iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Dre-027360

Ensembl Protein ID

ENSDARP00000065337.3

UniProt Accession

Q6TNS2; Q6NYY5; Q7ZW90; PK1IP_DANRE

Genbank Protein ID

AAQ91257.1; AAH49528.2; AAH66416.2

Protein Name

p21-activated protein kinase-interacting protein 1-like; PAK1-interacting protein 1-like

Genbank Nucleotide ID

AY391445; BC049528; BC066416

Gene Name

pak1ip1; zgc:56683

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSDARG00000044488.4	ENSDART00000065338.4	ENSDARP00000065337.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	2.50e-28	97.8	209	244
UBD/Beta-Prp	1.10e-40	140.5	43	306

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 3    tdsvtclaf.sdtllvsGsdDgtikvWDlrtgvllk 37
           t +++cl+f  + ll++G+dD +++++D++++++++
   Q: 209  TKRISCLKFlKNSLLAVGGDDESVRIYDVTSQKCVC 244
           5679*****9548*********************97 PP

UBD/Beta-Prp

   S: 6    kghhksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghe 94
            ++h++ ++  ++s +++++atgs+d+ti+++d+ +++    l  h++++++++f  ++  l++g++D++i+vw+ ++ +c+ t+++h+
   Q: 43   HHAHTASLN--AVSSSNQFIATGSKDETIQLYDMCKKTEHGALLHHDGTISCLEFYGTS-HLLSGGQDGLICVWSTKKWECLKTIRAHK 128
           445555555..5566*******************************************8.8**************************** PP
   S: 95   dsvlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsv 183
            +v+sls++psg+  +s + d+t+r w+l +g       ++ ++   +v ++pdg+ ++   +D +v ++ l +++++ t     t+++
   Q: 129  GQVTSLSVHPSGKLALSVGTDKTLRTWNLIEGRSAF--IKNIKQNAEIVLWSPDGDKYAVVVND-KVDIYTLDSATIIGTIA--FTKRI 212
           *******************************99995..55556678899999999777777777.69**************5..6**** PP
   S: 184  yslsfdsngkelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfs..pnderlvsgssDgsiriW.....dlrsgdllktlqlhns 265
            +l+f +n+  l+ g++d +v+++d+ +++cv ++++h++ vk ++ +  ++   lv++s Dg i++W      ++s +ll++l+ ++ 
   Q: 213  SCLKFLKNS-LLAVGGDDESVRIYDVTSQKCVCEFKAHENRVKAIESFmkDDFCVLVTASNDGFIKLWklnleSIESPTLLGQLNTTA- 299
           *******96.9**********************************999433334577888********99555555555555555544. PP
   S: 266  svisvav 272
           ++++ +v
   Q: 300  RLTCLCV 306
           5555555 PP

Organism

Danio rerio

Functional Description
(View)

Negatively regulates the PAK1 kinase.

Protein Sequence
(Fasta)

MSECFTVMGD HIELVAGCYE QIVFGYRVCP ADEEWTIEPT FTHHAHTASL NAVSSSNQFI 60
ATGSKDETIQ LYDMCKKTEH GALLHHDGTI SCLEFYGTSH LLSGGQDGLI CVWSTKKWEC 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ACATGAACTT TTATCATGAA TTAATCAACT TCCGGTGGGC GTTAAAGGGT AAAACATGTC 60
TGCCTGCACG TTGCTGTGAA CATGTGAACC GTATTTTGCG TTCAGCAGAC CGTAGTTTTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0734--Signal transduction inhibitor
KW-0853--WD repeat

Interpro

IPR024977--Apc4_WD40_dom
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF12894--ANAPC4_WD40
PF00400--WD40

SMART

SM00320--WD40

Gene Ontology

GO:0005730--C:nucleolus
GO:0009968--P:negative regulation of signal transduction

KEGG

dre:336470

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000839	Aegilops tauschii	35.16	3.00e-13	67.80
IUUC-Aml-001803	Ailuropoda melanoleuca	56.86	5.00e-117	414.00
IUUC-Atr-003018	Amborella trichopoda	34.71	2.00e-51	197.00
IUUC-Apl-004199	Anas platyrhynchos	62.50	2.00e-117	415.00
IUUC-Aca-005157	Anolis carolinensis	59.70	2.00e-115	409.00
IUUC-Aly-006245	Arabidopsis lyrata	30.60	5.00e-42	164.00
IUUC-Ath-007309	Arabidopsis thaliana	30.28	5.00e-42	164.00
IUUC-Ago-007878	Ashbya gossypii	27.96	2.00e-30	126.00
IUUC-Acl-008015	Aspergillus clavatus	21.79	2.00e-16	80.90
IUUC-Afu-008760	Aspergillus fumigatus	22.88	2.00e-18	87.40
IUUC-Ani-009358	Aspergillus nidulans	23.54	2.00e-19	90.10
IUUC-Ame-011121	Astyanax mexicanus	67.14	3.00e-144	504.00
IUUC-Bgr-012152	Blumeria graminis	25.20	1.00e-19	90.90
IUUC-Bta-012383	Bos taurus	55.90	9.00e-114	403.00
IUUC-Bci-013752	Botrytis cinerea	24.88	2.00e-19	90.10
IUUC-Bdi-014505	Brachypodium distachyon	30.06	1.00e-24	107.00
IUUC-Bol-015458	Brassica oleracea	31.86	2.00e-43	169.00
IUUC-Bra-017790	Brassica rapa	31.86	5.00e-44	171.00
IUUC-Cja-018803	Callithrix jacchus	63.41	3.00e-106	378.00
IUUC-Cfa-020178	Canis familiaris	56.98	2.00e-116	412.00
IUUC-Cpo-021785	Cavia porcellus	64.69	7.00e-116	410.00
IUUC-Cre-022703	Chlamydomonas reinhardtii	33.00	3.00e-45	176.00
IUUC-Csa-023179	Chlorocebus sabaeus	57.94	2.00e-119	422.00
IUUC-Cho-025088	Choloepus hoffmanni	63.68	1.00e-84	306.00
IUUC-Cin-025484	Ciona intestinalis	33.33	5.00e-24	104.00
IUUC-Csv-025887	Ciona savignyi	37.57	2.00e-52	199.00
IUUC-Cgl-026525	Colletotrichum gloeosporioides	23.40	9.00e-20	91.70
IUUC-Cne-027021	Cryptococcus neoformans	29.43	2.00e-28	121.00
IUUC-Dno-029836	Dasypus novemcinctus	57.94	1.00e-117	416.00
IUUC-Dor-030677	Dipodomys ordii	65.58	4.00e-106	377.00
IUUC-Dme-032004	Drosophila melanogaster	30.74	3.00e-34	139.00
IUUC-Ete-032837	Echinops telfairi	64.98	5.00e-107	380.00
IUUC-Eca-033291	Equus caballus	57.18	5.00e-117	414.00
IUUC-Eeu-035347	Erinaceus europaeus	65.45	1.00e-106	379.00
IUUC-Fca-036577	Felis catus	61.34	1.00e-113	402.00
IUUC-Fal-036810	Ficedula albicollis	57.43	1.00e-113	403.00
IUUC-Fox-037844	Fusarium oxysporum	24.09	1.00e-20	94.70
IUUC-Fso-038338	Fusarium solani	24.39	4.00e-23	102.00
IUUC-Gmo-038537	Gadus morhua	63.36	7.00e-125	440.00
IUUC-Ggr-039772	Gaeumannomyces graminis	23.28	2.00e-17	84.30
IUUC-Gga-040566	Gallus gallus	61.38	2.00e-125	441.00
IUUC-Gac-042422	Gasterosteus aculeatus	67.53	1.00e-140	492.00
IUUC-Gma-044199	Glycine max	31.39	4.00e-40	158.00
IUUC-Ggo-045365	Gorilla gorilla	47.53	5.00e-88	318.00
IUUC-Hsa-046121	Homo sapiens	57.70	5.00e-119	421.00
IUUC-Hvu-047592	Hordeum vulgare	33.12	7.00e-17	80.10
IUUC-Itr-048361	Ictidomys tridecemlineatus	64.86	2.00e-112	399.00
IUUC-Kpa-049407	Komagataella pastoris	33.22	2.00e-40	160.00
IUUC-Lch-049767	Latimeria chalumnae	67.34	1.00e-125	442.00
IUUC-Lpe-051569	Leersia perrieri	29.47	3.00e-23	102.00
IUUC-Loc-051940	Lepisosteus oculatus	61.90	3.00e-123	434.00
IUUC-Lma-053288	Leptosphaeria maculans	24.59	4.00e-23	102.00
IUUC-Laf-054463	Loxodonta africana	57.06	5.00e-115	407.00
IUUC-Mcc-055412	Macaca mulatta	57.94	2.00e-119	422.00
IUUC-Mor-056986	Magnaporthe oryzae	23.58	2.00e-15	77.40
IUUC-Mpo-057401	Magnaporthe poae	23.11	3.00e-17	83.20
IUUC-Mtr-057886	Medicago truncatula	32.68	6.00e-39	154.00
IUUC-Mla-058862	Melampsora laricipopulina	27.73	4.00e-23	102.00
IUUC-Mga-060109	Meleagris gallopavo	62.83	4.00e-117	414.00
IUUC-Mvi-060326	Microbotryum violaceum	26.73	7.00e-30	125.00
IUUC-Mmr-060681	Microcebus murinus	64.03	1.00e-115	410.00
IUUC-Mdo-063004	Monodelphis domestica	57.06	2.00e-116	412.00
IUUC-Mmu-064184	Mus musculus	58.70	1.00e-110	392.00
IUUC-Mac-064987	Musa acuminata	32.47	1.00e-44	173.00
IUUC-Mpu-065847	Mustela putorius furo	57.06	7.00e-118	417.00
IUUC-Mlu-067608	Myotis lucifugus	60.94	2.00e-116	412.00
IUUC-Nfi-068531	Neosartorya fischeri	23.11	2.00e-18	87.40
IUUC-Nle-069302	Nomascus leucogenys	57.98	4.00e-119	421.00
IUUC-Ont-072591	Oreochromis niloticus	68.79	1.00e-122	432.00
IUUC-Oan-073558	Ornithorhynchus anatinus	57.43	2.00e-93	335.00
IUUC-Ocu-074558	Oryctolagus cuniculus	63.37	1.00e-106	380.00
IUUC-Ogl-076960	Oryza glaberrima	28.44	4.00e-27	115.00
IUUC-Ogu-078660	Oryza glumaepatula	27.50	3.00e-23	102.00
IUUC-Oin-079790	Oryza indica	28.93	2.00e-32	132.00
IUUC-Ome-081631	Oryza meridionalis	30.53	1.00e-18	87.40
IUUC-Oni-083082	Oryza nivara	28.30	1.00e-26	114.00
IUUC-Opu-083394	Oryza punctata	29.15	2.00e-31	129.00
IUUC-Oru-084461	Oryza rufipogon	31.13	3.00e-26	112.00
IUUC-Osa-085655	Oryza sativa	30.99	2.00e-26	112.00
IUUC-Ola-086955	Oryzias latipes	69.91	2.00e-147	514.00
IUUC-Olu-087657	Ostreococcus lucimarinus	32.04	3.00e-33	136.00
IUUC-Oga-088108	Otolemur garnettii	61.04	2.00e-115	409.00
IUUC-Oar-090019	Ovis aries	62.21	4.00e-115	408.00
IUUC-Ptr-091544	Pan troglodytes	57.70	5.00e-119	421.00
IUUC-Pan-092562	Papio anubis	57.94	2.00e-119	422.00
IUUC-Psi-094025	Pelodiscus sinensis	62.87	3.00e-94	338.00
IUUC-Pma-094322	Petromyzon marinus	58.74	4.00e-99	353.00
IUUC-Pno-095112	Phaeosphaeria nodorum	24.27	7.00e-16	79.00
IUUC-Ppa-095541	Physcomitrella patens	34.07	3.00e-43	169.00
IUUC-Pfo-096667	Poecilia formosa	64.76	3.00e-113	401.00
IUUC-Pab-098064	Pongo abelii	56.94	2.00e-117	415.00
IUUC-Pop-099969	Populus trichocarpa	33.87	3.00e-45	175.00
IUUC-Pca-101053	Procavia capensis	60.88	1.00e-115	409.00
IUUC-Ppe-101839	Prunus persica	31.95	7.00e-47	181.00
IUUC-Pva-102963	Pteropus vampyrus	58.99	3.00e-110	391.00
IUUC-Pgr-103276	Puccinia graminis	26.90	3.00e-21	96.70
IUUC-Pte-104117	Pyrenophora teres	24.41	1.00e-21	98.20
IUUC-Pyt-104649	Pyrenophora triticirepentis	25.40	2.00e-20	94.40
IUUC-Rno-105975	Rattus norvegicus	57.34	7.00e-113	400.00
IUUC-Sce-106226	Saccharomyces cerevisiae	27.80	1.00e-31	131.00
IUUC-Sha-106907	Sarcophilus harrisii	58.29	2.00e-117	415.00
IUUC-Sja-107867	Schizosaccharomyces japonicus	25.93	8.00e-24	104.00
IUUC-Spo-108377	Schizosaccharomyces pombe	29.56	1.00e-27	117.00
IUUC-Ssl-108647	Sclerotinia sclerotiorum	25.36	1.00e-19	90.90
IUUC-Smo-109068	Selaginella moellendorffii	31.75	8.00e-43	167.00
IUUC-Sit-110114	Setaria italica	29.25	6.00e-27	114.00
IUUC-Sly-111581	Solanum lycopersicum	29.52	2.00e-43	169.00
IUUC-Stu-112770	Solanum tuberosum	29.22	2.00e-42	166.00
IUUC-Sbi-114797	Sorghum bicolor	29.63	9.00e-25	107.00
IUUC-Sre-114941	Sporisorium reilianum	25.58	2.00e-33	137.00
IUUC-Ssc-116346	Sus scrofa	63.82	9.00e-116	410.00
IUUC-Tgu-116628	Taeniopygia guttata	64.10	8.00e-118	416.00
IUUC-Tru-117646	Takifugu rubripes	65.03	5.00e-130	457.00
IUUC-Tsy-119593	Tarsius syrichta	50.36	2.00e-72	266.00
IUUC-Tni-119872	Tetraodon nigroviridis	68.54	1.00e-129	456.00
IUUC-Tca-121500	Theobroma cacao	31.69	7.00e-43	167.00
IUUC-Tre-122151	Trichoderma reesei	25.36	1.00e-22	101.00
IUUC-Tae-125015	Triticum aestivum	31.13	3.00e-31	129.00
IUUC-Tbe-127959	Tupaia belangeri	62.67	7.00e-104	370.00
IUUC-Ttr-129125	Tursiops truncatus	63.37	4.00e-114	404.00
IUUC-Uma-129567	Ustilago maydis	30.34	5.00e-33	136.00
IUUC-Vda-129955	Verticillium dahliae	22.41	9.00e-17	81.60
IUUC-Vpa-130157	Vicugna pacos	70.91	5.00e-69	254.00
IUUC-Vvi-131065	Vitis vinifera	32.69	2.00e-40	159.00
IUUC-Xtr-132601	Xenopus tropicalis	56.53	3.00e-108	385.00
IUUC-Xma-133142	Xiphophorus maculatus	68.79	2.00e-128	452.00
IUUC-Yli-134580	Yarrowia lipolytica	27.84	1.00e-31	130.00
IUUC-Zma-135330	Zea mays	28.75	5.00e-32	131.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence