iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Pan-091729

Ensembl Protein ID

ENSPANP00000009724.1

UniProt Accession

A0A096NAK2; A0A096NAK2_PAPAN

Genbank Protein ID

ENSPANP00000009724

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AHZZ01101308

Gene Name

CUL4B

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPANG00000000965.1	ENSPANT00000023040.1	ENSPANP00000009724.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/Cullin	4.10e-221	736.0	206	801

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/Cullin

   S: 1    klreavkkilrqesvkkeyeelytavynlclskvgaklYkklkevleefi.kqvkkkveesedeq.lLktynreWekfreqlkvlrkif 87
           kl+eav++i++++s+k+++eely+av+nlc++k++a+lYk+l++++e++i +q+++ +e+s d+  +Lk++ r+W+++++q+ ++r+if
   Q: 206  KLKEAVEAIQNSTSIKYNLEELYQAVENLCSYKISANLYKQLRQICEDHIkAQIHQFREDSLDSVlFLKKIDRCWQNHCRQMIMIRSIF 294
           589***********************************************99************************************* PP
   S: 88   ayldrtyvkkskkvsevrkLaldlwrkeived..ikkrllelllklieaeRkgeavdrrllsgvveslveLslnklaiykesFEakfle 174
           ++ldrtyv +++++ ++++++l+l+r +i++d  +++++++ +l lie+eR+gea+dr+ll+++ ++l++L     +iy++sFE++fle
   Q: 295  LFLDRTYVLQNSMLPSIWDMGLELFRAHIISDqkVQNKTIDGILLLIERERNGEAIDRSLLRSLLSMLSDL-----QIYQDSFEQRFLE 378
           ********************************9**********************************9998.....9************ PP
   S: 175  atqefykaesaeflqenevdeYlkkvearlneeeeraaryleestetkLlevvekeliakhlesll.aelvallrdkktedlsrmykLl 262
           +t+++y+ae ++++qe+ev eYl++v++rl+ee +r+ +yl+++t+++L+++vek+l+ +hl+++l ++l++ll++++ +dls++y+L+
   Q: 379  ETNRLYAAEGQKLMQEREVPEYLHHVNKRLEEEADRLITYLDQTTQKSLIATVEKQLLGEHLTAILqKGLNNLLDENRIQDLSLLYQLF 467
           ****************************************************************9989********************* PP
   S: 263  srvlngleellkeleshikeqgkaaltaeekekdpkkyVerllelknklqklvseaFnndakFlkaldkafetfvnknsvlkaaksp.E 350
           srv+ g++ ll+++ ++ik  g+++++++ek+k+   +V++ll++k+k++++++ +F +++kF++a+++afetf+nk+     +++p E
   Q: 468  SRVRGGVQVLLQQWIEYIKAFGSTIVINPEKDKT---MVQELLDFKDKVDHIIDICFLKNEKFINAMKEAFETFINKR-----PNKPaE 548
           **********************************...*****************************************.....66666* PP
   S: 351  llAryiDqlLrksskglteeeleaqldkvllvfkyisekdvFekyYkkhLakRLlsgksasseaEesviekLkeecgaeftskLerMfq 439
           l+A+y+D++Lr+++k++t+eele++ldk++++f++i +kdvFe++Ykk+LakRLl+gksas +aE+s+++kLk+ecga+ftskLe+Mf+
   Q: 549  LIAKYVDSKLRAGNKEATDEELEKMLDKIMIIFRFIYGKDVFEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFK 637
           ***************************************************************************************** PP
   S: 440  dlkvSedlnrqFkeekenteesesvelsvlvLsagaWptasetekvsLPaelektiekfeefYlekhsgRkLqWqhtlgraelkaelkk 528
           d+++S+d+++qFk+ ++n++   ++el+v++L++g+Wpt+  +e v+LP+e+ k++e+f++fYl khsgRkLqWq tlg++ lkae+k+
   Q: 638  DMELSKDIMIQFKQYMQNQNVPGNIELTVNILTMGYWPTYVPME-VHLPPEMVKLQEIFKTFYLGKHSGRKLQWQSTLGHCVLKAEFKE 725
           ******************************************99.******************************************** PP
   S: 529  gkyelqVstfQmavLLafnnsekvsveelkkatelpeeeLrrtlqsLvsskkqvlkkepeskeieeedlfsvNqef 604
           gk+elqVs fQ++vLL+fn+ e++s+ee+k+at++++ eLrrtlqsL+++k++vl k+p++k+ie++d+f++N++f
   Q: 726  GKKELQVSLFQTLVLLMFNEGEEFSLEEIKQATGIEDGELRRTLQSLACGKARVLAKNPKGKDIEDGDKFICNDDF 801
           **************************************************************************98 PP

Organism

Papio anubis

Protein Sequence
(Fasta)

MKSVCPVTSG FSSPSPSAAA AAQEVRSATD GNTSTTPPTS AKKRKLNSSS SSSSNSSNER 60
EDFDSTSSSS STPPLQPRDS ASPSTSSFCL GVSVAASSHV PIQKKLRFED TLEFVGFDAK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTTCCCGCTC CTCCCCGTTT CTCCCGCCAC CCCCCCCACC CCCTCGCCTT CAGAAAGCTC 60
CAATCAGGAG CTCCAAAGGT GTCTCGAAGG CCCGCCCCCT CCTCCCATCC ACTTTTCTTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR016157--Cullin_CS
IPR016158--Cullin_homology
IPR001373--Cullin_N
IPR019559--Cullin_neddylation_domain
IPR016159--Cullin_repeat-like_dom
IPR011991--WHTH_DNA-bd_dom

PROSITE

PS01256--CULLIN_1
PS50069--CULLIN_2

Pfam

PF00888--Cullin
PF10557--Cullin_Nedd8

SMART

SM00182--CULLIN
SM00884--Cullin_Nedd8

Gene Ontology

GO:0031465--C:Cul4B-RING E3 ubiquitin ligase complex
GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0005654--C:nucleoplasm
GO:0003684--F:damaged DNA binding
GO:0035518--P:histone H2A monoubiquitination
GO:1900087--P:positive regulation of G1/S transition of mitotic cell cycle
GO:0045732--P:positive regulation of protein catabolic process
GO:0006511--P:ubiquitin-dependent protein catabolic process
GO:0070914--P:UV-damage excision repair

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000285	Aegilops tauschii	57.75	0.00e+00	830.00
IUUC-Aml-002062	Ailuropoda melanoleuca	99.33	0.00e+00	1717.00
IUUC-Atr-002727	Amborella trichopoda	57.31	0.00e+00	808.00
IUUC-Apl-004157	Anas platyrhynchos	94.08	0.00e+00	1512.00
IUUC-Aca-004430	Anolis carolinensis	92.29	0.00e+00	1456.00
IUUC-Aly-006547	Arabidopsis lyrata	58.98	0.00e+00	813.00
IUUC-Ath-006748	Arabidopsis thaliana	57.09	0.00e+00	809.00
IUUC-Ame-011580	Astyanax mexicanus	84.46	0.00e+00	1425.00
IUUC-Bta-013244	Bos taurus	98.23	0.00e+00	1676.00
IUUC-Bdi-014223	Brachypodium distachyon	55.18	0.00e+00	827.00
IUUC-Bol-016036	Brassica oleracea	58.21	0.00e+00	833.00
IUUC-Bra-017794	Brassica rapa	57.74	0.00e+00	835.00
IUUC-Cja-019180	Callithrix jacchus	99.78	0.00e+00	1709.00
IUUC-Cfa-021189	Canis familiaris	99.55	0.00e+00	1703.00
IUUC-Cpo-021928	Cavia porcellus	98.99	0.00e+00	1666.00
IUUC-Cre-022739	Chlamydomonas reinhardtii	46.35	1.00e-175	610.00
IUUC-Csa-023831	Chlorocebus sabaeus	100.00	0.00e+00	1729.00
IUUC-Cho-024959	Choloepus hoffmanni	96.55	0.00e+00	1016.00
IUUC-Cgl-026761	Colletotrichum gloeosporioides	39.85	8.00e-127	447.00
IUUC-Dre-027916	Danio rerio	88.90	0.00e+00	1420.00
IUUC-Dno-029483	Dasypus novemcinctus	89.67	0.00e+00	1544.00
IUUC-Dse-031159	Dothistroma septosporum	36.64	3.00e-123	436.00
IUUC-Ete-032775	Echinops telfairi	87.19	0.00e+00	1388.00
IUUC-Eca-033952	Equus caballus	97.01	0.00e+00	1664.00
IUUC-Eeu-034767	Erinaceus europaeus	92.86	0.00e+00	1494.00
IUUC-Fca-036211	Felis catus	98.47	0.00e+00	1519.00
IUUC-Fal-037248	Ficedula albicollis	94.88	0.00e+00	1514.00
IUUC-Gmo-038754	Gadus morhua	88.38	0.00e+00	1405.00
IUUC-Ggr-040003	Gaeumannomyces graminis	36.82	2.00e-106	380.00
IUUC-Gga-041002	Gallus gallus	90.43	0.00e+00	1518.00
IUUC-Gac-041555	Gasterosteus aculeatus	85.45	0.00e+00	1400.00
IUUC-Gma-043960	Glycine max	59.80	0.00e+00	847.00
IUUC-Ggo-045468	Gorilla gorilla	99.88	0.00e+00	1644.00
IUUC-Hsa-046848	Homo sapiens	99.89	0.00e+00	1711.00
IUUC-Itr-048365	Ictidomys tridecemlineatus	98.78	0.00e+00	1683.00
IUUC-Lch-049858	Latimeria chalumnae	86.45	0.00e+00	1490.00
IUUC-Lpe-051446	Leersia perrieri	56.75	0.00e+00	823.00
IUUC-Loc-052415	Lepisosteus oculatus	86.88	0.00e+00	1435.00
IUUC-Lma-053080	Leptosphaeria maculans	36.85	2.00e-135	476.00
IUUC-Laf-053701	Loxodonta africana	98.45	0.00e+00	1696.00
IUUC-Mcc-055538	Macaca mulatta	97.87	0.00e+00	1663.00
IUUC-Mor-057102	Magnaporthe oryzae	36.59	1.00e-118	421.00
IUUC-Mpo-057342	Magnaporthe poae	37.77	2.00e-104	373.00
IUUC-Mtr-058660	Medicago truncatula	57.97	0.00e+00	835.00
IUUC-Mla-058936	Melampsora laricipopulina	39.91	2.00e-114	406.00
IUUC-Mga-059754	Meleagris gallopavo	90.23	0.00e+00	1511.00
IUUC-Mvi-060455	Microbotryum violaceum	41.96	5.00e-146	511.00
IUUC-Mmr-060870	Microcebus murinus	98.78	0.00e+00	1701.00
IUUC-Mdo-062015	Monodelphis domestica	91.70	0.00e+00	1479.00
IUUC-Mmu-063751	Mus musculus	95.91	0.00e+00	1627.00
IUUC-Mac-064443	Musa acuminata	57.24	0.00e+00	841.00
IUUC-Mpu-065903	Mustela putorius furo	99.33	0.00e+00	1722.00
IUUC-Mlu-068213	Myotis lucifugus	98.21	0.00e+00	1678.00
IUUC-Nle-069480	Nomascus leucogenys	100.00	0.00e+00	1729.00
IUUC-Opr-071164	Ochotona princeps	91.77	0.00e+00	634.00
IUUC-Ont-071562	Oreochromis niloticus	81.83	0.00e+00	1261.00
IUUC-Oan-073607	Ornithorhynchus anatinus	94.64	0.00e+00	1491.00
IUUC-Ocu-074446	Oryctolagus cuniculus	99.56	0.00e+00	1721.00
IUUC-Oba-075198	Oryza barthii	57.02	0.00e+00	828.00
IUUC-Obr-076095	Oryza brachyantha	57.02	0.00e+00	828.00
IUUC-Ogl-077032	Oryza glaberrima	57.02	0.00e+00	828.00
IUUC-Ogu-078051	Oryza glumaepatula	57.46	0.00e+00	827.00
IUUC-Olo-080988	Oryza longistaminata	56.19	0.00e+00	818.00
IUUC-Ome-081600	Oryza meridionalis	56.19	0.00e+00	819.00
IUUC-Oni-082623	Oryza nivara	56.33	0.00e+00	820.00
IUUC-Opu-083762	Oryza punctata	56.06	0.00e+00	819.00
IUUC-Oru-084499	Oryza rufipogon	57.02	0.00e+00	828.00
IUUC-Ola-087157	Oryzias latipes	88.03	0.00e+00	1399.00
IUUC-Olu-087650	Ostreococcus lucimarinus	48.29	1.00e-180	626.00
IUUC-Oga-088416	Otolemur garnettii	96.81	0.00e+00	1601.00
IUUC-Oar-090230	Ovis aries	98.10	0.00e+00	1655.00
IUUC-Ptr-091153	Pan troglodytes	100.00	0.00e+00	1664.00
IUUC-Psi-093773	Pelodiscus sinensis	94.29	0.00e+00	1506.00
IUUC-Pma-094678	Petromyzon marinus	85.06	0.00e+00	1058.00
IUUC-Pno-094946	Phaeosphaeria nodorum	35.62	7.00e-113	401.00
IUUC-Ppa-095688	Physcomitrella patens	59.65	0.00e+00	885.00
IUUC-Pfo-096828	Poecilia formosa	89.00	0.00e+00	1420.00
IUUC-Pab-097816	Pongo abelii	91.43	0.00e+00	1530.00
IUUC-Pca-100858	Procavia capensis	78.59	0.00e+00	1247.00
IUUC-Ppe-101142	Prunus persica	59.94	0.00e+00	850.00
IUUC-Pva-102995	Pteropus vampyrus	92.47	0.00e+00	1573.00
IUUC-Ptt-103903	Puccinia triticina	41.16	4.00e-97	349.00
IUUC-Pte-104167	Pyrenophora teres	36.91	1.00e-134	473.00
IUUC-Pyt-104736	Pyrenophora triticirepentis	36.20	2.00e-133	470.00
IUUC-Rno-106119	Rattus norvegicus	96.57	0.00e+00	1639.00
IUUC-Sha-106958	Sarcophilus harrisii	87.28	0.00e+00	1501.00
IUUC-Sja-107940	Schizosaccharomyces japonicus	34.24	3.00e-112	399.00
IUUC-Spo-108109	Schizosaccharomyces pombe	34.18	7.00e-112	397.00
IUUC-Ssl-108537	Sclerotinia sclerotiorum	39.56	5.00e-129	455.00
IUUC-Smo-109313	Selaginella moellendorffii	60.00	0.00e+00	910.00
IUUC-Sit-110626	Setaria italica	58.03	0.00e+00	828.00
IUUC-Sly-111497	Solanum lycopersicum	60.23	0.00e+00	854.00
IUUC-Sar-113581	Sorex araneus	85.74	0.00e+00	1048.00
IUUC-Sbi-113931	Sorghum bicolor	58.03	0.00e+00	830.00
IUUC-Tgu-116462	Taeniopygia guttata	94.50	0.00e+00	1504.00
IUUC-Tru-118299	Takifugu rubripes	88.49	0.00e+00	1417.00
IUUC-Tsy-119517	Tarsius syrichta	100.00	0.00e+00	726.00
IUUC-Tni-120811	Tetraodon nigroviridis	87.10	0.00e+00	1391.00
IUUC-Tca-121626	Theobroma cacao	59.41	0.00e+00	844.00
IUUC-Tae-123442	Triticum aestivum	57.75	0.00e+00	829.00
IUUC-Tur-126032	Triticum urartu	57.75	0.00e+00	829.00
IUUC-Tme-127162	Tuber melanosporum	41.32	1.00e-140	494.00
IUUC-Tbe-127658	Tupaia belangeri	96.31	0.00e+00	1593.00
IUUC-Ttr-129112	Tursiops truncatus	90.57	0.00e+00	1503.00
IUUC-Vda-129701	Verticillium dahliae	39.28	4.00e-135	475.00
IUUC-Vpa-130217	Vicugna pacos	90.48	0.00e+00	1513.00
IUUC-Vvi-131133	Vitis vinifera	59.47	0.00e+00	853.00
IUUC-Xtr-132724	Xenopus tropicalis	91.76	0.00e+00	1461.00
IUUC-Xma-134149	Xiphophorus maculatus	89.24	0.00e+00	1432.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence