iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ame-011533

Ensembl Protein ID

ENSAMXP00000021486.1

UniProt Accession

W5LNS4; W5LNS4_ASTMX

Genbank Protein ID

ENSAMXP00000021486

Protein Name

Tyrosine-protein kinase

Genbank Nucleotide ID

APWO01021545

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSAMXG00000020869.1	ENSAMXT00000021486.1	ENSAMXP00000021486.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	3.40e-15	56.0	7	62

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 6    vqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
           + +lydyea ++d+L+++kG++ +++  ++++++W+++ + ++g  G +P+n+v+ ++
   Q: 7    FVALYDYEARTEDDLSFRKGEKFQIL--NSTEGDWWEARSLTTGGTGYIPSNYVAPVD 62
           789***********************..8999**********************9987 PP

Organism

Astyanax mexicanus

Protein Sequence
(Fasta)

SPGVTLFVAL YDYEARTEDD LSFRKGEKFQ ILNSTEGDWW EARSLTTGGT GYIPSNYVAP 60
VDSIQAEDWY FGKLGRKDAE RQLLSNGNPR GTFLIRESET TKGAYSLSIQ DWDDIKGDHV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TCTCCAGGAG TTACACTCTT TGTAGCACTT TATGATTATG AGGCAAGGAC AGAGGATGAC 60
CTCAGCTTCA GGAAAGGAGA AAAATTCCAG ATTCTCAACA GCACGTGAGT ATAAACTTAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0808--Transferase
KW-0829--Tyrosine-protein kinase

Interpro

IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR000980--SH2
IPR001452--SH3_domain
IPR008266--Tyr_kinase_AS
IPR020635--Tyr_kinase_cat_dom

PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00109--PROTEIN_KINASE_TYR
PS50001--SH2
PS50002--SH3

Pfam

PF07714--Pkinase_Tyr
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN
PR00109--TYRKINASE

SMART

SM00252--SH2
SM00326--SH3
SM00219--TyrKc

Gene Ontology

GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0005524--F:ATP binding
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity
GO:0034334--P:adherens junction maintenance
GO:0060027--P:convergent extension involved in gastrulation
GO:0001702--P:gastrulation with mouth forming second
GO:0042552--P:myelination
GO:0046777--P:protein autophosphorylation
GO:0051480--P:regulation of cytosolic calcium ion concentration
GO:0045859--P:regulation of protein kinase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002009	Ailuropoda melanoleuca	94.90	0.00e+00	904.00
IUUC-Aca-005065	Anolis carolinensis	95.12	0.00e+00	906.00
IUUC-Bta-012645	Bos taurus	94.90	0.00e+00	904.00
IUUC-Cel-018682	Caenorhabditis elegans	57.91	6.00e-149	520.00
IUUC-Cja-019027	Callithrix jacchus	94.90	0.00e+00	904.00
IUUC-Cfa-021163	Canis familiaris	94.90	0.00e+00	904.00
IUUC-Cpo-022315	Cavia porcellus	94.90	0.00e+00	904.00
IUUC-Csa-023721	Chlorocebus sabaeus	94.90	0.00e+00	905.00
IUUC-Cho-025014	Choloepus hoffmanni	94.90	0.00e+00	904.00
IUUC-Dre-027985	Danio rerio	98.46	0.00e+00	937.00
IUUC-Dor-031035	Dipodomys ordii	93.57	0.00e+00	888.00
IUUC-Dme-031976	Drosophila melanogaster	61.86	4.00e-164	571.00
IUUC-Eeu-034582	Erinaceus europaeus	93.87	2.00e-147	515.00
IUUC-Fca-035582	Felis catus	94.90	0.00e+00	904.00
IUUC-Gmo-038992	Gadus morhua	97.80	0.00e+00	932.00
IUUC-Gac-042461	Gasterosteus aculeatus	96.92	0.00e+00	926.00
IUUC-Ggo-044469	Gorilla gorilla	94.90	0.00e+00	905.00
IUUC-Hsa-045723	Homo sapiens	94.90	0.00e+00	905.00
IUUC-Itr-048519	Ictidomys tridecemlineatus	94.90	0.00e+00	904.00
IUUC-Lch-049825	Latimeria chalumnae	94.24	0.00e+00	897.00
IUUC-Loc-052531	Lepisosteus oculatus	95.82	0.00e+00	915.00
IUUC-Laf-053659	Loxodonta africana	94.90	0.00e+00	903.00
IUUC-Mga-060067	Meleagris gallopavo	94.91	0.00e+00	901.00
IUUC-Mmr-061194	Microcebus murinus	94.90	0.00e+00	904.00
IUUC-Mdo-062628	Monodelphis domestica	94.90	0.00e+00	904.00
IUUC-Mmu-063896	Mus musculus	94.90	0.00e+00	904.00
IUUC-Mpu-066333	Mustela putorius furo	94.90	0.00e+00	904.00
IUUC-Mlu-067315	Myotis lucifugus	94.90	0.00e+00	904.00
IUUC-Ont-072516	Oreochromis niloticus	98.24	0.00e+00	938.00
IUUC-Oan-073714	Ornithorhynchus anatinus	94.95	0.00e+00	911.00
IUUC-Ocu-074284	Oryctolagus cuniculus	94.90	0.00e+00	905.00
IUUC-Ola-087431	Oryzias latipes	97.58	0.00e+00	932.00
IUUC-Oar-089408	Ovis aries	94.90	0.00e+00	904.00
IUUC-Ptr-091068	Pan troglodytes	94.90	0.00e+00	905.00
IUUC-Pan-092217	Papio anubis	94.90	0.00e+00	905.00
IUUC-Psi-093602	Pelodiscus sinensis	94.90	0.00e+00	903.00
IUUC-Pfo-097084	Poecilia formosa	97.80	0.00e+00	933.00
IUUC-Pab-097673	Pongo abelii	94.46	0.00e+00	901.00
IUUC-Pca-100245	Procavia capensis	94.93	0.00e+00	909.00
IUUC-Pva-102645	Pteropus vampyrus	94.90	0.00e+00	905.00
IUUC-Rno-105372	Rattus norvegicus	94.90	0.00e+00	904.00
IUUC-Sha-107637	Sarcophilus harrisii	94.90	0.00e+00	903.00
IUUC-Stu-112331	Solanum tuberosum	29.74	2.00e-22	100.00
IUUC-Sar-113016	Sorex araneus	82.26	0.00e+00	763.00
IUUC-Ssc-116389	Sus scrofa	94.93	0.00e+00	909.00
IUUC-Tru-118241	Takifugu rubripes	98.03	0.00e+00	938.00
IUUC-Tni-120031	Tetraodon nigroviridis	98.02	0.00e+00	930.00
IUUC-Tbe-127707	Tupaia belangeri	94.47	0.00e+00	896.00
IUUC-Ttr-129145	Tursiops truncatus	94.90	0.00e+00	904.00
IUUC-Vpa-130815	Vicugna pacos	94.68	0.00e+00	895.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence