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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-064396
UUCD1 version UUC-MuM-00760
Ensembl Protein ID ENSMUSP00000058968.6
UniProt Accession Q8K0V2; DCNL3_MOUSE
Genbank Protein ID BAC26261.1; BAE33084.1; AAH30335.1
Protein Name DCN1-like protein 3; DCUN1 domain-containing protein 3; Defective in cullin neddylation protein 1-like protein 3
Genbank Nucleotide ID AK029043; AK155160; BC030335
Gene Name Dcun1d3
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000048787.13 ENSMUST00000059851.13 ENSMUSP00000058968.6
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemiRTarBasemicroRNATRANSFAC
RepTarmiRNAMapRAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
dbPAFPhosphositePlus
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/DCUN1 2.10e-84 283.5 87 278
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/DCUN1
   S: 2    skkkleelferYkdpqedligieglekfcedlgvdpediavLvlawkleaatlcefsreefldgltalgcdsieklqeklktleselkd 90
           s ++leelf+rYkd++ed+i++eg+e+fc+dl+vdp++++vL+lawk++aat+c+f+r+ef+dg++a+++dsi+++++++++l +e+k+
   Q: 87   SLQRLEELFRRYKDEREDAILEEGMERFCNDLCVDPTEFRVLLLAWKFQAATMCKFTRKEFFDGCKAISADSIDGICARFPSLLTEAKQ 175
           679************************************************************************************** PP
   S: 91   eqkfkdiYrfafnfakd..kgqksldldtaialwkLllaerefklldawlkfLeee..kkksiskDtWnllLefskviakdlsnYdeeg 175
           e+kfkd+Yrf+f+f++d  +gq+sl++++aialwkL+++++++++ld+wl+fL+e+  ++k+is+DtWn++L+f++vi +dlsnY+e++
   Q: 176  EDKFKDLYRFTFQFGLDseEGQRSLHREIAIALWKLVFTQNNPPVLDQWLNFLTENpsGIKGISRDTWNMFLNFTQVIGPDLSNYSEDE 264
           ***************998899**********************************9889****************************** PP
   S: 176  aWPvliDefveylk 189
           aWP+l+D+fve+++
   Q: 265  AWPSLFDTFVEWEM 278
           ************85 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Antagonizes DCUN1D1-mediated CUL1 neddylation by sequestering CUL1 at the cell membrane.
 Antagonizes DCUN1D1-mediated CUL1 neddylation by sequestering CUL1 at the cell membrane.
Protein Sequence
(Fasta)
MGQCVTKCKN PSSTLGSKNG DRDPSNKSHS RRGASHREEQ VPPCGKPAGD ILVNGTKKAE 60
AATEACQLPT SSGDAGRESK TNAEESSLQR LEELFRRYKD EREDAILEEG MERFCNDLCV 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-064396|E3,DCUN1|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CCTTTCCCCA GTCCCCCGCG ACTGGAGCCG GCGTCTCCAT CCTTACACTC ACTCAGCGTC 60
ACTCCTGCTT TTCCCCACCC ACAGGAGCCG GCTGGGAAGA GGCGGTGCCA GGAGCTCTGC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-064396|E3,DCUN1|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0449--Lipoprotein
KW-0472--Membrane
KW-0519--Myristate
KW-1185--Reference proteome
Interpro

IPR014764--DCN-prot
IPR005176--PONY_dom
PROSITE

PS51229--DCUN1
Pfam

PF03556--Cullin_binding
Gene Ontology

GO:0005737--C:cytoplasm
GO:0048471--C:perinuclear region of cytoplasm
GO:0005886--C:plasma membrane
GO:0000151--C:ubiquitin ligase complex
GO:0097602--F:cullin family protein binding
GO:0031624--F:ubiquitin conjugating enzyme binding
GO:0032182--F:ubiquitin-like protein binding
GO:0030308--P:negative regulation of cell growth
GO:0043065--P:positive regulation of apoptotic process
GO:0051443--P:positive regulation of ubiquitin-protein transferase activity
GO:0045116--P:protein neddylation
GO:0010332--P:response to gamma radiation
GO:0009314--P:response to radiation
GO:0010225--P:response to UV-C
KEGG mmu:233805
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001689 Ailuropoda melanoleuca 95.39 4.00e-164 570.00
IUUC-Apl-003497 Anas platyrhynchos 81.91 3.00e-143 501.00
IUUC-Aca-004961 Anolis carolinensis 79.28 1.00e-144 505.00
IUUC-Aor-009902 Aspergillus oryzae 33.33 2.00e-11 61.20
IUUC-Ame-011413 Astyanax mexicanus 64.39 1.00e-100 359.00
IUUC-Bta-013338 Bos taurus 96.05 9.00e-166 575.00
IUUC-Cja-019458 Callithrix jacchus 97.70 4.00e-169 586.00
IUUC-Cfa-020160 Canis familiaris 95.72 9.00e-165 572.00
IUUC-Cpo-021835 Cavia porcellus 96.38 2.00e-157 548.00
IUUC-Csa-023328 Chlorocebus sabaeus 98.03 1.00e-169 588.00
IUUC-Cho-024888 Choloepus hoffmanni 94.04 2.00e-162 565.00
IUUC-Cin-025134 Ciona intestinalis 55.61 5.00e-60 224.00
IUUC-Csv-025904 Ciona savignyi 50.41 2.00e-32 130.00
IUUC-Dre-027780 Danio rerio 64.39 9.00e-98 349.00
IUUC-Dno-028866 Dasypus novemcinctus 95.39 3.00e-163 567.00
IUUC-Dor-030387 Dipodomys ordii 95.72 2.00e-165 574.00
IUUC-Dme-032081 Drosophila melanogaster 45.61 4.00e-48 185.00
IUUC-Eca-033857 Equus caballus 95.72 8.00e-166 575.00
IUUC-Eeu-034825 Erinaceus europaeus 87.50 2.00e-148 518.00
IUUC-Fca-036130 Felis catus 96.05 1.00e-165 575.00
IUUC-Fal-037296 Ficedula albicollis 82.57 9.00e-143 499.00
IUUC-Gmo-039626 Gadus morhua 64.77 2.00e-98 352.00
IUUC-Ggr-039959 Gaeumannomyces graminis 26.64 5.00e-15 76.30
IUUC-Gga-040741 Gallus gallus 81.25 6.00e-140 489.00
IUUC-Gac-042271 Gasterosteus aculeatus 64.75 9.00e-93 333.00
IUUC-Ggo-044727 Gorilla gorilla 98.03 1.00e-169 588.00
IUUC-Hsa-046288 Homo sapiens 97.70 4.00e-169 587.00
IUUC-Itr-049054 Ictidomys tridecemlineatus 97.37 5.00e-177 613.00
IUUC-Lch-050289 Latimeria chalumnae 78.22 3.00e-133 467.00
IUUC-Loc-052455 Lepisosteus oculatus 71.22 1.00e-108 385.00
IUUC-Laf-054369 Loxodonta africana 93.75 1.00e-155 541.00
IUUC-Mcc-055413 Macaca mulatta 78.90 2.00e-122 431.00
IUUC-Meu-056535 Macropus eugenii 86.84 8.00e-153 532.00
IUUC-Mga-059290 Meleagris gallopavo 81.91 4.00e-142 497.00
IUUC-Mmr-060689 Microcebus murinus 97.37 2.00e-168 584.00
IUUC-Mdo-062128 Monodelphis domestica 86.18 6.00e-147 513.00
IUUC-Mpu-065926 Mustela putorius furo 95.39 4.00e-164 570.00
IUUC-Mlu-067044 Myotis lucifugus 93.75 4.00e-170 590.00
IUUC-Nle-069346 Nomascus leucogenys 98.03 1.00e-169 588.00
IUUC-Opr-070682 Ochotona princeps 96.71 5.00e-156 543.00
IUUC-Ont-071772 Oreochromis niloticus 68.46 1.00e-101 362.00
IUUC-Oan-072765 Ornithorhynchus anatinus 83.88 2.00e-145 508.00
IUUC-Ocu-074272 Oryctolagus cuniculus 91.21 4.00e-118 417.00
IUUC-Ola-087561 Oryzias latipes 69.10 8.00e-108 383.00
IUUC-Oga-088440 Otolemur garnettii 76.57 3.00e-123 434.00
IUUC-Oar-089403 Ovis aries 96.38 8.00e-167 579.00
IUUC-Ptr-091384 Pan troglodytes 98.03 1.00e-169 588.00
IUUC-Pan-092650 Papio anubis 98.03 1.00e-169 588.00
IUUC-Psi-093806 Pelodiscus sinensis 82.57 7.00e-135 473.00
IUUC-Pma-094196 Petromyzon marinus 49.85 1.00e-86 313.00
IUUC-Pfo-096584 Poecilia formosa 69.64 2.00e-105 375.00
IUUC-Pab-098605 Pongo abelii 98.03 1.00e-169 588.00
IUUC-Pca-100933 Procavia capensis 77.96 3.00e-114 404.00
IUUC-Pva-102172 Pteropus vampyrus 89.58 5.00e-160 556.00
IUUC-Rno-105406 Rattus norvegicus 99.01 5.00e-180 623.00
IUUC-Sha-106531 Sarcophilus harrisii 86.18 3.00e-152 530.00
IUUC-Sar-113051 Sorex araneus 75.33 8.00e-115 406.00
IUUC-Ssc-115555 Sus scrofa 95.72 1.00e-165 575.00
IUUC-Tgu-117178 Taeniopygia guttata 82.57 4.00e-144 503.00
IUUC-Tru-117876 Takifugu rubripes 65.32 7.00e-106 376.00
IUUC-Tsy-118790 Tarsius syrichta 96.20 4.00e-136 477.00
IUUC-Tni-119673 Tetraodon nigroviridis 65.56 1.00e-107 382.00
IUUC-Tbe-127429 Tupaia belangeri 97.04 2.00e-168 584.00
IUUC-Ttr-128467 Tursiops truncatus 96.05 3.00e-166 577.00
IUUC-Vpa-130376 Vicugna pacos 66.91 7.00e-96 343.00
IUUC-Xtr-132134 Xenopus tropicalis 79.64 1.00e-123 435.00
Created Date 25-Jun-2017

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