iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLACG00000011743.2	ENSLACT00000013433.1	ENSLACP00000013337.1
ENSLACG00000011743.2	ENSLACT00000025074.1	ENSLACP00000022245.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	5.70e-85	285.7	445	948

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgyeq 89
           tGl NlgNtCYmNSv+Q+L++ +++r+ +l+    +ln        ++l+k+lq+lf+ l ++++ a++pr++++a +   + f+  +q
   Q: 445  TGLINLGNTCYMNSVIQALFMATDFRRSVLS---LSLNGA------NSLMKKLQHLFAFLAHTQRAAYDPRNFFDASR--PPWFTPRSQ 522
           7******************************...666655......58***************************998..777****** PP
   S: 90   qDaqEflaflldqleeelkk........eknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfl 170
           qD++E+l+flld+l+ee k         ++n +  +e+ ++ +e + e++++k +++k+l++++F+g+l+++i cl+c+++s +eepf+
   Q: 523  QDCSEYLRFLLDRLHEEEKTlnaisskpSQNATAGKEMPNH-EEPNAEKPREKGNEEKTLVEKMFGGKLQTHICCLNCKSTSLKEEPFT 610
           ******************77777655533333333333333.455555899999*********************************** PP
   S: 171  dlslpvpgkeetkke.......................................................................... 185
           dlsl++   ++++                                                                            
   Q: 611  DLSLAFCPFSDSAAMqedlcsseaqadgsmlhlnsvpsvvdsktknsemhkppaeetgqesvisvetlqdlvsdsnacmattvpdsqlm 699
           ******9777665557899********************************************************************** PP
   S: 186  .................slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpl 257
                            s++d+++ f ++e l+g+nkyycekc ++q+aek++++   Pe+Lil L Rfs++ + ++r+ki ++v++p+
   Q: 700  vhstkslastaadkstlSVTDLISYFLAPEVLDGDNKYYCEKCASLQNAEKTMQIIDEPEYLILTLLRFSYDPKSHVRRKILDNVSLPQ 788
           ***************************************************************************************** PP
   S: 258  eLdlspfcts....................peekqke...............kkkYeLiavvvHsG.slssGHYvayvkn......... 301
            L+l    ts                                          ++ Y L+++vvHsG s++sGHY++y++n         
   Q: 789  VLQLPVKRTSsmdpshnlpslndftdngenL-----AkklkpsgveemqatqPVPYVLSSIVVHSGmSSESGHYYSYARNvtgsglppl 872
           ****977777455555555555555555550.....0555555555555555************************************* PP
   S: 302  ...................................ekgkWllfdDskVtevkeeevleetg....staYvlfYkrr 338
                                               +++W+lf+Ds+Vt ++ ++v++ t+    +taYvl+Y+++
   Q: 873  lcypadtqalsisqgqpisgdsvnlvlkqdsdstePSKEWFLFNDSRVTFTSFQSVQNITSrfpkDTAYVLLYRKQ 948
           ****************99999999999988887766777*******************999************986 PP

Organism

Latimeria chalumnae

Protein Sequence
(Fasta)

MDKILEGLVT SSHPLSLKKL IVKKVVESAE NSVSEEQCRA MFALTTRLIL LGEDAFQKQV 60
GHQVLEAYAR YHRSDFENFF NKNFVLDLLH QGYQSVDRKH VAILDYIHNG LKLIMSCPSV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGGAGGAGGG GGGGGGCGCG ATGACGCAAA AGCGCAGTGA CGTCGATTGT TCCCAACCTC 60
TCCGGCTTGA GAGGATGGAG GTTTCAGCGT CTGGATTCGA GCCGCGGCGG CGGGCCCGCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR001394--Peptidase_C19_UCH
IPR033840--USP38
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH

Gene Ontology

GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

lcm:102355397

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002174	Ailuropoda melanoleuca	70.95	0.00e+00	1381.00
IUUC-Apl-003435	Anas platyrhynchos	68.25	0.00e+00	1127.00
IUUC-Aca-004556	Anolis carolinensis	65.50	0.00e+00	1212.00
IUUC-Ame-010616	Astyanax mexicanus	60.87	0.00e+00	1227.00
IUUC-Bta-013544	Bos taurus	70.96	0.00e+00	1367.00
IUUC-Cja-018745	Callithrix jacchus	69.78	0.00e+00	1401.00
IUUC-Cfa-020434	Canis familiaris	67.96	0.00e+00	1342.00
IUUC-Cpo-021666	Cavia porcellus	70.12	0.00e+00	1338.00
IUUC-Csa-023965	Chlorocebus sabaeus	71.03	0.00e+00	1451.00
IUUC-Cho-024809	Choloepus hoffmanni	61.08	0.00e+00	906.00
IUUC-Cin-025604	Ciona intestinalis	31.78	3.00e-43	169.00
IUUC-Csv-026333	Ciona savignyi	44.71	2.00e-34	139.00
IUUC-Dre-028338	Danio rerio	60.50	0.00e+00	1228.00
IUUC-Dno-029372	Dasypus novemcinctus	70.43	0.00e+00	1398.00
IUUC-Dor-030752	Dipodomys ordii	67.73	0.00e+00	899.00
IUUC-Dme-031871	Drosophila melanogaster	28.79	5.00e-46	179.00
IUUC-Ete-032588	Echinops telfairi	61.24	0.00e+00	845.00
IUUC-Eca-034416	Equus caballus	71.63	0.00e+00	1441.00
IUUC-Eeu-035132	Erinaceus europaeus	55.13	0.00e+00	1021.00
IUUC-Fca-036137	Felis catus	71.13	0.00e+00	1418.00
IUUC-Fal-037297	Ficedula albicollis	68.03	0.00e+00	1310.00
IUUC-Gmo-038727	Gadus morhua	63.62	0.00e+00	1009.00
IUUC-Gga-041091	Gallus gallus	67.02	0.00e+00	1253.00
IUUC-Gac-042082	Gasterosteus aculeatus	62.66	0.00e+00	1135.00
IUUC-Ggo-045376	Gorilla gorilla	66.76	0.00e+00	1301.00
IUUC-Hsa-046444	Homo sapiens	71.03	0.00e+00	1432.00
IUUC-Itr-047976	Ictidomys tridecemlineatus	70.92	0.00e+00	1443.00
IUUC-Loc-052625	Lepisosteus oculatus	66.57	0.00e+00	1330.00
IUUC-Laf-053689	Loxodonta africana	70.79	0.00e+00	1408.00
IUUC-Mcc-055286	Macaca mulatta	71.20	0.00e+00	1441.00
IUUC-Mga-059905	Meleagris gallopavo	66.56	0.00e+00	1098.00
IUUC-Mmr-061397	Microcebus murinus	70.88	0.00e+00	1392.00
IUUC-Mdo-062833	Monodelphis domestica	72.28	0.00e+00	1474.00
IUUC-Mmu-063157	Mus musculus	69.96	0.00e+00	1380.00
IUUC-Mpu-066434	Mustela putorius furo	71.73	0.00e+00	1434.00
IUUC-Mlu-068178	Myotis lucifugus	70.82	0.00e+00	1362.00
IUUC-Nle-070153	Nomascus leucogenys	70.55	0.00e+00	1366.00
IUUC-Ont-072330	Oreochromis niloticus	61.57	0.00e+00	1238.00
IUUC-Oan-072709	Ornithorhynchus anatinus	70.11	0.00e+00	1090.00
IUUC-Ocu-074832	Oryctolagus cuniculus	70.75	0.00e+00	1388.00
IUUC-Ola-087003	Oryzias latipes	59.70	1.00e-47	182.00
IUUC-Oga-088517	Otolemur garnettii	68.06	0.00e+00	1338.00
IUUC-Oar-089472	Ovis aries	68.19	0.00e+00	1296.00
IUUC-Ptr-090996	Pan troglodytes	71.13	0.00e+00	1434.00
IUUC-Pan-091837	Papio anubis	69.52	0.00e+00	1401.00
IUUC-Psi-093236	Pelodiscus sinensis	69.71	0.00e+00	1036.00
IUUC-Pma-094349	Petromyzon marinus	52.84	0.00e+00	960.00
IUUC-Pfo-097193	Poecilia formosa	60.06	0.00e+00	1138.00
IUUC-Pab-098710	Pongo abelii	71.97	0.00e+00	1452.00
IUUC-Pca-100794	Procavia capensis	62.77	0.00e+00	1211.00
IUUC-Pva-102722	Pteropus vampyrus	70.96	0.00e+00	1416.00
IUUC-Rno-105743	Rattus norvegicus	71.00	0.00e+00	1379.00
IUUC-Sha-106563	Sarcophilus harrisii	70.79	0.00e+00	1182.00
IUUC-Sar-113533	Sorex araneus	62.00	0.00e+00	1190.00
IUUC-Ssc-116259	Sus scrofa	65.18	0.00e+00	1192.00
IUUC-Tgu-117475	Taeniopygia guttata	68.32	0.00e+00	1203.00
IUUC-Tru-118623	Takifugu rubripes	62.30	0.00e+00	1154.00
IUUC-Tsy-119250	Tarsius syrichta	68.83	0.00e+00	1071.00
IUUC-Tni-120441	Tetraodon nigroviridis	58.85	0.00e+00	1079.00
IUUC-Tbe-127936	Tupaia belangeri	60.92	0.00e+00	1102.00
IUUC-Ttr-128483	Tursiops truncatus	62.37	0.00e+00	1013.00
IUUC-Vpa-130303	Vicugna pacos	84.46	0.00e+00	931.00
IUUC-Xtr-132773	Xenopus tropicalis	69.37	0.00e+00	1353.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence