iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Cfa-021281

Ensembl Protein ID

ENSCAFP00000027005.3

UniProt Accession

F1PUV5; F1PUV5_CANLF

Genbank Protein ID

ENSCAFP00000027005

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAEX03003103

Gene Name

ARHGEF37

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCAFG00000018281.3	ENSCAFT00000029042.3	ENSCAFP00000027005.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	1.40e-10	41.2	606	663

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 5    kvqvlydyeaqnddeLtlkkGdvvlvi..ekeeqdegWlkgvkelegkrGlfPenFvekl 62
           +v + y++ a ++ e +l++G  v+v+  ++++ + +W     e +g+rG +P+ F +++
   Q: 606  QVVAVYPFVARSSHEVSLQAGQLVTVLeaQDKKGNPEWSLV--EVNGQRGYVPSSFLARA 663
           7899***********************9889999****977..9************9886 PP

Organism

Canis familiaris

Protein Sequence
(Fasta)

MAEHGTDEPS SRTGSPDGEC QVLEDRSLLH QRLAVRELID TEVSYLHMLQ LCASDIRSRL 60
QQLPQGDLDV LFSNIDDVIE VNNRFLHDLQ ETESREEEQV HLIGNLFLKF QEELERVYKV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCCGCAACCG CAGCTCTCGG CGCGGGCGGC CGGCCAGGGC ACCTCGGGGC CGGGGCGGGG 60
GCGGCGGCAA GGGCGGGGGC CGGGGCCGGG GCCGGGGCCG GGGCCCCCAA GGTCCCGGGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR027267--AH/BAR-dom
IPR004148--BAR_dom
IPR000219--DH-domain
IPR011511--SH3_2
IPR001452--SH3_domain

PROSITE

PS51021--BAR
PS50010--DH_2
PS50002--SH3

Pfam

PF03114--BAR
PF00621--RhoGEF
PF07653--SH3_2
PF14604--SH3_9

SMART

SM00721--BAR
SM00325--RhoGEF
SM00326--SH3

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005089--F:Rho guanyl-nucleotide exchange factor activity
GO:0043547--P:positive regulation of GTPase activity
GO:0035023--P:regulation of Rho protein signal transduction
GO:0007264--P:small GTPase mediated signal transduction

KEGG

cfa:489191

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ame-011907	Astyanax mexicanus	40.75	5.00e-130	458.00
IUUC-Bta-012848	Bos taurus	87.85	0.00e+00	1143.00
IUUC-Csa-023043	Chlorocebus sabaeus	84.59	0.00e+00	1099.00
IUUC-Dre-028496	Danio rerio	40.74	2.00e-130	459.00
IUUC-Ggo-044900	Gorilla gorilla	85.19	0.00e+00	1115.00
IUUC-Hsa-045684	Homo sapiens	84.59	0.00e+00	1137.00
IUUC-Lch-050096	Latimeria chalumnae	45.13	3.00e-163	568.00
IUUC-Loc-051937	Lepisosteus oculatus	42.53	7.00e-134	471.00
IUUC-Mcc-054950	Macaca mulatta	84.30	0.00e+00	1093.00
IUUC-Meu-056383	Macropus eugenii	67.69	1.00e-169	590.00
IUUC-Mdo-062021	Monodelphis domestica	67.90	0.00e+00	868.00
IUUC-Mmu-064186	Mus musculus	77.81	0.00e+00	1012.00
IUUC-Ptr-090508	Pan troglodytes	84.74	0.00e+00	1112.00
IUUC-Pan-092517	Papio anubis	84.15	0.00e+00	1078.00
IUUC-Pfo-096703	Poecilia formosa	38.38	2.00e-124	440.00
IUUC-Pab-098542	Pongo abelii	84.59	0.00e+00	1108.00
IUUC-Rno-105455	Rattus norvegicus	78.55	0.00e+00	1025.00
IUUC-Sha-106562	Sarcophilus harrisii	68.67	0.00e+00	878.00
IUUC-Ttr-128242	Tursiops truncatus	83.70	0.00e+00	1084.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence