iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Cfa-020694

Ensembl Protein ID

ENSCAFP00000000624.3

UniProt Accession

F6V0I8; F6V0I8_CANLF

Genbank Protein ID

ENSCAFP00000000624

Protein Name

Estrogen receptor; ER-alpha; Estradiol receptor; Nuclear receptor subfamily 3 group A member 1

Genbank Nucleotide ID

AAEX03000275

Gene Name

ESR1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCAFG00000000430.3	ENSCAFT00000000680.3	ENSCAFP00000000624.3

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
UBD/Alpha-Helix/UMI	89.09	0.00e+00	953.00	IUUC-Hsa-046944

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Canis familiaris

Functional Description
(View)

The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.

Protein Sequence
(Fasta)

MTLHTKASGM ALLHQIQGPE LDSLNRPQLK IPLERPLGEV YVDSSKPAVY NYPEAGAYDF 60
NAAPAAPAPL YGQSGLGYGP GSEAVAAAAF GANGLGGFPP LNSMSPSPPV LLHPPPQLSS 120

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Nucleotide Sequence
(Fasta)

GTTTACAGAA AGCAGTCAAC TGAGCTATTC GTGGAAAGGT TTGTGGCTTT GGTTAACGAG 60
GTGGAGGAGT ATTACATTTC AGCTGGAAAC ACATCCCTAG AATGCCAAAA CATTTATTCC 120

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Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0238--DNA-binding
KW-0446--Lipid-binding
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0675--Receptor
KW-1185--Reference proteome
KW-0754--Steroid-binding
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR000536--Nucl_hrmn_rcpt_lig-bd
IPR001723--Nuclear_hrmn_rcpt
IPR024178--Oest_rcpt/oest-rel_rcp
IPR001292--Oestr_rcpt
IPR024736--Oestrogen-typ_rcpt_final_C_dom
IPR001628--Znf_hrmn_rcpt
IPR013088--Znf_NHR/GATA

PROSITE

PS00031--NUCLEAR_REC_DBD_1
PS51030--NUCLEAR_REC_DBD_2

Pfam

PF12743--ESR1_C
PF00104--Hormone_recep
PF02159--Oest_recep
PF00105--zf-C4

PRINTS

PR00543--OESTROGENR
PR00398--STRDHORMONER
PR00047--STROIDFINGER

SMART

SM00430--HOLI
SM00399--ZnF_C4

Gene Ontology

GO:0005737--C:cytoplasm
GO:0000790--C:nuclear chromatin
GO:0005886--C:plasma membrane
GO:0035327--C:transcriptionally active chromatin
GO:0003682--F:chromatin binding
GO:0001046--F:core promoter sequence-specific DNA binding
GO:0034056--F:estrogen response element binding
GO:0000978--F:RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0038052--F:RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding
GO:0005496--F:steroid binding
GO:0001077--F:transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0008270--F:zinc ion binding
GO:0008209--P:androgen metabolic process
GO:0001547--P:antral ovarian follicle growth
GO:0071392--P:cellular response to estradiol stimulus
GO:0071391--P:cellular response to estrogen stimulus
GO:0002064--P:epithelial cell development
GO:0060750--P:epithelial cell proliferation involved in mammary gland duct elongation
GO:0008584--P:male gonad development
GO:0060749--P:mammary gland alveolus development
GO:0060745--P:mammary gland branching involved in pregnancy
GO:0043124--P:negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:1903799--P:negative regulation of production of miRNAs involved in gene silencing by miRNA
GO:0043433--P:negative regulation of sequence-specific DNA binding transcription factor activity
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0048146--P:positive regulation of fibroblast proliferation
GO:0051091--P:positive regulation of sequence-specific DNA binding transcription factor activity
GO:0060527--P:prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis
GO:0060523--P:prostate epithelial cord elongation
GO:0071168--P:protein localization to chromatin
GO:0042981--P:regulation of apoptotic process
GO:0060687--P:regulation of branching involved in prostate gland morphogenesis
GO:0050727--P:regulation of inflammatory response
GO:0034121--P:regulation of toll-like receptor signaling pathway
GO:0060065--P:uterus development
GO:0060068--P:vagina development

KEGG

cfa:403640

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001925	Ailuropoda melanoleuca	96.21	0.00e+00	825.00
IUUC-Apl-003688	Anas platyrhynchos	77.37	0.00e+00	788.00
IUUC-Aca-005222	Anolis carolinensis	75.63	0.00e+00	855.00
IUUC-Ame-010731	Astyanax mexicanus	57.42	1.00e-136	480.00
IUUC-Bta-013112	Bos taurus	85.23	0.00e+00	937.00
IUUC-Cja-019408	Callithrix jacchus	89.93	0.00e+00	977.00
IUUC-Cpo-021426	Cavia porcellus	82.72	0.00e+00	886.00
IUUC-Csa-023736	Chlorocebus sabaeus	92.81	0.00e+00	882.00
IUUC-Dre-027698	Danio rerio	56.29	4.00e-132	464.00
IUUC-Dno-029477	Dasypus novemcinctus	90.02	0.00e+00	763.00
IUUC-Dor-030572	Dipodomys ordii	90.09	0.00e+00	750.00
IUUC-Ete-032849	Echinops telfairi	70.51	0.00e+00	647.00
IUUC-Eca-033605	Equus caballus	84.73	0.00e+00	934.00
IUUC-Eeu-034683	Erinaceus europaeus	89.72	8.00e-108	384.00
IUUC-Fca-035928	Felis catus	95.75	0.00e+00	818.00
IUUC-Fal-036754	Ficedula albicollis	75.71	0.00e+00	876.00
IUUC-Gmo-038872	Gadus morhua	57.72	6.00e-112	397.00
IUUC-Gga-040988	Gallus gallus	77.78	0.00e+00	867.00
IUUC-Gac-042015	Gasterosteus aculeatus	64.19	5.00e-125	441.00
IUUC-Ggo-044749	Gorilla gorilla	89.77	0.00e+00	975.00
IUUC-Hsa-046944	Homo sapiens	89.09	0.00e+00	966.00
IUUC-Itr-048863	Ictidomys tridecemlineatus	87.12	0.00e+00	951.00
IUUC-Loc-052414	Lepisosteus oculatus	58.71	9.00e-179	619.00
IUUC-Mcc-054781	Macaca mulatta	89.93	0.00e+00	976.00
IUUC-Meu-056232	Macropus eugenii	84.37	0.00e+00	912.00
IUUC-Mga-059319	Meleagris gallopavo	78.29	0.00e+00	872.00
IUUC-Mmr-061636	Microcebus murinus	88.62	2.00e-163	568.00
IUUC-Mdo-062661	Monodelphis domestica	84.40	0.00e+00	919.00
IUUC-Mmu-063330	Mus musculus	87.00	0.00e+00	910.00
IUUC-Mpu-065757	Mustela putorius furo	90.13	0.00e+00	1000.00
IUUC-Mlu-067712	Myotis lucifugus	91.29	0.00e+00	866.00
IUUC-Nle-069283	Nomascus leucogenys	89.93	0.00e+00	954.00
IUUC-Opr-070391	Ochotona princeps	85.43	0.00e+00	957.00
IUUC-Ont-071369	Oreochromis niloticus	51.45	3.00e-117	415.00
IUUC-Oan-073734	Ornithorhynchus anatinus	74.34	7.00e-134	469.00
IUUC-Ocu-074292	Oryctolagus cuniculus	87.67	0.00e+00	950.00
IUUC-Oba-075103	Oryza barthii	28.21	5.00e-03	35.80
IUUC-Ogu-079042	Oryza glumaepatula	28.21	1.00e-03	38.10
IUUC-Olo-080944	Oryza longistaminata	28.21	2.00e-03	35.40
IUUC-Oni-082560	Oryza nivara	28.21	4.00e-03	36.20
IUUC-Ola-087052	Oryzias latipes	50.63	2.00e-125	442.00
IUUC-Oga-088586	Otolemur garnettii	88.48	0.00e+00	944.00
IUUC-Oar-090156	Ovis aries	91.72	0.00e+00	825.00
IUUC-Ptr-091321	Pan troglodytes	89.93	0.00e+00	976.00
IUUC-Pan-092851	Papio anubis	89.77	0.00e+00	973.00
IUUC-Psi-093434	Pelodiscus sinensis	76.68	0.00e+00	906.00
IUUC-Pfo-097379	Poecilia formosa	57.58	2.00e-130	459.00
IUUC-Pab-097735	Pongo abelii	89.93	0.00e+00	975.00
IUUC-Pva-102125	Pteropus vampyrus	86.74	0.00e+00	944.00
IUUC-Rno-106121	Rattus norvegicus	86.86	0.00e+00	907.00
IUUC-Sha-107547	Sarcophilus harrisii	84.56	0.00e+00	918.00
IUUC-Sar-113650	Sorex araneus	73.78	3.00e-171	594.00
IUUC-Tgu-117175	Taeniopygia guttata	76.05	0.00e+00	878.00
IUUC-Tru-117545	Takifugu rubripes	54.99	2.00e-134	473.00
IUUC-Tsy-119586	Tarsius syrichta	77.01	0.00e+00	826.00
IUUC-Tni-120121	Tetraodon nigroviridis	56.06	2.00e-135	476.00
IUUC-Tbe-127548	Tupaia belangeri	82.43	0.00e+00	640.00
IUUC-Ttr-128374	Tursiops truncatus	82.38	0.00e+00	863.00
IUUC-Vpa-130464	Vicugna pacos	81.42	3.00e-154	537.00
IUUC-Xtr-132171	Xenopus tropicalis	68.67	0.00e+00	723.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence