iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
TRANSFAC
Post-translational Modifications (PTMs)
dbPPT
Protein Expression/Proteomics

Status

Reviewed

Details

Family	Domain	References (PMIDs)
DUB/USP	USP	17554311

Classification

Family	E-value	Score	Start	End
DUB/USP	1.40e-72	245.6	107	440
ULD/UDP/UBQ/UBQ_Other	8.60e-05	23.2	964	1024

Active Site

Position(s)	Description	Evidence
115	Nucleophile
359	Proton acceptor	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}

Domain Profile

DUB/USP

   S: 2    GlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgyeqqDaqEflafl 99
           Gl+Nlg+tCY NS+LQcL++ + +re +++ + + l+       ++++l+++++lf++l  s+k+ v+  +++k+l+      ++  qqD++Efl+ l
   Q: 107  GLTNLGATCYANSILQCLYMNTAFREGVFSVEVHVLK-------QNPVLDQIARLFAQLHASQKSFVDSDAFVKTLEL-----DNGVQQDTHEFLTLL 192
           9*****************************4444444.......468*****************************95.....5567*********** PP
   S: 100  ldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvs...sreepfldlslpvpgkeetkkeslqdcLesf 194
           l+ le+ l                         +   k k++++dlF g++++ ++c +c++ s   s+ e+f+ l+l+v+g +     sl+ +L+++
   Q: 193  LSLLERCL------------------------LHSGVKAKTIVQDLFSGSVSHVTTCSKCGRDSeasSKMEDFYALELNVKGLK-----SLDASLNDY 261
           ********........................4678999*********************988766699***************.....9******** PP
   S: 195  tkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfctspeekqkekkkYeLiavvvHsG.sls 291
            + e+l+g+n+y+c +c+++++a++ +kl++lP+v++++LkR+ f  ++  ++ki+++++fp+ Ld+ + +++++++   k +Y+L+av++H+G  ++
   Q: 262  LSLEQLNGDNQYFCGSCNARVDATRCIKLRTLPPVITFQLKRCIFLPKTTAKKKITSSFSFPQVLDMGSRLAESSQN---KLTYDLSAVLIHKGsAVN 356
           *********************************************************************99996655...89**************** PP
   S: 292  sGHYvayvknekgk.WllfdDskVtevkeeevleetg......................................staYvlfYk 336
           sGHYva++k+ek + W++fdD++V+e+ +   +e ++                                      s+aY+l+Y 
   Q: 357  SGHYVAHIKDEKTGlWWEFDDEHVSELGKRPCNEASSstpqsesngtassgnitdgiqsgssdcrsaiksevfssSDAYMLMYS 440
           **********99999************877777766689999*****************************************6 PP

ULD/UDP/UBQ/UBQ_Other

   S: 10   gseltlkvnpsdtVaeLKekiekklgippeqqrLiykGkiL.eddktLadyglkdgstihl 69
           g  ++lkv+ ++tV +LK++i ++lg+  e q L    k++ ++  tLad ++++g+ + +
   Q: 964  GNLTSLKVSATTTVYQLKMMIWELLGVMKENQELHKGSKVIdQESATLADMNIFPGDRLWV 1024
           5668899*************************************************99855 PP

Organism

Arabidopsis thaliana

Functional Description
(View)

Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins. Deubiquitinates H2BK143ub1 of histone H2B.

Protein Sequence
(Fasta)

MSRPNTRNKN KRQRPDAVDS SSQILRKIHE ANDVTDDDIN QLFMIWKPVC QGCRVNTRDN 60
PNCFCGLVPP LNGSRKSGLW QKTSEIIQSL GPDPTLDRRD SESTPAGLTN LGATCYANSI 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CAAAGGGCAA AAAAAAAGGT GAAATAGAAT TAACAAGGAA AAAAAAAAAA GATTTCGCTG 60
TGGAGAAGAA GAAGACGAAG GAGTAAAAGA AGAAGACGGA GAAGTTTGAG CTTGTGAAGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0539--Nucleus
KW-0645--Protease
KW-1185--Reference proteome
KW-0677--Repeat
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR006615--Pept_C19_DUSP
IPR001394--Peptidase_C19_UCH
IPR029071--Ubiquitin-rel_dom
IPR000626--Ubiquitin_dom
IPR033841--USP48
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS51283--DUSP
PS50053--UBIQUITIN_2
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH

SMART

SM00695--DUSP

Gene Ontology

GO:0005730--C:nucleolus
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0016579--P:protein deubiquitination
GO:0048316--P:seed development
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

ath:AT3G49600

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000130	Aegilops tauschii	55.66	0.00e+00	1110.00
IUUC-Aml-001357	Ailuropoda melanoleuca	31.14	5.00e-77	282.00
IUUC-Atr-002976	Amborella trichopoda	55.49	0.00e+00	1121.00
IUUC-Apl-003773	Anas platyrhynchos	28.16	7.00e-76	278.00
IUUC-Aca-004466	Anolis carolinensis	32.00	6.00e-76	277.00
IUUC-Aly-006249	Arabidopsis lyrata	93.19	0.00e+00	1989.00
IUUC-Ame-011554	Astyanax mexicanus	32.28	5.00e-83	302.00
IUUC-Bta-012573	Bos taurus	31.19	3.00e-79	289.00
IUUC-Bdi-014149	Brachypodium distachyon	56.75	0.00e+00	1154.00
IUUC-Bol-016289	Brassica oleracea	83.66	0.00e+00	1754.00
IUUC-Bra-017494	Brassica rapa	81.46	0.00e+00	1698.00
IUUC-Cja-019991	Callithrix jacchus	30.35	1.00e-79	291.00
IUUC-Cfa-020294	Canis familiaris	31.50	2.00e-80	293.00
IUUC-Cpo-021706	Cavia porcellus	31.21	8.00e-77	281.00
IUUC-Cre-022636	Chlamydomonas reinhardtii	40.58	7.00e-66	246.00
IUUC-Csa-023931	Chlorocebus sabaeus	31.02	1.00e-80	294.00
IUUC-Cho-024566	Choloepus hoffmanni	27.91	1.00e-29	124.00
IUUC-Cin-025307	Ciona intestinalis	34.66	9.00e-35	139.00
IUUC-Csv-026006	Ciona savignyi	23.87	2.00e-59	223.00
IUUC-Cne-027065	Cryptococcus neoformans	23.99	1.00e-50	194.00
IUUC-Dre-027624	Danio rerio	33.33	3.00e-86	313.00
IUUC-Dno-029633	Dasypus novemcinctus	31.47	4.00e-68	252.00
IUUC-Dor-030809	Dipodomys ordii	35.76	6.00e-45	175.00
IUUC-Ete-032818	Echinops telfairi	30.38	5.00e-63	235.00
IUUC-Eca-033692	Equus caballus	30.87	4.00e-80	292.00
IUUC-Eeu-035185	Erinaceus europaeus	31.25	4.00e-34	139.00
IUUC-Fca-035676	Felis catus	31.02	3.00e-80	292.00
IUUC-Fal-036913	Ficedula albicollis	31.58	2.00e-80	293.00
IUUC-Gmo-038532	Gadus morhua	31.24	4.00e-81	295.00
IUUC-Gga-041041	Gallus gallus	31.32	4.00e-80	292.00
IUUC-Gac-042570	Gasterosteus aculeatus	31.80	5.00e-80	292.00
IUUC-Gma-043910	Glycine max	59.56	0.00e+00	1219.00
IUUC-Ggo-045367	Gorilla gorilla	36.53	9.00e-57	214.00
IUUC-Hsa-046019	Homo sapiens	30.87	2.00e-80	293.00
IUUC-Hvu-047303	Hordeum vulgare	60.76	2.00e-175	608.00
IUUC-Itr-048319	Ictidomys tridecemlineatus	31.11	2.00e-80	293.00
IUUC-Lch-049989	Latimeria chalumnae	31.62	3.00e-82	299.00
IUUC-Lpe-051612	Leersia perrieri	56.86	0.00e+00	1144.00
IUUC-Loc-052756	Lepisosteus oculatus	31.95	1.00e-80	294.00
IUUC-Laf-054043	Loxodonta africana	30.97	1.00e-80	294.00
IUUC-Mcc-054986	Macaca mulatta	30.82	7.00e-81	295.00
IUUC-Meu-056228	Macropus eugenii	36.31	6.00e-54	205.00
IUUC-Mtr-058762	Medicago truncatula	60.26	0.00e+00	1224.00
IUUC-Mga-059896	Meleagris gallopavo	31.91	5.00e-81	295.00
IUUC-Mvi-060269	Microbotryum violaceum	34.66	3.00e-45	177.00
IUUC-Mmr-060887	Microcebus murinus	30.87	2.00e-79	290.00
IUUC-Mdo-062506	Monodelphis domestica	30.54	1.00e-79	291.00
IUUC-Mmu-063642	Mus musculus	30.56	3.00e-81	296.00
IUUC-Mac-064896	Musa acuminata	57.01	0.00e+00	1187.00
IUUC-Mpu-066194	Mustela putorius furo	31.13	1.00e-80	293.00
IUUC-Mlu-067233	Myotis lucifugus	30.84	1.00e-78	287.00
IUUC-Nle-069052	Nomascus leucogenys	30.66	1.00e-80	294.00
IUUC-Opr-070890	Ochotona princeps	30.35	3.00e-75	276.00
IUUC-Ont-071450	Oreochromis niloticus	30.81	3.00e-82	299.00
IUUC-Ocu-073796	Oryctolagus cuniculus	31.61	7.00e-68	251.00
IUUC-Oba-075563	Oryza barthii	55.82	0.00e+00	1158.00
IUUC-Obr-076394	Oryza brachyantha	55.96	0.00e+00	1152.00
IUUC-Ogl-077339	Oryza glaberrima	70.42	1.00e-123	435.00
IUUC-Ogu-079007	Oryza glumaepatula	55.27	0.00e+00	1133.00
IUUC-Oin-079997	Oryza indica	55.82	0.00e+00	1158.00
IUUC-Olo-080364	Oryza longistaminata	54.77	0.00e+00	1144.00
IUUC-Ome-081165	Oryza meridionalis	55.32	0.00e+00	1134.00
IUUC-Oni-083026	Oryza nivara	55.82	0.00e+00	1158.00
IUUC-Opu-083284	Oryza punctata	56.11	0.00e+00	1147.00
IUUC-Oru-084797	Oryza rufipogon	55.82	0.00e+00	1158.00
IUUC-Osa-086221	Oryza sativa	70.42	1.00e-123	435.00
IUUC-Ola-086568	Oryzias latipes	29.40	4.00e-82	299.00
IUUC-Oga-088687	Otolemur garnettii	30.50	1.00e-80	294.00
IUUC-Oar-090345	Ovis aries	31.11	1.00e-76	280.00
IUUC-Ptr-090734	Pan troglodytes	30.87	2.00e-80	293.00
IUUC-Pan-091704	Papio anubis	36.70	2.00e-59	223.00
IUUC-Psi-092937	Pelodiscus sinensis	32.21	2.00e-67	250.00
IUUC-Ppa-095808	Physcomitrella patens	45.86	0.00e+00	833.00
IUUC-Pab-098129	Pongo abelii	30.87	2.00e-80	293.00
IUUC-Pop-099738	Populus trichocarpa	60.56	0.00e+00	1244.00
IUUC-Pca-100647	Procavia capensis	35.76	2.00e-45	177.00
IUUC-Ppe-102091	Prunus persica	62.16	0.00e+00	1331.00
IUUC-Pva-102719	Pteropus vampyrus	30.39	6.00e-77	281.00
IUUC-Rno-105363	Rattus norvegicus	30.87	4.00e-80	292.00
IUUC-Sha-107620	Sarcophilus harrisii	30.25	3.00e-78	286.00
IUUC-Smo-109579	Selaginella moellendorffii	44.63	0.00e+00	773.00
IUUC-Sit-110683	Setaria italica	54.94	0.00e+00	1114.00
IUUC-Sly-111377	Solanum lycopersicum	59.31	0.00e+00	1176.00
IUUC-Stu-111969	Solanum tuberosum	62.43	0.00e+00	663.00
IUUC-Sar-113099	Sorex araneus	32.21	2.00e-67	250.00
IUUC-Sbi-113833	Sorghum bicolor	70.07	3.00e-109	387.00
IUUC-Tgu-117519	Taeniopygia guttata	30.72	1.00e-70	261.00
IUUC-Tru-117651	Takifugu rubripes	31.28	3.00e-82	299.00
IUUC-Tsy-119201	Tarsius syrichta	28.74	5.00e-65	242.00
IUUC-Tni-120840	Tetraodon nigroviridis	28.85	4.00e-82	299.00
IUUC-Tca-121674	Theobroma cacao	64.00	0.00e+00	1369.00
IUUC-Tae-125814	Triticum aestivum	56.18	0.00e+00	1122.00
IUUC-Tur-126599	Triticum urartu	55.49	0.00e+00	1113.00
IUUC-Tbe-127782	Tupaia belangeri	26.93	2.00e-57	216.00
IUUC-Ttr-128312	Tursiops truncatus	30.24	1.00e-76	281.00
IUUC-Vpa-130348	Vicugna pacos	30.21	6.00e-77	281.00
IUUC-Vvi-131353	Vitis vinifera	62.21	0.00e+00	1315.00
IUUC-Xtr-132172	Xenopus tropicalis	29.56	3.00e-54	206.00
IUUC-Xma-133263	Xiphophorus maculatus	29.03	5.00e-79	288.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence