iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Eca-034274

Ensembl Protein ID

ENSECAP00000009059.1

UniProt Accession

F6ZN21; F6ZN21_HORSE

Protein Name

Uncharacterized protein

Gene Name

PHIP

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSECAG00000010684.1	ENSECAT00000011576.1	ENSECAP00000009059.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	4.60e-34	115.1	118	155
UBD/Beta-Prp	6.30e-52	176.8	217	478

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvll 36
           gH +sv+c+ f  + +++ +GsdD+ +k+W +++g+ll
   Q: 118  GHLSSVYCVTFdRTgRRIFTGSDDCLVKIWATDDGRLL 155
           8**********955599*****************9987 PP

UBD/Beta-Prp

   S: 19   spdksllatgsrdgtikvwdvttgkl.....lrsl.sgheaevtavk..fspdgkilvtgseDrtikvw..dlstgkcvhtlkghedsv 97
           s +k++l ++++dgti  w ++ g+l      +++ +   ++v+ ++  fs  g +l+tgs+D++i+v+     +++ ++ l+ h+d+v
   Q: 217  SGSKRYLSSTGADGTICFWLWDAGTLkinprPAKFtERPRPGVQMICssFSAGGMFLATGSTDHIIRVYffGSGQPEKISELEFHTDKV 305
           67899***********999999999988988555547777888765522777888**************777779999*********** PP
   S: 98   lslsfspsgdklvsGshdrtirvwdletgqclee................tlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgk 170
            s++fs +++++vsGs+d t+r+w+ + +++ +                  +++++  v++v+++  ++ ++++ ++ t+++W++ tg+
   Q: 306  DSIQFSNTSNRFVSGSRDGTARIWQFKRREWKSIlldmatrpagqnlqgmEDKVTKMKVTMVAWDRHDSTVITAVNNMTLKVWNSYTGQ 394
           ********************************99***************99999999******************************** PP
   S: 171  llrtltgghtdsvysls...fdsngkelvsgsldgtvklwdlqtgecvrtlnght.....dnvksvrfspnderlvsgssDgsiriW 249
           l++ l g h+d v  l+   fd+  + l s+++dg v++wdl +g  +r++ +         v + + sp++++++++ s+g + i+
   Q: 395  LIHVLMG-HEDEVFVLEphpFDP--RVLFSAGHDGNVIVWDLARGVKIRSYFNMIegqghGAVFDCKCSPDGQHFACTDSHGHLLIF 478
           ******9.*********999999..89******************999998875544444566667777999999999999888887 PP

Organism

Equus caballus

Protein Sequence
(Fasta)

VKYYRHLAPD HLLQICHRLG PLLEQEIPQS VPGVQTLLGA GRQSLLRTNK SCRHVVWKGS 60
ALAALHCGRP PESPINYGSP PSIADTLFSR KLNGKYRLER LVPTAVYQHM KMHKRILGHL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CATAATAGGT GAAGTATTAC AGACATTTAG CACCTGATCA CTTGCTGCAA ATATGTCATC 60
GACTAGGACC TCTTCTTGAA CAAGAAATTC CACAAAGCGT TCCTGGAGTA CAAACCTTAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0103--Bromodomain
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0853--WD repeat

Interpro

IPR001487--Bromodomain
IPR018359--Bromodomain_CS
IPR028738--PHIP
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00633--BROMODOMAIN_1
PS50014--BROMODOMAIN_2
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00439--Bromodomain
PF00400--WD40

PRINTS

PR00503--BROMODOMAIN

SMART

SM00297--BROMO
SM00320--WD40

Gene Ontology

GO:0070062--C:extracellular exosome
GO:0005634--C:nucleus
GO:0007010--P:cytoskeleton organization
GO:0008286--P:insulin receptor signaling pathway
GO:2001237--P:negative regulation of extrinsic apoptotic signaling pathway
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0008360--P:regulation of cell shape
GO:0006357--P:regulation of transcription from RNA polymerase II promoter

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-001113	Aegilops tauschii	30.49	7.00e-53	203.00
IUUC-Aml-002299	Ailuropoda melanoleuca	97.67	0.00e+00	3200.00
IUUC-Atr-002600	Amborella trichopoda	33.27	2.00e-64	241.00
IUUC-Apl-003700	Anas platyrhynchos	86.77	0.00e+00	2877.00
IUUC-Aca-004474	Anolis carolinensis	82.49	0.00e+00	2731.00
IUUC-Bta-013125	Bos taurus	96.82	0.00e+00	3155.00
IUUC-Bdi-014797	Brachypodium distachyon	33.40	5.00e-56	213.00
IUUC-Cja-018868	Callithrix jacchus	94.77	0.00e+00	3208.00
IUUC-Cfa-021179	Canis familiaris	97.95	0.00e+00	3136.00
IUUC-Cpo-022077	Cavia porcellus	91.17	0.00e+00	3079.00
IUUC-Csa-023618	Chlorocebus sabaeus	97.04	0.00e+00	3238.00
IUUC-Cho-024794	Choloepus hoffmanni	90.32	0.00e+00	873.00
IUUC-Csv-025813	Ciona savignyi	44.02	4.00e-170	591.00
IUUC-Dre-028029	Danio rerio	80.86	0.00e+00	1254.00
IUUC-Dno-030048	Dasypus novemcinctus	96.93	0.00e+00	3170.00
IUUC-Dor-030195	Dipodomys ordii	89.83	0.00e+00	1460.00
IUUC-Ete-032748	Echinops telfairi	85.56	0.00e+00	1182.00
IUUC-Eeu-034688	Erinaceus europaeus	86.11	0.00e+00	1434.00
IUUC-Fca-035451	Felis catus	97.02	0.00e+00	3097.00
IUUC-Fal-037465	Ficedula albicollis	86.37	0.00e+00	2831.00
IUUC-Gmo-039451	Gadus morhua	68.58	0.00e+00	724.00
IUUC-Gga-040798	Gallus gallus	86.53	0.00e+00	2869.00
IUUC-Gma-043340	Glycine max	34.65	2.00e-66	248.00
IUUC-Ggo-045347	Gorilla gorilla	98.75	0.00e+00	1616.00
IUUC-Hsa-046757	Homo sapiens	97.16	0.00e+00	3209.00
IUUC-Hvu-047706	Hordeum vulgare	31.84	7.00e-38	150.00
IUUC-Itr-048843	Ictidomys tridecemlineatus	94.03	0.00e+00	1190.00
IUUC-Lch-050646	Latimeria chalumnae	79.11	0.00e+00	2667.00
IUUC-Lpe-051619	Leersia perrieri	30.21	1.00e-63	238.00
IUUC-Laf-054140	Loxodonta africana	97.10	0.00e+00	3256.00
IUUC-Mcc-055061	Macaca mulatta	97.16	0.00e+00	3242.00
IUUC-Mmr-060837	Microcebus murinus	96.76	0.00e+00	3206.00
IUUC-Mdo-061903	Monodelphis domestica	91.78	0.00e+00	3082.00
IUUC-Mmu-063772	Mus musculus	94.99	0.00e+00	3169.00
IUUC-Mac-065343	Musa acuminata	30.45	4.00e-66	247.00
IUUC-Mpu-066359	Mustela putorius furo	97.45	0.00e+00	2993.00
IUUC-Mlu-067928	Myotis lucifugus	95.91	0.00e+00	3196.00
IUUC-Nle-070094	Nomascus leucogenys	97.33	0.00e+00	3217.00
IUUC-Opr-070971	Ochotona princeps	74.53	0.00e+00	955.00
IUUC-Ont-072221	Oreochromis niloticus	76.66	0.00e+00	1236.00
IUUC-Oan-073185	Ornithorhynchus anatinus	87.82	0.00e+00	2870.00
IUUC-Ocu-074033	Oryctolagus cuniculus	94.69	0.00e+00	2875.00
IUUC-Oba-075709	Oryza barthii	31.37	2.00e-56	214.00
IUUC-Obr-076619	Oryza brachyantha	29.75	2.00e-63	238.00
IUUC-Ogl-077493	Oryza glaberrima	26.93	4.00e-29	124.00
IUUC-Ogu-078641	Oryza glumaepatula	24.08	1.00e-29	126.00
IUUC-Oin-079669	Oryza indica	31.13	3.00e-52	199.00
IUUC-Olo-080755	Oryza longistaminata	31.65	3.00e-54	207.00
IUUC-Oni-082991	Oryza nivara	27.58	1.00e-39	159.00
IUUC-Opu-083233	Oryza punctata	29.27	1.00e-57	219.00
IUUC-Oru-085195	Oryza rufipogon	31.37	2.00e-56	214.00
IUUC-Oga-088578	Otolemur garnettii	96.76	0.00e+00	3185.00
IUUC-Oar-090247	Ovis aries	96.93	0.00e+00	3151.00
IUUC-Ptr-091266	Pan troglodytes	96.99	0.00e+00	3191.00
IUUC-Pan-092734	Papio anubis	97.21	0.00e+00	3242.00
IUUC-Pfo-096191	Poecilia formosa	73.54	0.00e+00	1999.00
IUUC-Pab-098402	Pongo abelii	97.21	0.00e+00	3211.00
IUUC-Pop-099185	Populus trichocarpa	35.62	1.00e-70	262.00
IUUC-Pca-101128	Procavia capensis	87.44	0.00e+00	2890.00
IUUC-Ppe-101849	Prunus persica	31.02	9.00e-65	243.00
IUUC-Pva-103058	Pteropus vampyrus	97.27	0.00e+00	1613.00
IUUC-Rno-106013	Rattus norvegicus	93.86	0.00e+00	3158.00
IUUC-Sha-107496	Sarcophilus harrisii	91.67	0.00e+00	3079.00
IUUC-Sit-110017	Setaria italica	31.50	4.00e-55	210.00
IUUC-Sly-111348	Solanum lycopersicum	32.20	2.00e-65	245.00
IUUC-Sar-113520	Sorex araneus	92.61	0.00e+00	1565.00
IUUC-Sbi-114195	Sorghum bicolor	29.18	4.00e-51	196.00
IUUC-Ssc-115461	Sus scrofa	94.03	0.00e+00	3075.00
IUUC-Tgu-116821	Taeniopygia guttata	86.15	0.00e+00	2828.00
IUUC-Tsy-119132	Tarsius syrichta	85.16	0.00e+00	2600.00
IUUC-Tae-125478	Triticum aestivum	30.65	1.00e-62	235.00
IUUC-Tur-126809	Triticum urartu	30.23	2.00e-60	228.00
IUUC-Tbe-127479	Tupaia belangeri	93.08	0.00e+00	1462.00
IUUC-Ttr-128427	Tursiops truncatus	93.18	0.00e+00	3031.00
IUUC-Vpa-130160	Vicugna pacos	94.31	0.00e+00	3071.00
IUUC-Vvi-131362	Vitis vinifera	33.86	4.00e-66	247.00
IUUC-Xtr-132717	Xenopus tropicalis	74.58	0.00e+00	2471.00
IUUC-Xma-134120	Xiphophorus maculatus	79.68	0.00e+00	1196.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence