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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-063240
UUCD1 version UUC-MuM-00672
Ensembl Protein ID ENSMUSP00000006301.4
UniProt Accession Q8BUI3; D3Z2P9; Q3TIG2; Q8BKI3; Q9DBW4; LRWD1_MOUSE
Genbank Protein ID BAB23500.1; BAC34810.1; BAC39318.1; BAE32292.1; BAE39194.1; BAE39884.1; AAH48397.1
Protein Name Leucine-rich repeat and WD repeat-containing protein 1; ORC-associated protein; Origin recognition complex-associated protein
Genbank Nucleotide ID AK004717; AK051910; AK084948; AK153976; AK167020; AK167868; AC087420
Gene Name Lrwd1; LRWD1; Orca
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000029703.10 ENSMUST00000006301.10 ENSMUSP00000006301.4
ENSMUSG00000029703.10 ENSMUST00000128255.1 ENSMUSP00000119546.1
ENSMUSG00000029703.10 ENSMUST00000150406.1 ENSMUSP00000121513.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
microRNATRANSFACRAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
PhosphositePlus
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 7.50e-09 36.7 393 423
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 2    Htdsvtclaf..sd.tllvsGsdDgtikvWD 29
           H+  +  l+f  s  t+l ++s+D+ i +WD
   Q: 393  HKKAIATLCFspSHeTHLFTASYDKRIILWD 423
           88889999***7557**************** PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Required for G1/S transition. Recruits and stabilizes the origin recognition complex (ORC) onto chromatin during G1 to establish pre-replication complex (preRC) and to heterochromatic sites in post-replicated cells. Binds a combination of DNA and histone methylation repressive marks on heterochromatin. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3 in a cooperative manner with DNA methylation (By similarity). Required for silencing of major satellite repeats. May be important ORC2, ORC3 and ORC4 stability.
 Required for G1/S transition. Recruits and stabilizes the origin recognition complex (ORC) onto chromatin during G1 to establish pre-replication complex (preRC) and to heterochromatic sites in post-replicated cells. Binds a combination of DNA and histone methylation repressive marks on heterochromatin. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3 in a cooperative manner with DNA methylation (By similarity). Required for silencing of major satellite repeats. May be important ORC2, ORC3 and ORC4 stability.
Protein Sequence
(Fasta)
MAPLTPQLLL QRGRPKTDKL GKIQSLNLSG LQLLSEHLDP NLLGRLKKLR ELDLSNNLLE 60
TLPANLGLSH LRILRCTNNQ LGDVTALHQF PELEELNLEG NPFLTVSDNL KVSFLLPKLR 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063240|E3,WD_repeat|Mus musculus
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Nucleotide Sequence
(Fasta)
TTCCTTCCGG TCGCAACGGA CTCGCAAAGG GTTTGTTGTG CGCCACCTCC TGGGCTCCCC 60
GGCAGCGGGC CTTAGCGACC GGACTTCGTG GAGGCGCGGG TTCGGTTGAG CCCTCGGCCA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063240|E3,WD_repeat|Mus musculus
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Sequence Source Ensembl
Keyword

KW-0137--Centromere
KW-0156--Chromatin regulator
KW-0158--Chromosome
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0235--DNA replication
KW-0995--Kinetochore
KW-0433--Leucine-rich repeat
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0779--Telomere
KW-0832--Ubl conjugation
KW-0853--WD repeat
Interpro

IPR032675--L_dom-like
IPR001611--Leu-rich_rpt
IPR025875--Leu-rich_rpt_4
IPR003591--Leu-rich_rpt_typical-subtyp
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
PROSITE

PS51450--LRR
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF12799--LRR_4
PF00400--WD40
SMART

SM00369--LRR_TYP
SM00320--WD40
Gene Ontology

GO:0000777--C:condensed chromosome kinetochore
GO:0005829--C:cytosol
GO:0000776--C:kinetochore
GO:0005815--C:microtubule organizing center
GO:0005664--C:nuclear origin of replication recognition complex
GO:0005730--C:nucleolus
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0005721--C:pericentric heterochromatin
GO:0031933--C:telomeric heterochromatin
GO:0003682--F:chromatin binding
GO:0008327--F:methyl-CpG binding
GO:0035064--F:methylated histone binding
GO:0006325--P:chromatin organization
GO:0016569--P:covalent chromatin modification
GO:0006260--P:DNA replication
GO:0071169--P:establishment of protein localization to chromatin
KEGG mmu:71735
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001948 Ailuropoda melanoleuca 76.28 1.00e-178 620.00
IUUC-Bta-012858 Bos taurus 73.15 0.00e+00 927.00
IUUC-Cja-019702 Callithrix jacchus 77.50 0.00e+00 939.00
IUUC-Cfa-020910 Canis familiaris 77.38 0.00e+00 967.00
IUUC-Cpo-022523 Cavia porcellus 74.27 0.00e+00 977.00
IUUC-Csa-023359 Chlorocebus sabaeus 77.35 0.00e+00 970.00
IUUC-Dno-029426 Dasypus novemcinctus 77.93 0.00e+00 947.00
IUUC-Dor-030654 Dipodomys ordii 72.19 0.00e+00 771.00
IUUC-Eca-034035 Equus caballus 75.77 0.00e+00 944.00
IUUC-Eeu-034711 Erinaceus europaeus 72.86 2.00e-161 562.00
IUUC-Gmo-039096 Gadus morhua 35.96 4.00e-109 389.00
IUUC-Ggo-044714 Gorilla gorilla 77.35 0.00e+00 942.00
IUUC-Hsa-046826 Homo sapiens 77.66 0.00e+00 944.00
IUUC-Laf-054449 Loxodonta africana 77.35 0.00e+00 966.00
IUUC-Mcc-055193 Macaca mulatta 77.81 0.00e+00 945.00
IUUC-Mmr-061572 Microcebus murinus 75.46 0.00e+00 965.00
IUUC-Mpu-066295 Mustela putorius furo 76.39 0.00e+00 959.00
IUUC-Mlu-067766 Myotis lucifugus 77.66 0.00e+00 998.00
IUUC-Nle-069200 Nomascus leucogenys 75.50 0.00e+00 881.00
IUUC-Ola-086965 Oryzias latipes 39.87 1.00e-89 324.00
IUUC-Oga-088411 Otolemur garnettii 72.01 0.00e+00 955.00
IUUC-Oar-089415 Ovis aries 73.46 0.00e+00 871.00
IUUC-Ptr-090663 Pan troglodytes 77.50 0.00e+00 943.00
IUUC-Pan-092467 Papio anubis 77.08 0.00e+00 923.00
IUUC-Pab-098479 Pongo abelii 77.97 0.00e+00 946.00
IUUC-Pca-101023 Procavia capensis 65.74 0.00e+00 770.00
IUUC-Pva-102812 Pteropus vampyrus 72.84 0.00e+00 930.00
IUUC-Rno-105469 Rattus norvegicus 90.14 0.00e+00 1142.00
IUUC-Ssc-115884 Sus scrofa 78.40 0.00e+00 1011.00
IUUC-Tbe-127247 Tupaia belangeri 78.35 1.00e-120 427.00
IUUC-Ttr-128723 Tursiops truncatus 77.62 0.00e+00 981.00
Created Date 25-Jun-2017

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