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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Ath-006748
UUCD1 version UUC-ArT-00624
Ensembl Protein ID AT5G46210.1
UniProt Accession Q8LGH4; Q84LL5; Q8RWT9; Q9FGP0; CUL4_ARATH
Genbank Protein ID CAC85265.1; BAB08502.1; AED95353.1; AAM14063.1; AAM60859.1
Protein Name Cullin-4
Genbank Nucleotide ID AJ318018; AB025620; CP002688; AY091113; AY084267
Gene Name CUL4; At5g46210; MDE13.3
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
AT5G46210 AT5G46210.1 AT5G46210.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
Protein-protein Interaction
iRefIndexPINAHINTMentha
Post-translational Modifications (PTMs)
dbPPTdbPTM
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/Cullin 9.00e-185 616.8 98 693
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/Cullin
   S: 1    klreavkkilrqesvkkeyeelytavynlclskvgaklYkklkevleefi.kqvkkkveesedeq.lLktynreWekfreqlkvlrkifayldrtyvk 96
           kl++a+++i  ++++  ++e ly+av nlcl+k++ klY+++++ +ee+i +++++ v +++d + +L  ++++W++f+ q+ ++r+i + ldr+yv 
   Q: 98   KLQSAIRAIFLKKKISFDLESLYQAVDNLCLHKLDGKLYDQIEKECEEHIsAALQSLVGQNTDLTvFLSRVEKCWQDFCDQMLMIRSIALTLDRKYVI 195
           5899**********************************************888999***999*999******************************** PP
   S: 97   kskkvsevrkLaldlwrkeived..ikkrllelllklieaeRkgeavdrrllsgvveslveLslnklaiykesFEakfleatqefykaesaeflqene 192
           ++ +v + ++++l+l+rk++     +++r+++ ll +ie+eR  eav+r lls + +++  L+     iy esFE++fle t+efy+ae  +++q+++
   Q: 196  QNPNVRSLWEMGLQLFRKHLSLApeVEQRTVKGLLSMIEKERLAEAVNRTLLSHLLKMFTALG-----IYMESFEKPFLEGTSEFYAAEGMKYMQQSD 288
           ******************9865556************************************96.....****************************** PP
   S: 193  vdeYlkkvearlneeeeraaryleestetkLlevvekeliakhlesll.aelvallrdkktedlsrmykLlsrvlngleellkeleshikeqgkaalt 289
           v eYlk+ve rl+ee+er+  y ++ t ++L+++ve++l++ h+  +l +++  l++  +tedl+rm  L+srv n le l++ l+s++++ g+++++
   Q: 289  VPEYLKHVEGRLHEENERCILYIDAVTRKPLITTVERQLLERHILVVLeKGFTTLMDGRRTEDLQRMQTLFSRV-NALESLRQALSSYVRKTGQKIVM 385
           *******************************************988887************************9.68********************* PP
   S: 290  aeekekdpkkyVerllelknklqklvseaFnndakFlkaldkafetfvnknsvlkaakspEllAryiDqlLrksskglteeeleaqldkvllvfkyis 387
           +eek+kd   +V++ll++k  l+ + +e+F +++ F ++++ +fe+ +n +      + +El+A++ D++Lr+++kg+ eeele  l+kvl++f++i+
   Q: 386  DEEKDKD---MVQSLLDFKASLDIIWEESFYKNESFGNTIKDSFEHLINLR----QNRPAELIAKFLDEKLRAGNKGTSEEELESVLEKVLVLFRFIQ 476
           *******...****************************************9....56666************************************** PP
   S: 388  ekdvFekyYkkhLakRLlsgksasseaEesviekLkeecgaeftskLerMfqdlkvSedlnrqFkeeken.teesesvelsvlvLsagaWptasetek 484
           +kdvFe++Ykk+LakRLl+gksas +aE+s+i+kLk+ecg +ft+kLe+Mf+d+++S+++n+ Fk+  ++ t+   ++e+sv vL++g+Wpt++ +  
   Q: 477  GKDVFEAFYKKDLAKRLLLGKSASIDAEKSMISKLKTECGSQFTNKLEGMFKDIELSKEINESFKQSSQArTKLPSGIEMSVHVLTTGYWPTYPPMD- 573
           *****************************************************************887761555699*****************988. PP
   S: 485  vsLPaelektiekfeefYlekhsgRkLqWqhtlgraelkaelkkgkyelqVstfQmavLLafnnsekvsveelkkatelpeeeLrrtlqsLvsskkqv 582
           v+LP+el+ ++++f+efYl+k sgR+L Wq +lg++ lka ++kgk+el+Vs fQ++vL++fn+  k+s+e++k++t ++++eLrrtlqsL+++k +v
   Q: 574  VKLPHELNVYQDIFKEFYLSKYSGRRLMWQNSLGHCVLKADFSKGKKELAVSLFQAVVLMLFNDAMKLSFEDIKDSTSIEDKELRRTLQSLACGKVRV 671
           ************************************************************************************************** PP
   S: 583  lkkepeskeieeedlfsvNqef 604
           l+k+p+++++e++d f +N+ef
   Q: 672  LQKNPKGRDVEDGDEFEFNDEF 693
           *********************9 PP
   
Organism Arabidopsis thaliana
Functional Description
(View)

Functional Description


     Component of the CUL4-RBX1-CDD (COP10-DDB1a-DET1) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Participates in the CDD complex to light-mediated control of development. May repress photomorphogenesis through enhancing COP1 E3 ubiquitin-protein ligase activity. Acts together with the CUL4-DDB1-COP1-SPA E3 ubiquitin-protein ligase complexes in the repression of photomorphogenesis and flowering time. Component ot the CUL4-RBX1-DDB1-PRL1 E3 ubiquitin-protein ligase complex which mediates ubiquitination and subsequent degradation of AKIN10. Component of the CUL4-RBX1-DDB1-DWA1/DWA2 E3 ubiquitin-protein ligase complex that acts as negative regulator in abscisic acid (ABA) signaling and may target ABI5 for degradation.
 Component of the CUL4-RBX1-CDD (COP10-DDB1a-DET1) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Participates in the CDD complex to light-mediated control of development. May repress photomorphogenesis through enhancing COP1 E3 ubiquitin-protein ligase activity. Acts together with the CUL4-DDB1-COP1-SPA E3 ubiquitin-protein ligase complexes in the repression of photomorphogenesis and flowering time. Component ot the CUL4-RBX1-DDB1-PRL1 E3 ubiquitin-protein ligase complex which mediates ubiquitination and subsequent degradation of AKIN10. Component of the CUL4-RBX1-DDB1-DWA1/DWA2 E3 ubiquitin-protein ligase complex that acts as negative regulator in abscisic acid (ABA) signaling and may target ABI5 for degradation.
Protein Sequence
(Fasta)
MSLPTKRSTF SAASASDDSS YSSPPMKKAK NDLHHSPQHP NTADKVVGFH MEEDPTPAAA 60
NLSRKKATLP QPTKKFVIKL NKAKPTLPTN FEENTWEKLQ SAIRAIFLKK KISFDLESLY 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Ath-006748|E3,Cullin|Arabidopsis thaliana
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GGGTCGGGTC TAAATCGCGA GTTTTCGCGT AGGTTTGAGC AAAAAAAAAA AGAGAGAGAG 60
TGCACAGTGC GCTTTTGGTA GAGAGAAAGG GTTGTTATTA TTTAGGATTG ATGTCTTCTT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Ath-006748|E3,Cullin|Arabidopsis thaliana
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0938--Abscisic acid signaling pathway
KW-0181--Complete proteome
KW-1017--Isopeptide bond
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
Interpro

IPR016157--Cullin_CS
IPR016158--Cullin_homology
IPR001373--Cullin_N
IPR019559--Cullin_neddylation_domain
IPR016159--Cullin_repeat-like_dom
IPR011991--WHTH_DNA-bd_dom
PROSITE

PS01256--CULLIN_1
PS50069--CULLIN_2
Pfam

PF00888--Cullin
PF10557--Cullin_Nedd8
SMART

SM00182--CULLIN
SM00884--Cullin_Nedd8
Gene Ontology

GO:0080008--C:Cul4-RING E3 ubiquitin ligase complex
GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0000151--C:ubiquitin ligase complex
GO:0031625--F:ubiquitin protein ligase binding
GO:0009738--P:abscisic acid-activated signaling pathway
GO:0048825--P:cotyledon development
GO:0006281--P:DNA repair
GO:0009908--P:flower development
GO:0010154--P:fruit development
GO:0009755--P:hormone-mediated signaling pathway
GO:0048366--P:leaf development
GO:0010100--P:negative regulation of photomorphogenesis
GO:0009640--P:photomorphogenesis
GO:0000209--P:protein polyubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0048367--P:shoot system development
GO:0048575--P:short-day photoperiodism, flowering
GO:0010182--P:sugar mediated signaling pathway
KEGG ath:AT5G46210
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000285 Aegilops tauschii 77.76 0.00e+00 1169.00
IUUC-Aml-002062 Ailuropoda melanoleuca 57.09 0.00e+00 843.00
IUUC-Atr-002727 Amborella trichopoda 81.27 0.00e+00 1182.00
IUUC-Apl-004157 Anas platyrhynchos 57.49 0.00e+00 851.00
IUUC-Aca-004430 Anolis carolinensis 58.60 0.00e+00 841.00
IUUC-Aly-006547 Arabidopsis lyrata 98.11 0.00e+00 1511.00
IUUC-Acl-008359 Aspergillus clavatus 34.38 3.00e-119 422.00
IUUC-Afl-008567 Aspergillus flavus 36.86 9.00e-130 457.00
IUUC-Afu-008833 Aspergillus fumigatus 35.14 3.00e-128 452.00
IUUC-Ani-009373 Aspergillus nidulans 36.34 5.00e-133 468.00
IUUC-Ang-009622 Aspergillus niger 36.91 9.00e-133 467.00
IUUC-Aor-010241 Aspergillus oryzae 37.01 1.00e-129 456.00
IUUC-Ate-010251 Aspergillus terreus 37.82 3.00e-137 481.00
IUUC-Ame-011580 Astyanax mexicanus 58.55 0.00e+00 834.00
IUUC-Bgr-012219 Blumeria graminis 36.12 4.00e-113 401.00
IUUC-Bta-013244 Bos taurus 57.09 0.00e+00 842.00
IUUC-Bci-013744 Botrytis cinerea 36.86 1.00e-122 433.00
IUUC-Bdi-014223 Brachypodium distachyon 78.17 0.00e+00 1186.00
IUUC-Bol-015666 Brassica oleracea 90.30 0.00e+00 1424.00
IUUC-Bra-017794 Brassica rapa 89.43 0.00e+00 1415.00
IUUC-Cja-019180 Callithrix jacchus 57.09 0.00e+00 843.00
IUUC-Cfa-021189 Canis familiaris 57.22 0.00e+00 843.00
IUUC-Cpo-021928 Cavia porcellus 58.56 0.00e+00 842.00
IUUC-Cre-022739 Chlamydomonas reinhardtii 53.31 0.00e+00 689.00
IUUC-Csa-023831 Chlorocebus sabaeus 57.09 0.00e+00 843.00
IUUC-Cho-024899 Choloepus hoffmanni 63.37 0.00e+00 633.00
IUUC-Cin-025727 Ciona intestinalis 54.96 0.00e+00 640.00
IUUC-Csv-026117 Ciona savignyi 45.19 0.00e+00 669.00
IUUC-Cgl-026761 Colletotrichum gloeosporioides 36.04 2.00e-125 442.00
IUUC-Cme-027355 Cyanidioschyzon merolae 32.76 1.00e-107 383.00
IUUC-Dre-027916 Danio rerio 57.52 0.00e+00 832.00
IUUC-Dno-028879 Dasypus novemcinctus 54.76 0.00e+00 765.00
IUUC-Dor-030698 Dipodomys ordii 57.84 0.00e+00 803.00
IUUC-Dse-031159 Dothistroma septosporum 34.30 4.00e-119 421.00
IUUC-Dme-031652 Drosophila melanogaster 54.34 0.00e+00 784.00
IUUC-Ete-033101 Echinops telfairi 54.70 0.00e+00 751.00
IUUC-Eca-033952 Equus caballus 58.10 0.00e+00 835.00
IUUC-Eeu-034767 Erinaceus europaeus 59.11 0.00e+00 789.00
IUUC-Fca-036211 Felis catus 56.88 0.00e+00 837.00
IUUC-Fal-037248 Ficedula albicollis 57.62 0.00e+00 849.00
IUUC-Fox-037854 Fusarium oxysporum 36.68 1.00e-116 413.00
IUUC-Fso-038138 Fusarium solani 36.35 1.00e-125 442.00
IUUC-Gmo-038754 Gadus morhua 58.21 0.00e+00 831.00
IUUC-Ggr-040003 Gaeumannomyces graminis 34.71 1.00e-96 347.00
IUUC-Gga-041002 Gallus gallus 57.89 0.00e+00 849.00
IUUC-Gac-041555 Gasterosteus aculeatus 58.40 0.00e+00 830.00
IUUC-Gma-043960 Glycine max 85.66 0.00e+00 1241.00
IUUC-Ggo-045468 Gorilla gorilla 56.21 0.00e+00 792.00
IUUC-Hsa-046848 Homo sapiens 57.09 0.00e+00 844.00
IUUC-Hvu-047510 Hordeum vulgare 70.71 0.00e+00 664.00
IUUC-Itr-048365 Ictidomys tridecemlineatus 57.22 0.00e+00 844.00
IUUC-Lch-049858 Latimeria chalumnae 58.13 0.00e+00 851.00
IUUC-Lpe-051446 Leersia perrieri 80.43 0.00e+00 1206.00
IUUC-Loc-051804 Lepisosteus oculatus 57.50 0.00e+00 820.00
IUUC-Lma-053080 Leptosphaeria maculans 34.16 7.00e-129 454.00
IUUC-Laf-053701 Loxodonta africana 57.28 0.00e+00 842.00
IUUC-Mcc-055538 Macaca mulatta 56.55 0.00e+00 828.00
IUUC-Meu-056492 Macropus eugenii 46.63 1.00e-78 287.00
IUUC-Mor-057102 Magnaporthe oryzae 34.53 2.00e-115 409.00
IUUC-Mpo-057342 Magnaporthe poae 35.36 5.00e-100 358.00
IUUC-Mtr-058660 Medicago truncatula 84.20 0.00e+00 1248.00
IUUC-Mla-058936 Melampsora laricipopulina 39.55 5.00e-107 381.00
IUUC-Mga-059754 Meleagris gallopavo 57.49 0.00e+00 851.00
IUUC-Mvi-060455 Microbotryum violaceum 42.95 4.00e-147 514.00
IUUC-Mmr-060870 Microcebus murinus 56.95 0.00e+00 839.00
IUUC-Mdo-062015 Monodelphis domestica 57.22 0.00e+00 842.00
IUUC-Mmu-063751 Mus musculus 56.95 0.00e+00 845.00
IUUC-Mac-064443 Musa acuminata 77.47 0.00e+00 1240.00
IUUC-Mpu-065903 Mustela putorius furo 57.22 0.00e+00 843.00
IUUC-Mlu-068213 Myotis lucifugus 58.56 0.00e+00 842.00
IUUC-Nfi-068363 Neosartorya fischeri 35.50 8.00e-129 454.00
IUUC-Ncr-068950 Neurospora crassa 34.99 3.00e-114 405.00
IUUC-Nle-069480 Nomascus leucogenys 57.09 0.00e+00 843.00
IUUC-Ont-071562 Oreochromis niloticus 56.00 0.00e+00 821.00
IUUC-Oan-073607 Ornithorhynchus anatinus 57.62 0.00e+00 848.00
IUUC-Ocu-074446 Oryctolagus cuniculus 58.56 0.00e+00 841.00
IUUC-Oba-075198 Oryza barthii 80.49 0.00e+00 1200.00
IUUC-Obr-076095 Oryza brachyantha 80.08 0.00e+00 1198.00
IUUC-Ogl-077032 Oryza glaberrima 80.49 0.00e+00 1201.00
IUUC-Ogu-078051 Oryza glumaepatula 80.49 0.00e+00 1201.00
IUUC-Oin-079399 Oryza indica 74.35 0.00e+00 1062.00
IUUC-Olo-080988 Oryza longistaminata 79.38 0.00e+00 1192.00
IUUC-Ome-081600 Oryza meridionalis 79.38 0.00e+00 1192.00
IUUC-Oni-082623 Oryza nivara 79.51 0.00e+00 1192.00
IUUC-Opu-083762 Oryza punctata 78.64 0.00e+00 1188.00
IUUC-Oru-084499 Oryza rufipogon 80.49 0.00e+00 1200.00
IUUC-Ola-087157 Oryzias latipes 57.20 0.00e+00 831.00
IUUC-Olu-087650 Ostreococcus lucimarinus 53.05 0.00e+00 687.00
IUUC-Oga-088416 Otolemur garnettii 56.55 0.00e+00 816.00
IUUC-Oar-090230 Ovis aries 57.09 0.00e+00 842.00
IUUC-Ptr-091153 Pan troglodytes 57.09 0.00e+00 843.00
IUUC-Pan-091729 Papio anubis 57.09 0.00e+00 843.00
IUUC-Psi-093773 Pelodiscus sinensis 57.37 0.00e+00 845.00
IUUC-Pma-094678 Petromyzon marinus 53.51 7.00e-175 606.00
IUUC-Pno-094946 Phaeosphaeria nodorum 34.52 3.00e-108 385.00
IUUC-Ppa-095688 Physcomitrella patens 75.63 0.00e+00 1155.00
IUUC-Pfo-097037 Poecilia formosa 56.38 0.00e+00 813.00
IUUC-Pab-097622 Pongo abelii 58.08 0.00e+00 813.00
IUUC-Pop-099751 Populus trichocarpa 72.01 5.00e-167 580.00
IUUC-Pca-100391 Procavia capensis 54.56 9.00e-177 612.00
IUUC-Ppe-101142 Prunus persica 85.71 0.00e+00 1273.00
IUUC-Pva-102995 Pteropus vampyrus 62.23 3.00e-180 624.00
IUUC-Pgr-103334 Puccinia graminis 36.91 3.00e-101 362.00
IUUC-Ptt-103903 Puccinia triticina 40.64 1.00e-86 314.00
IUUC-Pte-104167 Pyrenophora teres 34.26 4.00e-129 454.00
IUUC-Pyt-104736 Pyrenophora triticirepentis 34.06 9.00e-128 450.00
IUUC-Rno-106119 Rattus norvegicus 56.82 0.00e+00 843.00
IUUC-Sha-106958 Sarcophilus harrisii 57.35 0.00e+00 848.00
IUUC-Sja-107940 Schizosaccharomyces japonicus 33.57 2.00e-101 362.00
IUUC-Spo-108109 Schizosaccharomyces pombe 33.04 8.00e-105 374.00
IUUC-Ssl-108537 Sclerotinia sclerotiorum 37.34 5.00e-122 431.00
IUUC-Smo-108872 Selaginella moellendorffii 77.42 0.00e+00 1206.00
IUUC-Sit-110626 Setaria italica 79.97 0.00e+00 1195.00
IUUC-Sly-111497 Solanum lycopersicum 85.44 0.00e+00 1260.00
IUUC-Sar-113581 Sorex araneus 50.47 3.00e-172 597.00
IUUC-Sbi-113931 Sorghum bicolor 79.84 0.00e+00 1196.00
IUUC-Sre-114943 Sporisorium reilianum 37.92 6.00e-125 441.00
IUUC-Ssc-116133 Sus scrofa 56.56 0.00e+00 790.00
IUUC-Tgu-116462 Taeniopygia guttata 57.49 0.00e+00 843.00
IUUC-Tru-118299 Takifugu rubripes 57.89 0.00e+00 838.00
IUUC-Tsy-119517 Tarsius syrichta 69.14 4.00e-143 501.00
IUUC-Tni-119798 Tetraodon nigroviridis 56.66 0.00e+00 810.00
IUUC-Tca-121626 Theobroma cacao 87.38 0.00e+00 1277.00
IUUC-Tre-121907 Trichoderma reesei 35.14 3.00e-117 415.00
IUUC-Tvi-122568 Trichoderma virens 34.96 1.00e-118 419.00
IUUC-Tae-123442 Triticum aestivum 78.06 0.00e+00 1176.00
IUUC-Tur-126032 Triticum urartu 79.44 0.00e+00 1163.00
IUUC-Tme-127162 Tuber melanosporum 39.87 7.00e-138 484.00
IUUC-Tbe-127658 Tupaia belangeri 57.71 0.00e+00 807.00
IUUC-Ttr-129112 Tursiops truncatus 53.21 0.00e+00 760.00
IUUC-Uma-129531 Ustilago maydis 36.32 1.00e-108 387.00
IUUC-Vda-129701 Verticillium dahliae 35.22 2.00e-127 449.00
IUUC-Vpa-130217 Vicugna pacos 50.80 0.00e+00 712.00
IUUC-Vvi-131133 Vitis vinifera 86.14 0.00e+00 1264.00
IUUC-Xtr-132761 Xenopus tropicalis 56.95 0.00e+00 808.00
IUUC-Xma-134149 Xiphophorus maculatus 57.30 0.00e+00 834.00
IUUC-Zma-135529 Zea mays 79.56 0.00e+00 1194.00
Created Date 25-Jun-2017

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