iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mga-060106

Ensembl Protein ID

ENSMGAP00000017322.1

UniProt Accession

G3UP34; G3UP34_MELGA

Protein Name

Uncharacterized protein

Gene Name

VAV2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMGAG00000006722.2	ENSMGAT00000020158.1	ENSMGAP00000017322.1
ENSMGAG00000006722.2	ENSMGAT00000007625.2	ENSMGAP00000006863.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	1.90e-18	65.9	811	862

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 8    vlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvek 61
           + y++ a +  eL+l++Gdvv++ +    d+gW+kg  e++g+ G fP+ +ve+
   Q: 811  ARYNFAARDMRELSLREGDVVKIYSRIGGDQGWWKG--ETNGRVGWFPSTYVEE 862
           67**********************************..9*************86 PP

Organism

Meleagris gallopavo

Protein Sequence
(Fasta)

MEEWRQCGRW LIDCKVLPPN HRVVWPSAVV FDLAQALRDG VLLCQLLHNL PGSIDLKDIN 60
FRPQMSQFLC LKNIRTFLKV CHDKFGLRNS DLFDPFDLFD VRDFGKVISA VSRLSFHSIA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGAGGAGT GGCGGCAGTG CGGGCGGTGG TTGATCGACT GCAAAGTTTT GCCCCCCAAC 60
CACCGCGTGG TTTGGCCCTC GGCGGTGGTC TTCGACCTGG CGCAGGCGCT GCGGGACGGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0344--Guanine-nucleotide releasing factor
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0727--SH2 domain
KW-0728--SH3 domain
KW-0862--Zinc

Interpro

IPR022613--CAMSAP_CH
IPR001715--CH-domain
IPR000219--DH-domain
IPR001331--GDS_CDC24_CS
IPR002219--PE/DAG-bd
IPR011993--PH_dom-like
IPR001849--PH_domain
IPR000980--SH2
IPR011511--SH3_2
IPR001452--SH3_domain

PROSITE

PS50021--CH
PS00741--DH_1
PS50010--DH_2
PS50003--PH_DOMAIN
PS50001--SH2
PS50002--SH3
PS00479--ZF_DAG_PE_1
PS50081--ZF_DAG_PE_2

Pfam

PF00130--C1_1
PF11971--CAMSAP_CH
PF00169--PH
PF00621--RhoGEF
PF00017--SH2
PF07653--SH3_2

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN

SMART

SM00109--C1
SM00033--CH
SM00233--PH
SM00325--RhoGEF
SM00252--SH2
SM00326--SH3

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005886--C:plasma membrane
GO:0046872--F:metal ion binding
GO:0005089--F:Rho guanyl-nucleotide exchange factor activity
GO:0016477--P:cell migration
GO:0030032--P:lamellipodium assembly
GO:0043552--P:positive regulation of phosphatidylinositol 3-kinase activity
GO:0030193--P:regulation of blood coagulation
GO:0008361--P:regulation of cell size
GO:0010468--P:regulation of gene expression
GO:0035023--P:regulation of Rho protein signal transduction
GO:0007264--P:small GTPase mediated signal transduction

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001437	Ailuropoda melanoleuca	88.25	0.00e+00	1401.00
IUUC-Apl-003262	Anas platyrhynchos	97.93	0.00e+00	1632.00
IUUC-Aca-004628	Anolis carolinensis	68.38	0.00e+00	947.00
IUUC-Ath-007352	Arabidopsis thaliana	34.29	2.00e-03	37.00
IUUC-Ame-011608	Astyanax mexicanus	80.09	0.00e+00	1424.00
IUUC-Bta-013147	Bos taurus	89.43	0.00e+00	1262.00
IUUC-Cja-018877	Callithrix jacchus	87.89	0.00e+00	1347.00
IUUC-Cfa-020315	Canis familiaris	86.28	0.00e+00	1192.00
IUUC-Cpo-021543	Cavia porcellus	88.32	0.00e+00	1273.00
IUUC-Csa-024204	Chlorocebus sabaeus	88.50	0.00e+00	1529.00
IUUC-Cin-025115	Ciona intestinalis	36.42	5.00e-144	504.00
IUUC-Csv-025995	Ciona savignyi	36.44	1.00e-147	516.00
IUUC-Dre-028308	Danio rerio	82.45	0.00e+00	1448.00
IUUC-Dno-029584	Dasypus novemcinctus	83.31	0.00e+00	1105.00
IUUC-Dor-031014	Dipodomys ordii	78.16	0.00e+00	1165.00
IUUC-Eca-033448	Equus caballus	87.36	0.00e+00	1498.00
IUUC-Eeu-035182	Erinaceus europaeus	80.05	0.00e+00	643.00
IUUC-Fca-035460	Felis catus	88.01	0.00e+00	1264.00
IUUC-Fal-036684	Ficedula albicollis	95.40	0.00e+00	1623.00
IUUC-Gmo-038816	Gadus morhua	75.80	0.00e+00	1109.00
IUUC-Gga-040999	Gallus gallus	96.20	0.00e+00	1626.00
IUUC-Gac-041353	Gasterosteus aculeatus	77.34	0.00e+00	1164.00
IUUC-Ggo-044558	Gorilla gorilla	90.32	0.00e+00	1539.00
IUUC-Hsa-046208	Homo sapiens	90.43	0.00e+00	1541.00
IUUC-Itr-047931	Ictidomys tridecemlineatus	86.70	0.00e+00	1162.00
IUUC-Loc-052827	Lepisosteus oculatus	80.16	0.00e+00	1457.00
IUUC-Laf-054009	Loxodonta africana	86.88	0.00e+00	1478.00
IUUC-Mcc-055054	Macaca mulatta	90.32	0.00e+00	1539.00
IUUC-Mmr-061118	Microcebus murinus	89.86	0.00e+00	1535.00
IUUC-Mdo-062380	Monodelphis domestica	87.76	0.00e+00	1274.00
IUUC-Mmu-063135	Mus musculus	91.71	0.00e+00	1577.00
IUUC-Mpu-066135	Mustela putorius furo	85.41	0.00e+00	1377.00
IUUC-Nle-069465	Nomascus leucogenys	83.98	0.00e+00	1410.00
IUUC-Ont-071945	Oreochromis niloticus	81.64	0.00e+00	1420.00
IUUC-Oan-073384	Ornithorhynchus anatinus	87.97	0.00e+00	1201.00
IUUC-Ola-087499	Oryzias latipes	76.36	0.00e+00	1084.00
IUUC-Oga-088444	Otolemur garnettii	86.66	0.00e+00	1246.00
IUUC-Oar-089576	Ovis aries	84.87	0.00e+00	1172.00
IUUC-Ptr-090507	Pan troglodytes	91.47	0.00e+00	1548.00
IUUC-Pan-092325	Papio anubis	88.82	0.00e+00	1508.00
IUUC-Psi-094021	Pelodiscus sinensis	91.93	0.00e+00	1548.00
IUUC-Pma-094372	Petromyzon marinus	53.92	0.00e+00	712.00
IUUC-Pfo-096732	Poecilia formosa	81.65	0.00e+00	1431.00
IUUC-Pab-098426	Pongo abelii	73.95	0.00e+00	1095.00
IUUC-Pca-100295	Procavia capensis	89.07	0.00e+00	1427.00
IUUC-Rno-105332	Rattus norvegicus	90.90	0.00e+00	1509.00
IUUC-Sha-106529	Sarcophilus harrisii	92.33	0.00e+00	1248.00
IUUC-Ssc-116176	Sus scrofa	88.85	0.00e+00	1382.00
IUUC-Tgu-116917	Taeniopygia guttata	97.13	0.00e+00	1486.00
IUUC-Tru-118398	Takifugu rubripes	80.22	0.00e+00	1014.00
IUUC-Tni-120819	Tetraodon nigroviridis	80.55	0.00e+00	1226.00
IUUC-Xtr-132747	Xenopus tropicalis	79.86	0.00e+00	1367.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence