iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Lch-049943

Ensembl Protein ID

ENSLACP00000018445.2

UniProt Accession

H3B974; H3B974_LATCH

Genbank Protein ID

ENSLACP00000018445

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AFYH01049366

Gene Name

TLE4

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLACG00000016244.2	ENSLACT00000018578.2	ENSLACP00000018445.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	3.80e-22	77.7	578	616
UBD/Beta-Prp	3.10e-40	138.4	446	615

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvllk 37
           gHtd+ +c++  +d t l++G+ D+t++ WDlr+g++l+
   Q: 578  GHTDGASCIDIsNDgTKLWTGGLDNTVRSWDLREGRQLQ 616
           8***********999*********************998 PP

UBD/Beta-Prp

   S: 50   gheaevtavkfspdgkilvtgseDrtikvwdls...tgkcvhtlk..ghedsvlslsfspsgdklvsGshdrtirvwdletgqclee.t 132
           +h + v av++s+ +   v ++  + +kvwd+s   + ++v+ l   + +++++s+++ p+g +l++G++ +t+ +wdl   +   +  
   Q: 446  SHGEVVCAVTISNPTR-HVYTGGKGCVKVWDIShpgNKSPVSQLDclNRDNYIRSCRLLPDGRTLIVGGEASTLSIWDLAAPTPRIKaE 533
           4555788899999985.555555579*******999888999988889*******************************9988766658 PP
   S: 133  lsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvyslsfdsngkelvsgsldgtvklwdlqtgecv 215
           l+    +   ++++pd+++++s++ D+ + +Wdl +++l+r+++g htd   +++++ +g+ l +g+ld+tv+ wdl++g+ +
   Q: 534  LTSSAPACYALAISPDSKVCFSCCSDGNIAVWDLHNQTLVRQFQG-HTDGASCIDISNDGTKLWTGGLDNTVRSWDLREGRQL 615
           88888888999*********************************9.********************************99754 PP

Organism

Latimeria chalumnae

Protein Sequence
(Fasta)

MLVCLFPNSL KLECEKLASE KTEMQRHYVM YYEMSYGLNI EMHKQAEIVK RLNAICAQVI 60
PFLSQEHQQQ VVQAVERAKQ VTMAELNAII GQQLQAQHLS HGHGLPVPLT PHPSGLQPPA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATTTTGAGGG TCTTTGTCTG CGATTCCAGC AATATTTATG CTCGTTTGTT TGTTTCCAAA 60
CAGTTTGAAG TTGGAGTGTG AAAAACTGGC CAGCGAGAAG ACCGAAATGC AACGCCATTA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0853--WD repeat

Interpro

IPR005617--Groucho/TLE_N
IPR009146--Groucho_enhance
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF03920--TLE_N
PF00400--WD40

PRINTS

PR01850--GROUCHOFAMLY

SMART

SM00320--WD40

Gene Ontology

GO:0005634--C:nucleus
GO:0006355--P:regulation of transcription, DNA-templated

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001746	Ailuropoda melanoleuca	84.15	0.00e+00	1028.00
IUUC-Aca-005279	Anolis carolinensis	96.01	0.00e+00	1201.00
IUUC-Bta-012646	Bos taurus	95.74	0.00e+00	1218.00
IUUC-Cel-018361	Caenorhabditis elegans	58.15	6.00e-121	427.00
IUUC-Cja-019079	Callithrix jacchus	95.74	0.00e+00	1250.00
IUUC-Cfa-020987	Canis familiaris	95.87	0.00e+00	1246.00
IUUC-Cpo-021606	Cavia porcellus	93.96	0.00e+00	1207.00
IUUC-Csa-023445	Chlorocebus sabaeus	96.15	0.00e+00	1233.00
IUUC-Cho-024590	Choloepus hoffmanni	86.77	0.00e+00	1149.00
IUUC-Csv-026174	Ciona savignyi	57.39	1.00e-161	563.00
IUUC-Dno-028979	Dasypus novemcinctus	95.82	0.00e+00	1175.00
IUUC-Dor-030533	Dipodomys ordii	89.60	0.00e+00	1110.00
IUUC-Dme-031576	Drosophila melanogaster	86.87	0.00e+00	669.00
IUUC-Ete-032887	Echinops telfairi	84.94	0.00e+00	1108.00
IUUC-Eca-034397	Equus caballus	95.87	0.00e+00	1218.00
IUUC-Fca-036030	Felis catus	95.88	0.00e+00	1244.00
IUUC-Fal-037460	Ficedula albicollis	96.15	0.00e+00	1237.00
IUUC-Gga-040416	Gallus gallus	96.42	0.00e+00	1236.00
IUUC-Ggo-045633	Gorilla gorilla	91.96	0.00e+00	1231.00
IUUC-Hsa-046461	Homo sapiens	92.09	0.00e+00	1234.00
IUUC-Itr-048974	Ictidomys tridecemlineatus	96.02	0.00e+00	1228.00
IUUC-Loc-052835	Lepisosteus oculatus	94.66	0.00e+00	1201.00
IUUC-Laf-053425	Loxodonta africana	96.29	0.00e+00	1251.00
IUUC-Mcc-055766	Macaca mulatta	92.09	0.00e+00	1234.00
IUUC-Mmr-061317	Microcebus murinus	92.58	0.00e+00	1234.00
IUUC-Mdo-062956	Monodelphis domestica	96.29	0.00e+00	1222.00
IUUC-Mmu-063576	Mus musculus	95.87	0.00e+00	1225.00
IUUC-Mpu-066410	Mustela putorius furo	96.20	0.00e+00	1219.00
IUUC-Mlu-067456	Myotis lucifugus	95.37	0.00e+00	1204.00
IUUC-Nle-069495	Nomascus leucogenys	96.15	0.00e+00	1233.00
IUUC-Opr-070645	Ochotona princeps	89.10	0.00e+00	1171.00
IUUC-Ont-071419	Oreochromis niloticus	85.64	0.00e+00	1093.00
IUUC-Oan-072842	Ornithorhynchus anatinus	93.45	0.00e+00	1213.00
IUUC-Ocu-074453	Oryctolagus cuniculus	96.29	0.00e+00	1234.00
IUUC-Ola-087090	Oryzias latipes	85.62	0.00e+00	1097.00
IUUC-Oga-087939	Otolemur garnettii	96.15	0.00e+00	1229.00
IUUC-Oar-090347	Ovis aries	95.65	0.00e+00	1194.00
IUUC-Ptr-091048	Pan troglodytes	96.15	0.00e+00	1233.00
IUUC-Pan-091973	Papio anubis	91.20	0.00e+00	1177.00
IUUC-Psi-093586	Pelodiscus sinensis	96.41	0.00e+00	1148.00
IUUC-Pfo-097518	Poecilia formosa	84.82	0.00e+00	1060.00
IUUC-Pab-097539	Pongo abelii	92.06	0.00e+00	1203.00
IUUC-Pca-101137	Procavia capensis	85.89	0.00e+00	1098.00
IUUC-Rno-105314	Rattus norvegicus	95.66	0.00e+00	1157.00
IUUC-Ssc-116408	Sus scrofa	95.88	0.00e+00	1243.00
IUUC-Tgu-117068	Taeniopygia guttata	95.74	0.00e+00	1242.00
IUUC-Tru-118782	Takifugu rubripes	82.06	0.00e+00	1031.00
IUUC-Tsy-118884	Tarsius syrichta	82.97	0.00e+00	1050.00
IUUC-Tni-120404	Tetraodon nigroviridis	84.04	0.00e+00	1079.00
IUUC-Tbe-128013	Tupaia belangeri	88.10	0.00e+00	1164.00
IUUC-Vpa-130577	Vicugna pacos	84.76	3.00e-162	565.00
IUUC-Xtr-132974	Xenopus tropicalis	95.35	0.00e+00	1199.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence