iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Oan-073307

UUCD1 version

UUC-OrA-00469

Ensembl Protein ID

ENSOANP00000009681.2

UniProt Accession

F7CH55; F7CH55_ORNAN

Protein Name

Uncharacterized protein

Gene Name

CUL2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOANG00000006068.3	ENSOANT00000009683.2	ENSOANP00000009681.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/Cullin	4.00e-205	683.3	17	538

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/Cullin

   S: 2    lreavkkilrqesv.kkeyeelytavynlclsk...vgaklYkklkevleefikqvkkkveesedeqlLktynreWekfreqlkvlrki 86
           l +++k++++ ++v +++++++++++y+lc+++   +g++lY ++k +le++++++++kv es +eq+L +y+r+We++++++++++++
   Q: 17   LLATIKAVVMLDYVeRATWNDRFSDIYALCVAYpepLGERLYAETKVFLENHVRHLHEKVLES-EEQVLVMYHRYWEEYSKGADYMDCL 104
           5679***********************************************************.566********************** PP
   S: 87   fayldrtyvkk.................skkvsevrkLaldlwrkeivedikkrllelllklieaeRkgeavdrrllsgvveslveLsl 158
           ++yl+++++kk                 ++ ++e+ +Lald+wrk ++e++++ l+++ll+ i+++R ge  ++++++gv++s+v++++
   Q: 105  YRYLNTQFIKKnklteadlqygyggvdtNEPLMEIGELALDMWRKLMIEPLQAVLIRMLLREIKNDRCGEDPNQKVIHGVINSFVHVEQ 193
           ***********999999999998888777777********************************************************9 PP
   S: 159  nk....laiykesFEakfleatqefykaesaeflqenevdeYlkkvearlneeeeraaryleestetkLlevvekeliakhlesllael 243
           +k    l++y+e FE +fl++t e+yk+e++++lqe+++++Y++kv  rl++ee r+++yl++s+++k++++++++++a+hl++l+ae+
   Q: 194  YKkkfpLKFYQEIFECPFLTETGEYYKQEASNLLQESHCSQYMEKVLGRLKDEEMRCRKYLHPSSYSKVIHECQQRMVADHLQFLHAEC 282
           999************************************************************************************** PP
   S: 244  vallrdkktedlsrmykLlsrvlngleellkeleshikeqgkaaltaeekekdpkkyVerllelknklqklvseaFnndakFlkaldka 332
           ++++r++k++d+++my Ll+ v+ gl ++++el++hi+++g++a+++  +e++p+++Ve++le+++k+ +l+++++n d++F++aldka
   Q: 283  HNIIRQEKRNDMANMYTLLRAVSSGLPHMIQELQNHIHDEGLRATSNLSQENMPTQFVESVLEVHSKFVQLINTVLNGDQHFMSALDKA 371
           ***************************************************************************************** PP
   S: 333  fetfvnknsvlkaakspEllAryiDqlLrksskglteeeleaqldkvllvfkyisekdvFekyYkkhLakRLlsgksasseaEesviek 421
           ++++vn ++ ++ +k+pEllA+y+D+lL+ks+kg+te+e+e++l+++++vfkyi++kdvF+k+Y+++LakRL++g+s+s+++Ee++i+k
   Q: 372  LTSVVNYREPKSICKAPELLAKYCDNLLKKSAKGMTENEVEDKLTSFITVFKYIDDKDVFQKFYARMLAKRLIHGLSMSMDSEEAMINK 460
           ***************************************************************************************** PP
   S: 422  LkeecgaeftskLerMfqdlkvSedlnrqFk..eekenteesesvelsvlvLsagaWpta.setekvsLPaelektie 496
           Lk++cg+eftskL+rM++d++vS dln++F+   ++++t ++ +++++++vL+agaWp + +  +++++P+elek+++
   Q: 461  LKQACGYEFTSKLHRMYTDMSVSADLNNKFNnfIKNQDTTIDLGISFQIYVLQAGAWPLTqAPSSTFAIPQELEKSVQ 538
           *******************************88799**********************99666689*********987 PP

Organism

Ornithorhynchus anatinus

Protein Sequence
(Fasta)

MSLKPRVVDF DETWNKLLAT IKAVVMLDYV ERATWNDRFS DIYALCVAYP EPLGERLYAE 60
TKVFLENHVR HLHEKVLESE EQVLVMYHRY WEEYSKGADY MDCLYRYLNT QFIKKNKLTE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AAAAAAAAAA AATTGATGAA ATGCTAAATT CATGTCAACA CTGTGACTTC TTTCAGACTT 60
CAACACTAAA ACCCCACGAT GTCCCTGAAA CCAAGAGTGG TGGATTTTGA TGAAACATGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR016158--Cullin_homology
IPR001373--Cullin_N
IPR019559--Cullin_neddylation_domain
IPR016159--Cullin_repeat-like_dom
IPR011991--WHTH_DNA-bd_dom

PROSITE

PS50069--CULLIN_2

Pfam

PF00888--Cullin
PF10557--Cullin_Nedd8

SMART

SM00182--CULLIN
SM00884--Cullin_Nedd8

Gene Ontology

GO:0031462--C:Cul2-RING ubiquitin ligase complex
GO:0005730--C:nucleolus
GO:0005654--C:nucleoplasm
GO:0031625--F:ubiquitin protein ligase binding
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001969	Ailuropoda melanoleuca	92.39	0.00e+00	1469.00
IUUC-Apl-004067	Anas platyrhynchos	93.44	0.00e+00	1484.00
IUUC-Aca-004534	Anolis carolinensis	89.41	0.00e+00	1443.00
IUUC-Ame-011695	Astyanax mexicanus	89.94	0.00e+00	1437.00
IUUC-Bta-013074	Bos taurus	92.26	0.00e+00	1467.00
IUUC-Cel-018431	Caenorhabditis elegans	41.81	4.00e-175	607.00
IUUC-Cja-019371	Callithrix jacchus	92.39	0.00e+00	1469.00
IUUC-Cfa-020508	Canis familiaris	92.13	0.00e+00	1464.00
IUUC-Cpo-021851	Cavia porcellus	91.35	0.00e+00	1451.00
IUUC-Csa-023583	Chlorocebus sabaeus	92.39	0.00e+00	1462.00
IUUC-Cho-024308	Choloepus hoffmanni	86.86	0.00e+00	647.00
IUUC-Cin-025350	Ciona intestinalis	44.92	0.00e+00	695.00
IUUC-Csv-026096	Ciona savignyi	40.44	0.00e+00	632.00
IUUC-Dre-028828	Danio rerio	88.77	0.00e+00	1409.00
IUUC-Dno-029709	Dasypus novemcinctus	91.74	0.00e+00	1461.00
IUUC-Dor-030319	Dipodomys ordii	78.15	0.00e+00	909.00
IUUC-Dme-031938	Drosophila melanogaster	48.23	0.00e+00	722.00
IUUC-Ete-032756	Echinops telfairi	84.21	0.00e+00	835.00
IUUC-Eca-034019	Equus caballus	92.00	0.00e+00	1461.00
IUUC-Eeu-034914	Erinaceus europaeus	90.54	0.00e+00	1008.00
IUUC-Fca-035926	Felis catus	92.26	0.00e+00	1467.00
IUUC-Fal-037627	Ficedula albicollis	93.16	0.00e+00	1479.00
IUUC-Gmo-038728	Gadus morhua	89.05	0.00e+00	1415.00
IUUC-Gga-040820	Gallus gallus	90.30	0.00e+00	1472.00
IUUC-Gac-041293	Gasterosteus aculeatus	88.53	0.00e+00	1409.00
IUUC-Ggo-045235	Gorilla gorilla	89.70	0.00e+00	1422.00
IUUC-Hsa-046819	Homo sapiens	92.39	0.00e+00	1468.00
IUUC-Itr-048063	Ictidomys tridecemlineatus	90.23	0.00e+00	781.00
IUUC-Lch-049443	Latimeria chalumnae	91.35	0.00e+00	1449.00
IUUC-Loc-052798	Lepisosteus oculatus	90.46	0.00e+00	1434.00
IUUC-Laf-053379	Loxodonta africana	92.26	0.00e+00	1469.00
IUUC-Mcc-055702	Macaca mulatta	92.39	0.00e+00	1467.00
IUUC-Meu-056223	Macropus eugenii	68.81	0.00e+00	957.00
IUUC-Mga-060034	Meleagris gallopavo	93.05	0.00e+00	1478.00
IUUC-Mmr-061090	Microcebus murinus	92.52	0.00e+00	1469.00
IUUC-Mdo-062530	Monodelphis domestica	92.26	0.00e+00	1467.00
IUUC-Mmu-063857	Mus musculus	90.58	0.00e+00	1419.00
IUUC-Mpu-065915	Mustela putorius furo	92.39	0.00e+00	1469.00
IUUC-Mlu-068049	Myotis lucifugus	92.26	0.00e+00	1467.00
IUUC-Nle-069102	Nomascus leucogenys	88.42	0.00e+00	1080.00
IUUC-Opr-071197	Ochotona princeps	80.80	0.00e+00	1204.00
IUUC-Ont-071902	Oreochromis niloticus	88.39	0.00e+00	1415.00
IUUC-Ocu-074703	Oryctolagus cuniculus	91.48	0.00e+00	1457.00
IUUC-Ola-086789	Oryzias latipes	88.93	0.00e+00	1420.00
IUUC-Oga-088480	Otolemur garnettii	91.87	0.00e+00	1458.00
IUUC-Oar-089899	Ovis aries	92.39	0.00e+00	1469.00
IUUC-Ptr-090965	Pan troglodytes	92.26	0.00e+00	1468.00
IUUC-Pan-092920	Papio anubis	88.80	0.00e+00	1397.00
IUUC-Psi-093122	Pelodiscus sinensis	93.42	0.00e+00	1479.00
IUUC-Pma-094656	Petromyzon marinus	75.13	0.00e+00	1208.00
IUUC-Pfo-096342	Poecilia formosa	88.77	0.00e+00	1418.00
IUUC-Pab-097544	Pongo abelii	92.39	0.00e+00	1470.00
IUUC-Pca-100564	Procavia capensis	89.34	0.00e+00	755.00
IUUC-Pva-102179	Pteropus vampyrus	84.32	0.00e+00	654.00
IUUC-Rno-105439	Rattus norvegicus	90.84	0.00e+00	1422.00
IUUC-Sha-106654	Sarcophilus harrisii	92.13	0.00e+00	1466.00
IUUC-Sar-113138	Sorex araneus	87.48	0.00e+00	1368.00
IUUC-Ssc-115543	Sus scrofa	91.48	0.00e+00	992.00
IUUC-Tgu-117095	Taeniopygia guttata	93.17	0.00e+00	1479.00
IUUC-Tru-118593	Takifugu rubripes	79.03	0.00e+00	1353.00
IUUC-Tsy-119621	Tarsius syrichta	86.96	0.00e+00	912.00
IUUC-Tni-119697	Tetraodon nigroviridis	88.65	0.00e+00	1410.00
IUUC-Tbe-127831	Tupaia belangeri	84.13	0.00e+00	1177.00
IUUC-Ttr-129108	Tursiops truncatus	92.39	0.00e+00	1469.00
IUUC-Vpa-130414	Vicugna pacos	85.13	0.00e+00	700.00
IUUC-Xtr-132054	Xenopus tropicalis	88.65	0.00e+00	1411.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence