iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Bta-013251

UUCD1 version

UUC-BoT-01092

Ensembl Protein ID

ENSBTAP00000018104.4

UniProt Accession

Q9XSJ0; Q3MHN9; UCHL5_BOVIN

Genbank Protein ID

AAD31533.1; AAI05167.1

Protein Name

Ubiquitin carboxyl-terminal hydrolase isozyme L5; Ubiquitin C-terminal hydrolase UCH37; Ubiquitin thioesterase L5

Genbank Nucleotide ID

AF148446; BC105166

Gene Name

UCHL5; UCH37

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSBTAG00000013620.4	ENSBTAT00000018104.4	ENSBTAP00000018104.4

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/UCH	2.50e-101	339.6	1	320

Active Site

Position(s)	Description	Evidence
88	Nucleophile	ECO:0000250}
164	Proton donor	ECO:0000250}

Domain Profile

DUB/UCH

   S: 1    mnsqvkewleLesdPglftllvedfgvkrdiqveelysLdpenlglyqepvegllllFkinekressrksqvtsndlevvdediiktif 89
           m++++ ew+ +esdPg+ft+l++ fg+++  qvee++sL+pen++++ +pv+gl++lFk+++ +e +          +vv+++ ++tif
   Q: 1    MTGNAGEWCLMESDPGVFTELIKGFGCRGA-QVEEIWSLEPENFEKL-KPVHGLIFLFKWQPGEEPAG---------SVVQDSRLDTIF 78
           788999************************.****************.********************.........899********* PP
   S: 90   fakqvigNsCatyAllsvllncedklldlGttlsrlkestkaespenkalalgnqqvlecihnslariesrseperqdedneqytkeaf 178
           fakqvi+N+Cat+A++svllnc+++ ++lG+tls++ke+++++++ +k+lal+n++v++++hns+ar+++++ + +++++    +++af
   Q: 79   FAKQVINNACATQAIVSVLLNCTHQDVHLGETLSEFKEFSQSFDAAMKGLALSNSDVIRQVHNSFARQQMFEFDAKTAAK----EEDAF 163
           **************************************************************************999777....89*** PP
   S: 179  hfvsyvningrlyeldglkpfPldlgkkketeelkdklkvvraflerikllesdeirfnllaivadrrviktlrlnvlkid........ 259
           hfvsyv++ngrlyeldgl++ P+dlg+ ++++++ ++++ v+   +ri++++++eirfnl+aiv+dr++i+++++  l+ +        
   Q: 164  HFVSYVPVNGRLYELDGLREGPIDLGA-CNQDDWISAVRPVI--EKRIQKYSEGEIRFNLMAIVSDRKMIYEQKIAELQRQlaeepmdt 249
           **************************9.78999*********..******************************976654456666666 PP
   S: 260  keLlkLlkdieseeekieaqlddekekrkkfkiddirRtenydeficifikdlaregilrklveetisevrefg 333
            +  ++l++i+se++k+++ +++e++k k++ki++irR++ny  fi++++k+la++++l  lve+    + +++
   Q: 250  DQGSNMLSAIQSEVAKNQMLIEEEVQKLKRYKIENIRRKHNYLPFIMELLKTLAEHQQLIPLVEKA---KEKQN 320
           44568**********************************************************993...33344 PP

Organism

Bos taurus

Functional Description
(View)

Protease that specifically cleaves 'Lys-48'-linked polyubiquitin chains. Deubiquitinating enzyme associated with the 19S regulatory subunit of the 26S proteasome. Putative regulatory component of the INO80 complex; however is inactive in the INO80 complex and is activated by a transient interaction of the INO80 complex with the proteasome via ADRM1 (By similarity).

Protein Sequence
(Fasta)

MTGNAGEWCL MESDPGVFTE LIKGFGCRGA QVEEIWSLEP ENFEKLKPVH GLIFLFKWQP 60
GEEPAGSVVQ DSRLDTIFFA KQVINNACAT QAIVSVLLNC THQDVHLGET LSEFKEFSQS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTCGGGAAGT AGGCGGGGTG ACGTGTGGTG GACGAGCCCG CGGCGGGTTT GCCGAGCTCA 60
GTGGCCGGCG GTGGCAGGAG CGAGGGCCCG GGGCGCCCGG AGCCGGAGGT GGAGCGGGGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0227--DNA damage
KW-0233--DNA recombination
KW-0234--DNA repair
KW-0378--Hydrolase
KW-0539--Nucleus
KW-0645--Protease
KW-0647--Proteasome
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0833--Ubl conjugation pathway

Interpro

IPR001578--Peptidase_C12_UCH
IPR017390--Ubiquitinyl_hydrolase_UCH37
IPR033837--UCH37

Pfam

PF01088--Peptidase_C12

PRINTS

PR00707--UBCTHYDRLASE

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0031011--C:Ino80 complex
GO:0005739--C:mitochondrion
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0000502--C:proteasome complex
GO:0004866--F:endopeptidase inhibitor activity
GO:0070628--F:proteasome binding
GO:0003723--F:RNA binding
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0006310--P:DNA recombination
GO:0006281--P:DNA repair
GO:0048853--P:forebrain morphogenesis
GO:0021670--P:lateral ventricle development
GO:0030901--P:midbrain development
GO:0016579--P:protein deubiquitination
GO:0061136--P:regulation of proteasomal protein catabolic process
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

bta:282110

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000936	Aegilops tauschii	47.71	7.00e-84	303.00
IUUC-Aml-001866	Ailuropoda melanoleuca	99.04	0.00e+00	644.00
IUUC-Atr-002966	Amborella trichopoda	46.84	9.00e-80	290.00
IUUC-Apl-003306	Anas platyrhynchos	85.75	2.00e-175	608.00
IUUC-Aca-004763	Anolis carolinensis	95.50	3.00e-178	617.00
IUUC-Aly-005581	Arabidopsis lyrata	48.33	3.00e-80	291.00
IUUC-Ath-007283	Arabidopsis thaliana	48.63	1.00e-82	300.00
IUUC-Ago-007999	Ashbya gossypii	33.76	1.00e-33	136.00
IUUC-Acl-008231	Aspergillus clavatus	43.15	2.00e-52	199.00
IUUC-Afl-008557	Aspergillus flavus	38.03	3.00e-54	205.00
IUUC-Afu-008988	Aspergillus fumigatus	45.00	3.00e-54	205.00
IUUC-Ani-009420	Aspergillus nidulans	38.24	1.00e-52	200.00
IUUC-Ang-009859	Aspergillus niger	40.82	4.00e-49	188.00
IUUC-Aor-010145	Aspergillus oryzae	38.03	3.00e-54	205.00
IUUC-Ate-010347	Aspergillus terreus	41.73	5.00e-53	201.00
IUUC-Ame-010791	Astyanax mexicanus	89.97	2.00e-180	624.00
IUUC-Bgr-012298	Blumeria graminis	37.62	3.00e-49	188.00
IUUC-Bci-013786	Botrytis cinerea	37.57	2.00e-57	215.00
IUUC-Bdi-014132	Brachypodium distachyon	49.07	4.00e-82	298.00
IUUC-Bol-015611	Brassica oleracea	49.54	5.00e-84	304.00
IUUC-Bra-017769	Brassica rapa	49.39	7.00e-84	303.00
IUUC-Cel-018604	Caenorhabditis elegans	47.28	4.00e-82	297.00
IUUC-Cja-019768	Callithrix jacchus	89.74	6.00e-179	619.00
IUUC-Cfa-020207	Canis familiaris	99.04	0.00e+00	644.00
IUUC-Cpo-021925	Cavia porcellus	94.89	3.00e-177	613.00
IUUC-Cre-022919	Chlamydomonas reinhardtii	45.54	6.00e-74	270.00
IUUC-Csa-023958	Chlorocebus sabaeus	98.72	0.00e+00	644.00
IUUC-Cho-024928	Choloepus hoffmanni	100.00	1.00e-42	166.00
IUUC-Cin-025771	Ciona intestinalis	54.49	5.00e-100	357.00
IUUC-Csv-026149	Ciona savignyi	57.99	1.00e-102	366.00
IUUC-Cgl-026424	Colletotrichum gloeosporioides	37.64	6.00e-51	194.00
IUUC-Cne-026955	Cryptococcus neoformans	37.98	6.00e-55	207.00
IUUC-Cme-027104	Cyanidioschyzon merolae	33.15	1.00e-48	186.00
IUUC-Dre-027409	Danio rerio	89.06	7.00e-177	612.00
IUUC-Dno-028921	Dasypus novemcinctus	98.40	0.00e+00	640.00
IUUC-Dse-031170	Dothistroma septosporum	40.00	1.00e-58	219.00
IUUC-Dme-031677	Drosophila melanogaster	59.94	2.00e-115	408.00
IUUC-Ete-032707	Echinops telfairi	68.65	1.00e-117	416.00
IUUC-Eca-033776	Equus caballus	98.61	2.00e-169	587.00
IUUC-Eeu-035305	Erinaceus europaeus	79.79	5.00e-84	303.00
IUUC-Fca-035846	Felis catus	91.18	0.00e+00	626.00
IUUC-Fal-037597	Ficedula albicollis	93.40	2.00e-158	550.00
IUUC-Fox-037670	Fusarium oxysporum	43.00	2.00e-55	209.00
IUUC-Fso-038243	Fusarium solani	41.97	6.00e-55	207.00
IUUC-Gmo-038499	Gadus morhua	84.03	4.00e-160	556.00
IUUC-Ggr-039975	Gaeumannomyces graminis	41.06	3.00e-48	185.00
IUUC-Gga-040904	Gallus gallus	94.50	0.00e+00	641.00
IUUC-Gac-042058	Gasterosteus aculeatus	88.82	2.00e-169	587.00
IUUC-Gma-043030	Glycine max	49.55	2.00e-86	311.00
IUUC-Ggo-044699	Gorilla gorilla	92.51	2.00e-168	584.00
IUUC-Hsa-046227	Homo sapiens	98.40	0.00e+00	640.00
IUUC-Hvu-047359	Hordeum vulgare	47.42	6.00e-83	300.00
IUUC-Itr-048989	Ictidomys tridecemlineatus	90.12	0.00e+00	626.00
IUUC-Lch-049829	Latimeria chalumnae	92.33	5.00e-174	603.00
IUUC-Lpe-050899	Leersia perrieri	48.58	3.00e-78	285.00
IUUC-Loc-052264	Lepisosteus oculatus	90.45	6.00e-172	596.00
IUUC-Lma-053110	Leptosphaeria maculans	38.87	9.00e-49	187.00
IUUC-Laf-053639	Loxodonta africana	99.04	0.00e+00	644.00
IUUC-Mcc-055506	Macaca mulatta	98.72	0.00e+00	644.00
IUUC-Mor-057001	Magnaporthe oryzae	45.38	9.00e-55	207.00
IUUC-Mpo-057608	Magnaporthe poae	41.18	7.00e-33	133.00
IUUC-Mtr-057731	Medicago truncatula	48.36	5.00e-86	310.00
IUUC-Mla-059016	Melampsora laricipopulina	42.79	3.00e-43	167.00
IUUC-Mga-060178	Meleagris gallopavo	95.07	3.00e-172	597.00
IUUC-Mvi-060353	Microbotryum violaceum	38.32	3.00e-54	205.00
IUUC-Mmr-060738	Microcebus murinus	98.40	0.00e+00	640.00
IUUC-Mdo-062266	Monodelphis domestica	97.55	3.00e-120	423.00
IUUC-Mmu-063619	Mus musculus	96.49	0.00e+00	630.00
IUUC-Mac-065301	Musa acuminata	50.95	7.00e-89	320.00
IUUC-Mpu-066058	Mustela putorius furo	99.36	0.00e+00	645.00
IUUC-Mlu-067292	Myotis lucifugus	97.76	0.00e+00	631.00
IUUC-Nfi-068275	Neosartorya fischeri	39.55	1.00e-55	209.00
IUUC-Ncr-068713	Neurospora crassa	38.80	3.00e-57	215.00
IUUC-Nle-069013	Nomascus leucogenys	98.40	0.00e+00	642.00
IUUC-Opr-070628	Ochotona princeps	86.76	9.00e-170	589.00
IUUC-Ont-072688	Oreochromis niloticus	89.52	6.00e-170	589.00
IUUC-Oan-073004	Ornithorhynchus anatinus	96.34	9.00e-141	492.00
IUUC-Ocu-074303	Oryctolagus cuniculus	99.36	0.00e+00	647.00
IUUC-Oba-075002	Oryza barthii	48.19	2.00e-82	298.00
IUUC-Obr-076392	Oryza brachyantha	49.21	3.00e-80	291.00
IUUC-Ogl-077271	Oryza glaberrima	48.19	2.00e-82	298.00
IUUC-Ogu-078493	Oryza glumaepatula	48.19	6.00e-83	300.00
IUUC-Oin-080084	Oryza indica	48.19	6.00e-83	300.00
IUUC-Olo-080803	Oryza longistaminata	47.89	1.00e-82	299.00
IUUC-Ome-081146	Oryza meridionalis	46.99	1.00e-81	296.00
IUUC-Oni-082146	Oryza nivara	48.19	6.00e-83	300.00
IUUC-Opu-083633	Oryza punctata	48.90	2.00e-79	288.00
IUUC-Oru-084789	Oryza rufipogon	48.19	6.00e-83	300.00
IUUC-Osa-086196	Oryza sativa	48.19	6.00e-83	300.00
IUUC-Ola-087126	Oryzias latipes	89.46	3.00e-166	577.00
IUUC-Olu-087665	Ostreococcus lucimarinus	42.16	1.00e-69	256.00
IUUC-Oga-089140	Otolemur garnettii	90.00	8.00e-180	622.00
IUUC-Oar-090296	Ovis aries	99.04	0.00e+00	641.00
IUUC-Ptr-090566	Pan troglodytes	98.40	0.00e+00	640.00
IUUC-Pan-092052	Papio anubis	98.72	0.00e+00	644.00
IUUC-Psi-093723	Pelodiscus sinensis	95.14	4.00e-164	570.00
IUUC-Pma-094568	Petromyzon marinus	62.02	5.00e-107	380.00
IUUC-Pno-095120	Phaeosphaeria nodorum	39.47	2.00e-50	192.00
IUUC-Ppa-095761	Physcomitrella patens	47.95	1.00e-84	306.00
IUUC-Pfo-096210	Poecilia formosa	88.50	2.00e-169	587.00
IUUC-Pab-098463	Pongo abelii	98.40	0.00e+00	640.00
IUUC-Pop-099423	Populus trichocarpa	48.66	6.00e-85	307.00
IUUC-Pca-100108	Procavia capensis	97.15	1.00e-142	498.00
IUUC-Ppe-101176	Prunus persica	50.90	1.00e-85	309.00
IUUC-Pva-102629	Pteropus vampyrus	95.80	5.00e-147	513.00
IUUC-Pgr-103419	Puccinia graminis	39.88	5.00e-57	214.00
IUUC-Pte-104207	Pyrenophora teres	44.97	3.00e-33	134.00
IUUC-Pyt-104471	Pyrenophora triticirepentis	39.80	2.00e-57	216.00
IUUC-Rno-105579	Rattus norvegicus	86.96	3.00e-164	570.00
IUUC-Sha-106894	Sarcophilus harrisii	93.84	4.00e-154	536.00
IUUC-Sja-107732	Schizosaccharomyces japonicus	39.33	1.00e-59	223.00
IUUC-Spo-108371	Schizosaccharomyces pombe	42.38	3.00e-59	221.00
IUUC-Ssl-108467	Sclerotinia sclerotiorum	38.18	2.00e-47	182.00
IUUC-Smo-109396	Selaginella moellendorffii	51.69	6.00e-88	317.00
IUUC-Sit-110630	Setaria italica	49.54	5.00e-86	310.00
IUUC-Sly-110972	Solanum lycopersicum	50.48	8.00e-81	293.00
IUUC-Stu-112185	Solanum tuberosum	50.90	5.00e-89	320.00
IUUC-Sar-113294	Sorex araneus	82.34	6.00e-163	566.00
IUUC-Sbi-113951	Sorghum bicolor	49.85	2.00e-86	312.00
IUUC-Ssc-115501	Sus scrofa	97.98	2.00e-173	600.00
IUUC-Tgu-117152	Taeniopygia guttata	93.40	2.00e-158	550.00
IUUC-Tru-118388	Takifugu rubripes	88.50	2.00e-169	588.00
IUUC-Tsy-119109	Tarsius syrichta	98.72	0.00e+00	641.00
IUUC-Tni-120048	Tetraodon nigroviridis	88.50	5.00e-170	589.00
IUUC-Tca-121750	Theobroma cacao	50.30	6.00e-89	320.00
IUUC-Tre-122130	Trichoderma reesei	38.80	4.00e-55	207.00
IUUC-Tvi-122284	Trichoderma virens	39.67	4.00e-53	201.00
IUUC-Tae-124082	Triticum aestivum	48.02	2.00e-83	302.00
IUUC-Tur-126366	Triticum urartu	42.72	4.00e-66	245.00
IUUC-Tme-127187	Tuber melanosporum	40.40	3.00e-58	218.00
IUUC-Tbe-127619	Tupaia belangeri	89.55	6.00e-143	499.00
IUUC-Ttr-128867	Tursiops truncatus	87.76	7.00e-124	436.00
IUUC-Vda-129912	Verticillium dahliae	37.50	1.00e-52	199.00
IUUC-Vpa-130552	Vicugna pacos	99.52	3.00e-126	444.00
IUUC-Vvi-130881	Vitis vinifera	50.45	5.00e-85	307.00
IUUC-Xtr-131934	Xenopus tropicalis	85.71	3.00e-172	597.00
IUUC-Xma-133312	Xiphophorus maculatus	88.50	5.00e-169	586.00
IUUC-Yli-134487	Yarrowia lipolytica	40.34	1.00e-48	186.00
IUUC-Zma-135462	Zea mays	43.69	9.00e-72	263.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence