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Tag Content
UUCD2 ID IUUC-Mcc-055491
UUCD1 version UUC-MaM-01108
Ensembl Protein ID ENSMMUP00000007804.3
UniProt Accession F6V497; F6V497_MACMU
Genbank Protein ID ENSMMUP00000007804
Protein Name Ubiquitinyl hydrolase 1
Genbank Nucleotide ID JSUE03031651
Gene Name USP45
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMMUG00000005929.3 ENSMMUT00000008303.3 ENSMMUP00000007804.3
ENSMMUG00000005929.3 ENSMMUT00000072006.1 ENSMMUP00000054491.1
Status Unreviewed
Classification
Family E-Value Score Start End
DUB/USP 2.30e-85 287.9 192 765
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   DUB/USP
   S: 2    GlkNlgNtCYmNSvLQcLsnipelrellle..kkkeklneenp..............kepkgellkslqklfeelwkskkkavsprell 74
           G++NlgNtC++N+v+Q L+++  l++ ++e  +  ++++ +                 ++ g+l+++l  +++++ +++k+  sp+ l+
   Q: 192  GITNLGNTCFFNAVMQNLAQTYTLTDRMNEikE--SSTKLK-IfpssdsqldplvveLSRPGPLTSALFLFLHSMKETEKGPLSPNVLF 277
           9*****************************542..333222.23445566666777777777*************************** PP
   S: 75   kalkkeaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsde......aeekkkkknkslisdlFqgqlksqikcl 157
           ++l+++a++f+ ++qqD+qE+l++lld++++e +k+ + ++ +++++ ++++ d+      + + k+  + ++i+++F g+l+s+++c+
   Q: 278  NQLCQKAPRFKDFQQQDSQELLHYLLDAVRTEETKRIQASILKAFNNPTTKTADDetrkkvKAYGKEGVKMNFIDRIFIGELTSTVMCE 366
           *********************************99888888888888877777773443335555555555****************** PP
   S: 158  ecdnvssreepfldlslpvpgkeetkke............................................................. 185
           ec+n+s+ ++pf+d+slp+ +++++                                                                
   Q: 367  ECANISTVKDPFIDISLPIIEERSQLIHdrkcirklsgetvvtyqkkenlemngdslmfarlmnsesplnesptddsekeashsesnvd 455
           ********************999876669************************************************************ PP
   S: 186  ......................................................................................... 185
                                                                                                    
   Q: 456  adseasesesaskqtelfrsssgsgvhtdgplyppsagelvynketdsgdkqmaeaiselhlrstvtghqdfdrenqplsisnnlcfle 544
           ***************************************************************************************** PP
   S: 186  ...........................slqdcLesftkeeelegenkyycekckkkqe...................aekklklkklPe 228
                                      s+q+cL +ft+ e l g+nk+ ce+c+k+++                   a+k+l ++ +P 
   Q: 545  gkhlrphspqnafqtlsqtyittskecSVQSCLYQFTSMELLMGNNKLLCENCTKNKQkyqeetsfaekkvegvytnARKQLLISAVPA 633
           ******************************************************88888999999999999999999************ PP
   S: 229  vLilhLkRfsfseeqksrekinkkvefpleLdlspfctspeekqke..kkkYeLiavvvHsGslssGHYvayvkn.............. 301
           vLilhLkRf  ++++ s +k+n++v+fpl+Ldl+pfc+ ++++ +   k+ Y L+++v HsGs+++GHY+ayvk               
   Q: 634  VLILHLKRF--HQAGLSLRKVNRHVDFPLMLDLAPFCSATCKNASMgdKVLYGLYGIVEHSGSMREGHYTAYVKVrtpsrklsehptkk 720
           *********..9999************************8877655669**************************99999999999999 PP
   S: 302  ............ekgkWllfdDskVtevkeeevleetgstaYvlfYkr 337
                       + g+W++++D++V++v+e++ l+   ++aY+lfY+r
   Q: 721  ksvpglkeadseSAGQWVHVSDTYVQVVPESRALS---AQAYLLFYER 765
           9999999888877888*******************...********98 PP
   
Organism Macaca mulatta
Protein Sequence
(Fasta)
MRVKDPSKAL PEKAKRSKRP TVPHEEDSSD DIAVGLTCQH VSHAISVNHV KRAIAENLWS 60
VCSECLKERR FYDGQPVLPS DIWLCLKCGF QGCGKNSESQ HSLKHFKNSR IEPHCIIINL 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mcc-055491|DUB,USP|Macaca mulatta
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CAGCGGCGGT GTGGTCGCCG CAGTTTCTCG GTCTTCGCTT TGGCGACCTT GACCCGCTTG 60
TGGGTGGGCG AGGCTGGAAG AGAGGCTCCC CACCCCCCTC GGCTTCCCGA TCCCTGGGGG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mcc-055491|DUB,USP|Macaca mulatta
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP
PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP
Pfam

PF00443--UCH
PF02148--zf-UBP
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0006281--P:DNA repair
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002331 Ailuropoda melanoleuca 79.20 1.00e-169 590.00
IUUC-Apl-003512 Anas platyrhynchos 64.68 0.00e+00 999.00
IUUC-Aca-004284 Anolis carolinensis 58.92 0.00e+00 906.00
IUUC-Ame-010735 Astyanax mexicanus 60.69 1.00e-85 310.00
IUUC-Bta-012880 Bos taurus 77.90 0.00e+00 1192.00
IUUC-Cja-019144 Callithrix jacchus 87.25 0.00e+00 1415.00
IUUC-Cfa-020971 Canis familiaris 84.58 0.00e+00 680.00
IUUC-Cpo-022497 Cavia porcellus 66.67 0.00e+00 1021.00
IUUC-Csa-023910 Chlorocebus sabaeus 92.36 0.00e+00 1416.00
IUUC-Cho-024358 Choloepus hoffmanni 65.59 2.00e-98 352.00
IUUC-Dre-028106 Danio rerio 61.22 2.00e-143 503.00
IUUC-Dno-029456 Dasypus novemcinctus 70.22 0.00e+00 635.00
IUUC-Dor-030438 Dipodomys ordii 60.71 0.00e+00 871.00
IUUC-Dme-031870 Drosophila melanogaster 47.31 2.00e-35 145.00
IUUC-Ete-032736 Echinops telfairi 61.42 0.00e+00 887.00
IUUC-Eca-034211 Equus caballus 78.27 0.00e+00 1244.00
IUUC-Eeu-034797 Erinaceus europaeus 86.67 1.00e-76 280.00
IUUC-Fca-035947 Felis catus 73.95 0.00e+00 1068.00
IUUC-Fal-037199 Ficedula albicollis 64.34 0.00e+00 876.00
IUUC-Gmo-039228 Gadus morhua 60.76 3.00e-140 492.00
IUUC-Gga-040823 Gallus gallus 57.17 6.00e-143 501.00
IUUC-Gac-042406 Gasterosteus aculeatus 60.25 1.00e-132 466.00
IUUC-Ggo-045402 Gorilla gorilla 89.34 0.00e+00 1447.00
IUUC-Hsa-046430 Homo sapiens 88.96 0.00e+00 1448.00
IUUC-Itr-048855 Ictidomys tridecemlineatus 74.31 0.00e+00 671.00
IUUC-Lch-049547 Latimeria chalumnae 56.00 0.00e+00 858.00
IUUC-Loc-052842 Lepisosteus oculatus 65.65 5.00e-156 545.00
IUUC-Laf-053988 Loxodonta africana 77.68 0.00e+00 1248.00
IUUC-Meu-056256 Macropus eugenii 63.78 2.00e-120 426.00
IUUC-Mtr-057945 Medicago truncatula 31.58 4.00e-34 140.00
IUUC-Mla-059026 Melampsora laricipopulina 31.22 2.00e-16 80.90
IUUC-Mga-059833 Meleagris gallopavo 53.99 1.00e-143 503.00
IUUC-Mmr-060952 Microcebus murinus 80.20 0.00e+00 1250.00
IUUC-Mdo-062642 Monodelphis domestica 66.91 0.00e+00 1011.00
IUUC-Mmu-063945 Mus musculus 73.72 0.00e+00 1150.00
IUUC-Mpu-065944 Mustela putorius furo 71.27 0.00e+00 1082.00
IUUC-Mlu-067049 Myotis lucifugus 77.32 0.00e+00 1176.00
IUUC-Nle-069828 Nomascus leucogenys 89.23 0.00e+00 1445.00
IUUC-Opr-070672 Ochotona princeps 70.54 1.00e-142 500.00
IUUC-Ont-072121 Oreochromis niloticus 59.84 9.00e-129 454.00
IUUC-Oan-073656 Ornithorhynchus anatinus 60.94 0.00e+00 954.00
IUUC-Ocu-074323 Oryctolagus cuniculus 77.26 0.00e+00 1187.00
IUUC-Ola-087238 Oryzias latipes 60.15 2.00e-143 503.00
IUUC-Oga-088379 Otolemur garnettii 74.64 0.00e+00 1185.00
IUUC-Oar-089718 Ovis aries 78.14 0.00e+00 1197.00
IUUC-Ptr-091358 Pan troglodytes 89.20 0.00e+00 1451.00
IUUC-Pan-092023 Papio anubis 93.74 0.00e+00 1526.00
IUUC-Psi-093256 Pelodiscus sinensis 63.35 0.00e+00 923.00
IUUC-Ppa-095584 Physcomitrella patens 29.36 3.00e-35 144.00
IUUC-Pfo-097285 Poecilia formosa 53.50 5.00e-114 405.00
IUUC-Pab-098539 Pongo abelii 89.58 0.00e+00 1451.00
IUUC-Pop-099588 Populus trichocarpa 32.09 6.00e-34 139.00
IUUC-Pca-100610 Procavia capensis 62.69 0.00e+00 838.00
IUUC-Pva-102985 Pteropus vampyrus 90.00 0.00e+00 696.00
IUUC-Rno-105538 Rattus norvegicus 73.11 0.00e+00 1154.00
IUUC-Sha-107022 Sarcophilus harrisii 73.46 5.00e-169 588.00
IUUC-Sja-107712 Schizosaccharomyces japonicus 28.21 1.00e-21 98.20
IUUC-Sar-113637 Sorex araneus 67.32 0.00e+00 993.00
IUUC-Ssc-115870 Sus scrofa 77.14 0.00e+00 1233.00
IUUC-Tgu-116907 Taeniopygia guttata 65.45 0.00e+00 1013.00
IUUC-Tru-117835 Takifugu rubripes 52.37 3.00e-103 369.00
IUUC-Tsy-118869 Tarsius syrichta 73.96 0.00e+00 1143.00
IUUC-Tni-119716 Tetraodon nigroviridis 64.53 3.00e-88 319.00
IUUC-Tbe-128041 Tupaia belangeri 65.16 0.00e+00 935.00
IUUC-Ttr-128901 Tursiops truncatus 76.41 0.00e+00 1192.00
IUUC-Vpa-130331 Vicugna pacos 77.67 0.00e+00 1118.00
IUUC-Xtr-131794 Xenopus tropicalis 64.34 4.00e-143 502.00
Created Date 25-Jun-2017

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