iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mga-060067

Ensembl Protein ID

ENSMGAP00000014175.1

UniProt Accession

G1NL23; G1NL23_MELGA

Protein Name

Tyrosine-protein kinase

Gene Name

FYN

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMGAG00000013415.2	ENSMGAT00000015099.1	ENSMGAP00000014175.1
ENSMGAG00000013415.2	ENSMGAT00000018840.1	ENSMGAP00000017439.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	2.00e-15	56.2	88	143

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 6    vqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
           + +lydyea ++d+L+++kG++ +++  ++ +++W+++ + ++g  G +P+n+v+ ++
   Q: 88   FVALYDYEARTEDDLSFHKGEKFQIL--NSSEGDWWEARSLTTGETGYIPSNYVAPVD 143
           789***********************..89999*********************9987 PP

Organism

Meleagris gallopavo

Protein Sequence
(Fasta)

IMGCVQCKDK EATKLTDERD GSLTQSSGYR YGTDPTPQHY PSFGVTSIPN YNNFHATGGQ 60
GLTVFGGVNS SSHTGTLRTR GGTGVTLFVA LYDYEARTED DLSFHKGEKF QILNSSEGDW 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GATTTTAGAT AATGGGCTGT GTGCAATGTA AGGACAAAGA GGCAACAAAA CTGACTGACG 60
AGAGGGATGG GAGTTTAACA CAAAGCTCAG GCTACCGCTA TGGCACAGAT CCCACGCCAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0808--Transferase
KW-0829--Tyrosine-protein kinase

Interpro

IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR000980--SH2
IPR001452--SH3_domain
IPR008266--Tyr_kinase_AS
IPR020635--Tyr_kinase_cat_dom

PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00109--PROTEIN_KINASE_TYR
PS50001--SH2
PS50002--SH3

Pfam

PF07714--Pkinase_Tyr
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN
PR00109--TYRKINASE

SMART

SM00252--SH2
SM00326--SH3
SM00219--TyrKc

Gene Ontology

GO:0005884--C:actin filament
GO:0005829--C:cytosol
GO:0030425--C:dendrite
GO:0005768--C:endosome
GO:0045121--C:membrane raft
GO:0005886--C:plasma membrane
GO:0014069--C:postsynaptic density
GO:0005524--F:ATP binding
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity
GO:0004871--F:signal transducer activity
GO:0050798--P:activated T cell proliferation
GO:0036120--P:cellular response to platelet-derived growth factor stimulus
GO:0071560--P:cellular response to transforming growth factor beta stimulus
GO:0048813--P:dendrite morphogenesis
GO:0050966--P:detection of mechanical stimulus involved in sensory perception of pain
GO:0030900--P:forebrain development
GO:1902951--P:negative regulation of dendritic spine maintenance
GO:0010629--P:negative regulation of gene expression
GO:0042177--P:negative regulation of protein catabolic process
GO:0031397--P:negative regulation of protein ubiquitination
GO:0001764--P:neuron migration
GO:0043123--P:positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:1901216--P:positive regulation of neuron death
GO:0010976--P:positive regulation of neuron projection development
GO:1900182--P:positive regulation of protein localization to nucleus
GO:0090314--P:positive regulation of protein targeting to membrane
GO:0042523--P:positive regulation of tyrosine phosphorylation of Stat5 protein
GO:0046777--P:protein autophosphorylation
GO:1905664--P:regulation of calcium ion import across plasma membrane
GO:0008360--P:regulation of cell shape
GO:1904645--P:response to beta-amyloid
GO:0045471--P:response to ethanol
GO:0050852--P:T cell receptor signaling pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002009	Ailuropoda melanoleuca	98.88	0.00e+00	1079.00
IUUC-Apl-003716	Anas platyrhynchos	93.88	0.00e+00	1014.00
IUUC-Aca-005065	Anolis carolinensis	98.70	0.00e+00	1075.00
IUUC-Ame-011533	Astyanax mexicanus	94.96	0.00e+00	908.00
IUUC-Bta-012645	Bos taurus	98.70	0.00e+00	1077.00
IUUC-Bol-016049	Brassica oleracea	31.61	2.00e-17	84.00
IUUC-Cja-019027	Callithrix jacchus	98.88	0.00e+00	1079.00
IUUC-Cfa-021163	Canis familiaris	98.88	0.00e+00	1079.00
IUUC-Cpo-022315	Cavia porcellus	98.88	0.00e+00	1079.00
IUUC-Csa-023721	Chlorocebus sabaeus	98.70	0.00e+00	1077.00
IUUC-Cho-025014	Choloepus hoffmanni	99.07	0.00e+00	1081.00
IUUC-Dre-027985	Danio rerio	92.75	0.00e+00	1055.00
IUUC-Dno-030043	Dasypus novemcinctus	90.17	0.00e+00	1055.00
IUUC-Dor-031035	Dipodomys ordii	97.58	0.00e+00	1060.00
IUUC-Eca-033928	Equus caballus	89.36	0.00e+00	826.00
IUUC-Eeu-034582	Erinaceus europaeus	97.70	0.00e+00	676.00
IUUC-Fca-035582	Felis catus	98.88	0.00e+00	1079.00
IUUC-Fal-037320	Ficedula albicollis	94.05	0.00e+00	1014.00
IUUC-Gmo-038992	Gadus morhua	91.11	0.00e+00	1032.00
IUUC-Gga-041262	Gallus gallus	94.05	0.00e+00	1014.00
IUUC-Gac-042461	Gasterosteus aculeatus	90.71	0.00e+00	1034.00
IUUC-Ggo-044469	Gorilla gorilla	97.77	0.00e+00	1073.00
IUUC-Hsa-045723	Homo sapiens	98.70	0.00e+00	1077.00
IUUC-Itr-048519	Ictidomys tridecemlineatus	98.88	0.00e+00	1079.00
IUUC-Lch-049825	Latimeria chalumnae	93.12	0.00e+00	1012.00
IUUC-Loc-052531	Lepisosteus oculatus	91.64	0.00e+00	1043.00
IUUC-Laf-053659	Loxodonta africana	98.70	0.00e+00	1077.00
IUUC-Mcc-055039	Macaca mulatta	92.63	0.00e+00	1004.00
IUUC-Mmr-061194	Microcebus murinus	98.88	0.00e+00	1079.00
IUUC-Mdo-062628	Monodelphis domestica	98.70	0.00e+00	1078.00
IUUC-Mmu-063896	Mus musculus	98.88	0.00e+00	1079.00
IUUC-Mpu-066333	Mustela putorius furo	98.88	0.00e+00	1080.00
IUUC-Mlu-067315	Myotis lucifugus	98.88	0.00e+00	1079.00
IUUC-Nle-068978	Nomascus leucogenys	93.12	0.00e+00	1006.00
IUUC-Ont-071783	Oreochromis niloticus	92.02	0.00e+00	1019.00
IUUC-Oan-073714	Ornithorhynchus anatinus	99.12	0.00e+00	942.00
IUUC-Ocu-074284	Oryctolagus cuniculus	98.70	0.00e+00	1077.00
IUUC-Ola-087431	Oryzias latipes	91.82	0.00e+00	1046.00
IUUC-Oga-088789	Otolemur garnettii	93.12	0.00e+00	1004.00
IUUC-Oar-089408	Ovis aries	98.70	0.00e+00	1077.00
IUUC-Ptr-091068	Pan troglodytes	98.70	0.00e+00	1077.00
IUUC-Pan-092217	Papio anubis	98.70	0.00e+00	1077.00
IUUC-Psi-093602	Pelodiscus sinensis	99.26	0.00e+00	1081.00
IUUC-Pfo-097084	Poecilia formosa	92.57	0.00e+00	1053.00
IUUC-Pab-097673	Pongo abelii	98.33	0.00e+00	1073.00
IUUC-Pca-100245	Procavia capensis	96.92	0.00e+00	963.00
IUUC-Pva-102645	Pteropus vampyrus	97.21	0.00e+00	1043.00
IUUC-Rno-105372	Rattus norvegicus	98.70	0.00e+00	1078.00
IUUC-Sha-107637	Sarcophilus harrisii	98.33	0.00e+00	1064.00
IUUC-Sar-113016	Sorex araneus	87.73	0.00e+00	935.00
IUUC-Ssc-116389	Sus scrofa	98.51	0.00e+00	1072.00
IUUC-Tgu-117206	Taeniopygia guttata	94.05	0.00e+00	1014.00
IUUC-Tru-118241	Takifugu rubripes	91.51	0.00e+00	1045.00
IUUC-Tni-120031	Tetraodon nigroviridis	91.82	0.00e+00	1041.00
IUUC-Tbe-127707	Tupaia belangeri	96.55	0.00e+00	967.00
IUUC-Ttr-129145	Tursiops truncatus	98.88	0.00e+00	1079.00
IUUC-Vpa-130815	Vicugna pacos	96.07	0.00e+00	1023.00
IUUC-Xtr-132293	Xenopus tropicalis	91.08	0.00e+00	983.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence