
IUUC-Mmu-064378	Mus musculus	60.76	0.00e+00	1159.00
IUUC-Mpu-066293	Mustela putorius furo	70.82	0.00e+00	1313.00
IUUC-Nle-069978	Nomascus leucogenys	73.05	0.00e+00	1487.00
IUUC-Opr-070190	Ochotona princeps	57.98	0.00e+00	655.00
IUUC-Ont-071328	Oreochromis niloticus	36.97	9.00e-177	614.00
IUUC-Oga-088780	Otolemur garnettii	64.99	0.00e+00	1263.00
IUUC-Oar-090307	Ovis aries	73.43	0.00e+00	1445.00
IUUC-Ptr-091567	Pan troglodytes	73.47	0.00e+00	1472.00
IUUC-Pan-091802	Papio anubis	68.12	0.00e+00	1375.00
IUUC-Pab-098024	Pongo abelii	56.70	0.00e+00	1068.00
IUUC-Pva-102382	Pteropus vampyrus	71.22	0.00e+00	1376.00
IUUC-Rno-105768	Rattus norvegicus	57.62	0.00e+00	1118.00
IUUC-Sha-106525	Sarcophilus harrisii	52.09	0.00e+00	1018.00
IUUC-Sar-113014	Sorex araneus	60.52	2.00e-156	546.00
IUUC-Vpa-130214	Vicugna pacos	68.84	0.00e+00	1258.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence