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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046139
UUCD1 version UUC-HoS-00436
Ensembl Protein ID ENSP00000265094.5
UniProt Accession Q9UKB1; B2RC98; Q9P2S8; Q9P2S9; Q9Y4C6; FBW1B_HUMAN
Genbank Protein ID AAF04528.1; BAA92329.1; BAA92330.1; BAA92331.1; BAA31671.1; BAG37495.1; AAH26213.1
Protein Name F-box/WD repeat-containing protein 11; F-box and WD repeats protein beta-TrCP2; F-box/WD repeat-containing protein 1B; Homologous to Slimb protein
Genbank Nucleotide ID AF176022; AB033279; AB033280; AB033281; AB014596; AK314999; BC026213
Gene Name FBXW11; BTRCP2; FBW1B; FBXW1B; KIAA0696
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000072803.17 ENST00000296933.10 ENSP00000296933.6
ENSG00000072803.17 ENST00000265094.9 ENSP00000265094.5
ENSG00000072803.17 ENST00000393802.6 ENSP00000377391.2
ENSG00000072803.17 ENST00000523843.5 ENSP00000430104.1
ENSG00000072803.17 ENST00000517395.5 ENSP00000428753.1
ENSG00000072803.17 ENST00000518752.1 ENSP00000429818.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
miRWalkmiRecordsRepTarmiRNAMap
SomamiRmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Disease-associated Information
GWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
BioGRIDmUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 adaptor/Cullin RING/SCF/F-box F-box 17873516; 16775333; 21310048; 18782782; 7479976; 20347421
E3 adaptor/Cullin RING/DCX/DWD WD_repeat 8909296; 17873516; 18782782; 7479976; 19966869
Classification
Family E-value Score Start End
E3 adaptor/Cullin RING/SCF/F-box 0.00072 21.3 129 167
E3 adaptor/Cullin RING/DCX/DWD 4.40e-57 189.1 441 475
UBD/Beta-Prp 2.20e-68 232.3 354 519
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/SCF/F-box
   S: 108  eeilveilklldkeellraarvcrrwqelasqkalwktv 146
           ++i  +il++ld+++l++a++vc++wq+++s+  lwk++
   Q: 129  DHIAENILSYLDARSLCAAELVCKEWQRVISEGMLWKKL 167
           468999*********************99999****987 PP
   

   E3 adaptor/Cullin RING/DCX/DWD
   S: 1    gHtdsvtclafsd.tllvsGsdDgtikvWDlrtgvl 35
           gH++ v+c++f d +++vsG++Dg+ikvWDl    +
   Q: 441  GHEELVRCIRF-DnKRIVSGAYDGKIKVWDLQAALD 475
           8**********.44****************977665 PP
   

   UBD/Beta-Prp
   S: 43   kllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvlslsfspsgdklvsGshdrtirvwdletgqcleetls 134
           +l r l gh a+v+ v+f+++  ++v++s Drtikvw+ st++ v+tl+gh++ + +l++      +vsGs+d+tir+wd+e g cl+ +l+
   Q: 354  TLRRVLVGHRAAVNVVDFDDK--YIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQYRD--RLVVSGSSDNTIRLWDIECGACLR-VLE 440
           4556679*************9..8**************************************..************************.*** PP
   S: 135  ghdgvvncvvvhpdgnllvsGslDrtvrlWdl.........ktgkllrtltgghtdsvyslsfdsngkelvsgsldgtvklwdl 209
           gh+++v+c++++   + +vsG++D+++++Wdl         ++  +lrtl + h ++v  l+fd+  ++++s s+d t+ +wd+
   Q: 441  GHEELVRCIRFDN--KRIVSGAYDGKIKVWDLqaaldprapASTLCLRTLVE-HSGRVFRLQFDE--FQIISSSHDDTILIWDF 519
           ************9..***********************************99.************..99**************7 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins. SCF(FBXW11) mediates the ubiquitination of phosphorylated CTNNB1 and participates in Wnt signaling. SCF(FBXW11) mediates the ubiquitination of phosphorylated NFKBIA, which degradation frees the associated NFKB1 to translocate into the nucleus and to activate transcription. SCF(FBXW11) mediates the ubiquitination of IFNAR1. SCF(FBXW11) mediates the ubiquitination of CEP68; this is required for centriole separation during mitosis (PubMed:25503564). Involved in the oxidative stress-induced a ubiquitin-mediated decrease in RCAN1. Mediates the degradation of CDC25A induced by ionizing radiation in cells progressing through S phase and thus may function in the intra-S-phase checkpoint. Has an essential role in the control of the clock-dependent transcription via degradation of phosphorylated PER1 and phosphorylated PER2. Is target of human immunodeficiency virus type 1 (HIV-1) protein VPU to polyubiquitinate and deplete BST2 from cells and antagonize its antiviral action.
 Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins. SCF(FBXW11) mediates the ubiquitination of phosphorylated CTNNB1 and participates in Wnt signaling. SCF(FBXW11) mediates the ubiquitination of phosphorylated NFKBIA, which degradation frees the associated NFKB1 to translocate into the nucleus and to activate transcription. SCF(FBXW11) mediates the ubiquitination of IFNAR1. SCF(FBXW11) mediates the ubiquitination of CEP68; this is required for centriole separation during mitosis (PubMed:25503564). Involved in the oxidative stress-induced a ubiquitin-mediated decrease in RCAN1. Mediates the degradation of CDC25A induced by ionizing radiation in cells progressing through S phase and thus may function in the intra-S-phase checkpoint. Has an essential role in the control of the clock-dependent transcription via degradation of phosphorylated PER1 and phosphorylated PER2. Is target of human immunodeficiency virus type 1 (HIV-1) protein VPU to polyubiquitinate and deplete BST2 from cells and antagonize its antiviral action.
Protein Sequence
(Fasta)
MEPDSVIEDK TIELMCSVPR SLWLGCANLV ESMCALSCLQ SMPSVRCLQI SNGTSSVIVS 60
RKRPSEGNYQ KEKDLCIKYF DQWSESDQVE FVEHLISRMC HYQHGHINSY LKPMLQRDFI 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046139|E3,F-box;E3,WD_repeat;UBD,Beta-Prp|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GTAGTCGTGG CGCTCTCGAG GCCCTGCCAT GAGCAAGCTC TTAACTCTTC AGGTCTGCAC 60
GTCCTACGCC CACCGTCCAG TGCTACTCTC AGCTCGGAGT TCAGCTTCGG GCTGCCAAGA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046139|E3,F-box;E3,WD_repeat;UBD,Beta-Prp|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0090--Biological rhythms
KW-0131--Cell cycle
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0833--Ubl conjugation pathway
KW-0853--WD repeat
KW-0879--Wnt signaling pathway
Interpro

IPR021977--Beta-TrCP_D
IPR001810--F-box_dom
IPR020472--G-protein_beta_WD-40_rep
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
PROSITE

PS50181--FBOX
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF12125--Beta-TrCP_D
PF12937--F-box-like
PF00400--WD40
PRINTS

PR00320--GPROTEINBRPT
SMART

SM01028--Beta-TrCP_D
SM00256--FBOX
SM00320--WD40
Gene Ontology

GO:0005813--C:centrosome
GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0019005--C:SCF ubiquitin ligase complex
GO:0000151--C:ubiquitin ligase complex
GO:0061630--F:ubiquitin protein ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0038095--P:Fc-epsilon receptor signaling pathway
GO:0000086--P:G2/M transition of mitotic cell cycle
GO:0042347--P:negative regulation of NF-kappaB import into nucleus
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0038061--P:NIK/NF-kappaB signaling
GO:0042753--P:positive regulation of circadian rhythm
GO:0045862--P:positive regulation of proteolysis
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0006470--P:protein dephosphorylation
GO:0031648--P:protein destabilization
GO:0000209--P:protein polyubiquitination
GO:0016567--P:protein ubiquitination
GO:0048511--P:rhythmic process
GO:0031146--P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0002223--P:stimulatory C-type lectin receptor signaling pathway
GO:0051403--P:stress-activated MAPK cascade
GO:0050852--P:T cell receptor signaling pathway
GO:0016055--P:Wnt signaling pathway
KEGG hsa:23291
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001397 Ailuropoda melanoleuca 100.00 0.00e+00 1120.00
IUUC-Apl-003449 Anas platyrhynchos 94.76 0.00e+00 1068.00
IUUC-Ang-009766 Aspergillus niger 31.41 5.00e-52 199.00
IUUC-Ame-011174 Astyanax mexicanus 83.92 0.00e+00 983.00
IUUC-Bta-012920 Bos taurus 100.00 0.00e+00 1023.00
IUUC-Cja-018879 Callithrix jacchus 100.00 0.00e+00 1120.00
IUUC-Cfa-020021 Canis familiaris 100.00 0.00e+00 1120.00
IUUC-Cpo-022151 Cavia porcellus 99.60 0.00e+00 1014.00
IUUC-Csa-024095 Chlorocebus sabaeus 100.00 0.00e+00 1021.00
IUUC-Cho-024658 Choloepus hoffmanni 99.62 1.00e-155 543.00
IUUC-Dre-028160 Danio rerio 92.34 0.00e+00 953.00
IUUC-Dno-029485 Dasypus novemcinctus 88.96 0.00e+00 890.00
IUUC-Dor-030498 Dipodomys ordii 99.43 0.00e+00 1082.00
IUUC-Eca-033804 Equus caballus 100.00 0.00e+00 1036.00
IUUC-Fca-035887 Felis catus 94.29 0.00e+00 1038.00
IUUC-Fal-036783 Ficedula albicollis 95.48 0.00e+00 1038.00
IUUC-Gmo-038590 Gadus morhua 88.03 0.00e+00 974.00
IUUC-Gga-040628 Gallus gallus 95.10 0.00e+00 1033.00
IUUC-Gac-041305 Gasterosteus aculeatus 88.58 0.00e+00 992.00
IUUC-Ggo-044604 Gorilla gorilla 100.00 0.00e+00 1120.00
IUUC-Lch-050460 Latimeria chalumnae 97.17 0.00e+00 996.00
IUUC-Laf-053968 Loxodonta africana 96.27 0.00e+00 1108.00
IUUC-Mcc-055822 Macaca mulatta 91.58 0.00e+00 1063.00
IUUC-Mga-059225 Meleagris gallopavo 98.99 0.00e+00 1008.00
IUUC-Mvi-060284 Microbotryum violaceum 44.95 2.00e-69 257.00
IUUC-Mmr-060746 Microcebus murinus 100.00 0.00e+00 1120.00
IUUC-Mdo-062005 Monodelphis domestica 99.39 0.00e+00 1016.00
IUUC-Mmu-063851 Mus musculus 95.91 0.00e+00 1105.00
IUUC-Mpu-065716 Mustela putorius furo 100.00 0.00e+00 1022.00
IUUC-Mlu-067001 Myotis lucifugus 100.00 0.00e+00 1021.00
IUUC-Nle-069788 Nomascus leucogenys 93.73 0.00e+00 1033.00
IUUC-Opr-071229 Ochotona princeps 99.82 0.00e+00 1118.00
IUUC-Ont-071792 Oreochromis niloticus 89.57 0.00e+00 998.00
IUUC-Oan-072782 Ornithorhynchus anatinus 95.48 0.00e+00 1038.00
IUUC-Ocu-074894 Oryctolagus cuniculus 96.27 0.00e+00 1108.00
IUUC-Ola-086985 Oryzias latipes 85.87 0.00e+00 998.00
IUUC-Oga-088604 Otolemur garnettii 99.80 0.00e+00 1020.00
IUUC-Oar-090412 Ovis aries 96.05 0.00e+00 1043.00
IUUC-Ptr-091039 Pan troglodytes 99.82 0.00e+00 1118.00
IUUC-Pan-092770 Papio anubis 96.12 0.00e+00 1060.00
IUUC-Psi-093887 Pelodiscus sinensis 94.19 0.00e+00 1063.00
IUUC-Pno-094808 Phaeosphaeria nodorum 29.50 2.00e-45 177.00
IUUC-Pfo-096783 Poecilia formosa 86.22 0.00e+00 1002.00
IUUC-Pva-102547 Pteropus vampyrus 99.81 0.00e+00 1105.00
IUUC-Rno-105246 Rattus norvegicus 95.67 0.00e+00 1041.00
IUUC-Sha-107339 Sarcophilus harrisii 99.39 0.00e+00 1016.00
IUUC-Sja-107743 Schizosaccharomyces japonicus 35.38 5.00e-74 271.00
IUUC-Tgu-116541 Taeniopygia guttata 94.75 0.00e+00 1069.00
IUUC-Tru-117671 Takifugu rubripes 85.16 0.00e+00 989.00
IUUC-Tni-120359 Tetraodon nigroviridis 85.79 0.00e+00 939.00
IUUC-Tbe-127418 Tupaia belangeri 93.74 0.00e+00 1005.00
IUUC-Ttr-129131 Tursiops truncatus 100.00 0.00e+00 1119.00
IUUC-Vpa-130668 Vicugna pacos 99.63 0.00e+00 1107.00
IUUC-Xma-133187 Xiphophorus maculatus 95.36 1.00e-157 548.00
Created Date 25-Jun-2017

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