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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-063851
UUCD1 version UUC-MuM-00452
Ensembl Protein ID ENSMUSP00000075721.7
UniProt Accession Q5SRY7; Q3TGM9; Q3TLZ8; Q8BY90; Q8K022; Q923H0; FBW1B_MOUSE
Genbank Protein ID AAK72095.1; BAC30975.1; BAE28749.1; BAE31012.1; BAE35617.1; BAE38644.1; BAE40519.1; CAI25519.1; CAI25519.1; CAI25520.1; CAI25520.1; CAI26097.1; CAI26097.1; CAI26098.1; CAI26098.1; AAH34261.1
Protein Name F-box/WD repeat-containing protein 11; F-box and WD repeats protein beta-TrCP2; F-box/WD repeat-containing protein 1B; Homologous to Slimb protein
Genbank Nucleotide ID AY038079; AK041532; AK149139; AK152181; AK160086; AK166226; AK168667; AL669844; AL669951; AL669844; AL669951; AL669951; AL669844; AL669951; AL669844; BC034261
Gene Name Fbxw11; Btrcp2; Fbw1b; Fbxw1b
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000020271.17 ENSMUST00000109366.7 ENSMUSP00000104991.1
ENSMUSG00000020271.17 ENSMUST00000093205.12 ENSMUSP00000090893.6
ENSMUSG00000020271.17 ENSMUST00000143290.1 ENSMUSP00000116834.1
ENSMUSG00000020271.17 ENSMUST00000076383.7 ENSMUSP00000075721.7
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemiRTarBasemicroRNATRANSFAC
RepTarmiRNAMapRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
Mentha
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusmUbiSiDa
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 5.40e-57 188.3 462 496
UBD/Beta-Prp 3.80e-69 234.2 375 540
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 1    gHtdsvtclafsd.tllvsGsdDgtikvWDlrtgvl 35
           gH++ v+c++f d +++vsG++Dg+ikvWDl    +
   Q: 462  GHEELVRCIRF-DnKRIVSGAYDGKIKVWDLQAALD 496
           8**********.44****************977665 PP
   

   UBD/Beta-Prp
   S: 43   kllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvlslsfspsgdklvsGshdrtirvwdletgqclee 131
           +l r l gh a+v+ v+f+++  ++v++s Drtikvw+ st++ v+tl+gh++ + +l++      +vsGs+d+tir+wd+e g cl+ 
   Q: 375  TLRRVLVGHRAAVNVVDFDDK--YIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQYRD--RLVVSGSSDNTIRLWDIECGACLR- 458
           4555679*************9..8**************************************..************************. PP
   S: 132  tlsghdgvvncvvvhpdgnllvsGslDrtvrlWdl.........ktgkllrtltgghtdsvyslsfdsngkelvsgsldgtvklwdl 209
           +l+gh+++v+c++++   + +vsG++D+++++Wdl         ++  +lrtl + h ++v  l+fd+  ++++s s+d t+ +wd+
   Q: 459  VLEGHEELVRCIRFDN--KRIVSGAYDGKIKVWDLqaaldprapASTLCLRTLVE-HSGRVFRLQFDE--FQIISSSHDDTILIWDF 540
           ***************9..***********************************99.************..99**************7 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins. SCF(FBXW11) mediates the ubiquitination of phosphorylated CTNNB1 and participates in Wnt signaling. SCF(FBXW11) mediates the ubiquitination of phosphorylated NFKBIA, which degradation frees the associated NFKB1 to translocate into the nucleus and to activate transcription. SCF(FBXW11) mediates the ubiquitination of IFNAR1. SCF(FBXW11) mediates the ubiquitination of CEP68; this is required for centriole separation during mitosis (By similarity). Involved in the oxidative stress-induced a ubiquitin-mediated decrease in RCAN1. Mediates the degradation of CDC25A induced by ionizing radiation in cells progressing through S phase and thus may function in the intra-S-phase checkpoint. Has an essential role in the control of the clock-dependent transcription via degradation of phosphorylated PER1 and phosphorylated PER2. Is target of human immunodeficiency virus type 1 (HIV-1) protein VPU to polyubiquitinate and deplete BST2 from cells and antagonize its antiviral action.
 Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins. SCF(FBXW11) mediates the ubiquitination of phosphorylated CTNNB1 and participates in Wnt signaling. SCF(FBXW11) mediates the ubiquitination of phosphorylated NFKBIA, which degradation frees the associated NFKB1 to translocate into the nucleus and to activate transcription. SCF(FBXW11) mediates the ubiquitination of IFNAR1. SCF(FBXW11) mediates the ubiquitination of CEP68; this is required for centriole separation during mitosis (By similarity). Involved in the oxidative stress-induced a ubiquitin-mediated decrease in RCAN1. Mediates the degradation of CDC25A induced by ionizing radiation in cells progressing through S phase and thus may function in the intra-S-phase checkpoint. Has an essential role in the control of the clock-dependent transcription via degradation of phosphorylated PER1 and phosphorylated PER2. Is target of human immunodeficiency virus type 1 (HIV-1) protein VPU to polyubiquitinate and deplete BST2 from cells and antagonize its antiviral action.
Protein Sequence
(Fasta)
MEPDSVIEDK TIELMCSVPR SLWLGCANLV ESMCALSCLQ SMPSVRCLQN TSVMEDQNED 60
ESPKKSALWQ ISNGTSSVIV SRKRPSEGNY QKEKDLCIKY FDQWSESDQV EFVEHLISRM 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063851|E3,WD_repeat;UBD,Beta-Prp|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GCGTCCTGCG TCGGCCGAGG GTGAGGGCGG AGCTGCGGGC GGCCCGGGCG GGCTGGCAGC 60
TAGAGTGGGT GCGAGAGCTG CCTCCACCGC CGCCGCCGCC ACCGCCTCCT CCGCCCGGGC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063851|E3,WD_repeat;UBD,Beta-Prp|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0090--Biological rhythms
KW-0131--Cell cycle
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0833--Ubl conjugation pathway
KW-0853--WD repeat
KW-0879--Wnt signaling pathway
Interpro

IPR021977--Beta-TrCP_D
IPR001810--F-box_dom
IPR020472--G-protein_beta_WD-40_rep
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
PROSITE

PS50181--FBOX
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF12125--Beta-TrCP_D
PF12937--F-box-like
PF00400--WD40
PRINTS

PR00320--GPROTEINBRPT
SMART

SM01028--Beta-TrCP_D
SM00256--FBOX
SM00320--WD40
Gene Ontology

GO:0005813--C:centrosome
GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0019005--C:SCF ubiquitin ligase complex
GO:0004842--F:ubiquitin-protein transferase activity
GO:0007049--P:cell cycle
GO:0042347--P:negative regulation of NF-kappaB import into nucleus
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0042753--P:positive regulation of circadian rhythm
GO:0045862--P:positive regulation of proteolysis
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0006470--P:protein dephosphorylation
GO:0031648--P:protein destabilization
GO:0000209--P:protein polyubiquitination
GO:0016567--P:protein ubiquitination
GO:0042752--P:regulation of circadian rhythm
GO:0048511--P:rhythmic process
GO:0031146--P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0016055--P:Wnt signaling pathway
KEGG mmu:103583
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001397 Ailuropoda melanoleuca 95.91 0.00e+00 1105.00
IUUC-Apl-003449 Anas platyrhynchos 97.83 0.00e+00 1118.00
IUUC-Ang-009766 Aspergillus niger 31.65 1.00e-52 201.00
IUUC-Ame-011174 Astyanax mexicanus 86.22 0.00e+00 1014.00
IUUC-Bta-012920 Bos taurus 98.46 0.00e+00 1062.00
IUUC-Cel-018392 Caenorhabditis elegans 63.36 0.00e+00 637.00
IUUC-Cja-018879 Callithrix jacchus 95.91 0.00e+00 1105.00
IUUC-Cfa-020021 Canis familiaris 95.91 0.00e+00 1105.00
IUUC-Cpo-022151 Cavia porcellus 98.83 0.00e+00 1049.00
IUUC-Csa-024095 Chlorocebus sabaeus 99.22 0.00e+00 1050.00
IUUC-Cho-024658 Choloepus hoffmanni 91.90 7.00e-152 530.00
IUUC-Dre-028160 Danio rerio 89.62 0.00e+00 962.00
IUUC-Dno-029485 Dasypus novemcinctus 89.00 0.00e+00 928.00
IUUC-Dor-030498 Dipodomys ordii 95.26 0.00e+00 1067.00
IUUC-Eca-033804 Equus caballus 95.59 0.00e+00 1022.00
IUUC-Fca-035887 Felis catus 93.25 0.00e+00 1071.00
IUUC-Fal-036783 Ficedula albicollis 98.68 0.00e+00 1087.00
IUUC-Gmo-038590 Gadus morhua 85.26 0.00e+00 970.00
IUUC-Gga-040628 Gallus gallus 98.31 0.00e+00 1082.00
IUUC-Gac-041305 Gasterosteus aculeatus 85.79 0.00e+00 988.00
IUUC-Ggo-044604 Gorilla gorilla 95.91 0.00e+00 1105.00
IUUC-Hsa-046139 Homo sapiens 95.91 0.00e+00 1105.00
IUUC-Lch-050460 Latimeria chalumnae 97.08 0.00e+00 1035.00
IUUC-Laf-053968 Loxodonta africana 99.29 0.00e+00 1158.00
IUUC-Mcc-055822 Macaca mulatta 94.56 0.00e+00 1110.00
IUUC-Mga-059225 Meleagris gallopavo 98.25 0.00e+00 1042.00
IUUC-Mvi-060284 Microbotryum violaceum 44.95 1.00e-69 258.00
IUUC-Mmr-060746 Microcebus murinus 95.91 0.00e+00 1105.00
IUUC-Mdo-062005 Monodelphis domestica 98.63 0.00e+00 1045.00
IUUC-Mpu-065716 Mustela putorius furo 98.45 0.00e+00 1055.00
IUUC-Mlu-067001 Myotis lucifugus 99.22 0.00e+00 1050.00
IUUC-Nle-069788 Nomascus leucogenys 96.12 0.00e+00 1019.00
IUUC-Opr-071229 Ochotona princeps 95.74 0.00e+00 1104.00
IUUC-Ont-071792 Oreochromis niloticus 86.71 0.00e+00 994.00
IUUC-Oan-072782 Ornithorhynchus anatinus 98.68 0.00e+00 1087.00
IUUC-Ocu-074894 Oryctolagus cuniculus 99.29 0.00e+00 1158.00
IUUC-Ola-086985 Oryzias latipes 87.63 0.00e+00 1021.00
IUUC-Oga-088604 Otolemur garnettii 89.64 0.00e+00 1050.00
IUUC-Oar-090412 Ovis aries 99.25 0.00e+00 1093.00
IUUC-Ptr-091039 Pan troglodytes 96.09 0.00e+00 1107.00
IUUC-Pan-092770 Papio anubis 99.26 0.00e+00 1110.00
IUUC-Psi-093887 Pelodiscus sinensis 97.28 0.00e+00 1113.00
IUUC-Pno-094808 Phaeosphaeria nodorum 29.50 2.00e-45 177.00
IUUC-Pfo-096783 Poecilia formosa 87.99 0.00e+00 1025.00
IUUC-Pva-102547 Pteropus vampyrus 95.71 0.00e+00 1091.00
IUUC-Rno-105246 Rattus norvegicus 100.00 0.00e+00 1098.00
IUUC-Sha-107339 Sarcophilus harrisii 98.63 0.00e+00 1045.00
IUUC-Sja-107743 Schizosaccharomyces japonicus 35.32 3.00e-74 272.00
IUUC-Spo-108200 Schizosaccharomyces pombe 31.71 4.00e-66 245.00
IUUC-Tgu-116541 Taeniopygia guttata 97.83 0.00e+00 1119.00
IUUC-Tru-117671 Takifugu rubripes 87.46 0.00e+00 1018.00
IUUC-Tni-120359 Tetraodon nigroviridis 89.58 0.00e+00 951.00
IUUC-Tbe-127418 Tupaia belangeri 89.78 0.00e+00 990.00
IUUC-Ttr-129131 Tursiops truncatus 95.91 0.00e+00 1106.00
IUUC-Vpa-130668 Vicugna pacos 95.54 0.00e+00 1094.00
IUUC-Xma-133187 Xiphophorus maculatus 95.36 4.00e-158 550.00
Created Date 25-Jun-2017

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