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Tag Content
iUUCD ID IUUC-Cre-023015
Ensembl Protein ID EDP06508
UniProt Accession A8IC48; URM1_CHLRE
Genbank Protein ID EDP06508.1
Protein Name Ubiquitin-related modifier 1 homolog
Genbank Nucleotide ID DS496115
Gene Name URM1; CHLREDRAFT_111518
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
CHLREDRAFT_111518 EDP06508 EDP06508
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
ULD/UDP/UBQ/UBQ_Other 40.59 6.00e-18 83.60 IUUC-Sce-106366
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Chlamydomonas reinhardtii
Functional Description
(View)

Functional Description



     Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by MOCS3. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.
Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by MOCS3. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.
Protein Sequence
(Fasta)
MVKVKIEFSG GLELLFGNQK QHDVDVPVQE GKQLTAGHLI AWTRDNMLRE RPELFVKGHT 60
VRPGILVLIN ECDWELSGAT ESTISDGDVV VFISTLHGG 99
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Protein Fasta Sequence



>IUUC-Cre-023015|ULD,UBQ_Other|Chlamydomonas reinhardtii
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Nucleotide Sequence
(Fasta)
ATGGTAAAGG TTAAGATAGA GTTCAGGTGC GTGCAGTGGC GCAAATGGGG CTTTGCACTC 60
CCCATATGCT GGCCGCACGC TGTGTGAATC CAGCCCACGG CGTAAACATG GCCGCCGCTT 120
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Nucleotide Fasta Sequence



>IUUC-Cre-023015|ULD,UBQ_Other|Chlamydomonas reinhardtii
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Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-1017--Isopeptide bond
KW-1185--Reference proteome
KW-0819--tRNA processing
KW-0833--Ubl conjugation pathway

Interpro

IPR012675--Beta-grasp_dom
IPR016155--Mopterin_synth/thiamin_S_b
IPR015221--Urm1

Pfam

PF09138--Urm1

Gene Ontology

GO:0005737--C:cytoplasm
GO:0034227--P:tRNA thio-modification

KEGG cre:CHLREDRAFT_111518
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002254 Ailuropoda melanoleuca 52.04 9.00e-26 106.00
IUUC-Atr-003089 Amborella trichopoda 59.60 2.00e-32 128.00
IUUC-Apl-003382 Anas platyrhynchos 53.26 5.00e-24 100.00
IUUC-Aca-004981 Anolis carolinensis 53.06 7.00e-26 106.00
IUUC-Aly-005517 Arabidopsis lyrata 57.61 1.00e-27 112.00
IUUC-Ath-006718 Arabidopsis thaliana 55.56 1.00e-24 102.00
IUUC-Ago-007917 Ashbya gossypii 46.53 7.00e-23 96.70
IUUC-Acl-008054 Aspergillus clavatus 56.60 6.00e-14 66.60
IUUC-Afl-008704 Aspergillus flavus 42.70 3.00e-17 77.80
IUUC-Aor-009890 Aspergillus oryzae 44.55 2.00e-21 92.40
IUUC-Bta-012448 Bos taurus 52.04 1.00e-25 105.00
IUUC-Bci-013865 Botrytis cinerea 42.57 2.00e-20 89.00
IUUC-Bdi-014980 Brachypodium distachyon 53.49 3.00e-23 97.80
IUUC-Bol-016055 Brassica oleracea 59.04 2.00e-26 108.00
IUUC-Bra-016845 Brassica rapa 59.04 2.00e-26 108.00
IUUC-Cel-018485 Caenorhabditis elegans 32.35 7.00e-09 50.10
IUUC-Cja-019587 Callithrix jacchus 53.06 5.00e-26 107.00
IUUC-Cfa-020653 Canis familiaris 51.02 2.00e-25 105.00
IUUC-Cpo-021622 Cavia porcellus 53.06 5.00e-26 107.00
IUUC-Csa-023756 Chlorocebus sabaeus 50.00 3.00e-19 85.50
IUUC-Cgl-026518 Colletotrichum gloeosporioides 42.57 7.00e-21 90.50
IUUC-Cne-026953 Cryptococcus neoformans 46.60 1.00e-22 97.10
IUUC-Cme-027314 Cyanidioschyzon merolae 47.52 2.00e-20 88.20
IUUC-Dre-027884 Danio rerio 57.29 3.00e-26 108.00
IUUC-Dno-029262 Dasypus novemcinctus 48.28 8.00e-19 84.30
IUUC-Dor-030601 Dipodomys ordii 50.00 2.00e-12 61.60
IUUC-Dme-031893 Drosophila melanogaster 53.54 7.00e-25 103.00
IUUC-Ete-032773 Echinops telfairi 52.08 1.00e-24 102.00
IUUC-Eca-034187 Equus caballus 52.04 7.00e-26 106.00
IUUC-Eeu-034808 Erinaceus europaeus 48.98 4.00e-25 103.00
IUUC-Fca-036107 Felis catus 51.02 2.00e-25 105.00
IUUC-Fal-036607 Ficedula albicollis 54.35 1.00e-24 102.00
IUUC-Fox-037698 Fusarium oxysporum 46.53 2.00e-22 95.50
IUUC-Gmo-039492 Gadus morhua 52.04 3.00e-24 101.00
IUUC-Ggr-039965 Gaeumannomyces graminis 47.47 2.00e-19 85.90
IUUC-Gga-041268 Gallus gallus 52.04 1.00e-25 105.00
IUUC-Gac-042111 Gasterosteus aculeatus 55.10 5.00e-27 110.00
IUUC-Gma-043240 Glycine max 53.01 6.00e-24 100.00
IUUC-Ggo-045176 Gorilla gorilla 53.33 1.00e-13 67.00
IUUC-Hsa-046077 Homo sapiens 53.06 2.00e-20 88.60
IUUC-Itr-048111 Ictidomys tridecemlineatus 54.44 3.00e-18 80.90
IUUC-Kpa-049157 Komagataella pastoris 39.60 7.00e-18 80.10
IUUC-Lch-049889 Latimeria chalumnae 54.08 1.00e-26 109.00
IUUC-Lpe-050783 Leersia perrieri 52.50 9.00e-23 96.30
IUUC-Loc-052400 Lepisosteus oculatus 52.04 7.00e-25 103.00
IUUC-Lma-053259 Leptosphaeria maculans 49.50 4.00e-23 97.40
IUUC-Laf-053596 Loxodonta africana 52.00 6.00e-25 103.00
IUUC-Mcc-054845 Macaca mulatta 53.76 2.00e-23 98.60
IUUC-Meu-055968 Macropus eugenii 54.08 6.00e-27 110.00
IUUC-Mor-057126 Magnaporthe oryzae 45.54 2.00e-18 82.40
IUUC-Mpo-057311 Magnaporthe poae 45.54 7.00e-20 87.80
IUUC-Mtr-058266 Medicago truncatula 54.12 1.00e-24 102.00
IUUC-Mla-058847 Melampsora laricipopulina 39.42 4.00e-12 61.20
IUUC-Mga-059468 Meleagris gallopavo 53.26 3.00e-24 100.00
IUUC-Mvi-060235 Microbotryum violaceum 59.38 1.00e-15 73.90
IUUC-Mdo-061948 Monodelphis domestica 53.06 7.00e-27 110.00
IUUC-Mmu-063946 Mus musculus 54.17 3.00e-26 107.00
IUUC-Mac-064812 Musa acuminata 53.01 1.00e-22 95.90
IUUC-Mpu-066763 Mustela putorius furo 52.04 9.00e-26 106.00
IUUC-Mlu-066970 Myotis lucifugus 53.33 3.00e-19 84.00
IUUC-Ncr-068824 Neurospora crassa 48.04 1.00e-23 99.40
IUUC-Nle-069849 Nomascus leucogenys 53.33 6.00e-19 84.30
IUUC-Opr-070227 Ochotona princeps 53.06 5.00e-26 107.00
IUUC-Ont-072530 Oreochromis niloticus 53.06 7.00e-26 106.00
IUUC-Oan-073191 Ornithorhynchus anatinus 53.33 8.00e-24 99.80
IUUC-Ocu-074460 Oryctolagus cuniculus 51.02 2.00e-25 105.00
IUUC-Oba-075499 Oryza barthii 51.81 3.00e-22 95.50
IUUC-Obr-076896 Oryza brachyantha 54.76 7.00e-23 98.60
IUUC-Ogl-077834 Oryza glaberrima 51.81 1.00e-22 95.90
IUUC-Ogu-078622 Oryza glumaepatula 51.81 1.00e-22 95.90
IUUC-Oin-079358 Oryza indica 51.81 4.00e-22 95.90
IUUC-Olo-081035 Oryza longistaminata 51.55 7.00e-25 104.00
IUUC-Oni-082425 Oryza nivara 51.81 1.00e-22 95.90
IUUC-Opu-083461 Oryza punctata 52.44 5.00e-22 95.10
IUUC-Oru-084875 Oryza rufipogon 55.88 9.00e-20 85.90
IUUC-Oga-089128 Otolemur garnettii 52.04 5.00e-26 107.00
IUUC-Oar-089896 Ovis aries 52.04 1.00e-25 105.00
IUUC-Ptr-091618 Pan troglodytes 53.33 1.00e-13 66.60
IUUC-Pan-092238 Papio anubis 46.24 2.00e-19 85.90
IUUC-Psi-093879 Pelodiscus sinensis 54.26 3.00e-25 104.00
IUUC-Pma-094484 Petromyzon marinus 56.25 2.00e-21 92.00
IUUC-Ppa-095801 Physcomitrella patens 51.81 5.00e-23 97.10
IUUC-Pfo-097192 Poecilia formosa 55.10 7.00e-26 106.00
IUUC-Pab-098203 Pongo abelii 53.06 3.00e-20 88.20
IUUC-Pop-099614 Populus trichocarpa 55.56 7.00e-24 99.80
IUUC-Pca-100507 Procavia capensis 52.00 5.00e-19 83.60
IUUC-Ppe-101174 Prunus persica 56.57 9.00e-31 122.00
IUUC-Pva-102735 Pteropus vampyrus 52.04 1.00e-22 95.90
IUUC-Pgr-103510 Puccinia graminis 38.10 1.00e-12 63.20
IUUC-Ptt-103918 Puccinia triticina 37.14 7.00e-13 63.90
IUUC-Pte-104173 Pyrenophora teres 48.51 2.00e-24 102.00
IUUC-Pyt-104806 Pyrenophora triticirepentis 47.52 9.00e-24 99.80
IUUC-Rno-105820 Rattus norvegicus 53.12 1.00e-25 105.00
IUUC-Sce-106366 Saccharomyces cerevisiae 40.59 7.00e-19 83.60
IUUC-Sja-107727 Schizosaccharomyces japonicus 40.21 3.00e-15 71.60
IUUC-Spo-108074 Schizosaccharomyces pombe 42.57 2.00e-12 61.60
IUUC-Smo-108944 Selaginella moellendorffii 56.67 1.00e-25 105.00
IUUC-Sit-110277 Setaria italica 54.22 1.00e-24 102.00
IUUC-Sly-111505 Solanum lycopersicum 56.79 1.00e-24 102.00
IUUC-Stu-112076 Solanum tuberosum 55.56 4.00e-24 100.00
IUUC-Sbi-114274 Sorghum bicolor 48.86 9.00e-24 99.80
IUUC-Sre-114953 Sporisorium reilianum 51.96 9.00e-24 99.80
IUUC-Ssc-115418 Sus scrofa 51.02 1.00e-25 105.00
IUUC-Tgu-117311 Taeniopygia guttata 54.35 1.00e-24 102.00
IUUC-Tru-118598 Takifugu rubripes 56.04 4.00e-24 100.00
IUUC-Tni-120109 Tetraodon nigroviridis 55.56 1.00e-24 102.00
IUUC-Tca-120942 Theobroma cacao 53.09 2.00e-24 101.00
IUUC-Tre-122099 Trichoderma reesei 47.87 3.00e-17 77.80
IUUC-Tvi-122285 Trichoderma virens 46.53 3.00e-19 85.10
IUUC-Tae-125193 Triticum aestivum 53.01 4.00e-23 97.40
IUUC-Tur-126677 Triticum urartu 46.32 2.00e-20 89.00
IUUC-Tme-127120 Tuber melanosporum 47.52 4.00e-23 97.80
IUUC-Tbe-128050 Tupaia belangeri 40.82 6.00e-14 67.00
IUUC-Ttr-129019 Tursiops truncatus 51.02 1.00e-25 105.00
IUUC-Uma-129483 Ustilago maydis 50.00 5.00e-23 97.40
IUUC-Vda-129690 Verticillium dahliae 35.71 2.00e-13 65.50
IUUC-Vvi-131174 Vitis vinifera 56.79 9.00e-25 102.00
IUUC-Xma-133862 Xiphophorus maculatus 55.10 7.00e-26 106.00
IUUC-Yli-134398 Yarrowia lipolytica 40.40 7.00e-18 80.10
IUUC-Zma-134964 Zea mays 49.41 5.00e-22 94.00
Created Date 25-Jun-2017

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