iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSRNOG00000003545.7	ENSRNOT00000077153.1	ENSRNOP00000072164.1
ENSRNOG00000003545.7	ENSRNOT00000004881.6	ENSRNOP00000004881.4

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
microRNA	RAID2
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/UCH	2.00e-93	313.9	117	332

Active Site

Position(s)	Description	Evidence
65	Nucleophile	{ECO:0000256\|PIRSR:PIRSR038120-1}
176	Proton donor	{ECO:0000256\|PIRSR:PIRSR038120-1}

Domain Profile

DUB/UCH

   S: 116  ldlGttlsrlkestkaespenkalalgnqqvlecihnslariesrseperqdedneqytkeafhfvsyvningrlyeldglkpfPldlg 204
           ++lG+tls++ke+++++++ +k+lal+n++v++++hns+ar+++++ +++++++    +++afhfvsyv++ngrlyeldgl++ P+dlg
   Q: 117  VHLGETLSEFKEFSQSFDAAMKGLALSNSDVIRQVHNSFARQQMFEFDTKTSAK----EEDAFHFVSYVPVNGRLYELDGLREGPIDLG 201
           69*************************************************888....79***************************** PP
   S: 205  kkketeelkdklkvvraflerikllesdeirfnllaivadrrviktlrlnvlkid........keLlkLlkdieseeekieaqlddeke 285
           + ++++++  +++ v+   +ri++++++eirfnl+aiv+dr++i+++++  l+ +         +   +l++i+se++++++ +++e++
   Q: 202  A-CNQDDWITAVRPVI--EKRIQKYSEGEIRFNLMAIVSDRKMIYEQKIAELQRQlaeepmdtDQGSTVLSAIQSEVARNQMLIEEEVQ 287
           9.78899*********..******************************976554455556555445679******************** PP
   S: 286  krkkfkiddirRtenydeficifikdlaregilrklveetisevrefg 333
           k k++ki++irR++ny  fi++++k+la++++l  lve+    + +++
   Q: 288  KLKRYKIENIRRKHNYLPFIMELLKTLAEHQQLIPLVEKA---KEKQN 332
           *************************************993...33344 PP

Organism

Rattus norvegicus

Protein Sequence
(Fasta)

MSGCRGAQVE EIWSLEPENF EKLKPVHGLI FLFKWQPGEE PAGSVVQDSR LETIFFAKQV 60
INNACATQAI VSVLLNCTHQ DVHLGETLSE FKEFSQSFDA AMKGLALSNS DVIRQDVHLG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TCAGACATTG TTATTCAAAT AAATTAACAT AAGCAAGTGC TTGGTCAGCA TGGTGCTATT 60
TTGACTATGA GCTTTGCTTT CATTTTATTT TGGGGGGATA TATTTCTTAT TCTTCTTTTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1267--Proteomics identification
KW-1185--Reference proteome

Interpro

IPR001578--Peptidase_C12_UCH
IPR033837--UCH37

Pfam

PF01088--Peptidase_C12

Gene Ontology

GO:0031597--C:cytosolic proteasome complex
GO:0031011--C:Ino80 complex
GO:0005739--C:mitochondrion
GO:0005654--C:nucleoplasm
GO:0004866--F:endopeptidase inhibitor activity
GO:0003723--F:RNA binding
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0048853--P:forebrain morphogenesis
GO:0021670--P:lateral ventricle development
GO:0030901--P:midbrain development
GO:0016579--P:protein deubiquitination
GO:0061136--P:regulation of proteasomal protein catabolic process
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000936	Aegilops tauschii	41.03	1.00e-71	263.00
IUUC-Aml-001866	Ailuropoda melanoleuca	86.69	1.00e-162	565.00
IUUC-Atr-002966	Amborella trichopoda	43.26	5.00e-73	268.00
IUUC-Apl-003306	Anas platyrhynchos	77.66	2.00e-159	554.00
IUUC-Aca-004763	Anolis carolinensis	83.59	6.00e-157	546.00
IUUC-Aly-005581	Arabidopsis lyrata	42.57	8.00e-68	250.00
IUUC-Ath-007283	Arabidopsis thaliana	42.86	2.00e-70	258.00
IUUC-Acl-008231	Aspergillus clavatus	38.71	3.00e-43	168.00
IUUC-Afl-008557	Aspergillus flavus	33.55	5.00e-44	171.00
IUUC-Afu-008988	Aspergillus fumigatus	39.92	7.00e-44	171.00
IUUC-Ani-009420	Aspergillus nidulans	35.83	4.00e-44	171.00
IUUC-Ang-009859	Aspergillus niger	36.25	5.00e-40	157.00
IUUC-Aor-010145	Aspergillus oryzae	33.55	5.00e-44	171.00
IUUC-Ate-010347	Aspergillus terreus	37.79	8.00e-43	167.00
IUUC-Ame-010791	Astyanax mexicanus	79.35	5.00e-158	550.00
IUUC-Bgr-012298	Blumeria graminis	33.78	2.00e-39	155.00
IUUC-Bta-013251	Bos taurus	86.96	4.00e-164	570.00
IUUC-Bci-013786	Botrytis cinerea	34.09	1.00e-47	183.00
IUUC-Bdi-014132	Brachypodium distachyon	43.07	1.00e-69	256.00
IUUC-Bol-015611	Brassica oleracea	43.02	5.00e-71	261.00
IUUC-Bra-017769	Brassica rapa	43.02	6.00e-71	260.00
IUUC-Cel-018604	Caenorhabditis elegans	40.49	6.00e-64	237.00
IUUC-Cja-019768	Callithrix jacchus	79.49	2.00e-157	548.00
IUUC-Cfa-020207	Canis familiaris	86.69	1.00e-162	565.00
IUUC-Cpo-021925	Cavia porcellus	82.66	4.00e-153	533.00
IUUC-Cre-022919	Chlamydomonas reinhardtii	39.77	4.00e-61	228.00
IUUC-Csa-023958	Chlorocebus sabaeus	87.27	9.00e-165	572.00
IUUC-Cho-024928	Choloepus hoffmanni	98.70	3.00e-42	165.00
IUUC-Cin-025771	Ciona intestinalis	47.16	1.00e-82	299.00
IUUC-Csv-026149	Ciona savignyi	51.51	9.00e-86	310.00
IUUC-Cgl-026424	Colletotrichum gloeosporioides	33.77	4.00e-48	184.00
IUUC-Cne-026955	Cryptococcus neoformans	33.43	4.00e-45	175.00
IUUC-Cme-027104	Cyanidioschyzon merolae	29.68	1.00e-34	140.00
IUUC-Dre-027409	Danio rerio	78.17	1.00e-154	538.00
IUUC-Dno-028921	Dasypus novemcinctus	86.07	2.00e-161	561.00
IUUC-Dse-031170	Dothistroma septosporum	35.69	6.00e-48	184.00
IUUC-Dme-031677	Drosophila melanogaster	54.09	2.00e-99	355.00
IUUC-Ete-032707	Echinops telfairi	62.54	4.00e-98	351.00
IUUC-Eca-033776	Equus caballus	86.38	1.00e-162	565.00
IUUC-Eeu-035305	Erinaceus europaeus	62.63	3.00e-62	231.00
IUUC-Fca-035846	Felis catus	80.00	1.00e-157	548.00
IUUC-Fal-037597	Ficedula albicollis	81.73	2.00e-151	527.00
IUUC-Fox-037670	Fusarium oxysporum	38.93	1.00e-46	180.00
IUUC-Fso-038243	Fusarium solani	37.25	1.00e-45	176.00
IUUC-Gmo-038499	Gadus morhua	74.61	2.00e-140	491.00
IUUC-Ggr-039975	Gaeumannomyces graminis	38.00	1.00e-39	157.00
IUUC-Gga-040904	Gallus gallus	83.48	2.00e-164	571.00
IUUC-Gac-042058	Gasterosteus aculeatus	78.33	2.00e-148	518.00
IUUC-Gma-043763	Glycine max	42.21	2.00e-72	266.00
IUUC-Ggo-044699	Gorilla gorilla	81.07	3.00e-146	511.00
IUUC-Hsa-046227	Homo sapiens	87.00	1.00e-163	568.00
IUUC-Hvu-047359	Hordeum vulgare	41.16	5.00e-71	261.00
IUUC-Itr-048989	Ictidomys tridecemlineatus	79.10	2.00e-157	548.00
IUUC-Lch-049829	Latimeria chalumnae	80.80	4.00e-151	527.00
IUUC-Lpe-050899	Leersia perrieri	42.34	3.00e-66	245.00
IUUC-Loc-052264	Lepisosteus oculatus	80.19	4.00e-151	526.00
IUUC-Lma-053110	Leptosphaeria maculans	34.25	2.00e-40	159.00
IUUC-Laf-053639	Loxodonta africana	86.69	1.00e-162	565.00
IUUC-Mcc-055506	Macaca mulatta	87.27	1.00e-164	572.00
IUUC-Mor-057001	Magnaporthe oryzae	39.84	4.00e-45	174.00
IUUC-Mpo-057608	Magnaporthe poae	34.76	1.00e-24	105.00
IUUC-Mtr-057731	Medicago truncatula	42.17	5.00e-73	267.00
IUUC-Mla-059016	Melampsora laricipopulina	40.49	1.00e-36	145.00
IUUC-Mga-060178	Meleagris gallopavo	83.78	2.00e-165	574.00
IUUC-Mvi-060353	Microbotryum violaceum	35.76	7.00e-45	174.00
IUUC-Mmr-060738	Microcebus murinus	86.38	2.00e-162	565.00
IUUC-Mdo-062266	Monodelphis domestica	81.36	3.00e-102	363.00
IUUC-Mmu-063619	Mus musculus	88.24	8.00e-165	572.00
IUUC-Mac-065301	Musa acuminata	44.71	3.00e-76	278.00
IUUC-Mpu-066058	Mustela putorius furo	87.00	3.00e-163	567.00
IUUC-Mlu-067292	Myotis lucifugus	85.76	1.00e-159	555.00
IUUC-Nfi-068275	Neosartorya fischeri	35.42	2.00e-45	176.00
IUUC-Ncr-068713	Neurospora crassa	36.96	2.00e-50	192.00
IUUC-Nle-069013	Nomascus leucogenys	86.96	3.00e-164	571.00
IUUC-Opr-070628	Ochotona princeps	78.51	7.00e-155	540.00
IUUC-Ont-072688	Oreochromis niloticus	79.08	8.00e-149	519.00
IUUC-Oan-073004	Ornithorhynchus anatinus	83.15	4.00e-134	470.00
IUUC-Ocu-074303	Oryctolagus cuniculus	87.00	2.00e-163	568.00
IUUC-Oba-075002	Oryza barthii	42.36	5.00e-70	258.00
IUUC-Obr-076392	Oryza brachyantha	42.94	5.00e-68	251.00
IUUC-Ogl-077271	Oryza glaberrima	42.36	5.00e-70	258.00
IUUC-Ogu-078493	Oryza glumaepatula	42.24	1.00e-70	259.00
IUUC-Oin-080084	Oryza indica	42.24	1.00e-70	259.00
IUUC-Olo-080803	Oryza longistaminata	41.95	3.00e-70	258.00
IUUC-Ome-081146	Oryza meridionalis	41.09	2.00e-69	255.00
IUUC-Oni-082146	Oryza nivara	42.24	1.00e-70	259.00
IUUC-Opu-083633	Oryza punctata	42.64	3.00e-67	248.00
IUUC-Oru-084789	Oryza rufipogon	42.24	1.00e-70	259.00
IUUC-Osa-086196	Oryza sativa	42.24	1.00e-70	259.00
IUUC-Ola-087126	Oryzias latipes	78.95	4.00e-145	507.00
IUUC-Olu-087665	Ostreococcus lucimarinus	35.64	8.00e-57	213.00
IUUC-Oga-089140	Otolemur garnettii	79.71	4.00e-158	550.00
IUUC-Oar-090296	Ovis aries	86.69	5.00e-163	566.00
IUUC-Ptr-090566	Pan troglodytes	87.00	1.00e-163	568.00
IUUC-Pan-092052	Papio anubis	87.27	1.00e-164	572.00
IUUC-Psi-093723	Pelodiscus sinensis	83.28	4.00e-157	546.00
IUUC-Pma-094568	Petromyzon marinus	54.66	1.00e-100	359.00
IUUC-Pno-095120	Phaeosphaeria nodorum	34.01	8.00e-41	160.00
IUUC-Ppa-095761	Physcomitrella patens	41.62	3.00e-71	261.00
IUUC-Pfo-096210	Poecilia formosa	78.02	3.00e-148	517.00
IUUC-Pab-098463	Pongo abelii	87.00	1.00e-163	568.00
IUUC-Pop-099423	Populus trichocarpa	43.50	2.00e-72	265.00
IUUC-Pca-100108	Procavia capensis	83.20	3.00e-121	427.00
IUUC-Ppe-101176	Prunus persica	44.82	4.00e-73	268.00
IUUC-Pva-102629	Pteropus vampyrus	81.62	4.00e-124	437.00
IUUC-Pgr-103419	Puccinia graminis	36.15	1.00e-44	173.00
IUUC-Pte-104207	Pyrenophora teres	34.97	3.00e-22	97.40
IUUC-Pyt-104471	Pyrenophora triticirepentis	34.28	3.00e-46	178.00
IUUC-Sha-106894	Sarcophilus harrisii	81.99	4.00e-147	513.00
IUUC-Sja-107732	Schizosaccharomyces japonicus	33.44	2.00e-48	185.00
IUUC-Spo-108371	Schizosaccharomyces pombe	36.48	6.00e-48	184.00
IUUC-Ssl-108467	Sclerotinia sclerotiorum	34.84	5.00e-44	171.00
IUUC-Smo-109396	Selaginella moellendorffii	45.45	6.00e-76	277.00
IUUC-Sit-110630	Setaria italica	43.15	1.00e-72	266.00
IUUC-Sly-110972	Solanum lycopersicum	45.11	8.00e-77	280.00
IUUC-Stu-112185	Solanum tuberosum	44.83	2.00e-76	279.00
IUUC-Sar-113294	Sorex araneus	72.25	7.00e-143	499.00
IUUC-Sbi-113951	Sorghum bicolor	43.44	5.00e-73	267.00
IUUC-Ssc-115501	Sus scrofa	87.00	2.00e-163	567.00
IUUC-Tgu-117152	Taeniopygia guttata	81.73	2.00e-151	527.00
IUUC-Tru-118388	Takifugu rubripes	78.02	1.00e-148	519.00
IUUC-Tsy-119109	Tarsius syrichta	86.69	6.00e-163	566.00
IUUC-Tni-120048	Tetraodon nigroviridis	78.02	4.00e-149	520.00
IUUC-Tca-121750	Theobroma cacao	44.19	1.00e-75	276.00
IUUC-Tre-122130	Trichoderma reesei	33.33	1.00e-44	173.00
IUUC-Tvi-122284	Trichoderma virens	34.47	1.00e-42	167.00
IUUC-Tae-125344	Triticum aestivum	41.59	5.00e-69	254.00
IUUC-Tur-126366	Triticum urartu	38.89	8.00e-61	227.00
IUUC-Tme-127187	Tuber melanosporum	36.51	6.00e-49	187.00
IUUC-Tbe-127619	Tupaia belangeri	78.26	2.00e-137	481.00
IUUC-Ttr-128867	Tursiops truncatus	76.07	1.00e-118	419.00
IUUC-Vda-129912	Verticillium dahliae	32.69	2.00e-43	169.00
IUUC-Vpa-130552	Vicugna pacos	82.65	5.00e-104	370.00
IUUC-Vvi-130881	Vitis vinifera	44.32	3.00e-72	265.00
IUUC-Xtr-131934	Xenopus tropicalis	75.52	5.00e-151	526.00
IUUC-Xma-133312	Xiphophorus maculatus	78.02	3.00e-148	517.00
IUUC-Zma-135639	Zea mays	44.21	3.00e-67	248.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence