iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Xtr-132477

Ensembl Protein ID

ENSXETP00000003085.3

UniProt Accession

F7BN18; F7BN18_XENTR

Genbank Protein ID

ENSXETP00000003085

Protein Name

Tyrosine-protein kinase

Genbank Nucleotide ID

AAMC01054380

Gene Name

abl1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSXETG00000001464.3	ENSXETT00000003085.3	ENSXETP00000003085.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	2.60e-14	53.1	63	120

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 3    kekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
            +++ +lyd+ a+ d++L+++kG++++v+  ++++++W+++  ++++ +G +P+n+++ ++
   Q: 63   PNLFVALYDFVASGDNTLSITKGEKLRVL-GYNHNGEWCEA--QTKNGQGWVPSNYITPVN 120
           68899************************.***********..79999**********997 PP

Organism

Xenopus tropicalis

Protein Sequence
(Fasta)

MLEICLKLVG CKSKKGLSSS SSCYLEEALQ RPTVSDIEPQ GLSEAARWNS KENLLSGPSE 60
NDPNLFVALY DFVASGDNTL SITKGEKLRV LGYNHNGEWC EAQTKNGQGW VPSNYITPVN 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGTTGGAAA TCTGCTTGAA GTTGGTGGGT TGCAAATCCA AGAAAGGGCT CTCCTCGTCC 60
TCCAGCTGCT ATCTCGAAGG TGAGATAAGG GGGTGTCAGT GGGGAAAAGG GGTTGGGCGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0808--Transferase
KW-0829--Tyrosine-protein kinase

Interpro

IPR033221--ABL1
IPR015015--F-actin_binding
IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR000980--SH2
IPR001452--SH3_domain
IPR008266--Tyr_kinase_AS
IPR020635--Tyr_kinase_cat_dom

PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00109--PROTEIN_KINASE_TYR
PS50001--SH2
PS50002--SH3

Pfam

PF08919--F_actin_bind
PF07714--Pkinase_Tyr
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00401--SH2DOMAIN
PR00109--TYRKINASE

SMART

SM00808--FABD
SM00252--SH2
SM00326--SH3
SM00219--TyrKc

Gene Ontology

GO:0031234--C:extrinsic component of cytoplasmic side of plasma membrane
GO:0005524--F:ATP binding
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity
GO:0005102--F:receptor binding
GO:0030154--P:cell differentiation
GO:0045087--P:innate immune response
GO:0038083--P:peptidyl-tyrosine autophosphorylation
GO:0032956--P:regulation of actin cytoskeleton organization
GO:0042127--P:regulation of cell proliferation
GO:0007169--P:transmembrane receptor protein tyrosine kinase signaling pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001550	Ailuropoda melanoleuca	66.01	0.00e+00	1205.00
IUUC-Apl-003452	Anas platyrhynchos	69.54	0.00e+00	1286.00
IUUC-Aca-005312	Anolis carolinensis	72.78	0.00e+00	1111.00
IUUC-Ame-011903	Astyanax mexicanus	68.74	0.00e+00	927.00
IUUC-Bta-012351	Bos taurus	72.85	0.00e+00	1123.00
IUUC-Cja-019491	Callithrix jacchus	66.94	0.00e+00	1252.00
IUUC-Cfa-021256	Canis familiaris	66.10	0.00e+00	1274.00
IUUC-Cpo-022046	Cavia porcellus	74.78	0.00e+00	1127.00
IUUC-Csa-023046	Chlorocebus sabaeus	67.84	0.00e+00	1274.00
IUUC-Dre-028190	Danio rerio	69.87	0.00e+00	898.00
IUUC-Dno-029853	Dasypus novemcinctus	71.38	0.00e+00	1093.00
IUUC-Eca-033720	Equus caballus	64.55	0.00e+00	1231.00
IUUC-Eeu-035173	Erinaceus europaeus	70.62	0.00e+00	1015.00
IUUC-Fca-035967	Felis catus	73.66	0.00e+00	1095.00
IUUC-Fal-036723	Ficedula albicollis	69.39	0.00e+00	1281.00
IUUC-Gmo-039550	Gadus morhua	71.15	0.00e+00	964.00
IUUC-Gga-040481	Gallus gallus	76.31	0.00e+00	1092.00
IUUC-Gac-041643	Gasterosteus aculeatus	68.30	0.00e+00	984.00
IUUC-Ggo-045299	Gorilla gorilla	66.07	0.00e+00	1255.00
IUUC-Hsa-047033	Homo sapiens	94.67	5.00e-40	154.00
IUUC-Itr-047935	Ictidomys tridecemlineatus	74.82	0.00e+00	1101.00
IUUC-Lch-050530	Latimeria chalumnae	71.38	0.00e+00	1086.00
IUUC-Laf-053609	Loxodonta africana	74.44	0.00e+00	1073.00
IUUC-Mcc-055654	Macaca mulatta	67.17	0.00e+00	1266.00
IUUC-Mga-059270	Meleagris gallopavo	69.08	0.00e+00	1283.00
IUUC-Mmr-060593	Microcebus murinus	72.08	0.00e+00	1110.00
IUUC-Mdo-062227	Monodelphis domestica	78.44	0.00e+00	1055.00
IUUC-Mmu-064002	Mus musculus	71.60	0.00e+00	1138.00
IUUC-Mpu-066197	Mustela putorius furo	74.09	0.00e+00	1115.00
IUUC-Mlu-067255	Myotis lucifugus	66.22	0.00e+00	1256.00
IUUC-Nle-069977	Nomascus leucogenys	69.18	0.00e+00	972.00
IUUC-Ont-072307	Oreochromis niloticus	59.50	0.00e+00	1078.00
IUUC-Oan-073100	Ornithorhynchus anatinus	72.81	0.00e+00	1147.00
IUUC-Ocu-074892	Oryctolagus cuniculus	71.26	0.00e+00	996.00
IUUC-Ola-087389	Oryzias latipes	66.50	0.00e+00	937.00
IUUC-Oga-088145	Otolemur garnettii	76.21	0.00e+00	1092.00
IUUC-Oar-090432	Ovis aries	73.73	0.00e+00	1108.00
IUUC-Ptr-090800	Pan troglodytes	66.76	0.00e+00	1267.00
IUUC-Psi-093078	Pelodiscus sinensis	67.90	0.00e+00	1313.00
IUUC-Pfo-096979	Poecilia formosa	64.32	0.00e+00	914.00
IUUC-Pca-100874	Procavia capensis	95.52	0.00e+00	651.00
IUUC-Pva-102415	Pteropus vampyrus	74.15	0.00e+00	1107.00
IUUC-Rno-105370	Rattus norvegicus	72.87	0.00e+00	1143.00
IUUC-Sha-106711	Sarcophilus harrisii	75.94	0.00e+00	1108.00
IUUC-Ssc-115472	Sus scrofa	75.55	0.00e+00	1093.00
IUUC-Tgu-117037	Taeniopygia guttata	74.13	0.00e+00	1130.00
IUUC-Tru-118324	Takifugu rubripes	66.83	0.00e+00	940.00
IUUC-Tsy-119216	Tarsius syrichta	83.49	0.00e+00	909.00
IUUC-Tni-119950	Tetraodon nigroviridis	66.17	0.00e+00	915.00
IUUC-Ttr-128209	Tursiops truncatus	72.20	0.00e+00	1118.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence