iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ame-010702

Ensembl Protein ID

ENSAMXP00000020649.1

UniProt Accession

W5LLD7; W5LLD7_ASTMX

Genbank Protein ID

ENSAMXP00000020649

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

APWO01025684

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSAMXG00000020014.1	ENSAMXT00000020649.1	ENSAMXP00000020649.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	7.00e-78	262.6	2466	2789

Active Site

Position(s)	Description	Evidence
2759	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 16   EegldlgGvtreflallskelqnpd..lglf.lysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldlplsksfykl 99
           +e+ + +G+tr ++++ +++  + d  ++lf +  +++ ++ +p +++      +l++F+ +Gr+lg++l +++l++++l+++++k 
   Q: 2466 QENRKRHGSTRSVVDMELDDPDDGDdnAPLFyQPGKRGFYSPRPGKNTE----ARLNCFRNIGRILGLCLLQNELCPITLNRHVIKV 2548
           5667778999999888888888877777888233333666666666654....89******************************** PP
   S: 100  llgkklsledleevdpelykslkeikena...esdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvveyrlk 183
           llg+k++++d++ +dp +y+sl ++ ++    e++   +++dl+f ++ ++ +   ++eL++gG+n+pVt +N +eYv++++e+r+ 
   Q: 2549 LLGRKVNWHDFAFFDPVMYESLRQLIRHSqtgEAEAVFAAMDLAFAIDLCKEEGSGQVELLTGGANMPVTPQNVYEYVRKYAEHRML 2635
           *********************7777666546666899999*********************************************** PP
   S: 184  egikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspai....qwFwevleefsseerkafLq 266
              ++ ++a+r+G+ +v+p++ l+ +t+e+++ll++G+ e++v++l ++t+++++  e+ +++    +wFw+++e++s++er++++ 
   Q: 2636 VVAEQPLHAMRKGLLDVLPKNALEDLTAEDFRLLVNGCGEVNVQMLISFTSFNDESGENAEKLlqfkRWFWSIVEKMSMTERQDLVY 2722
           ****************************************************9999999999989999******************* PP
   S: 267  FvTgssrlPl..gGfaelkprlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           F+T+s++lP+  +Gf++++  +++ir   +d++lP++nTC+++L +P Yssk+ilk+kLl+Ai++ k+F++
   Q: 2723 FWTSSPSLPAseEGFQPMP--SITIRP-PDDQHLPTANTCISRLYVPLYSSKQILKQKLLLAIKT-KNFGF 2789
           **********999******..799999.99**********************************9.99875 PP

Organism

Astyanax mexicanus

Protein Sequence
(Fasta)

MTSIHFVVHP LPGTEDQLND RLREVSEKLN KYNCNSHPQL NLLEQATLKQ CVVGPNHAGF 60
LLEDGRICRI SFAVQPDRLE LGKPDGNDGS KLSSGSGTGR TSRPGRTSDP PWFLSGSDTL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGACCTCCA TACACTTCGT GGTTCACCCG CTGCCCGGGA CCGAGGACCA GCTCAATGAC 60
AGGTAGCCCG GCTAACGGAG AGAGAGAGCC GGGGGGGAAA ACACACACTC CCCGCTGATT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0472--Membrane
KW-1185--Reference proteome
KW-0808--Transferase
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0833--Ubl conjugation pathway

Interpro

IPR024725--E3_UbLigase_EDD_UBA
IPR000569--HECT_dom
IPR002004--PABP_HYD
IPR009091--RCC1/BLIP-II

PROSITE

PS50237--HECT
PS51309--PABC

Pfam

PF11547--E3_UbLigase_EDD
PF00632--HECT
PF00658--PABP

SMART

SM00119--HECTc
SM00517--PolyA

Gene Ontology

GO:0016021--C:integral component of membrane
GO:0003723--F:RNA binding
GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002217	Ailuropoda melanoleuca	85.25	0.00e+00	2492.00
IUUC-Apl-004165	Anas platyrhynchos	84.85	0.00e+00	2500.00
IUUC-Aca-004577	Anolis carolinensis	84.88	0.00e+00	2434.00
IUUC-Bta-012313	Bos taurus	84.86	0.00e+00	2494.00
IUUC-Cel-018165	Caenorhabditis elegans	31.50	3.00e-80	295.00
IUUC-Cja-019858	Callithrix jacchus	84.80	0.00e+00	2524.00
IUUC-Cfa-020973	Canis familiaris	84.91	0.00e+00	2499.00
IUUC-Cpo-022065	Cavia porcellus	89.35	0.00e+00	941.00
IUUC-Csa-023985	Chlorocebus sabaeus	84.91	0.00e+00	2527.00
IUUC-Cho-025034	Choloepus hoffmanni	79.59	0.00e+00	922.00
IUUC-Cin-025715	Ciona intestinalis	45.54	0.00e+00	788.00
IUUC-Csv-026131	Ciona savignyi	47.05	0.00e+00	676.00
IUUC-Dre-027730	Danio rerio	93.76	0.00e+00	2720.00
IUUC-Dno-029123	Dasypus novemcinctus	83.16	0.00e+00	2420.00
IUUC-Dor-030757	Dipodomys ordii	87.79	0.00e+00	1316.00
IUUC-Dme-032192	Drosophila melanogaster	52.72	1.00e-175	612.00
IUUC-Ete-032292	Echinops telfairi	78.58	0.00e+00	1484.00
IUUC-Eca-034347	Equus caballus	84.74	0.00e+00	2484.00
IUUC-Eeu-034873	Erinaceus europaeus	78.96	0.00e+00	2298.00
IUUC-Fca-036485	Felis catus	84.71	0.00e+00	2464.00
IUUC-Fal-037071	Ficedula albicollis	84.85	0.00e+00	2509.00
IUUC-Gmo-039589	Gadus morhua	89.30	0.00e+00	2601.00
IUUC-Gga-041195	Gallus gallus	83.11	0.00e+00	2438.00
IUUC-Gac-042538	Gasterosteus aculeatus	89.99	0.00e+00	2618.00
IUUC-Ggo-045351	Gorilla gorilla	84.71	0.00e+00	2529.00
IUUC-Hsa-045941	Homo sapiens	84.91	0.00e+00	2521.00
IUUC-Itr-048635	Ictidomys tridecemlineatus	84.74	0.00e+00	2493.00
IUUC-Lch-050480	Latimeria chalumnae	84.90	0.00e+00	2509.00
IUUC-Loc-052664	Lepisosteus oculatus	85.49	0.00e+00	2551.00
IUUC-Laf-053960	Loxodonta africana	86.20	0.00e+00	1393.00
IUUC-Mcc-054703	Macaca mulatta	84.96	0.00e+00	2520.00
IUUC-Meu-056431	Macropus eugenii	79.94	0.00e+00	729.00
IUUC-Mga-059289	Meleagris gallopavo	84.65	0.00e+00	2553.00
IUUC-Mmr-061737	Microcebus murinus	84.30	0.00e+00	2430.00
IUUC-Mdo-062499	Monodelphis domestica	84.74	0.00e+00	2498.00
IUUC-Mmu-063273	Mus musculus	84.35	0.00e+00	2464.00
IUUC-Mpu-066907	Mustela putorius furo	84.91	0.00e+00	2495.00
IUUC-Mlu-067942	Myotis lucifugus	84.84	0.00e+00	2519.00
IUUC-Nle-069527	Nomascus leucogenys	84.80	0.00e+00	2525.00
IUUC-Opr-070626	Ochotona princeps	71.26	1.00e-163	572.00
IUUC-Ont-071951	Oreochromis niloticus	90.03	0.00e+00	2605.00
IUUC-Oan-072958	Ornithorhynchus anatinus	84.85	0.00e+00	2479.00
IUUC-Ocu-074503	Oryctolagus cuniculus	84.47	0.00e+00	2476.00
IUUC-Ola-086757	Oryzias latipes	88.92	0.00e+00	2614.00
IUUC-Oga-088781	Otolemur garnettii	84.69	0.00e+00	2486.00
IUUC-Oar-089274	Ovis aries	84.86	0.00e+00	2494.00
IUUC-Ptr-090669	Pan troglodytes	84.97	0.00e+00	2523.00
IUUC-Pan-092226	Papio anubis	84.97	0.00e+00	2512.00
IUUC-Psi-093502	Pelodiscus sinensis	84.65	0.00e+00	2490.00
IUUC-Pma-094454	Petromyzon marinus	68.41	6.00e-171	595.00
IUUC-Pfo-096173	Poecilia formosa	89.73	0.00e+00	2632.00
IUUC-Pab-098355	Pongo abelii	83.12	0.00e+00	1400.00
IUUC-Pca-100570	Procavia capensis	77.78	0.00e+00	797.00
IUUC-Pva-102572	Pteropus vampyrus	76.58	0.00e+00	1056.00
IUUC-Rno-104916	Rattus norvegicus	84.46	0.00e+00	2490.00
IUUC-Sha-106653	Sarcophilus harrisii	85.08	0.00e+00	2503.00
IUUC-Sar-113517	Sorex araneus	83.22	0.00e+00	1193.00
IUUC-Ssc-115470	Sus scrofa	86.67	0.00e+00	2207.00
IUUC-Tgu-116932	Taeniopygia guttata	84.51	0.00e+00	2493.00
IUUC-Tru-117682	Takifugu rubripes	90.20	0.00e+00	2603.00
IUUC-Tsy-119417	Tarsius syrichta	82.39	0.00e+00	2138.00
IUUC-Tni-120442	Tetraodon nigroviridis	85.06	0.00e+00	2369.00
IUUC-Tbe-127456	Tupaia belangeri	74.74	0.00e+00	909.00
IUUC-Ttr-128606	Tursiops truncatus	85.37	0.00e+00	1317.00
IUUC-Vpa-130112	Vicugna pacos	80.82	0.00e+00	2320.00
IUUC-Xtr-131929	Xenopus tropicalis	83.31	0.00e+00	2452.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence