iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Cancer Mutation
ICGC	COSMIC	CGAP	IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
AREsite	CircNet	microRNA	TRANSFAC
TargetScan	miRcode	RAID2
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/BCR/BTB_Other: BTB	3.80e-09	38.4	34	99

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/BCR/BTB_Other: BTB

   S: 1    aDvilvvggeeffahkivLaasSsvFyalflmeleesksklmveik.d.vqpevfrallkFlYtgkld 66
           +Dv+l+ +ge ++ah ++L+a+S++F   ++ e + +  +++v+++ + ++ + +r l++FlYt++++
   Q: 34   CDVLLQAEGEAVPAHCCILSACSPFFTERLERERPAQ--GGKVVLElGgLKISTLRKLVDFLYTSEME 99
           8**********************************87..5777777745***************9976 PP

Organism

Homo sapiens

Protein Sequence
(Fasta)

MCSPASPKIL YRNPRFLRLA FLQLHHQQQS DVFCDVLLQA EGEAVPAHCC ILSACSPFFT 60
ERLERERPAQ GGKVVLELGG LKISTLRKLV DFLYTSEMEV SQEEAQDVLS AARQLRVSEL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AATGTTTCCT TAAAAGTGTT AACTTGAAGA TTATACCTGT GGAGCTGGGA TGTGGTGCTC 60
AGGAAGAATA TAAGTAGTCA GCATTGTAGC AGTTGAGTCT CAGTGGTAAT GGAAATGAGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0621--Polymorphism
KW-1185--Reference proteome

Interpro

IPR000210--BTB/POZ_dom
IPR011333--SKP1/BTB/POZ

PROSITE

PS50097--BTB

Pfam

PF00651--BTB

SMART

SM00225--BTB

Gene Ontology

GO:0031463--C:Cul3-RING ubiquitin ligase complex
GO:0016567--P:protein ubiquitination

KEGG

hsa:643376

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001410	Ailuropoda melanoleuca	80.98	0.00e+00	1038.00
IUUC-Aca-004942	Anolis carolinensis	46.21	2.00e-65	242.00
IUUC-Bta-013155	Bos taurus	75.33	0.00e+00	846.00
IUUC-Cja-019452	Callithrix jacchus	87.80	0.00e+00	1163.00
IUUC-Cfa-021093	Canis familiaris	80.85	0.00e+00	1069.00
IUUC-Csa-023681	Chlorocebus sabaeus	95.23	0.00e+00	1310.00
IUUC-Dno-028941	Dasypus novemcinctus	83.22	0.00e+00	1132.00
IUUC-Fca-036261	Felis catus	79.21	0.00e+00	1088.00
IUUC-Ggo-045054	Gorilla gorilla	98.60	0.00e+00	1340.00
IUUC-Itr-048572	Ictidomys tridecemlineatus	82.66	0.00e+00	1078.00
IUUC-Lch-049466	Latimeria chalumnae	56.18	6.00e-22	95.10
IUUC-Mmr-061750	Microcebus murinus	85.17	0.00e+00	1128.00
IUUC-Mmu-064238	Mus musculus	73.53	0.00e+00	983.00
IUUC-Mpu-066842	Mustela putorius furo	79.89	0.00e+00	1119.00
IUUC-Mlu-066967	Myotis lucifugus	81.12	0.00e+00	1081.00
IUUC-Nle-069435	Nomascus leucogenys	95.51	0.00e+00	1323.00
IUUC-Ocu-073990	Oryctolagus cuniculus	80.03	0.00e+00	1006.00
IUUC-Oga-088320	Otolemur garnettii	82.24	0.00e+00	1079.00
IUUC-Oar-089495	Ovis aries	72.42	0.00e+00	887.00
IUUC-Ptr-090667	Pan troglodytes	99.02	0.00e+00	1330.00
IUUC-Pan-092508	Papio anubis	95.65	0.00e+00	1316.00
IUUC-Rno-105877	Rattus norvegicus	74.35	0.00e+00	982.00
IUUC-Sha-106671	Sarcophilus harrisii	62.26	0.00e+00	733.00
IUUC-Spo-108201	Schizosaccharomyces pombe	38.10	4.70e-01	29.30

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence